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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Six6
Z-value: 0.87
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Transcription factors associated with Six6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Six6 | rn6_v1_chr6_+_95816749_95816749 | -0.16 | 5.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_75144903 Show fit | 45.92 |
ENSRNOT00000002329
|
HRAS-like suppressor |
|
| chr16_+_68633720 Show fit | 40.49 |
ENSRNOT00000081838
|
sperm motility kinase-like |
|
| chr3_+_70327193 Show fit | 39.14 |
ENSRNOT00000089165
|
fibrous sheath-interacting protein 2 |
|
| chr11_+_52828116 Show fit | 38.57 |
ENSRNOT00000035340
|
coiled-coil domain containing 54 |
|
| chr16_-_54628458 Show fit | 29.22 |
ENSRNOT00000042587
|
ADAM metallopeptidase domain 24 |
|
| chr1_-_201702963 Show fit | 26.95 |
ENSRNOT00000031258
|
similar to RIKEN cDNA 1700022C21 |
|
| chr15_-_5417570 Show fit | 26.58 |
ENSRNOT00000061525
|
Spetex-2F protein |
|
| chr6_-_86223052 Show fit | 26.18 |
ENSRNOT00000046828
|
fibrous sheath CABYR binding protein |
|
| chr12_+_24158766 Show fit | 25.84 |
ENSRNOT00000001963
|
C-C motif chemokine ligand 26 |
|
| chr9_+_53440272 Show fit | 25.69 |
ENSRNOT00000059159
|
hypothetical protein LOC685203 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Six6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 49.6 | GO:0035404 | histone-serine phosphorylation(GO:0035404) |
| 3.8 | 45.9 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 7.3 | 29.2 | GO:0060468 | prevention of polyspermy(GO:0060468) |
| 1.4 | 25.8 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 4.7 | 23.5 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.6 | 17.9 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 2.8 | 16.9 | GO:0090598 | male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598) |
| 1.6 | 16.5 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 15.7 | GO:0006508 | proteolysis(GO:0006508) |
| 3.1 | 15.6 | GO:0035063 | nuclear speck organization(GO:0035063) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 49.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.3 | 47.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 4.6 | 45.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 37.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 28.3 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 26.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.5 | 26.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.9 | 19.5 | GO:0000800 | lateral element(GO:0000800) |
| 0.4 | 17.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.4 | 16.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 65.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 3.3 | 49.6 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.3 | 32.1 | GO:0004620 | phospholipase activity(GO:0004620) |
| 8.6 | 25.8 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 1.0 | 25.7 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 24.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 23.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 3.9 | 23.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 23.0 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.4 | 21.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 11.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 8.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 8.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 7.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 7.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 3.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.1 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 2.8 | ST GA13 PATHWAY | G alpha 13 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 16.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.2 | 12.5 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.7 | 9.2 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.2 | 9.2 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.1 | 9.1 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.4 | 9.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 8.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 7.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.3 | 7.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |