ISMARA results: Sox3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox3_Sox10

Z-value: 1.18

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Transcription factors associated with Sox3_Sox10

Gene Symbol	Gene ID	Gene Info
Sox10 NCBI RGD Ensembl	ENSRNOG00000011305	SRY box 10

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox10	rn6_v1_chr7_-_120403523_120403523	0.73	1.4e-54	Click!

Activity profile of Sox3_Sox10 motif

Sorted Z-values of Sox3_Sox10 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_79406381 Show fit	111.88	ENSRNOT00000022303 ENSRNOT00000058295 ENSRNOT00000058296 ENSRNOT00000022280	Mbp NCBI RGD Ensembl Show fit	myelin basic protein
chr8_+_128824508 Show fit	94.44	ENSRNOT00000025343	Mobp NCBI RGD Ensembl Show fit	myelin-associated oligodendrocyte basic protein
chr3_+_35014538 Show fit	73.81	ENSRNOT00000006341	Kif5c NCBI RGD Ensembl Show fit	kinesin family member 5C
chr5_+_49311030 Show fit	71.41	ENSRNOT00000010850	Cnr1 NCBI RGD Ensembl Show fit	cannabinoid receptor 1
chr9_+_73334618 Show fit	63.70	ENSRNOT00000092717	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr3_-_44086006 Show fit	56.06	ENSRNOT00000034449 ENSRNOT00000082604	Ermn NCBI RGD Ensembl Show fit	ermin
chr7_-_136853957 Show fit	54.96	ENSRNOT00000008985	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2
chr16_-_39476025 Show fit	54.95	ENSRNOT00000014312	Gpm6a NCBI RGD Ensembl Show fit	glycoprotein m6a
chr5_+_64326733 Show fit	54.91	ENSRNOT00000065775	Tmeff1 NCBI RGD Ensembl Show fit	transmembrane protein with EGF-like and two follistatin-like domains 1
chr7_-_136853154 Show fit	53.79	ENSRNOT00000087376	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox3_Sox10

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	162.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.0	115.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
37.3	111.9	GO:1904209	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
9.1	108.7	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
18.5	73.8	GO:0098961	dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
23.8	71.4	GO:0099552	trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
1.5	54.9	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.4	54.2	GO:0007411	axon guidance(GO:0007411)
2.5	48.3	GO:0021860	pyramidal neuron development(GO:0021860)
3.6	46.4	GO:0097113	AMPA glutamate receptor clustering(GO:0097113)

Showing 1 to 10 of 258 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	219.5	GO:0005874	microtubule(GO:0005874)
0.2	206.5	GO:0005887	integral component of plasma membrane(GO:0005887)
31.4	188.6	GO:0033269	internode region of axon(GO:0033269)
1.2	110.7	GO:0042734	presynaptic membrane(GO:0042734)
0.6	100.0	GO:0043204	perikaryon(GO:0043204)
10.2	91.5	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.5	85.4	GO:0043209	myelin sheath(GO:0043209)
4.9	73.8	GO:0035253	ciliary rootlet(GO:0035253)
0.4	71.0	GO:0014069	postsynaptic density(GO:0014069)
1.7	64.6	GO:0044295	axonal growth cone(GO:0044295)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	225.9	GO:0008017	microtubule binding(GO:0008017)
17.2	206.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.1	121.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.7	108.7	GO:0005080	protein kinase C binding(GO:0005080)
0.2	101.8	GO:0005509	calcium ion binding(GO:0005509)
4.1	94.3	GO:0002162	dystroglycan binding(GO:0002162)
0.5	76.3	GO:0051015	actin filament binding(GO:0051015)
7.4	73.8	GO:0034190	apolipoprotein receptor binding(GO:0034190)
1.1	73.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
17.9	71.4	GO:0004949	cannabinoid receptor activity(GO:0004949)

Showing 1 to 10 of 174 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	85.4	PID LKB1 PATHWAY	LKB1 signaling events
1.7	66.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
2.1	43.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
3.3	42.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.9	36.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.6	35.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.9	29.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.6	25.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
1.1	23.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	21.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	94.2	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
5.1	91.6	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
4.4	79.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	67.6	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	53.6	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
3.2	51.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
1.4	35.6	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
1.9	26.8	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5	26.7	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
1.9	24.5	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels

Showing 1 to 10 of 66 entries

Results for Sox3_Sox10

Z-value: 1.18

Motif logo

Transcription factors associated with Sox3_Sox10

Activity-expression correlation:

Activity profile of Sox3_Sox10 motif

Sorted Z-values of Sox3_Sox10 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox3_Sox10

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: