Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Six3_Six1_Six2

Z-value: 0.60

Motif logo

Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
ENSRNOG00000057031 SIX homeobox 3
ENSRNOG00000022777 SIX homeobox 1
ENSRNOG00000058827 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six3rn6_v1_chr6_+_8886591_8886730-0.411.6e-14Click!
Six1rn6_v1_chr6_-_95934296_959342960.116.0e-02Click!
Six2rn6_v1_chr6_-_8956276_8956276-0.081.3e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_141893674 39.43 ENSRNOT00000019059
ENSRNOT00000085988
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
chr8_+_33514042 37.26 ENSRNOT00000081614
ENSRNOT00000081525
potassium voltage-gated channel subfamily J member 1
chr4_-_51199570 28.67 ENSRNOT00000010788
solute carrier family 13 member 1
chr2_-_53413638 26.88 ENSRNOT00000021081
growth hormone receptor
chr1_-_198104109 22.55 ENSRNOT00000026186
sulfotransferase family 1A member 1
chr1_-_189182306 21.56 ENSRNOT00000021249
glycoprotein 2
chr5_+_118743632 21.21 ENSRNOT00000013785
phosphoglucomutase 1
chr1_-_189181901 18.39 ENSRNOT00000092022
glycoprotein 2
chr10_+_53713938 17.18 ENSRNOT00000004236
ENSRNOT00000086599
ENSRNOT00000085582
myosin heavy chain 2
chr17_-_46115004 16.78 ENSRNOT00000087838
acyloxyacyl hydrolase
chr4_-_155867708 16.34 ENSRNOT00000051525
C-type lectin domain family 4, member A2
chr18_-_40716686 15.08 ENSRNOT00000000172
cysteine dioxygenase type 1
chr15_+_57290849 14.44 ENSRNOT00000014909
carboxypeptidase B2
chr13_-_95943761 13.19 ENSRNOT00000005961
adenylosuccinate synthase
chrX_+_156336450 12.28 ENSRNOT00000082124
solute carrier family 10, member 3
chrX_-_114232939 12.21 ENSRNOT00000042639
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_158090173 10.89 ENSRNOT00000088766
ENSRNOT00000079516
ENSRNOT00000092026
taste 1 receptor member 2
chr4_+_156050054 9.74 ENSRNOT00000039855
C-type lectin domain family 4, member A
chr1_-_13341952 9.51 ENSRNOT00000079531
epithelial cell transforming 2 like
chrX_+_16050780 9.23 ENSRNOT00000079054
chloride voltage-gated channel 5
chr1_-_76517134 8.28 ENSRNOT00000064593
ENSRNOT00000085775
alcohol sulfotransferase-like
chr10_+_70298519 7.93 ENSRNOT00000035730
ENSRNOT00000076233
ENSRNOT00000076445
ENSRNOT00000076133
schlafen family member 5
chr17_-_32076181 7.86 ENSRNOT00000074842
leukocyte elastase inhibitor A-like
chr1_-_167700332 7.31 ENSRNOT00000092890
tripartite motif-containing 21
chr2_+_44664124 7.19 ENSRNOT00000066098
phospholipid phosphatase 1
chr1_+_201981357 6.90 ENSRNOT00000027999
acyl-CoA dehydrogenase, short/branched chain
chr2_-_182846061 6.67 ENSRNOT00000013025
toll-like receptor 2
chr11_-_61470046 6.49 ENSRNOT00000073436
N-alpha-acetyltransferase 50-like
chr1_-_213650247 6.28 ENSRNOT00000019679
cytochrome c oxidase, subunit VIIIb
chr1_-_100530183 6.06 ENSRNOT00000067754
myosin binding protein C, fast-type
chr5_+_124442293 5.96 ENSRNOT00000041922
similar to novel protein
chr8_+_70630767 5.88 ENSRNOT00000051353
immunoglobulin superfamily, DCC subclass, member 3
chrX_+_123912361 5.77 ENSRNOT00000092622
reproductive homeobox 5
chr4_+_1436254 5.72 ENSRNOT00000088564
olfactory receptor 1232
chr9_-_92524739 5.68 ENSRNOT00000089889
solute carrier family 16, member 14
chr4_+_72718458 5.45 ENSRNOT00000044780
Rho guanine nucleotide exchange factor 5
chr14_+_45062662 5.35 ENSRNOT00000059124
toll-like receptor 10
chr7_-_119797098 5.27 ENSRNOT00000009994
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_-_168260536 5.10 ENSRNOT00000072551
vomeronasal 1 receptor 55
chr1_+_229107911 5.09 ENSRNOT00000016484
olfactory receptor 338
chr4_+_156752082 5.09 ENSRNOT00000084588
ENSRNOT00000068407
CD163 molecule
chr2_-_80667481 4.97 ENSRNOT00000016784
trio Rho guanine nucleotide exchange factor
chr11_-_61470348 4.96 ENSRNOT00000083841
N-alpha-acetyltransferase 50-like
chr19_+_15195565 4.78 ENSRNOT00000090865
ENSRNOT00000078874
carboxylesterase 1D
chr7_+_117643206 4.69 ENSRNOT00000077588
aarF domain containing kinase 5
chr4_+_66276835 4.51 ENSRNOT00000007544
formation of mitochondrial complex V assembly factor 1
chr1_-_77893509 4.50 ENSRNOT00000015059
glioma tumor suppressor candidate region gene 1
chr13_+_113373578 4.45 ENSRNOT00000009900
plexin A2
chr1_-_214252456 4.44 ENSRNOT00000023504
interferon regulatory factor 7
chr4_-_164453171 4.42 ENSRNOT00000077539
ENSRNOT00000083610
ENSRNOT00000079975
Ly49 stimulatory receptor 6
chr3_-_112614503 4.37 ENSRNOT00000071591
regulator of microtubule dynamics protein 3-like
chr18_+_57516347 4.35 ENSRNOT00000082215
predicted gene 9949
chr2_-_193136520 4.33 ENSRNOT00000042142
keratinocyte proline-rich protein
chr10_-_14848967 4.27 ENSRNOT00000080944
somatostatin receptor 5
chr11_+_73936750 4.15 ENSRNOT00000002350
ATPase 13A3
chr1_+_88686731 4.09 ENSRNOT00000028222
RNA polymerase II subunit I
chr1_+_79289164 4.00 ENSRNOT00000024155

chr17_-_67945037 3.92 ENSRNOT00000023033
Kruppel-like factor 6
chr5_+_173148884 3.83 ENSRNOT00000041753
hCG1994130-like
chr2_-_210116038 3.63 ENSRNOT00000074950
similar to NADH-ubiquinone oxidoreductase B9 subunit (Complex I-B9) (CI-B9)
chr2_+_211159062 3.62 ENSRNOT00000027099
myosin binding protein H-like
chr5_-_160423811 3.61 ENSRNOT00000018864
EF-hand domain family, member D2
chr7_-_60860990 3.47 ENSRNOT00000009511
RAP1B, member of RAS oncogene family
chr2_-_187786700 3.47 ENSRNOT00000092257
ENSRNOT00000092612
ENSRNOT00000068360
solute carrier family 25, member 44
chr12_-_16201632 3.46 ENSRNOT00000001688
carbohydrate sulfotransferase 12
chr7_-_9104719 3.43 ENSRNOT00000088247
olfactory receptor 6C74-like
chr1_-_91042230 3.26 ENSRNOT00000073107
DNA-directed RNA polymerase II subunit RPB9
chr4_-_119568736 3.10 ENSRNOT00000041234
aprataxin and PNKP like factor
chr3_-_59166356 3.01 ENSRNOT00000047713

chr2_+_78245459 2.97 ENSRNOT00000089551
protein FAM134B
chr6_-_140216072 2.92 ENSRNOT00000072365

chr7_+_9279620 2.77 ENSRNOT00000011225
olfactory receptor 1064
chr1_-_214159157 2.74 ENSRNOT00000091292
ENSRNOT00000022241
ribonuclease/angiogenin inhibitor 1
chr9_-_11108741 2.70 ENSRNOT00000072357
coiled-coil domain containing 94
chr6_+_96834525 2.60 ENSRNOT00000077935
hypoxia inducible factor 1 alpha subunit
chr1_+_68239314 2.59 ENSRNOT00000070823
vomeronasal 1 receptor 109
chr14_+_18983853 2.57 ENSRNOT00000003836
Ras association domain family member 6
chr1_-_169386939 2.54 ENSRNOT00000023007
olfactory receptor 150
chr4_+_45034123 2.46 ENSRNOT00000078255
suppression of tumorigenicity 7
chr2_-_195935878 2.42 ENSRNOT00000028440
cingulin
chr1_+_91042635 2.35 ENSRNOT00000028211
tubulin-folding cofactor B
chr3_-_152179193 2.33 ENSRNOT00000026700
RNA binding motif protein 12
chr1_+_172807389 2.31 ENSRNOT00000088537
olfactory receptor 271
chr19_+_38422164 2.30 ENSRNOT00000017174
NAD(P)H quinone dehydrogenase 1
chr15_+_28295368 2.29 ENSRNOT00000013786
solute carrier family 39 member 2
chr1_-_225830300 2.28 ENSRNOT00000072584
ENSRNOT00000027502
secretoglobin, family 2A, member 2
chr6_-_115352681 2.18 ENSRNOT00000005873
general transcription factor 2A subunit 1
chr8_+_32604365 2.11 ENSRNOT00000071210

chr8_-_76940094 2.07 ENSRNOT00000082709
ENSRNOT00000084313
ring finger protein 111
chr14_-_25585222 2.06 ENSRNOT00000042106
similar to 60S ribosomal protein L9
chr16_+_7758996 2.06 ENSRNOT00000061063
biotinidase
chr13_-_84331905 2.06 ENSRNOT00000004965
dual specificity phosphatase 27 (putative)
chr10_+_17261541 2.04 ENSRNOT00000005478
SH3 and PX domains 2B
chr3_+_73425801 2.04 ENSRNOT00000040714
olfactory receptor 477
chr6_+_137323713 2.02 ENSRNOT00000029017
phospholipase D family, member 4
chr4_-_68832216 1.99 ENSRNOT00000031345
taste receptor, type 2, member 138
chr3_-_77494108 1.91 ENSRNOT00000047726
olfactory receptor 662
chr9_-_85617954 1.85 ENSRNOT00000077331
serpin family E member 2
chr3_+_78086943 1.84 ENSRNOT00000047425
olfactory receptor 691
chr7_-_10430992 1.83 ENSRNOT00000047433
zinc finger protein 709-like 1
chr8_+_20230082 1.82 ENSRNOT00000044463
olfactory receptor 1165
chrX_+_9956370 1.75 ENSRNOT00000082316
peripheral plasma membrane protein CASK-like
chr4_+_72428128 1.75 ENSRNOT00000007157
olfactory receptor 811
chr9_+_23379200 1.69 ENSRNOT00000074110
glycine-N-acyltransferase-like 3
chr1_+_68176904 1.68 ENSRNOT00000044950
vomeronasal 1 receptor 28
chr19_+_34616768 1.64 ENSRNOT00000051194
ribosomal protein S27a, pseudogene 6
chr2_+_35935670 1.62 ENSRNOT00000076875
ENSRNOT00000075753
serine protease inhibitor Kazal-type 5-like
chr18_+_35121967 1.56 ENSRNOT00000017522
serine peptidase inhibitor, Kazal type 5
chr5_-_64622360 1.54 ENSRNOT00000073545
olfactory receptor 841
chr11_+_43194348 1.53 ENSRNOT00000075303
olfactory receptor 1532
chr3_-_145641654 1.49 ENSRNOT00000008101
ENSRNOT00000008047
zinc finger protein 596-like
chr1_+_172813394 1.49 ENSRNOT00000090059
olfactory receptor 272
chr1_+_229267916 1.45 ENSRNOT00000073717
ENSRNOT00000082670
ENSRNOT00000076941
serine protease inhibitor Kazal-type 5-like
chr8_+_133210473 1.45 ENSRNOT00000082774
chemokine (C-C motif) receptor 5
chr4_+_170518673 1.41 ENSRNOT00000011803
activating transcription factor 7 interacting protein
chr10_+_31813814 1.40 ENSRNOT00000009573
hepatitis A virus cellular receptor 1
chrX_-_102039530 1.40 ENSRNOT00000085348

chr1_+_57692836 1.39 ENSRNOT00000083968
ENSRNOT00000019358
chromodomain helicase DNA binding protein 1
chr10_+_60849405 1.39 ENSRNOT00000066983
hypothetical protein LOC687896
chr10_+_14656812 1.38 ENSRNOT00000024904
protease, serine, 34
chr5_-_155728300 1.37 ENSRNOT00000029025
cell division cycle 42
chr18_+_35384743 1.35 ENSRNOT00000076143
ENSRNOT00000074593
serine protease inhibitor Kazal-type 5-like
chr7_+_114997103 1.33 ENSRNOT00000010224
protein tyrosine phosphatase type IVA, member 3
chr4_-_121969446 1.33 ENSRNOT00000085001
vomeronasal 1 receptor 99
chr6_+_64224861 1.30 ENSRNOT00000093159
ENSRNOT00000093664
patatin-like phospholipase domain containing 8
chr20_-_4818568 1.30 ENSRNOT00000001115
DExD-box helicase 39B
chr1_-_71909138 1.27 ENSRNOT00000029591
NLR family, pyrin domain containing 9
chr13_+_9464906 1.26 ENSRNOT00000071756
olfactory receptor 6C74-like
chr2_+_26240385 1.26 ENSRNOT00000024292
coagulation factor II (thrombin) receptor-like 2
chr8_+_40258985 1.25 ENSRNOT00000044652
olfactory receptor 1196
chr10_+_36477692 1.24 ENSRNOT00000044464
olfactory receptor 1405
chr1_+_87045335 1.21 ENSRNOT00000084393
galectin 7
chr1_-_228014924 1.16 ENSRNOT00000042091
oocyte secreted protein 2
chr5_-_64615714 1.10 ENSRNOT00000007462
similar to olfactory receptor Olr841
chr1_+_168489077 1.10 ENSRNOT00000021191
olfactory receptor 96
chr13_-_34253910 1.08 ENSRNOT00000092847
translin
chr10_-_104689178 1.05 ENSRNOT00000011328
mitochondrial ribosomal protein L38
chr3_+_158964146 1.05 ENSRNOT00000073941
olfactory receptor 8B8-like
chr3_-_102826379 1.01 ENSRNOT00000073423
olfactory receptor 769
chr1_-_60828260 1.00 ENSRNOT00000059671
vomeronasal 1 receptor pseudogene 112
chr3_-_78595778 1.00 ENSRNOT00000084255
olfactory receptor 715
chr8_-_37093082 0.99 ENSRNOT00000072767
prostate and testis expressed protein F
chr1_+_87045796 0.91 ENSRNOT00000027620
galectin 7
chrX_+_19854836 0.90 ENSRNOT00000075010

chr8_-_43055175 0.89 ENSRNOT00000074413
olfactory receptor 8G1-like
chr3_+_21276213 0.87 ENSRNOT00000041835
olfactory receptor 428
chr8_+_69753373 0.86 ENSRNOT00000066973
timeless interacting protein
chr1_-_168587241 0.85 ENSRNOT00000021254
olfactory receptor 104
chrX_+_77076106 0.83 ENSRNOT00000091527
ENSRNOT00000089381
ATPase copper transporting alpha
chr8_-_21453190 0.83 ENSRNOT00000078192
zinc finger protein 26
chrX_+_23416395 0.82 ENSRNOT00000089821

chr13_-_111948753 0.75 ENSRNOT00000048074
hydroxysteroid 11-beta dehydrogenase 1
chr11_+_73693814 0.75 ENSRNOT00000081081
ENSRNOT00000002354
ENSRNOT00000090940
large 60S subunit nuclear export GTPase 1
chr8_+_42409187 0.74 ENSRNOT00000072605
olfactory receptor 1256
chr1_-_167884690 0.74 ENSRNOT00000091372
olfactory receptor 61
chr18_-_68934953 0.73 ENSRNOT00000058894

chr15_+_35942770 0.73 ENSRNOT00000072814
olfactory receptor 1278
chr12_-_16126953 0.72 ENSRNOT00000001682
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_+_59326803 0.71 ENSRNOT00000052426
olfactory receptor 840
chr3_-_113091770 0.67 ENSRNOT00000068132
leucine carboxyl methyltransferase 2
chr16_-_81714346 0.67 ENSRNOT00000092552
lysosomal-associated membrane protein 1
chrX_-_77418525 0.61 ENSRNOT00000092303
fibronectin type III domain containing 3C1
chr1_-_171162912 0.59 ENSRNOT00000074866
olfactory receptor 229
chr10_+_62566732 0.58 ENSRNOT00000021368
TAO kinase 1
chr17_+_77195247 0.54 ENSRNOT00000081940
optineurin
chr6_-_127571016 0.54 ENSRNOT00000057322
serine (or cysteine) peptidase inhibitor, clade A, member 1F
chr7_+_10937599 0.50 ENSRNOT00000008758
sirtuin 6
chr7_-_11195866 0.50 ENSRNOT00000005640
deoxyhypusine hydroxylase/monooxygenase
chr8_-_37026142 0.46 ENSRNOT00000060446
rCG22807-like
chrX_+_105575759 0.36 ENSRNOT00000088760
armadillo repeat containing, X-linked 3
chr8_+_19289506 0.35 ENSRNOT00000044135
olfactory receptor 1143
chr1_+_230160365 0.31 ENSRNOT00000088190
olfactory receptor 361
chr1_-_149529350 0.29 ENSRNOT00000052226
vomeronasal 2 receptor, 43
chr4_-_150520363 0.27 ENSRNOT00000065579
zinc finger protein 9
chr1_-_169770188 0.27 ENSRNOT00000072602
olfactory receptor 165
chr14_+_70780623 0.23 ENSRNOT00000083871
ENSRNOT00000058803
LIM domain binding 2
chr2_-_211690716 0.18 ENSRNOT00000027690
fibronectin type III domain containing 7
chr5_+_146294030 0.17 ENSRNOT00000073637

chr1_+_72280117 0.14 ENSRNOT00000021077
ret finger protein-like 4A
chr12_+_17253791 0.00 ENSRNOT00000083814
zinc finger AN1-type containing 2A

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.4 37.3 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
10.0 39.9 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
9.9 39.4 GO:1903976 negative regulation of glial cell migration(GO:1903976)
5.0 15.1 GO:0042412 taurine biosynthetic process(GO:0042412)
4.8 14.4 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
4.4 13.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
3.2 22.5 GO:0009812 flavonoid metabolic process(GO:0009812)
3.0 26.9 GO:0019530 allantoin metabolic process(GO:0000255) isoleucine metabolic process(GO:0006549) creatine metabolic process(GO:0006600) taurine metabolic process(GO:0019530) creatinine metabolic process(GO:0046449)
2.7 21.2 GO:0019388 galactose catabolic process(GO:0019388)
2.2 6.7 GO:0032741 central nervous system myelin formation(GO:0032289) positive regulation of interleukin-18 production(GO:0032741) detection of diacyl bacterial lipopeptide(GO:0042496) response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572) detection of bacterial lipopeptide(GO:0070340)
2.2 10.9 GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste(GO:0001582)
1.7 28.7 GO:1902358 sulfate transmembrane transport(GO:1902358)
1.7 26.9 GO:0031034 myosin filament assembly(GO:0031034)
1.6 4.8 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.3 2.6 GO:0080033 cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033)
1.2 3.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
1.1 5.4 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.9 7.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.8 3.1 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.7 4.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.7 4.3 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.7 3.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.7 1.4 GO:0071338 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.7 5.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.7 3.9 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.6 3.0 GO:0061709 reticulophagy(GO:0061709)
0.5 6.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 4.4 GO:0060174 limb bud formation(GO:0060174)
0.5 1.4 GO:2000464 positive regulation of astrocyte chemotaxis(GO:2000464)
0.5 12.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 1.8 GO:0061107 seminal vesicle development(GO:0061107)
0.3 2.0 GO:0002051 osteoblast fate commitment(GO:0002051) positive regulation of adipose tissue development(GO:1904179)
0.3 1.3 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.3 4.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.3 2.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.3 1.4 GO:0010046 response to mycotoxin(GO:0010046)
0.3 1.6 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.3 0.8 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.2 7.9 GO:0019835 cytolysis(GO:0019835)
0.2 7.3 GO:0006379 mRNA cleavage(GO:0006379)
0.2 0.7 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.2 0.8 GO:1904959 negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
0.2 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.2 7.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.2 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 16.8 GO:0044264 cellular polysaccharide metabolic process(GO:0044264)
0.2 8.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 1.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.9 GO:0048478 replication fork protection(GO:0048478)
0.1 0.5 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 1.3 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 6.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 6.0 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 1.3 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.4 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 1.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 2.3 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 2.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 5.9 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.5 GO:0061734 negative regulation of receptor recycling(GO:0001920) parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.1 2.1 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 2.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 61.4 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 2.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 6.8 GO:0002250 adaptive immune response(GO:0002250)
0.0 5.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 1.9 GO:0006909 phagocytosis(GO:0006909)
0.0 0.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 2.7 GO:0045765 regulation of angiogenesis(GO:0045765)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 26.9 GO:0070195 growth hormone receptor complex(GO:0070195)
2.2 6.7 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
2.2 10.9 GO:1903768 sweet taste receptor complex(GO:1903767) taste receptor complex(GO:1903768)
1.9 17.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.8 9.7 GO:0005859 muscle myosin complex(GO:0005859)
0.4 6.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 2.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.3 1.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 26.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 40.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 4.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 1.4 GO:0000322 storage vacuole(GO:0000322)
0.2 0.7 GO:0061474 phagolysosome membrane(GO:0061474)
0.2 1.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.2 3.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 6.0 GO:0001772 immunological synapse(GO:0001772)
0.1 1.3 GO:0005688 U6 snRNP(GO:0005688)
0.1 19.0 GO:0030018 Z disc(GO:0030018)
0.1 8.2 GO:0005811 lipid particle(GO:0005811)
0.1 7.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.9 GO:0031298 replication fork protection complex(GO:0031298)
0.1 3.1 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 92.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 3.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 5.3 GO:0005884 actin filament(GO:0005884)
0.1 2.4 GO:0016459 myosin complex(GO:0016459)
0.1 2.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 4.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 75.1 GO:0016021 integral component of membrane(GO:0016021)
0.0 3.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 18.6 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 37.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
7.5 22.5 GO:0050656 steroid sulfotransferase activity(GO:0050294) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
6.7 26.9 GO:0004903 growth hormone receptor activity(GO:0004903)
6.6 39.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
4.2 21.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
2.7 10.9 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
2.2 6.7 GO:0042498 diacyl lipopeptide binding(GO:0042498)
2.0 12.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.8 28.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
1.2 4.8 GO:0004771 sterol esterase activity(GO:0004771)
0.9 3.5 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.7 9.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.7 4.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.7 2.1 GO:0047708 biotinidase activity(GO:0047708)
0.7 7.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.5 15.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.5 14.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 1.4 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
0.5 2.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 1.4 GO:0032427 GBD domain binding(GO:0032427)
0.5 2.7 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.4 6.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.4 8.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 39.9 GO:0003823 antigen binding(GO:0003823)
0.3 4.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.3 1.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.3 1.7 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.3 2.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 2.0 GO:0004630 phospholipase D activity(GO:0004630)
0.3 0.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 12.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.2 6.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 3.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 7.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 0.8 GO:0032767 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
0.2 1.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.3 GO:0017070 U6 snRNA binding(GO:0017070) U4 snRNA binding(GO:0030621)
0.1 2.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 11.2 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.5 GO:0001155 TFIIIA-class transcription factor binding(GO:0001155)
0.1 16.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 11.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 30.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 5.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 8.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.4 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 2.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 4.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 22.4 GO:0005549 odorant binding(GO:0005549)
0.1 3.5 GO:0019003 GDP binding(GO:0019003)
0.0 2.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 27.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.7 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 5.6 GO:0003924 GTPase activity(GO:0003924)
0.0 2.4 GO:0003774 motor activity(GO:0003774)
0.0 2.2 GO:0005496 steroid binding(GO:0005496)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 10.1 GO:0003779 actin binding(GO:0003779)
0.0 0.7 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 29.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.4 20.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.3 21.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 6.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 5.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 6.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 3.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 1.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 16.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 1.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 39.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
2.0 28.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.7 22.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.7 6.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.3 26.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.1 13.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.1 21.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
1.0 37.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.6 10.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 15.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 4.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4 6.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.4 4.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 1.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.3 4.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.3 6.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 3.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 5.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 2.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 6.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.3 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 5.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 2.3 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 4.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases