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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Scrt2
Z-value: 1.05
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Transcription factors associated with Scrt2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Scrt2 | rn6_v1_chr3_+_147585947_147585947 | 0.57 | 4.5e-29 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_49676540 Show fit | 59.92 |
ENSRNOT00000022032
ENSRNOT00000082205 |
FXYD domain-containing ion transport regulator 6 |
|
| chr2_-_119537837 Show fit | 53.94 |
ENSRNOT00000015200
|
peroxisomal biogenesis factor 5-like |
|
| chr14_-_43143973 Show fit | 53.21 |
ENSRNOT00000003248
|
ubiquitin C-terminal hydrolase L1 |
|
| chr2_+_121165137 Show fit | 47.48 |
ENSRNOT00000016236
|
SRY box 2 |
|
| chr9_-_85243001 Show fit | 46.52 |
ENSRNOT00000020219
|
secretogranin II |
|
| chr18_-_6782996 Show fit | 42.93 |
ENSRNOT00000090320
|
aquaporin 4 |
|
| chr18_-_6782757 Show fit | 42.77 |
ENSRNOT00000068150
|
aquaporin 4 |
|
| chr1_-_93949187 Show fit | 41.76 |
ENSRNOT00000018956
|
zinc finger protein 536 |
|
| chr10_+_58332588 Show fit | 38.46 |
ENSRNOT00000081954
|
WSC domain containing 1 |
|
| chrX_+_17171605 Show fit | 37.77 |
ENSRNOT00000048236
|
nudix (nucleoside diphosphate linked moiety X)-type motif 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Scrt2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.4 | 85.7 | GO:0060354 | negative regulation of cell adhesion molecule production(GO:0060354) |
| 11.4 | 68.3 | GO:0098912 | membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) |
| 6.2 | 62.4 | GO:0007412 | axon target recognition(GO:0007412) |
| 1.0 | 59.9 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 7.7 | 53.9 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) positive regulation of corticotropin secretion(GO:0051461) |
| 11.9 | 47.5 | GO:0030910 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 3.1 | 46.5 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 6.6 | 46.3 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 4.6 | 41.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 9.4 | 37.8 | GO:0071543 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 112.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.4 | 85.7 | GO:0046930 | pore complex(GO:0046930) |
| 5.7 | 68.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 4.9 | 53.9 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 1.0 | 53.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 1.1 | 51.1 | GO:0031941 | filamentous actin(GO:0031941) |
| 3.1 | 50.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.3 | 47.5 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 5.8 | 35.1 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.1 | 33.1 | GO:0061695 | transferase complex, transferring phosphorus-containing groups(GO:0061695) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 85.7 | GO:0015250 | water channel activity(GO:0015250) |
| 11.4 | 68.3 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 1.3 | 59.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 10.8 | 53.9 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 13.3 | 53.2 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 3.0 | 47.5 | GO:0035198 | miRNA binding(GO:0035198) |
| 1.6 | 44.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 5.2 | 41.8 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.6 | 38.5 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 9.4 | 37.8 | GO:0034431 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 53.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.7 | 35.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.7 | 30.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.5 | 22.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 20.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 14.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 12.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 7.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 85.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 1.6 | 35.4 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 2.0 | 35.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.1 | 33.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 3.4 | 30.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 22.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 22.5 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 12.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.6 | 11.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 8.9 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |