Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Runx1

Z-value: 2.07

Motif logo

logo of

Transcription factors associated with Runx1

Gene Symbol Gene ID Gene Info
Runx1
ENSRNOG00000001704 runt-related transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx1rn6_v1_chr11_-_33003021_330030210.905.4e-114Click!

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_206342066 141.47 ENSRNOT00000026556
Ptpn22
protein tyrosine phosphatase, non-receptor type 22
chr1_-_226887156 112.68 ENSRNOT00000054809
ENSRNOT00000028347
Cd6
Cd6 molecule
chr3_-_44177689 112.51 ENSRNOT00000006387
Cytip
cytohesin 1 interacting protein
chr11_-_33003021 107.82 ENSRNOT00000084134
Runx1
runt-related transcription factor 1
chr10_-_31493419 98.44 ENSRNOT00000009211
Itk
IL2-inducible T-cell kinase
chr14_+_3058993 94.34 ENSRNOT00000002807
Gfi1
growth factor independent 1 transcriptional repressor
chr10_-_56506446 83.00 ENSRNOT00000021357
Acap1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr9_+_18564927 75.84 ENSRNOT00000061014
Runx2
runt-related transcription factor 2
chr11_-_60547201 74.56 ENSRNOT00000093151
Btla
B and T lymphocyte associated
chr1_-_198577226 73.60 ENSRNOT00000055013
Spn
sialophorin
chrX_+_15155230 73.46 ENSRNOT00000073289
ENSRNOT00000051439
Was
Wiskott-Aldrich syndrome
chr2_-_149325913 72.11 ENSRNOT00000036690
Gpr171
G protein-coupled receptor 171
chr10_-_70871066 71.03 ENSRNOT00000015139
Ccl3
C-C motif chemokine ligand 3
chr6_+_109562587 67.81 ENSRNOT00000011563
Batf
basic leucine zipper ATF-like transcription factor
chr6_-_137664133 64.40 ENSRNOT00000018613
Gpr132
G protein-coupled receptor 132
chr11_-_60546997 62.96 ENSRNOT00000083124
ENSRNOT00000050092
Btla
B and T lymphocyte associated
chr2_-_203413124 61.63 ENSRNOT00000077898
ENSRNOT00000056140
Cd101
CD101 molecule
chr3_+_18970574 60.11 ENSRNOT00000088394
AABR07051665.1

chr9_+_67546408 58.15 ENSRNOT00000013701
Cd28
Cd28 molecule
chr13_+_89774764 55.75 ENSRNOT00000005619
Arhgap30
Rho GTPase activating protein 30
chr2_-_44981458 53.53 ENSRNOT00000014134
Gzma
granzyme A
chrX_+_14578264 52.85 ENSRNOT00000038994
Cybb
cytochrome b-245 beta chain
chr3_+_19141133 51.46 ENSRNOT00000058323
AABR07051675.1

chr3_-_146491837 51.31 ENSRNOT00000061469
Vsx1
visual system homeobox 1
chr3_+_19441604 46.37 ENSRNOT00000090581
AABR07051692.1

chr13_+_92146586 44.47 ENSRNOT00000004659
Olr1588
olfactory receptor 1588
chr20_-_2678141 43.48 ENSRNOT00000072377
ENSRNOT00000083833
C4a
complement component 4A (Rodgers blood group)
chr7_-_142352382 42.99 ENSRNOT00000048488
Galnt6
polypeptide N-acetylgalactosaminyltransferase 6
chr20_-_4508197 42.78 ENSRNOT00000086027
ENSRNOT00000000514
C4a
complement component 4A (Rodgers blood group)
chr20_-_4316715 42.22 ENSRNOT00000031704
C4b
complement C4B (Chido blood group)
chr4_+_145413230 41.46 ENSRNOT00000056508
Il17re
interleukin 17 receptor E
chr7_-_144880092 40.60 ENSRNOT00000055281
Nfe2
nuclear factor, erythroid 2
chr5_+_151362019 39.65 ENSRNOT00000077083
ENSRNOT00000067801
Wasf2
WAS protein family, member 2
chrX_-_159841072 39.62 ENSRNOT00000001158
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor 6
chr1_+_192233910 39.56 ENSRNOT00000016418
ENSRNOT00000016442
Prkcb
protein kinase C, beta
chr3_+_19366370 35.12 ENSRNOT00000086557
AABR07051689.1

chr1_-_82004538 34.95 ENSRNOT00000087572
Pou2f2
POU class 2 homeobox 2
chr13_-_83202864 34.92 ENSRNOT00000003976
Xcl1
X-C motif chemokine ligand 1
chr15_-_42947656 34.43 ENSRNOT00000030007
Ptk2b
protein tyrosine kinase 2 beta
chr13_-_92210052 31.70 ENSRNOT00000004670
Olr1592
olfactory receptor 1592
chr10_-_88036040 31.51 ENSRNOT00000018851
Krt13
keratin 13
chr3_+_18787606 30.78 ENSRNOT00000090508
AABR07051658.1

chr1_-_82003691 29.31 ENSRNOT00000084569
Pou2f2
POU class 2 homeobox 2
chr1_+_228690119 28.69 ENSRNOT00000087169
Pfpl
pore forming protein-like
chr10_-_66873948 25.33 ENSRNOT00000039261
Evi2a
ecotropic viral integration site 2A
chr10_-_83655182 25.09 ENSRNOT00000007897
Abi3
ABI family, member 3
chr8_-_96132634 22.67 ENSRNOT00000041655
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr9_+_47165342 22.01 ENSRNOT00000020144
Il1rl1
interleukin 1 receptor-like 1
chr3_+_55369214 21.42 ENSRNOT00000067161
Nostrin
nitric oxide synthase trafficking
chr8_+_48569328 21.39 ENSRNOT00000084030
Ccdc153
coiled-coil domain containing 153
chr1_+_129255396 21.30 ENSRNOT00000040147
Fam169b
family with sequence similarity 169, member B
chr5_+_25253010 21.22 ENSRNOT00000061333
Rbm12b
RNA binding motif protein 12B
chr1_-_219544328 21.13 ENSRNOT00000025847
Grk2
G protein-coupled receptor kinase 2
chr13_+_92249759 20.84 ENSRNOT00000089352
Olr1596
olfactory receptor 1596
chr14_+_35683442 20.68 ENSRNOT00000003085
Chic2
cysteine-rich hydrophobic domain 2
chr6_+_52631092 20.46 ENSRNOT00000014054
Atxn7l1
ataxin 7-like 1
chr20_+_4852671 19.85 ENSRNOT00000001111
Lta
lymphotoxin alpha
chr5_+_25725683 19.73 ENSRNOT00000087602
LOC679087
similar to swan
chr8_-_40137390 19.37 ENSRNOT00000042717
Panx3
pannexin 3
chr17_-_53688966 19.14 ENSRNOT00000078643
LOC100912163
AT-rich interactive domain-containing protein 4B-like
chr1_+_197999037 19.03 ENSRNOT00000091065
Apobr
apolipoprotein B receptor
chr16_-_6675746 18.88 ENSRNOT00000025858
Prkcd
protein kinase C, delta
chr20_+_2088533 18.36 ENSRNOT00000001012
ENSRNOT00000079021
Znrd1
zinc ribbon domain containing 1
chr10_+_75087892 18.11 ENSRNOT00000065910
Mpo
myeloperoxidase
chr3_+_18805220 17.79 ENSRNOT00000071216
Igkv4-86
immunoglobulin kappa variable 4-86
chr20_+_4852496 17.18 ENSRNOT00000088936
Lta
lymphotoxin alpha
chrX_-_15768522 16.34 ENSRNOT00000077391
Foxp3
forkhead box P3
chr20_-_22459025 16.32 ENSRNOT00000000792
Egr2
early growth response 2
chr3_+_21764377 16.29 ENSRNOT00000063938
Gpr21
G protein-coupled receptor 21
chr8_-_96266342 15.81 ENSRNOT00000078891
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_66673071 14.67 ENSRNOT00000034769
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr7_+_61337381 14.50 ENSRNOT00000009919
Ifng
interferon gamma
chr14_+_86828355 14.45 ENSRNOT00000088611
Ccm2
CCM2 scaffolding protein
chr11_+_88122271 12.00 ENSRNOT00000002540
Sdf2l1
stromal cell-derived factor 2-like 1
chr1_+_197999336 11.87 ENSRNOT00000023555
Apobr
apolipoprotein B receptor
chr19_+_10024947 11.56 ENSRNOT00000061392
Cfap20
cilia and flagella associated protein 20
chr9_+_71247781 11.21 ENSRNOT00000049654
Creb1
cAMP responsive element binding protein 1
chr5_-_86554102 11.13 ENSRNOT00000083340
ENSRNOT00000007710
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr4_-_180722358 10.87 ENSRNOT00000040645
Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
chr9_-_15700235 10.25 ENSRNOT00000088713
ENSRNOT00000035907
Trerf1
transcriptional regulating factor 1
chr14_-_81399353 10.15 ENSRNOT00000018340
Add1
adducin 1
chr10_-_39604070 10.02 ENSRNOT00000032333
Csf2
colony stimulating factor 2
chr2_+_116032455 10.01 ENSRNOT00000066495
Phc3
polyhomeotic homolog 3
chr7_+_121930615 9.92 ENSRNOT00000091270
ENSRNOT00000033975
Tnrc6b
trinucleotide repeat containing 6B
chr10_+_104582955 8.55 ENSRNOT00000009733
Unk
unkempt family zinc finger
chr3_+_170399302 8.03 ENSRNOT00000035245
Cass4
Cas scaffolding protein family member 4
chr3_+_66673246 7.86 ENSRNOT00000081338
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr10_+_64336200 7.62 ENSRNOT00000046519
Rpl37
ribosomal protein L37
chr10_+_63677396 7.51 ENSRNOT00000005100
Slc43a2
solute carrier family 43 member 2
chr16_+_83824430 7.19 ENSRNOT00000032918
Irs2
insulin receptor substrate 2
chr9_+_95202632 7.13 ENSRNOT00000025652
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr2_+_205553163 6.56 ENSRNOT00000039572
Nras
neuroblastoma RAS viral oncogene homolog
chr1_+_100577056 6.20 ENSRNOT00000026992
Napsa
napsin A aspartic peptidase
chr8_-_48736506 5.50 ENSRNOT00000016227
Ccdc84
coiled-coil domain containing 84
chr9_+_42871950 5.19 ENSRNOT00000089673
Arid5a
AT-rich interaction domain 5A
chr7_-_60778136 5.18 ENSRNOT00000029493
Slc35e3
solute carrier family 35, member E3
chr7_-_62162453 5.17 ENSRNOT00000010720
Cand1
cullin-associated and neddylation-dissociated 1
chr1_+_277261681 4.88 ENSRNOT00000022724
Plekhs1
pleckstrin homology domain containing S1
chr4_-_40036563 4.57 ENSRNOT00000084531
Tmem168
transmembrane protein 168
chr14_-_84820415 4.37 ENSRNOT00000057501
Mtmr3
myotubularin related protein 3
chr10_-_65200109 4.29 ENSRNOT00000030501
Nufip2
NUFIP2, FMR1 interacting protein 2
chr15_-_27716008 3.67 ENSRNOT00000011741
Ttc5
tetratricopeptide repeat domain 5
chr5_-_56753832 3.53 ENSRNOT00000073045
Sec61gl
SEC61 gamma subunit-like
chr1_+_192933540 3.37 ENSRNOT00000035770
Rbbp6
RB binding protein 6, ubiquitin ligase
chr9_-_81864202 3.29 ENSRNOT00000084964
Zfp142
zinc finger protein 142
chr7_-_144322240 3.11 ENSRNOT00000089290
LOC100912282
calcium-binding and coiled-coil domain-containing protein 1-like
chr2_-_210550490 2.62 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
Csf1
colony stimulating factor 1
chr3_+_104816987 2.35 ENSRNOT00000042103
ENSRNOT00000044625
Fmn1
formin 1
chr7_-_145450233 2.27 ENSRNOT00000092974
ENSRNOT00000021523
Calcoco1
calcium binding and coiled coil domain 1
chr17_-_22143324 2.17 ENSRNOT00000019361
Edn1
endothelin 1
chr2_+_24546536 1.13 ENSRNOT00000014036
Otp
orthopedia homeobox
chr8_+_122076759 0.59 ENSRNOT00000012545
Clasp2
cytoplasmic linker associated protein 2
chr2_-_187622373 0.58 ENSRNOT00000026396
Rhbg
Rh family B glycoprotein
chr5_-_151898022 0.45 ENSRNOT00000000133
Pigv
phosphatidylinositol glycan anchor biosynthesis, class V
chr14_+_33010300 0.08 ENSRNOT00000002809
Igfbp7
insulin-like growth factor binding protein 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
58.8 176.4 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
35.9 107.8 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
31.4 94.3 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
21.4 64.3 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
19.3 57.8 GO:0001807 regulation of type IV hypersensitivity(GO:0001807)
17.6 52.9 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
17.2 34.4 GO:2000537 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
14.2 71.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
13.8 137.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
13.2 39.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
12.6 75.8 GO:0002051 osteoblast fate commitment(GO:0002051)
12.3 37.0 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
12.2 73.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
8.9 98.4 GO:0001865 NK T cell differentiation(GO:0001865)
8.7 112.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
8.2 24.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
8.0 72.4 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
7.3 22.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
6.4 38.5 GO:0090367 negative regulation of mRNA modification(GO:0090367)
6.2 67.8 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
6.0 18.1 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
6.0 72.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
5.7 51.3 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
5.4 16.3 GO:0045077 peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) negative regulation of interferon-gamma biosynthetic process(GO:0045077)
5.4 16.3 GO:0021569 rhombomere 3 development(GO:0021569)
5.3 42.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
4.8 58.1 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
4.1 40.6 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
3.7 11.2 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
3.0 21.1 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
2.7 86.3 GO:0006958 complement activation, classical pathway(GO:0006958)
2.6 31.5 GO:0043587 tongue morphogenesis(GO:0043587)
2.4 7.2 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
2.2 19.4 GO:0034214 protein hexamerization(GO:0034214)
1.9 11.6 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
1.9 39.6 GO:0072673 lamellipodium morphogenesis(GO:0072673)
1.7 5.2 GO:0010265 SCF complex assembly(GO:0010265)
1.7 10.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.6 14.4 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
1.6 11.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
1.6 10.9 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.4 64.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
1.3 2.6 GO:1904124 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.1 12.0 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
1.1 2.2 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.0 57.0 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.9 9.9 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.9 8.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.6 22.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.6 18.4 GO:0006379 mRNA cleavage(GO:0006379)
0.6 2.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.5 16.3 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.4 6.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.4 20.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.3 31.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 6.6 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.2 30.9 GO:0006641 triglyceride metabolic process(GO:0006641)
0.2 1.9 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.2 0.6 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 7.5 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.2 4.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 43.0 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.2 5.2 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.2 92.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 1.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 73.7 GO:0030155 regulation of cell adhesion(GO:0030155)
0.1 41.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 25.1 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.1 0.5 GO:0097502 mannosylation(GO:0097502)
0.1 3.4 GO:0061053 somite development(GO:0061053)
0.1 21.4 GO:0006897 endocytosis(GO:0006897)
0.0 5.4 GO:0016055 Wnt signaling pathway(GO:0016055)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)
0.0 7.6 GO:0006412 translation(GO:0006412)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
37.6 112.7 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
5.3 52.9 GO:0043020 NADPH oxidase complex(GO:0043020)
4.9 73.6 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
4.8 38.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937) GAIT complex(GO:0097452)
4.4 39.6 GO:0031209 SCAR complex(GO:0031209)
3.7 11.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
2.0 34.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.9 42.2 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
1.6 58.1 GO:0001772 immunological synapse(GO:0001772)
1.1 18.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.1 10.1 GO:0008290 F-actin capping protein complex(GO:0008290)
1.1 12.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.1 239.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.0 94.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.9 107.8 GO:0005604 basement membrane(GO:0005604)
0.9 2.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.7 11.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.7 10.0 GO:0035102 PRC1 complex(GO:0035102)
0.6 19.4 GO:0005921 gap junction(GO:0005921)
0.6 73.5 GO:0005884 actin filament(GO:0005884)
0.6 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 6.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.5 2.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 39.6 GO:0031526 brush border membrane(GO:0031526)
0.5 153.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 4.3 GO:0042788 polysomal ribosome(GO:0042788)
0.4 64.7 GO:0030027 lamellipodium(GO:0030027)
0.4 89.2 GO:0005938 cell cortex(GO:0005938)
0.4 40.6 GO:0016605 PML body(GO:0016605)
0.3 21.1 GO:0043198 dendritic shaft(GO:0043198)
0.3 20.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.3 91.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 18.9 GO:0016363 nuclear matrix(GO:0016363)
0.2 86.3 GO:0030424 axon(GO:0030424)
0.1 49.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 11.6 GO:0005814 centriole(GO:0005814)
0.1 77.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 7.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 120.3 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.4 GO:0045095 keratin filament(GO:0045095)
0.0 4.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 4.6 GO:0030133 transport vesicle(GO:0030133)
0.0 2.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 12.0 GO:0005615 extracellular space(GO:0005615)
0.0 5.6 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
22.5 112.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
19.8 39.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
7.3 22.0 GO:0002114 interleukin-33 receptor activity(GO:0002114)
6.3 18.9 GO:0070976 TIR domain binding(GO:0070976)
6.2 30.9 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
6.0 42.2 GO:0001849 complement component C1q binding(GO:0001849)
6.0 72.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
5.9 52.9 GO:0016175 NAD(P)H oxidase activity(GO:0016174) superoxide-generating NADPH oxidase activity(GO:0016175)
5.4 16.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
5.2 41.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
4.9 34.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
4.8 19.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)
3.9 43.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
3.7 11.2 GO:1990763 arrestin family protein binding(GO:1990763)
3.5 21.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
3.2 73.5 GO:0043274 phospholipase binding(GO:0043274)
3.2 107.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.9 58.1 GO:0015026 coreceptor activity(GO:0015026)
2.8 22.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
2.7 10.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
2.4 38.5 GO:0008143 poly(A) binding(GO:0008143)
2.4 12.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
2.0 16.3 GO:0051525 NFAT protein binding(GO:0051525)
1.7 142.1 GO:1990782 protein tyrosine kinase binding(GO:1990782)
1.6 98.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.5 66.1 GO:0030544 Hsp70 protein binding(GO:0030544)
1.4 10.1 GO:0042608 T cell receptor binding(GO:0042608)
1.4 8.6 GO:1990715 mRNA CDS binding(GO:1990715)
1.3 2.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.2 40.6 GO:0050699 WW domain binding(GO:0050699)
1.1 75.8 GO:0070491 repressing transcription factor binding(GO:0070491)
1.0 34.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.0 37.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.9 4.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.7 2.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.7 16.3 GO:0071837 HMG box domain binding(GO:0071837)
0.5 132.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 65.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 18.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.4 18.1 GO:0004601 peroxidase activity(GO:0004601)
0.4 86.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.4 29.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 102.4 GO:0005096 GTPase activator activity(GO:0005096)
0.4 42.0 GO:0017124 SH3 domain binding(GO:0017124)
0.3 7.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 2.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 6.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 5.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 39.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 7.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 72.0 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.1 7.6 GO:0019843 rRNA binding(GO:0019843)
0.1 11.7 GO:0005126 cytokine receptor binding(GO:0005126)
0.0 101.1 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 35.5 GO:0003677 DNA binding(GO:0003677)
0.0 0.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 6.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 3.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 10.0 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 76.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
3.4 276.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
2.6 34.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
2.5 172.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
2.1 139.1 PID IL12 2PATHWAY IL12-mediated signaling events
2.0 53.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
2.0 83.0 PID ARF6 PATHWAY Arf6 signaling events
1.5 77.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
1.5 92.5 PID RAC1 PATHWAY RAC1 signaling pathway
1.3 105.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
1.3 39.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
1.2 26.1 PID IGF1 PATHWAY IGF1 pathway
1.1 18.1 PID IL23 PATHWAY IL23-mediated signaling events
0.8 14.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.6 10.9 ST ADRENERGIC Adrenergic Pathway
0.5 16.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 2.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 3.7 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.2 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 171.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
6.2 86.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
3.8 34.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
3.4 58.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
2.8 137.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
2.7 75.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.6 39.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
2.6 73.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
2.1 106.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
2.1 39.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.5 52.9 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.4 21.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
1.2 41.0 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
1.0 14.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.9 13.7 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.8 43.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.5 9.9 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.4 40.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 66.6 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.3 10.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 7.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 5.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 31.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 11.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 4.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 7.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 5.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)