ISMARA results: Rreb1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rreb1

Z-value: 0.95

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Transcription factors associated with Rreb1

Gene Symbol	Gene ID	Gene Info
Rreb1 NCBI RGD Ensembl	ENSRNOG00000015701	ras responsive element binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rreb1	rn6_v1_chr17_-_27665266_27665266	0.46	2.8e-18	Click!

Activity profile of Rreb1 motif

Sorted Z-values of Rreb1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_100577056 Show fit	62.20	ENSRNOT00000026992	Napsa NCBI RGD Ensembl Show fit	napsin A aspartic peptidase
chr9_-_80167033 Show fit	30.63	ENSRNOT00000023530	Igfbp5 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 5
chr8_-_7426611 Show fit	27.91	ENSRNOT00000031492	Arhgap42 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 42
chr1_+_40086470 Show fit	21.05	ENSRNOT00000021895	Iyd NCBI RGD Ensembl Show fit	iodotyrosine deiodinase
chr18_-_64177729 Show fit	20.91	ENSRNOT00000022347	Mc2r NCBI RGD Ensembl Show fit	melanocortin 2 receptor
chr6_+_3657325 Show fit	20.08	ENSRNOT00000010927	Tmem178a NCBI RGD Ensembl Show fit	transmembrane protein 178A
chr3_-_9326993 Show fit	19.27	ENSRNOT00000090137	Lamc3 NCBI RGD Ensembl Show fit	laminin subunit gamma 3
chr5_-_100647727 Show fit	18.63	ENSRNOT00000067435	Nfib NCBI RGD Ensembl Show fit	nuclear factor I/B
chr2_-_23289266 Show fit	18.17	ENSRNOT00000061708	Bhmt2 NCBI RGD Ensembl Show fit	betaine-homocysteine S-methyltransferase 2
chr5_-_7874909 Show fit	18.03	ENSRNOT00000064774	Prex2 NCBI RGD Ensembl Show fit	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Rreb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	62.2	GO:0043129	surfactant homeostasis(GO:0043129)
2.8	37.0	GO:0006570	tyrosine metabolic process(GO:0006570)
0.7	33.7	GO:0003009	skeletal muscle contraction(GO:0003009)
7.8	31.1	GO:0021740	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
7.7	30.6	GO:1904204	regulation of skeletal muscle hypertrophy(GO:1904204)
10.0	29.9	GO:0072714	response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
9.3	27.9	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
7.1	21.2	GO:0046864	isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
6.7	20.1	GO:0061347	planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.8	20.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)

Showing 1 to 10 of 172 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.4	62.2	GO:0097208	alveolar lamellar body(GO:0097208)
0.0	47.4	GO:0005615	extracellular space(GO:0005615)
0.1	37.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
3.1	31.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.5	30.9	GO:0009925	basal plasma membrane(GO:0009925)
5.1	30.6	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
2.4	28.5	GO:0005861	troponin complex(GO:0005861)
0.0	25.6	GO:1903561	extracellular vesicle(GO:1903561)
0.1	24.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	21.8	GO:0005902	microvillus(GO:0005902)

Showing 1 to 10 of 81 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	65.4	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
5.8	51.8	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.9	31.1	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
6.0	29.9	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
4.1	28.5	GO:0031014	troponin T binding(GO:0031014)
0.9	25.6	GO:0003785	actin monomer binding(GO:0003785)
2.9	22.9	GO:0008430	selenium binding(GO:0008430)
0.1	22.7	GO:0030246	carbohydrate binding(GO:0030246)
1.9	21.3	GO:0008242	omega peptidase activity(GO:0008242)
1.9	21.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)

Showing 1 to 10 of 128 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	50.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.6	46.9	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	43.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	26.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.5	24.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	18.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.5	18.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	17.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	17.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5	17.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	55.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.4	31.1	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
2.1	29.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.7	28.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	24.9	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
1.3	21.0	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
1.2	17.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.2	17.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.5	17.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	16.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 64 entries

Results for Rreb1

Z-value: 0.95

Motif logo

Transcription factors associated with Rreb1

Activity-expression correlation:

Activity profile of Rreb1 motif

Sorted Z-values of Rreb1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rreb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: