ISMARA results: Sox18

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox18_Sox12

Z-value: 1.00

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Transcription factors associated with Sox18_Sox12

Gene Symbol	Gene ID	Gene Info
Sox18 NCBI RGD Ensembl	ENSRNOG00000016248	SRY box 18
Sox12 NCBI RGD Ensembl	ENSRNOG00000007514	SRY box 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox18	rn6_v1_chr3_-_177179127_177179127	0.44	9.5e-17	Click!
Sox12	rn6_v1_chr3_-_147865393_147865393	-0.04	4.3e-01	Click!

Activity profile of Sox18_Sox12 motif

Sorted Z-values of Sox18_Sox12 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_12915734 Show fit	37.98	ENSRNOT00000089066	Txlnb NCBI RGD Ensembl Show fit	taxilin beta
chrX_+_159158194 Show fit	37.41	ENSRNOT00000043820 ENSRNOT00000001169 ENSRNOT00000083502	Fhl1 NCBI RGD Ensembl Show fit	four and a half LIM domains 1
chr3_-_37803112 Show fit	30.94	ENSRNOT00000059461	Neb NCBI RGD Ensembl Show fit	nebulin
chr6_-_23316962 Show fit	27.85	ENSRNOT00000065421	Clip4 NCBI RGD Ensembl Show fit	CAP-GLY domain containing linker protein family, member 4
chr9_-_97290639 Show fit	25.80	ENSRNOT00000026491 ENSRNOT00000056724	Iqca1 NCBI RGD Ensembl Show fit	IQ motif containing with AAA domain 1
chr13_-_93307199 Show fit	24.62	ENSRNOT00000065041	Rgs7 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 7
chr2_+_22950018 Show fit	23.73	ENSRNOT00000071804	Homer1 NCBI RGD Ensembl Show fit	homer scaffolding protein 1
chr2_-_191294374 Show fit	23.02	ENSRNOT00000067469	RGD1562234 NCBI RGD Ensembl Show fit	similar to S100 calcium-binding protein, ventral prostate
chr3_-_52849907 Show fit	22.63	ENSRNOT00000041096	Scn7a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 7
chr2_+_248398917 Show fit	19.22	ENSRNOT00000045855	Gbp1 NCBI RGD Ensembl Show fit	guanylate binding protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox18_Sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	156.4	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.6	96.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8	37.4	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
2.2	37.0	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.4	23.8	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.4	23.5	GO:0055078	sodium ion homeostasis(GO:0055078)
3.2	19.2	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.1	18.7	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
0.4	17.9	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
5.8	17.5	GO:0002353	kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541)

Showing 1 to 10 of 186 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	189.7	GO:0005886	plasma membrane(GO:0005886)
0.1	64.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	41.5	GO:0043209	myelin sheath(GO:0043209)
0.0	41.5	GO:0005615	extracellular space(GO:0005615)
1.4	27.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.3	27.3	GO:0030018	Z disc(GO:0030018)
0.1	25.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
1.2	24.6	GO:0044292	dendrite terminus(GO:0044292)
0.5	23.7	GO:0043034	costamere(GO:0043034)
4.8	19.2	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	164.6	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	106.1	GO:0005509	calcium ion binding(GO:0005509)
0.3	43.5	GO:0044325	ion channel binding(GO:0044325)
0.3	36.9	GO:0019905	syntaxin binding(GO:0019905)
0.9	27.8	GO:0005248	voltage-gated sodium channel activity(GO:0005248)
1.9	24.6	GO:0031681	G-protein beta-subunit binding(GO:0031681)
4.7	23.7	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2	20.4	GO:0016503	pheromone receptor activity(GO:0016503)
0.6	17.9	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
4.1	16.6	GO:0019002	GMP binding(GO:0019002)

Showing 1 to 10 of 146 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	33.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	26.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	15.7	PID EPHA FWDPATHWAY	EPHA forward signaling
0.4	15.6	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	14.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	13.8	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.3	12.0	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.4	11.7	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	9.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	30.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.8	27.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.9	18.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	17.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	16.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
1.5	16.6	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.6	14.5	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	13.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.7	13.7	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.6	13.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)

Showing 1 to 10 of 60 entries

Results for Sox18_Sox12

Z-value: 1.00

Motif logo

Transcription factors associated with Sox18_Sox12

Activity-expression correlation:

Activity profile of Sox18_Sox12 motif

Sorted Z-values of Sox18_Sox12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox18_Sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: