ISMARA results: Runx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Runx1

Z-value: 2.07

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Transcription factors associated with Runx1

Gene Symbol	Gene ID	Gene Info
Runx1 NCBI RGD Ensembl	ENSRNOG00000001704	runt-related transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Runx1	rn6_v1_chr11_-_33003021_33003021	0.90	5.4e-114	Click!

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_206342066 Show fit	141.47	ENSRNOT00000026556	Ptpn22 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 22
chr1_-_226887156 Show fit	112.68	ENSRNOT00000054809 ENSRNOT00000028347	Cd6 NCBI RGD Ensembl Show fit	Cd6 molecule
chr3_-_44177689 Show fit	112.51	ENSRNOT00000006387	Cytip NCBI RGD Ensembl Show fit	cytohesin 1 interacting protein
chr11_-_33003021 Show fit	107.82	ENSRNOT00000084134	Runx1 NCBI RGD Ensembl Show fit	runt-related transcription factor 1
chr10_-_31493419 Show fit	98.44	ENSRNOT00000009211	Itk NCBI RGD Ensembl Show fit	IL2-inducible T-cell kinase
chr14_+_3058993 Show fit	94.34	ENSRNOT00000002807	Gfi1 NCBI RGD Ensembl Show fit	growth factor independent 1 transcriptional repressor
chr10_-_56506446 Show fit	83.00	ENSRNOT00000021357	Acap1 NCBI RGD Ensembl Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr9_+_18564927 Show fit	75.84	ENSRNOT00000061014	Runx2 NCBI RGD Ensembl Show fit	runt-related transcription factor 2
chr11_-_60547201 Show fit	74.56	ENSRNOT00000093151	Btla NCBI RGD Ensembl Show fit	B and T lymphocyte associated
chr1_-_198577226 Show fit	73.60	ENSRNOT00000055013	Spn NCBI RGD Ensembl Show fit	sialophorin

Showing 1 to 10 of 115 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
58.8	176.4	GO:0071661	granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
13.8	137.5	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
8.7	112.7	GO:1900017	positive regulation of cytokine production involved in inflammatory response(GO:1900017)
35.9	107.8	GO:2000872	positive regulation of progesterone secretion(GO:2000872)
8.9	98.4	GO:0001865	NK T cell differentiation(GO:0001865)
31.4	94.3	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.2	92.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
2.7	86.3	GO:0006958	complement activation, classical pathway(GO:0006958)
12.6	75.8	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	73.7	GO:0030155	regulation of cell adhesion(GO:0030155)

Showing 1 to 10 of 74 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	239.9	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.5	153.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	120.3	GO:0005654	nucleoplasm(GO:0005654)
37.6	112.7	GO:0044214	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.9	107.8	GO:0005604	basement membrane(GO:0005604)
1.0	94.3	GO:0017053	transcriptional repressor complex(GO:0017053)
0.3	91.3	GO:0005667	transcription factor complex(GO:0005667)
0.4	89.2	GO:0005938	cell cortex(GO:0005938)
0.2	86.3	GO:0030424	axon(GO:0030424)
0.1	77.1	GO:0005887	integral component of plasma membrane(GO:0005887)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	142.1	GO:1990782	protein tyrosine kinase binding(GO:1990782)
0.5	132.1	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
22.5	112.7	GO:0070891	lipoteichoic acid binding(GO:0070891)
3.2	107.8	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.4	102.4	GO:0005096	GTPase activator activity(GO:0005096)
0.0	101.1	GO:0060089	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
1.6	98.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4	86.3	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
1.1	75.8	GO:0070491	repressing transcription factor binding(GO:0070491)
3.2	73.5	GO:0043274	phospholipase binding(GO:0043274)

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	276.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
2.5	172.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
2.1	139.1	PID IL12 2PATHWAY	IL12-mediated signaling events
1.3	105.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.5	92.5	PID RAC1 PATHWAY	RAC1 signaling pathway
2.0	83.0	PID ARF6 PATHWAY	Arf6 signaling events
1.5	77.4	PID RB 1PATHWAY	Regulation of retinoblastoma protein
4.2	76.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.0	53.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.3	39.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.4	171.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
2.8	137.5	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
2.1	106.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
6.2	86.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
2.7	75.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.6	73.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.4	66.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
3.4	58.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
1.5	52.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.8	43.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 10 of 29 entries

Results for Runx1

Z-value: 2.07

Motif logo

Transcription factors associated with Runx1

Activity-expression correlation:

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: