ISMARA results: Sin3a

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sin3a

Z-value: 0.82

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Transcription factors associated with Sin3a

Gene Symbol	Gene ID	Gene Info
Sin3a NCBI RGD Ensembl	ENSRNOG00000032254	SIN3 transcription regulator family member A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sin3a	rn6_v1_chr8_+_61762768_61762773	0.35	1.4e-10	Click!

Activity profile of Sin3a motif

Sorted Z-values of Sin3a motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_113319456 Show fit	23.09	ENSRNOT00000051354	Ckmt1 NCBI RGD Ensembl Show fit	creatine kinase, mitochondrial 1
chr20_-_1984737 Show fit	18.77	ENSRNOT00000040232 ENSRNOT00000051634 ENSRNOT00000079445	Gabbr1 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type B receptor subunit 1
chr15_+_15275541 Show fit	17.56	ENSRNOT00000012153	Cadps NCBI RGD Ensembl Show fit	calcium dependent secretion activator
chr3_-_160301552 Show fit	15.11	ENSRNOT00000014498	Rims4 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 4
chr8_+_111600532 Show fit	13.79	ENSRNOT00000081952	Rab6b NCBI RGD Ensembl Show fit	RAB6B, member RAS oncogene family
chr14_-_85191557 Show fit	13.62	ENSRNOT00000011604	Nefh NCBI RGD Ensembl Show fit	neurofilament heavy
chr3_+_160391106 Show fit	13.41	ENSRNOT00000016981	Ywhab NCBI RGD Ensembl Show fit	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr1_-_199270627 Show fit	12.66	ENSRNOT00000026063	Stx1b NCBI RGD Ensembl Show fit	syntaxin 1B
chr13_+_52976507 Show fit	12.45	ENSRNOT00000090599 ENSRNOT00000011324	Kif21b NCBI RGD Ensembl Show fit	kinesin family member 21B
chr9_+_73529612 Show fit	12.34	ENSRNOT00000032430	Unc80 NCBI RGD Ensembl Show fit	unc-80 homolog, NALCN activator

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sin3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	47.2	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5	40.3	GO:0099643	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.4	33.7	GO:0032091	negative regulation of protein binding(GO:0032091)
1.6	28.2	GO:0021860	pyramidal neuron development(GO:0021860)
2.1	27.1	GO:1901660	calcium ion export(GO:1901660)
1.4	27.0	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.4	24.5	GO:0008542	visual learning(GO:0008542)
2.7	21.3	GO:1990504	dense core granule exocytosis(GO:1990504)
2.3	20.9	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
2.3	20.4	GO:0030644	cellular chloride ion homeostasis(GO:0030644)

Showing 1 to 10 of 523 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	90.7	GO:0043204	perikaryon(GO:0043204)
0.0	76.5	GO:0016021	integral component of membrane(GO:0016021)
1.3	60.2	GO:0048786	presynaptic active zone(GO:0048786)
0.3	37.2	GO:0030426	growth cone(GO:0030426)
1.2	33.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
1.9	29.6	GO:0031045	dense core granule(GO:0031045)
0.2	28.7	GO:0098793	presynapse(GO:0098793)
0.7	27.0	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
1.0	26.3	GO:0043194	axon initial segment(GO:0043194)
0.4	25.0	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Showing 1 to 10 of 212 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	49.2	GO:0005096	GTPase activator activity(GO:0005096)
0.3	48.6	GO:0044325	ion channel binding(GO:0044325)
4.7	33.1	GO:0004111	creatine kinase activity(GO:0004111)
1.1	32.8	GO:0017075	syntaxin-1 binding(GO:0017075)
1.3	29.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
1.5	28.9	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
4.1	24.7	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
1.7	20.9	GO:0019911	structural constituent of myelin sheath(GO:0019911)
3.8	19.0	GO:0004103	choline kinase activity(GO:0004103)
2.7	19.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)

Showing 1 to 10 of 290 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	33.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	25.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	17.1	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	14.4	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4	13.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.3	11.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	9.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.4	8.7	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.3	8.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	8.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	47.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
2.1	31.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.3	29.0	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.9	25.5	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
1.0	24.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.9	22.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.2	21.9	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.9	20.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
1.1	19.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
1.4	19.0	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Showing 1 to 10 of 122 entries

Results for Sin3a

Z-value: 0.82

Motif logo

Transcription factors associated with Sin3a

Activity-expression correlation:

Activity profile of Sin3a motif

Sorted Z-values of Sin3a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sin3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: