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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Smad2

Z-value: 0.43

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
Smad2
ENSRNOG00000018140 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2rn6_v1_chr18_+_72550219_725502190.036.5e-01Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_253000760 22.97 ENSRNOT00000030024
Slc16a12
solute carrier family 16, member 12
chr5_-_137372524 14.66 ENSRNOT00000009061
Tmem125
transmembrane protein 125
chr4_-_117767772 12.87 ENSRNOT00000084170
LOC103690120
probable N-acetyltransferase CML1
chr2_-_40386669 11.73 ENSRNOT00000014074
Elovl7
ELOVL fatty acid elongase 7
chr14_+_87312203 10.51 ENSRNOT00000088032
Adcy1
adenylate cyclase 1
chr13_+_106463368 10.40 ENSRNOT00000003489
Esrrg
estrogen-related receptor gamma
chr2_-_220535751 7.43 ENSRNOT00000089082
Palmd
palmdelphin
chr4_-_117575154 6.94 ENSRNOT00000075813
LOC102556148
probable N-acetyltransferase CML2-like
chr1_+_100164400 6.84 ENSRNOT00000080334
LOC108348116
glandular kallikrein-3, submandibular-like
chr2_+_188449210 5.52 ENSRNOT00000027700
Pklr
pyruvate kinase, liver and RBC
chr17_+_81798756 4.97 ENSRNOT00000066826
Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
chr18_-_77579969 4.57 ENSRNOT00000034896
Sall3
spalt-like transcription factor 3
chr4_-_159192526 4.47 ENSRNOT00000026731
Kcna1
potassium voltage-gated channel subfamily A member 1
chr4_+_113968995 4.20 ENSRNOT00000079511
Rtkn
rhotekin
chr9_+_17340341 4.15 ENSRNOT00000026637
ENSRNOT00000026559
ENSRNOT00000042790
ENSRNOT00000044163
ENSRNOT00000083811
Vegfa
vascular endothelial growth factor A
chr7_+_97559841 3.98 ENSRNOT00000007326
Zhx2
zinc fingers and homeoboxes 2
chr3_-_154042099 3.73 ENSRNOT00000033525
Blcap
bladder cancer associated protein
chr7_-_143523457 3.66 ENSRNOT00000012943
ENSRNOT00000082264
Krt4
keratin 4
chr1_+_185427736 3.15 ENSRNOT00000064706
Plekha7
pleckstrin homology domain containing A7
chr5_+_134737030 3.13 ENSRNOT00000066161
ENSRNOT00000057061
Kncn
kinocilin
chr15_+_12827707 2.80 ENSRNOT00000012452
Fezf2
Fez family zinc finger 2
chr6_+_27768943 2.71 ENSRNOT00000015820
Kif3c
kinesin family member 3C
chr14_+_84368476 2.56 ENSRNOT00000006827
Rnf215
ring finger protein 215
chr7_-_70842405 2.37 ENSRNOT00000047449
Nxph4
neurexophilin 4
chr2_-_149417212 1.99 ENSRNOT00000018573
Gpr87
G protein-coupled receptor 87
chr3_+_172155496 1.21 ENSRNOT00000066279
Stx16
syntaxin 16
chr13_-_91872954 1.18 ENSRNOT00000004613
ENSRNOT00000079263
Cadm3
cell adhesion molecule 3
chr18_+_30864216 1.06 ENSRNOT00000027015
Pcdhga7
protocadherin gamma subfamily A, 7
chr3_+_102723402 0.62 ENSRNOT00000040298
Olr765
olfactory receptor 765
chr10_+_56453877 0.52 ENSRNOT00000031640
Plscr3
phospholipid scramblase 3
chr1_-_170933660 0.43 ENSRNOT00000045360
Olr219
olfactory receptor 219
chr7_-_139318455 0.31 ENSRNOT00000092029
Hdac7
histone deacetylase 7
chr11_+_1896209 0.21 ENSRNOT00000000909
Cggbp1
CGG triplet repeat binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.7 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.7 5.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.4 4.1 GO:0038189 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) cardiac vascular smooth muscle cell development(GO:0060948) positive regulation of lymphangiogenesis(GO:1901492)
0.9 4.5 GO:0050975 sensory perception of touch(GO:0050975)
0.7 23.0 GO:0072337 modified amino acid transport(GO:0072337)
0.7 2.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 3.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.6 5.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 10.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 10.5 GO:0007616 long-term memory(GO:0007616)
0.2 4.6 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.2 2.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 3.7 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 4.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 1.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 4.0 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 6.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 2.7 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 0.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.7 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 5.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 2.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.3 3.1 GO:0032437 cuticular plate(GO:0032437)
0.3 3.2 GO:0005915 zonula adherens(GO:0005915)
0.3 4.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 3.7 GO:0045095 keratin filament(GO:0045095)
0.0 4.1 GO:0005604 basement membrane(GO:0005604)
0.0 7.4 GO:0043197 dendritic spine(GO:0043197)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 26.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 11.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.4 GO:0050682 AF-2 domain binding(GO:0050682)
1.8 10.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.4 5.5 GO:0004743 pyruvate kinase activity(GO:0004743)
1.2 11.7 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.1 23.0 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.8 5.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 4.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.5 4.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2 3.2 GO:0070097 delta-catenin binding(GO:0070097)
0.2 4.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 19.8 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.2 2.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 2.7 GO:0019894 kinesin binding(GO:0019894)
0.0 6.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 3.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.4 4.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 5.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.7 11.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 4.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 5.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 5.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 10.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.7 REACTOME KINESINS Genes involved in Kinesins
0.1 4.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins