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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Smad3

Z-value: 1.10

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Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
Smad3
ENSRNOG00000008620 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3rn6_v1_chr8_-_68678349_686783490.053.9e-01Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_45297385 60.37 ENSRNOT00000041187
Hist3h2bb
histone cluster 3 H2B family member b
chr17_-_44748188 46.15 ENSRNOT00000081970
LOC103690190
histone H2A type 1-E
chr17_-_44841382 43.94 ENSRNOT00000080119
Hist1h2ak
histone cluster 1, H2ak
chr17_-_44815995 42.30 ENSRNOT00000091201
RGD1562378
histone H4 variant H4-v.1
chr17_+_44738643 40.06 ENSRNOT00000087643
LOC100910554
histone H2A type 1-like
chr17_+_44748482 34.13 ENSRNOT00000083765
Hist1h2bl
histone cluster 1 H2B family member l
chr17_+_44528125 33.77 ENSRNOT00000084538
LOC680322
similar to Histone H2A type 1
chr17_+_44520537 33.16 ENSRNOT00000077985
hist1h2ail2
histone cluster 1, H2ai-like2
chr2_-_95472115 32.90 ENSRNOT00000015720
Stmn2
stathmin 2
chr17_-_43770561 30.36 ENSRNOT00000088408
RGD1562378
histone H4 variant H4-v.1
chr15_+_52767442 29.52 ENSRNOT00000014441
LOC108348161
phytanoyl-CoA hydroxylase-interacting protein
chr2_+_83393282 28.09 ENSRNOT00000044871
Ctnnd2
catenin delta 2
chr4_-_170117325 25.19 ENSRNOT00000074198
LOC100912564
histone H4-like
chr3_-_94182714 24.99 ENSRNOT00000015073
LOC100362814
hypothetical protein LOC100362814
chr17_-_44520240 24.90 ENSRNOT00000086538
Hist1h2bh
histone cluster 1 H2B family member h
chr1_+_192233910 24.86 ENSRNOT00000016418
ENSRNOT00000016442
Prkcb
protein kinase C, beta
chr15_+_52148379 24.48 ENSRNOT00000074912
Phyhip
phytanoyl-CoA 2-hydroxylase interacting protein
chr17_+_44556039 23.85 ENSRNOT00000086540
Prss16
protease, serine 16
chr17_-_44744902 22.76 ENSRNOT00000085381
RGD1562378
histone H4 variant H4-v.1
chr17_-_43821536 21.64 ENSRNOT00000072286
RGD1562378
histone H4 variant H4-v.1
chr13_+_90723092 20.68 ENSRNOT00000010146
Kcnj10
ATP-sensitive inward rectifier potassium channel 10
chr17_-_44527801 20.43 ENSRNOT00000089643
Hist1h2bk
histone cluster 1 H2B family member k
chr7_+_123168811 20.22 ENSRNOT00000007091
Csdc2
cold shock domain containing C2
chr9_-_89193821 20.17 ENSRNOT00000090881
Sphkap
SPHK1 interactor, AKAP domain containing
chr8_+_58347736 18.88 ENSRNOT00000080227
ENSRNOT00000066222
Slc35f2
solute carrier family 35, member F2
chr17_+_43673294 18.63 ENSRNOT00000074109
Hist2h4a
histone cluster 2, H4
chr9_+_73319710 18.47 ENSRNOT00000092485
Map2
microtubule-associated protein 2
chr1_+_72860218 18.19 ENSRNOT00000024547
Syt5
synaptotagmin 5
chr1_-_226791773 18.14 ENSRNOT00000082482
ENSRNOT00000065376
ENSRNOT00000054812
ENSRNOT00000086669
LOC100911215
T-cell surface glycoprotein CD5-like
chr2_+_209839299 17.08 ENSRNOT00000092450
Kcna2
potassium voltage-gated channel subfamily A member 2
chr5_+_122100099 16.81 ENSRNOT00000007738
Pde4b
phosphodiesterase 4B
chr2_+_209838869 16.03 ENSRNOT00000092365
Kcna2
potassium voltage-gated channel subfamily A member 2
chr3_+_145032200 16.00 ENSRNOT00000068210
Syndig1
synapse differentiation inducing 1
chr13_+_48287873 15.86 ENSRNOT00000068223
Fam72a
family with sequence similarity 72, member A
chr8_-_72204730 15.47 ENSRNOT00000023810
Fbxl22
F-box and leucine-rich repeat protein 22
chr18_+_30398113 15.06 ENSRNOT00000027206
Pcdhb5
protocadherin beta 5
chr14_-_33677031 14.86 ENSRNOT00000002908
RGD1311575
hypothetical LOC289568
chr5_+_145257714 14.85 ENSRNOT00000019214
Dlgap3
DLG associated protein 3
chr2_-_210282352 14.75 ENSRNOT00000075653
Slc6a17
solute carrier family 6 member 17
chr1_-_84812486 13.98 ENSRNOT00000078369
AABR07002779.1

chrX_+_35869538 13.91 ENSRNOT00000058947
Ppef1
protein phosphatase with EF-hand domain 1
chr7_+_123482255 13.69 ENSRNOT00000064487
LOC688613
hypothetical protein LOC688613
chr13_+_99173484 13.10 ENSRNOT00000080574
ENSRNOT00000088654
Lefty2
Left-right determination factor 2
chr18_-_69780922 12.82 ENSRNOT00000079093
Me2
malic enzyme 2
chr7_-_116106368 12.60 ENSRNOT00000035678
Ly6k
lymphocyte antigen 6 complex, locus K
chr2_+_198360998 12.27 ENSRNOT00000046129
Hist2h2be
histone cluster 2, H2be
chr7_-_119996824 12.08 ENSRNOT00000011079
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr10_-_90393317 11.76 ENSRNOT00000028563
Fam171a2
family with sequence similarity 171, member A2
chr3_-_80000091 11.71 ENSRNOT00000079394
Madd
MAP-kinase activating death domain
chr5_+_48456757 11.52 ENSRNOT00000091482
Srsf12
serine and arginine rich splicing factor 12
chr9_-_65737538 11.35 ENSRNOT00000014939
Trak2
trafficking kinesin protein 2
chr6_-_115513354 10.85 ENSRNOT00000005881
Ston2
stonin 2
chr2_-_198360678 10.83 ENSRNOT00000051917
Hist2h2ac
histone cluster 2 H2A family member c
chr8_-_115358046 10.73 ENSRNOT00000017607
Grm2
glutamate metabotropic receptor 2
chr1_-_101236065 10.33 ENSRNOT00000066834
Cd37
CD37 molecule
chrX_+_114929029 10.26 ENSRNOT00000006459
Pak3
p21 (RAC1) activated kinase 3
chr15_+_31395772 10.07 ENSRNOT00000075087
AABR07017824.1

chr13_-_51076852 9.57 ENSRNOT00000078993
Adora1
adenosine A1 receptor
chr14_-_35149608 9.39 ENSRNOT00000003050
ENSRNOT00000090654
Kit
KIT proto-oncogene receptor tyrosine kinase
chr7_-_93280009 9.39 ENSRNOT00000064877
Samd12
sterile alpha motif domain containing 12
chr6_+_86823684 8.45 ENSRNOT00000086081
ENSRNOT00000006574
Fancm
Fanconi anemia, complementation group M
chr18_+_30474947 7.81 ENSRNOT00000027188
Pcdhb9
protocadherin beta 9
chr3_+_152752091 7.68 ENSRNOT00000037177
Dlgap4
DLG associated protein 4
chr1_-_165997751 7.67 ENSRNOT00000050227
P2ry6
pyrimidinergic receptor P2Y6
chr8_-_72284852 7.27 ENSRNOT00000080319
ENSRNOT00000057739
Usp3
ubiquitin specific peptidase 3
chr5_+_155935554 7.25 ENSRNOT00000031855
LOC100911993
ubiquitin carboxyl-terminal hydrolase 48-like
chr15_+_31456265 6.90 ENSRNOT00000075092
AABR07017825.1

chr1_-_80514728 6.87 ENSRNOT00000081565
Clasrp
CLK4-associating serine/arginine rich protein
chr10_+_106264434 6.75 ENSRNOT00000003891
Sept9
septin 9
chr3_-_52510507 6.58 ENSRNOT00000091259
Scn1a
sodium voltage-gated channel alpha subunit 1
chr12_+_16950728 6.28 ENSRNOT00000060370
Ints1
integrator complex subunit 1
chr8_+_117780891 5.92 ENSRNOT00000077236
Shisa5
shisa family member 5
chr1_-_213987053 5.76 ENSRNOT00000072774
LOC100911519
p53-induced protein with a death domain-like
chr11_+_84972132 5.73 ENSRNOT00000034498
Lamp3
lysosomal-associated membrane protein 3
chr3_-_112676556 5.57 ENSRNOT00000014664
Cdan1
codanin 1
chr18_+_3861539 5.37 ENSRNOT00000015363
Lama3
laminin subunit alpha 3
chrX_-_20807216 5.19 ENSRNOT00000075757
Fam156b
family with sequence similarity 156, member B
chr6_-_140880070 4.87 ENSRNOT00000073779
LOC691828
uncharacterized LOC691828
chr8_-_46757781 4.78 ENSRNOT00000085294
AABR07073392.1

chr10_+_45297937 4.61 ENSRNOT00000066367
Trim17
tripartite motif-containing 17
chr18_+_64008048 4.54 ENSRNOT00000083414
Ldlrad4
low density lipoprotein receptor class A domain containing 4
chr10_+_49541051 4.48 ENSRNOT00000041606
Pmp22
peripheral myelin protein 22
chr11_-_84583542 4.24 ENSRNOT00000064212
Yeats2
YEATS domain containing 2
chr1_+_259958310 4.17 ENSRNOT00000019751
LOC103689954
ectonucleoside triphosphate diphosphohydrolase 1
chr1_-_81152384 4.15 ENSRNOT00000026263
ENSRNOT00000077305
Zfp94
zinc finger protein 94
chr18_+_30424814 4.09 ENSRNOT00000073425
Pcdhb7
protocadherin beta 7
chr4_-_7228675 3.86 ENSRNOT00000064386
Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_206417143 3.72 ENSRNOT00000091863
ENSRNOT00000073836
LOC100302465
hypothetical LOC100302465
chr10_+_104483042 3.63 ENSRNOT00000007362
Sap30bp
SAP30 binding protein
chr16_+_84465656 3.60 ENSRNOT00000043188
LOC689713
LRRGT00175
chr12_+_18074033 3.56 ENSRNOT00000001727
LOC103689975
integrator complex subunit 1-like
chr7_+_16304954 3.56 ENSRNOT00000050751
Olr927
olfactory receptor 927
chr2_-_12312287 3.55 ENSRNOT00000048860
AABR07007399.1

chr7_+_115956276 3.53 ENSRNOT00000007773
Them6
thioesterase superfamily member 6
chr3_-_111037425 3.40 ENSRNOT00000085628
Ppp1r14d
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr15_+_31051414 3.36 ENSRNOT00000090250
AABR07017783.4

chr20_-_6960481 3.11 ENSRNOT00000093172
Mtch1
mitochondrial carrier 1
chr1_+_69853553 2.95 ENSRNOT00000042086
Zfp954
zinc finger protein 954
chr12_-_12407561 2.88 ENSRNOT00000037251
Bhlha15
basic helix-loop-helix family, member a15
chr4_+_155437675 2.78 ENSRNOT00000031353
Dppa3
developmental pluripotency-associated 3
chr3_-_79282493 2.55 ENSRNOT00000049832
Ptprj
protein tyrosine phosphatase, receptor type, J
chr2_-_59084059 2.49 ENSRNOT00000086323
ENSRNOT00000088701
Spef2
sperm flagellar 2
chr1_+_167066516 2.43 ENSRNOT00000000474
Numa1
nuclear mitotic apparatus protein 1
chr18_+_55797198 2.42 ENSRNOT00000026334
ENSRNOT00000026394
Dctn4
dynactin subunit 4
chr20_+_3148665 2.27 ENSRNOT00000086026
RT1-N2
RT1 class Ib, locus N2
chr7_+_11054333 2.20 ENSRNOT00000007202
Gna15
guanine nucleotide binding protein, alpha 15
chr2_-_59181863 1.89 ENSRNOT00000079636
Spef2
sperm flagellar 2
chr1_+_213040024 1.77 ENSRNOT00000050237
Olr300
olfactory receptor 300
chr7_+_142905758 1.70 ENSRNOT00000078663
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr1_+_209768696 1.68 ENSRNOT00000022406
Glrx3
glutaredoxin 3
chr3_+_159887036 1.67 ENSRNOT00000031868
R3hdml
R3H domain containing-like
chr18_+_867048 1.64 ENSRNOT00000065494
Colec12
collectin sub-family member 12
chr1_-_165606375 1.62 ENSRNOT00000024290
Mrpl48
mitochondrial ribosomal protein L48
chr6_-_142534112 1.54 ENSRNOT00000073598
Ighv1-49
immunoglobulin heavy variable 1-49
chr1_+_84612448 1.45 ENSRNOT00000032991
AABR07071891.1

chr5_-_69517277 1.28 ENSRNOT00000079848
Olr850
olfactory receptor 850
chr10_+_56453877 1.05 ENSRNOT00000031640
Plscr3
phospholipid scramblase 3
chr9_+_20951260 0.85 ENSRNOT00000016906
Adgrf4
adhesion G protein-coupled receptor F4
chr19_-_37525762 0.85 ENSRNOT00000023606
Atp6v0d1
ATPase H+ transporting V0 subunit D1
chr9_-_43127887 0.81 ENSRNOT00000021685
Ankrd39
ankyrin repeat domain 39
chr5_+_162385173 0.80 ENSRNOT00000048232
Pramef12
PRAME family member 12
chr5_+_167331035 0.51 ENSRNOT00000024443
Rere
arginine-glutamic acid dipeptide repeats
chr1_-_212912199 0.35 ENSRNOT00000045179
Olr295
olfactory receptor 295

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 160.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
8.3 24.9 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
6.9 20.7 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
5.5 33.1 GO:0021633 optic nerve structural organization(GO:0021633)
4.9 14.7 GO:0015820 leucine transport(GO:0015820)
4.7 32.9 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
3.9 11.7 GO:0036395 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276)
3.8 11.3 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
3.2 9.6 GO:0032900 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
2.8 16.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
2.6 10.3 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
2.3 9.4 GO:0038109 Kit signaling pathway(GO:0038109) melanocyte migration(GO:0097324) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
2.0 15.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
1.8 32.7 GO:0002227 innate immune response in mucosa(GO:0002227)
1.8 174.1 GO:0006342 chromatin silencing(GO:0006342)
1.4 11.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
1.3 12.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.2 12.8 GO:1902031 regulation of NADP metabolic process(GO:1902031)
1.0 85.3 GO:0006334 nucleosome assembly(GO:0006334)
1.0 16.0 GO:0097091 synaptic vesicle clustering(GO:0097091)
1.0 9.8 GO:0034472 snRNA 3'-end processing(GO:0034472)
1.0 10.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.0 7.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.9 2.8 GO:0044726 protection of DNA demethylation of female pronucleus(GO:0044726)
0.8 4.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.7 20.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.6 29.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.6 38.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.5 18.5 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.5 6.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 6.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 8.4 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.4 12.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.3 7.3 GO:0016578 histone deubiquitination(GO:0016578)
0.3 1.7 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.3 1.6 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.3 4.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.3 2.9 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.3 1.7 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.3 4.5 GO:0032060 bleb assembly(GO:0032060)
0.3 2.6 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 2.4 GO:0007097 nuclear migration(GO:0007097)
0.2 20.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 5.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.2 27.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.5 GO:0031497 chromatin assembly(GO:0031497)
0.2 0.5 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.2 2.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 3.7 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.1 2.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.1 5.9 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 1.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 4.7 GO:0035987 endodermal cell differentiation(GO:0035987)
0.1 3.9 GO:0000060 protein import into nucleus, translocation(GO:0000060)
0.1 4.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 17.3 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 2.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 3.1 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 15.5 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 2.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 4.3 GO:0006397 mRNA processing(GO:0006397)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 160.9 GO:0000788 nuclear nucleosome(GO:0000788)
4.7 326.2 GO:0000786 nucleosome(GO:0000786)
3.6 18.2 GO:1990769 proximal neuron projection(GO:1990769)
2.1 33.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.1 18.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.9 5.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
1.0 20.7 GO:0097449 astrocyte projection(GO:0097449)
0.9 8.4 GO:0071821 FANCM-MHF complex(GO:0071821)
0.9 5.4 GO:0005608 laminin-3 complex(GO:0005608)
0.9 14.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.8 16.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.8 2.4 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.7 6.7 GO:0031105 septin complex(GO:0031105)
0.6 9.8 GO:0032039 integrator complex(GO:0032039)
0.5 9.6 GO:0032279 asymmetric synapse(GO:0032279)
0.4 7.3 GO:0070938 contractile ring(GO:0070938)
0.4 4.4 GO:0002177 manchette(GO:0002177)
0.4 11.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 2.4 GO:0005869 dynactin complex(GO:0005869)
0.3 12.9 GO:0001772 immunological synapse(GO:0001772)
0.3 9.4 GO:0042629 mast cell granule(GO:0042629)
0.3 6.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 2.8 GO:0001940 male pronucleus(GO:0001940)
0.2 34.0 GO:0030018 Z disc(GO:0030018)
0.2 16.0 GO:0043198 dendritic shaft(GO:0043198)
0.2 4.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 4.5 GO:0043218 compact myelin(GO:0043218)
0.2 32.9 GO:0030426 growth cone(GO:0030426)
0.2 28.1 GO:0043204 perikaryon(GO:0043204)
0.2 10.7 GO:0042734 presynaptic membrane(GO:0042734)
0.2 38.2 GO:0008021 synaptic vesicle(GO:0008021)
0.2 15.8 GO:0031526 brush border membrane(GO:0031526)
0.1 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 12.8 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.0 7.7 GO:0030425 dendrite(GO:0030425)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 24.9 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
5.2 20.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
3.6 10.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
2.6 7.7 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
2.1 12.8 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
1.9 9.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
1.6 9.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.9 16.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.9 18.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.9 176.1 GO:0042393 histone binding(GO:0042393)
0.9 10.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.8 18.5 GO:0002162 dystroglycan binding(GO:0002162)
0.7 11.3 GO:0050811 GABA receptor binding(GO:0050811)
0.5 14.7 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.5 326.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.5 34.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 14.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 30.6 GO:0008013 beta-catenin binding(GO:0008013)
0.3 17.7 GO:0051018 protein kinase A binding(GO:0051018)
0.3 11.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 6.6 GO:0031402 sodium ion binding(GO:0031402)
0.2 17.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 13.9 GO:0030145 manganese ion binding(GO:0030145)
0.2 4.5 GO:0070412 R-SMAD binding(GO:0070412)
0.2 10.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 4.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 5.9 GO:0050699 WW domain binding(GO:0050699)
0.1 8.5 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 2.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 23.8 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 1.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) low-density lipoprotein particle binding(GO:0030169) pattern recognition receptor activity(GO:0038187)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 3.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 15.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.3 GO:0042605 peptide antigen binding(GO:0042605)
0.0 12.1 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 8.4 GO:0004518 nuclease activity(GO:0004518)
0.0 4.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 18.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 6.7 GO:0005525 GTP binding(GO:0005525)
0.0 2.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 6.3 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 24.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 4.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.3 5.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 18.5 PID LKB1 PATHWAY LKB1 signaling events
0.2 10.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 11.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 9.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 8.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 2.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 8.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 181.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
1.3 24.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.0 17.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.7 20.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 12.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.6 13.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.6 10.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 16.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 9.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.4 18.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 8.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.3 20.4 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.2 2.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.7 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 2.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation