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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rreb1

Z-value: 0.95

Motif logo

Transcription factors associated with Rreb1

Gene Symbol Gene ID Gene Info
ENSRNOG00000015701 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rreb1rn6_v1_chr17_-_27665266_276652660.462.8e-18Click!

Activity profile of Rreb1 motif

Sorted Z-values of Rreb1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_100577056 62.20 ENSRNOT00000026992
napsin A aspartic peptidase
chr9_-_80167033 30.63 ENSRNOT00000023530
insulin-like growth factor binding protein 5
chr8_-_7426611 27.91 ENSRNOT00000031492
Rho GTPase activating protein 42
chr1_+_40086470 21.05 ENSRNOT00000021895
iodotyrosine deiodinase
chr18_-_64177729 20.91 ENSRNOT00000022347
melanocortin 2 receptor
chr6_+_3657325 20.08 ENSRNOT00000010927
transmembrane protein 178A
chr3_-_9326993 19.27 ENSRNOT00000090137
laminin subunit gamma 3
chr5_-_100647727 18.63 ENSRNOT00000067435
nuclear factor I/B
chr2_-_23289266 18.17 ENSRNOT00000061708
betaine-homocysteine S-methyltransferase 2
chr5_-_7874909 18.03 ENSRNOT00000064774
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_215609645 17.78 ENSRNOT00000076140
ENSRNOT00000027487
troponin I2, fast skeletal type
chr7_-_120077612 17.58 ENSRNOT00000011750
galectin 2
chr20_+_4363508 17.53 ENSRNOT00000077205
advanced glycosylation end product-specific receptor
chr7_+_38742051 17.49 ENSRNOT00000006070
decorin
chr10_-_10767389 17.20 ENSRNOT00000066754
small integral membrane protein 22
chr12_+_41543696 16.10 ENSRNOT00000079639
two pore segment channel 1
chr6_+_111180108 15.93 ENSRNOT00000082027
glutathione S-transferase zeta 1
chr1_-_131460473 15.58 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr12_+_17734133 15.42 ENSRNOT00000042117
platelet derived growth factor subunit A
chr10_+_86950557 15.37 ENSRNOT00000014153
insulin-like growth factor binding protein 4
chr1_-_256813711 15.30 ENSRNOT00000021055
retinol binding protein 4
chr2_+_236625357 15.19 ENSRNOT00000081248
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr19_-_40925660 14.88 ENSRNOT00000023645
MTSS1L, I-BAR domain containing
chr3_+_8832740 14.63 ENSRNOT00000022552
phytanoyl-CoA dioxygenase domain containing 1
chr1_+_191829555 14.09 ENSRNOT00000067138
sodium channel epithelial 1 beta subunit
chr12_+_38144855 13.81 ENSRNOT00000032274
hydroxycarboxylic acid receptor 1
chr2_+_23289374 13.59 ENSRNOT00000090666
ENSRNOT00000032783
dimethylglycine dehydrogenase
chr2_+_60949256 13.51 ENSRNOT00000025323
ENSRNOT00000040701
alpha-methylacyl-CoA racemase
chr14_-_92577936 13.22 ENSRNOT00000086154
cordon-bleu WH2 repeat protein
chr10_+_56710464 13.10 ENSRNOT00000065370
ENSRNOT00000064064
asialoglycoprotein receptor 2
chr5_-_100647298 12.51 ENSRNOT00000067538
ENSRNOT00000013092
nuclear factor I/B
chr8_+_62472095 12.50 ENSRNOT00000026473
cytochrome P450, family 1, subfamily a, polypeptide 1
chr20_+_4363152 12.36 ENSRNOT00000000508
ENSRNOT00000084841
ENSRNOT00000072848
ENSRNOT00000077561
advanced glycosylation end product-specific receptor
chr10_-_58973020 12.32 ENSRNOT00000020379
smoothelin-like 2
chr2_+_198303168 12.28 ENSRNOT00000056262
myotubularin related protein 11
chr2_-_195423787 12.05 ENSRNOT00000071603
selenium-binding protein 1
chr16_+_31734944 11.75 ENSRNOT00000059673
palladin, cytoskeletal associated protein
chr18_+_15467870 11.65 ENSRNOT00000091696
beta-1,4-galactosyltransferase 6
chr2_+_210045161 11.28 ENSRNOT00000024455
solute carrier family 16, member 4
chr16_+_4469468 11.04 ENSRNOT00000021164
wingless-type MMTV integration site family, member 5A
chr20_-_4542073 10.94 ENSRNOT00000000477
complement factor B
chr2_-_196113149 10.89 ENSRNOT00000088465
selenium binding protein 1
chr1_+_215609036 10.74 ENSRNOT00000076187
troponin I2, fast skeletal type
chr20_-_14025067 10.65 ENSRNOT00000093430
ENSRNOT00000074533
gamma-glutamyltransferase 1
chr16_+_20521956 10.64 ENSRNOT00000026597
pyroglutamyl-peptidase I
chr4_-_157372861 10.58 ENSRNOT00000021578
prolyl 3-hydroxylase 3
chr5_-_135001720 10.31 ENSRNOT00000035348
leucine rich adaptor protein 1
chr3_-_117766120 10.04 ENSRNOT00000056022
fibrillin 1
chr4_+_114835064 9.96 ENSRNOT00000031964
rhotekin
chr7_+_144647587 9.92 ENSRNOT00000022398
homeo box C4
chr1_-_22748422 9.81 ENSRNOT00000021944
solute carrier family 18 member B1
chr5_+_80920568 9.68 ENSRNOT00000076467
ENSRNOT00000076111
ENSRNOT00000040898
pregnancy-associated plasma protein A
chr11_-_37993204 9.60 ENSRNOT00000077050
ENSRNOT00000091614
ENSRNOT00000002683
family with sequence similarity 3, member B
chrX_-_75566481 9.59 ENSRNOT00000003714
zinc finger, DHHC-type containing 15
chr16_-_48981980 9.28 ENSRNOT00000014235
acyl-CoA synthetase long-chain family member 1
chr3_+_3310954 9.18 ENSRNOT00000061773
potassium sodium-activated channel subfamily T member 1
chr1_+_163445527 9.16 ENSRNOT00000020520
leucine rich repeat containing 32
chr3_-_29996865 9.15 ENSRNOT00000080382
zinc finger E-box binding homeobox 2
chr16_-_81912738 9.14 ENSRNOT00000087095
MCF.2 cell line derived transforming sequence-like
chr4_-_168297373 9.10 ENSRNOT00000066575
LDL receptor related protein 6
chr10_+_13797562 9.09 ENSRNOT00000011784
ENSRNOT00000083312
enoyl-CoA delta isomerase 1
chr6_+_107531528 9.07 ENSRNOT00000077555
acyl-CoA thioesterase 3
chr8_+_130401470 9.01 ENSRNOT00000043346
zinc finger and BTB domain containing 47
chr1_-_140262452 8.98 ENSRNOT00000046849
ENSRNOT00000045165
ENSRNOT00000025536
ENSRNOT00000041839
neurotrophic receptor tyrosine kinase 3
chr10_+_20320878 8.90 ENSRNOT00000009714
slit guidance ligand 3
chr1_+_107344904 8.80 ENSRNOT00000082582
growth arrest-specific 2
chr19_-_37916813 8.72 ENSRNOT00000026585
lecithin cholesterol acyltransferase
chr17_-_22143324 8.72 ENSRNOT00000019361
endothelin 1
chr10_+_86657285 8.57 ENSRNOT00000087346
thyroid hormone receptor alpha
chr14_+_84447885 8.52 ENSRNOT00000009150
GATS protein-like 3
chr3_+_72329967 8.40 ENSRNOT00000090256
solute carrier family 43, member 3
chr8_+_116771982 8.39 ENSRNOT00000083240

