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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rxrb

Z-value: 0.85

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Transcription factors associated with Rxrb

Gene Symbol Gene ID Gene Info
ENSRNOG00000000464 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rxrbrn6_v1_chr20_+_3827367_3827367-0.132.2e-02Click!

Activity profile of Rxrb motif

Sorted Z-values of Rxrb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_150052483 59.68 ENSRNOT00000022265
similar to chromosome 20 open reading frame 144
chr1_-_169334093 54.93 ENSRNOT00000032587
ubiquilin 3
chr10_-_82209459 54.73 ENSRNOT00000004377
spermatogenesis associated 20
chr13_-_74740458 51.76 ENSRNOT00000006548
testis expressed 35
chr7_+_77066955 49.76 ENSRNOT00000008700
outer dense fiber of sperm tails 1
chr19_-_42180981 48.46 ENSRNOT00000019577
polyamine modulated factor 1 binding protein 1
chr7_+_117326279 45.33 ENSRNOT00000050522
spermatogenesis and centriole associated 1
chr1_-_169321075 44.68 ENSRNOT00000055216
similar to ubiquilin 1 isoform 2
chr3_-_149356160 43.10 ENSRNOT00000037589
ENSRNOT00000081775
Sad1 and UNC84 domain containing 5
chr1_+_72644333 41.65 ENSRNOT00000048976
ENSRNOT00000065051
family with sequence similarity 71, member E2
chr9_+_92435896 38.56 ENSRNOT00000022901
F-box protein 36
chr6_+_101288951 37.66 ENSRNOT00000046901
RGD1562540
chr9_+_10004805 37.04 ENSRNOT00000074117
solute carrier family 25, member 41
chr5_-_57372239 36.37 ENSRNOT00000012975
aquaporin 7
chr15_+_2740784 36.28 ENSRNOT00000067781
dual specificity phosphatase 13
chrX_+_13992064 36.24 ENSRNOT00000036543
rCG42854-like
chr14_-_108284619 35.09 ENSRNOT00000078814
hypothetical protein LOC690352
chr14_-_108285008 33.22 ENSRNOT00000087501
hypothetical protein LOC690352
chr19_-_20508711 32.63 ENSRNOT00000032408
hypothetical protein LOC680913
chr3_-_2434257 32.20 ENSRNOT00000013278
sperm-tail PG-rich repeat containing 3
chr12_+_22142520 30.48 ENSRNOT00000038397
F-box protein 24
chr1_+_97712177 30.02 ENSRNOT00000027745
similar to RIKEN cDNA 4930433I11 gene
chr7_-_117326551 29.42 ENSRNOT00000086087

chr13_+_93751759 29.38 ENSRNOT00000065706
WD repeat domain 64
chr1_+_72635267 29.34 ENSRNOT00000090636
interleukin 11
chr11_-_32469566 28.60 ENSRNOT00000002718
similar to RIKEN cDNA 4930563D23
chr5_-_75116490 28.50 ENSRNOT00000042788
thioredoxin domain containing 8
chr20_+_4959294 28.32 ENSRNOT00000074223
heat shock protein family A (Hsp70) member 1 like
chr4_-_6062641 27.68 ENSRNOT00000074846
chaperonin containing TCP1, subunit 8 (theta)-like 1
chr5_-_136049551 27.66 ENSRNOT00000068395
ENSRNOT00000079371
kinesin family member 2C
chr10_-_55560422 26.58 ENSRNOT00000006883
RAN guanine nucleotide release factor
chr3_-_134406576 25.15 ENSRNOT00000081589
SEL1L2 ERAD E3 ligase adaptor subunit
chr6_-_136185651 23.28 ENSRNOT00000085594
BCL2-associated athanogene 5
chr6_-_136279399 22.47 ENSRNOT00000015333
BCL2-associated athanogene 5-like 1
chr1_+_97777685 15.12 ENSRNOT00000030895
similar to F49E2.5d
chr2_-_123851854 14.22 ENSRNOT00000023327
interleukin 2
chr17_+_57040023 13.39 ENSRNOT00000020204
cAMP responsive element modulator
chr11_-_4332255 13.30 ENSRNOT00000087133
cell adhesion molecule 2
chr5_+_168078748 12.78 ENSRNOT00000024798
urotensin 2
chr3_+_150055749 11.42 ENSRNOT00000055335
actin-like 10
chr14_-_37871051 8.81 ENSRNOT00000003087
SLAIN motif family, member 2
chr16_+_19044607 8.65 ENSRNOT00000085462
mediator complex subunit 26
chr6_+_21051327 8.54 ENSRNOT00000052131
family with sequence similarity 98, member A
chr4_-_120390164 7.80 ENSRNOT00000017323
ENSRNOT00000063950
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr2_-_122646445 7.73 ENSRNOT00000080100
defective in cullin neddylation 1 domain containing 1
chr5_+_169357517 7.12 ENSRNOT00000000079
acyl-CoA thioesterase 7
chr6_-_122721496 6.41 ENSRNOT00000079697
protein tyrosine phosphatase, non-receptor type 21
chr4_-_157486844 5.77 ENSRNOT00000038281
ENSRNOT00000022874
COP9 signalosome subunit 7A
chr9_-_115850634 5.15 ENSRNOT00000049720
leucine rich repeat containing 30
chr2_+_198312428 4.22 ENSRNOT00000028758
splicing factor 3b, subunit 4
chr7_-_123586919 3.73 ENSRNOT00000011484
NADH:ubiquinone oxidoreductase subunit A6
chr4_+_57715946 2.95 ENSRNOT00000079059
ENSRNOT00000034429
kelch domain containing 10
chr12_+_38368693 2.93 ENSRNOT00000083261
CAP-GLY domain containing linker protein 1
chr1_-_266919031 2.69 ENSRNOT00000044519
calcium homeostasis modulator 1
chr3_+_95715193 2.51 ENSRNOT00000089525
paired box 6
chr7_-_70480724 2.49 ENSRNOT00000090057
deltex E3 ubiquitin ligase 3
chr9_-_44786041 2.32 ENSRNOT00000067197
REV1, DNA directed polymerase
chr9_+_18564927 2.20 ENSRNOT00000061014
runt-related transcription factor 2
chr10_-_87521514 2.01 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr8_-_55087832 1.35 ENSRNOT00000032152
dihydrolipoamide S-acetyltransferase
chr10_-_87535438 0.94 ENSRNOT00000086873
keratin associated protein 2-4
chr2_+_118910587 0.77 ENSRNOT00000065518
zinc finger protein 639

Network of associatons between targets according to the STRING database.

First level regulatory network of Rxrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 45.8 GO:0061084 negative regulation of protein refolding(GO:0061084)
7.3 36.4 GO:0015793 glycerol transport(GO:0015793)
5.4 43.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
4.6 27.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
4.1 37.0 GO:0015866 ADP transport(GO:0015866)
3.7 29.3 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
3.6 14.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
3.0 26.6 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
2.6 12.8 GO:0010841 negative regulation of glomerular filtration(GO:0003105) positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
2.4 7.1 GO:0036115 medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115)
1.7 28.5 GO:0006662 glycerol ether metabolic process(GO:0006662)
1.4 28.3 GO:0042026 protein refolding(GO:0042026)
1.3 2.7 GO:0015867 ATP transport(GO:0015867)
1.1 7.8 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.9 27.7 GO:0006458 'de novo' protein folding(GO:0006458)
0.8 2.5 GO:0003322 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.6 2.9 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.6 5.8 GO:0000338 protein deneddylation(GO:0000338)
0.5 2.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.4 2.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 8.8 GO:0007020 microtubule nucleation(GO:0007020)
0.4 42.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 7.7 GO:0045116 protein neddylation(GO:0045116)
0.3 13.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 4.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 104.5 GO:0007283 spermatogenesis(GO:0007283)
0.1 1.3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 4.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 17.3 GO:0007010 cytoskeleton organization(GO:0007010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 98.2 GO:0001520 outer dense fiber(GO:0001520)
4.6 27.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
2.2 28.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.2 39.4 GO:0035371 microtubule plus-end(GO:0035371)
1.1 8.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.7 43.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 45.8 GO:0016234 inclusion body(GO:0016234)
0.4 36.4 GO:0031526 brush border membrane(GO:0031526)
0.3 25.3 GO:0014704 intercalated disc(GO:0014704)
0.3 28.5 GO:0036126 sperm flagellum(GO:0036126)
0.2 8.7 GO:0016592 mediator complex(GO:0016592)
0.2 5.8 GO:0008180 COP9 signalosome(GO:0008180)
0.2 4.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 45.3 GO:0005813 centrosome(GO:0005813)
0.1 49.6 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.1 3.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 24.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.9 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 36.4 GO:0015254 glycerol channel activity(GO:0015254)
6.6 26.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
4.1 37.0 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
3.6 28.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
2.8 14.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.8 7.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
1.4 30.6 GO:0051010 microtubule plus-end binding(GO:0051010)
1.3 7.8 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.3 45.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.9 27.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.7 36.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 28.3 GO:0051082 unfolded protein binding(GO:0051082)
0.5 45.8 GO:0051087 chaperone binding(GO:0051087)
0.5 7.7 GO:0097602 cullin family protein binding(GO:0097602)
0.3 2.5 GO:0003680 AT DNA binding(GO:0003680)
0.2 29.3 GO:0070851 growth factor receptor binding(GO:0070851)
0.2 1.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 6.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 8.7 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 10.0 GO:0005179 hormone activity(GO:0005179)
0.1 2.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 2.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 2.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 26.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.8 GO:0043621 protein self-association(GO:0043621)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 27.7 PID AURORA B PATHWAY Aurora B signaling
0.5 14.2 PID IL27 PATHWAY IL27-mediated signaling events
0.1 29.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.2 PID FGF PATHWAY FGF signaling pathway
0.0 2.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 36.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.9 27.7 REACTOME KINESINS Genes involved in Kinesins
0.5 13.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.4 14.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 2.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 4.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 10.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.3 REACTOME DNA REPAIR Genes involved in DNA Repair