chr8_-_39093277 8.37 ENSRNOT00000043344
roundabout homolog 4-like
chr8_+_39878955 8.32 ENSRNOT00000060300
roundabout homolog 4-like
chr15_-_8931983 8.30 ENSRNOT00000085322
thyroid hormone receptor beta
chrX_-_106715391 8.30 ENSRNOT00000017138
transcription elongation factor A like 8
chr2_-_186515135 7.88 ENSRNOT00000077375
kin of IRRE like (Drosophila)
chr7_+_117643206 7.70 ENSRNOT00000077588
aarF domain containing kinase 5
chr16_+_80729400 7.65 ENSRNOT00000036383
testis development related protein
chr14_+_37130743 7.57 ENSRNOT00000031756
leucine rich repeat containing 66
chr10_+_84119884 7.54 ENSRNOT00000009951
homeo box B9
chr2_-_188718704 7.52 ENSRNOT00000028010
zinc finger and BTB domain containing 7B
chr9_-_116222374 7.46 ENSRNOT00000090111
ENSRNOT00000067900
Rho GTPase activating protein 28
chr9_-_19476646 7.42 ENSRNOT00000013703
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr4_+_113968995 7.35 ENSRNOT00000079511
rhotekin
chr1_-_282251257 7.35 ENSRNOT00000015186
peroxiredoxin 3
chr10_+_90550147 7.13 ENSRNOT00000032944
frizzled class receptor 2
chr8_+_130581062 7.07 ENSRNOT00000014323
family with sequence similarity 198, member A
chr20_-_3822754 7.05 ENSRNOT00000000541
ENSRNOT00000077357
solute carrier family 39 member 7
chr1_+_266380973 7.01 ENSRNOT00000080509
WW domain binding protein 1-like
chr3_+_95232166 6.92 ENSRNOT00000017952
hypothetical protein LOC691083
chr1_-_170628915 6.90 ENSRNOT00000042865
dachsous cadherin-related 1
chrX_+_6791136 6.87 ENSRNOT00000003984
norrin-like
chr8_-_48597867 6.81 ENSRNOT00000077958
NLR family member X1
chr17_-_32661865 6.55 ENSRNOT00000022194
serpin family B member 9
chr7_+_1206648 6.53 ENSRNOT00000073689
protein S (alpha)
chr8_+_79323408 6.40 ENSRNOT00000088391
ENSRNOT00000090258
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr18_-_70924708 6.11 ENSRNOT00000025257
lipase G, endothelial type
chr6_+_26387877 5.94 ENSRNOT00000076105

chr7_+_116357175 5.90 ENSRNOT00000076790
lymphocyte antigen 6 complex, locus E
chr8_+_62925357 5.87 ENSRNOT00000011074
ENSRNOT00000090588
stimulated by retinoic acid 6
chr6_-_114488880 5.86 ENSRNOT00000087560

chr4_+_41364441 5.84 ENSRNOT00000087146
forkhead box P2
chr2_-_185303610 5.84 ENSRNOT00000093479
ENSRNOT00000046286
protease, serine 48
chr12_-_1816414 5.82 ENSRNOT00000041155
ENSRNOT00000067448
insulin receptor
chr10_+_56764927 5.79 ENSRNOT00000025308
C-type lectin domain family 10, member A
chr14_-_45002719 5.77 ENSRNOT00000002883
family with sequence similarity 114, member A1
chr10_-_95431312 5.75 ENSRNOT00000085552

chr8_+_99880073 5.70 ENSRNOT00000010765
phospholipid scramblase 4
chr13_+_73929136 5.67 ENSRNOT00000005425
nephrosis 2, idiopathic, steroid-resistant
chr1_-_247169693 5.66 ENSRNOT00000079875
adenylate kinase 3
chr13_-_90832138 5.59 ENSRNOT00000010930
immunoglobulin superfamily, member 9
chr3_+_150910398 5.57 ENSRNOT00000055310
tumor protein p53 inducible nuclear protein 2
chr3_-_82756953 5.52 ENSRNOT00000044121
1-aminocyclopropane-1-carboxylate synthase homolog
chr10_-_110863021 5.50 ENSRNOT00000071141
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr10_-_74298599 5.46 ENSRNOT00000007379
yippee-like 2
chr8_-_76579387 5.41 ENSRNOT00000090747
family with sequence similarity 81, member A
chr7_-_12275609 5.34 ENSRNOT00000086061
APC2, WNT signaling pathway regulator
chr6_-_122721496 5.34 ENSRNOT00000079697
protein tyrosine phosphatase, non-receptor type 21
chr14_-_45859908 5.34 ENSRNOT00000086994
phosphoglucomutase 2
chr4_+_120843453 5.23 ENSRNOT00000022534
transmembrane protein adipocyte associated 1
chr7_+_70807867 5.21 ENSRNOT00000010639
SH3 and cysteine rich domain 3
chr20_+_5067330 5.07 ENSRNOT00000037482
lymphocyte antigen 6 complex, locus G6E
chr4_+_162937774 5.06 ENSRNOT00000083188
C-type lectin domain family 2, member G
chrX_-_157312028 5.05 ENSRNOT00000077979
ATPase plasma membrane Ca2+ transporting 3
chr4_+_88834066 4.97 ENSRNOT00000009546
ATP-binding cassette, subfamily G (WHITE), member 2
chr6_+_107245820 4.89 ENSRNOT00000012757
papilin, proteoglycan-like sulfated glycoprotein
chr1_+_114258719 4.86 ENSRNOT00000088459
ENSRNOT00000016376
cytoplasmic FMR1 interacting protein 1
chr10_-_90030423 4.84 ENSRNOT00000092150
membrane palmitoylated protein 2
chr8_-_76579099 4.79 ENSRNOT00000088628
family with sequence similarity 81, member A
chr7_+_117763783 4.76 ENSRNOT00000021208
major facilitator superfamily domain containing 3
chr7_+_144577465 4.75 ENSRNOT00000021647
homeo box C10
chr8_+_95968652 4.69 ENSRNOT00000015057
5' nucleotidase, ecto
chr17_+_31493107 4.66 ENSRNOT00000023611
ENSRNOT00000086264
tubulin, beta 2A class IIa
chr7_-_143538579 4.63 ENSRNOT00000081518
keratin 79
chr6_+_127333590 4.56 ENSRNOT00000063970
interferon, alpha-inducible protein 27
chr12_+_25173005 4.54 ENSRNOT00000033200
ENSRNOT00000091328
CAP-GLY domain containing linker protein 2
chr2_-_33025271 4.51 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr5_+_126812187 4.48 ENSRNOT00000057372
low density lipoprotein receptor class A domain containing 1
chr3_+_35679750 4.39 ENSRNOT00000059588
LY6/PLAUR domain containing 6
chr14_+_36689096 4.37 ENSRNOT00000083100
ubiquitin specific peptidase 46
chr1_-_163328591 4.37 ENSRNOT00000034843
tsukushi, small leucine rich proteoglycan
chr7_-_116504853 4.37 ENSRNOT00000056557
similar to Ly6-C antigen gene
chr13_+_89586283 4.36 ENSRNOT00000079355
ENSRNOT00000049873
nuclear receptor subfamily 1, group I, member 3
chr2_+_226563050 4.30 ENSRNOT00000065111
breast cancer anti-estrogen resistance 3
chr7_+_77966722 4.29 ENSRNOT00000006142
collagen triple helix repeat containing 1
chr11_+_61083757 4.25 ENSRNOT00000002790
BOC cell adhesion associated, oncogene regulated
chr1_+_198655742 4.19 ENSRNOT00000023944
myosin light chain, phosphorylatable, fast skeletal muscle
chr13_+_89597138 4.14 ENSRNOT00000004662
apolipoprotein A2
chr1_-_19376301 4.14 ENSRNOT00000015547
Rho GTPase activating protein 18
chr1_-_277181345 4.14 ENSRNOT00000038017
ENSRNOT00000038038
nebulin-related anchoring protein
chr2_-_147779013 4.12 ENSRNOT00000022778
COMM domain containing 2
chr1_-_212622537 4.03 ENSRNOT00000025609
shadow of prion protein homolog (zebrafish)
chr15_+_83703791 3.98 ENSRNOT00000090637
Kruppel-like factor 5
chrX_+_128416722 3.98 ENSRNOT00000009336
ENSRNOT00000085110
X-linked inhibitor of apoptosis
chr10_-_76813386 3.96 ENSRNOT00000032388
noggin
chr20_+_5050327 3.94 ENSRNOT00000083353
dimethylarginine dimethylaminohydrolase 2
chr16_+_80729959 3.93 ENSRNOT00000082049
testis development related protein
chr3_-_162579201 3.93 ENSRNOT00000068328
zinc finger, MYND-type containing 8
chr16_-_81583916 3.89 ENSRNOT00000026281
transmembrane and coiled-coil domain-containing protein 3
chr7_-_70476340 3.83 ENSRNOT00000006800
Rho guanine nucleotide exchange factor 25
chr6_-_122572925 3.77 ENSRNOT00000090869

chr3_+_113376983 3.76 ENSRNOT00000020478
protein disulfide isomerase family A, member 3
chr2_+_189922996 3.71 ENSRNOT00000016499
S100 calcium binding protein A16
chr8_-_105462141 3.70 ENSRNOT00000066731
ENSRNOT00000078760
calsyntenin 2
chr7_-_12399910 3.68 ENSRNOT00000021677
RGD1562114
chr19_+_43251539 3.64 ENSRNOT00000024793
DEAD-box helicase 19A
chr6_-_126320726 3.62 ENSRNOT00000010101
legumain
chr13_-_35511020 3.61 ENSRNOT00000003413
RAS like proto-oncogene B
chr4_+_68634929 3.50 ENSRNOT00000081178
single stranded DNA binding protein 1
chr10_+_83476107 3.49 ENSRNOT00000075733
prohibitin
chr5_-_153252021 3.48 ENSRNOT00000023221
transmembrane protein 50A
chr10_+_53466870 3.40 ENSRNOT00000057503
phosphoinositide-interacting regulator of transient receptor potential channels
chr20_+_10265806 3.30 ENSRNOT00000001564
ENSRNOT00000086272
NADH:ubiquinone oxidoreductase subunit V3
chr8_+_69484174 3.28 ENSRNOT00000077290
ENSRNOT00000056518
similar to RIKEN cDNA 1110012L19
chr12_+_13323547 3.28 ENSRNOT00000074138
zinc finger protein 853
chr4_-_7311807 3.28 ENSRNOT00000012222
ENSRNOT00000089817
ATP binding cassette subfamily B member 8
chr5_+_155660553 3.25 ENSRNOT00000081893
wingless-type MMTV integration site family, member 4
chr7_-_70661891 3.25 ENSRNOT00000010240
inhibin beta C subunit
chr13_-_50509916 3.23 ENSRNOT00000076747
renin
chr18_-_28444880 3.18 ENSRNOT00000060696
proline rich basic protein 1
chr7_+_120153184 3.17 ENSRNOT00000013538
galectin 1
chr8_+_5993941 3.13 ENSRNOT00000014065
transmembrane protein 123
chr7_-_138100841 3.10 ENSRNOT00000039002
solute carrier family 38, member 2
chr1_+_216237697 3.04 ENSRNOT00000027760
Cd81 molecule
chr17_-_14627937 3.02 ENSRNOT00000020532
osteoglycin
chr20_-_32052855 2.97 ENSRNOT00000074989
hexokinase 1-like
chr16_-_20460959 2.97 ENSRNOT00000026457
phosphodiesterase 4C
chr2_+_142262236 2.95 ENSRNOT00000019057
lipoma HMGIC fusion partner
chr8_+_45797315 2.95 ENSRNOT00000059997

chr14_-_7384876 2.95 ENSRNOT00000086694
AF4/FMR2 family, member 1
chr2_-_23941084 2.91 ENSRNOT00000084729
secretory carrier membrane protein 1
chr7_+_116356324 2.89 ENSRNOT00000076407
ENSRNOT00000077022
ENSRNOT00000075873
lymphocyte antigen 6 complex, locus E
chr8_+_55202725 2.88 ENSRNOT00000029166
ALG9, alpha-1,2-mannosyltransferase
chrX_+_71528988 2.83 ENSRNOT00000075963
O-linked N-acetylglucosamine (GlcNAc) transferase
chr4_-_148446303 2.81 ENSRNOT00000017633
arachidonate 5-lipoxygenase
chr17_+_6683152 2.81 ENSRNOT00000061249
similar to CG9752-PA
chr6_-_77243677 2.71 ENSRNOT00000011419
MAP3K12 binding inhibitory protein 1
chr10_+_106828981 2.70 ENSRNOT00000073809
arylformamidase
chr11_+_46179940 2.68 ENSRNOT00000088152
Trk-fused gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Rreb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 29.9 GO:0072714 response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
9.3 27.9 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
7.8 31.1 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
7.7 30.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
7.1 21.2 GO:0046864 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
6.7 20.1 GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
5.2 15.6 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
5.1 15.4 GO:1990401 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
4.5 13.6 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
4.2 12.5 GO:0017143 insecticide metabolic process(GO:0017143)
3.7 62.2 GO:0043129 surfactant homeostasis(GO:0043129)
3.3 10.0 GO:2001205 negative regulation of osteoclast development(GO:2001205)
3.3 9.9 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
3.0 9.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
3.0 9.1 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
2.9 8.7 GO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583)
2.9 8.6 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
2.8 37.0 GO:0006570 tyrosine metabolic process(GO:0006570)
2.7 10.6 GO:0031179 peptide modification(GO:0031179)
2.6 13.2 GO:0001757 somite specification(GO:0001757)
2.6 18.2 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
2.5 17.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.4 7.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
2.3 6.9 GO:0072137 mitral valve formation(GO:0003192) condensed mesenchymal cell proliferation(GO:0072137)
2.2 9.0 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
2.2 8.9 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
2.2 15.2 GO:0000103 sulfate assimilation(GO:0000103)
2.1 8.3 GO:0008050 female courtship behavior(GO:0008050)
2.1 4.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
2.0 6.1 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
1.7 5.0 GO:1904612 glucuronoside metabolic process(GO:0019389) response to 2,3,7,8-tetrachlorodibenzodioxine(GO:1904612)
1.6 9.9 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
1.6 3.3 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
1.6 4.9 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
1.6 4.7 GO:0046086 adenosine biosynthetic process(GO:0046086)
1.5 7.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
1.4 5.7 GO:0072248 metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
1.4 5.7 GO:0006172 ADP biosynthetic process(GO:0006172)
1.3 4.0 GO:0060825 regulation of cytokine activity(GO:0060300) fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.3 6.5 GO:0052041 negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
1.3 15.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
1.3 3.8 GO:2000853 negative regulation of corticosterone secretion(GO:2000853)
1.2 3.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.2 9.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.1 12.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 8.7 GO:0034370 triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372)
1.1 4.3 GO:0043932 ossification involved in bone remodeling(GO:0043932)
1.0 3.0 GO:1904350 regulation of protein catabolic process in the vacuole(GO:1904350)
1.0 3.9 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
1.0 6.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
1.0 5.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.9 3.8 GO:1903334 response to benzene(GO:1901423) positive regulation of protein folding(GO:1903334)
0.9 9.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.9 4.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.9 2.6 GO:1903116 positive regulation of actin filament-based movement(GO:1903116)
0.8 19.3 GO:0014002 astrocyte development(GO:0014002)
0.8 7.5 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.8 5.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 2.5 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of renin secretion into blood stream(GO:1900135)
0.8 7.5 GO:1904424 regulation of GTP binding(GO:1904424)
0.8 5.8 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.8 3.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.8 11.8 GO:0003334 keratinocyte development(GO:0003334)
0.8 20.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.7 5.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.7 2.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.7 2.8 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.7 33.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.7 4.0 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.6 3.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.6 3.8 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.6 1.9 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.6 3.1 GO:0015838 amino-acid betaine transport(GO:0015838)
0.6 1.8 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.6 13.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.5 1.6 GO:0030091 protein repair(GO:0030091)
0.5 1.1 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.5 7.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.5 8.8 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.5 2.1 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.5 5.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.5 1.8 GO:0051684 maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.5 1.8 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.4 14.1 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.4 5.2 GO:0040016 embryonic cleavage(GO:0040016)
0.4 1.7 GO:0045402 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.4 4.4 GO:0008343 adult feeding behavior(GO:0008343)
0.4 4.0 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 0.7 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.3 1.0 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.3 12.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.3 2.4 GO:0070253 somatostatin secretion(GO:0070253)
0.3 17.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.3 12.3 GO:0097178 ruffle assembly(GO:0097178)
0.3 9.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 5.7 GO:0017121 phospholipid scrambling(GO:0017121)
0.3 6.5 GO:0042730 fibrinolysis(GO:0042730)
0.3 2.6 GO:0007220 Notch receptor processing(GO:0007220)
0.3 9.6 GO:0018345 protein palmitoylation(GO:0018345)
0.3 1.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 4.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 5.1 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.3 16.0 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.3 10.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.3 3.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.3 1.0 GO:0038109 Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.3 17.9 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.2 2.7 GO:0043545 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.2 3.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 2.5 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 2.6 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.2 0.8 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 7.6 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 4.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 1.2 GO:0022605 oogenesis stage(GO:0022605)
0.2 4.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 1.3 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 4.6 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.2 1.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 9.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 13.1 GO:0055088 lipid homeostasis(GO:0055088)
0.1 3.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 4.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 4.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 3.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 2.1 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 1.8 GO:0048243 norepinephrine secretion(GO:0048243)
0.1 1.8 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.1 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 5.3 GO:0007588 excretion(GO:0007588)
0.1 0.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.4 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 3.7 GO:1904407 positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 1.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 3.0 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 1.3 GO:0035357 peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.1 1.5 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 2.9 GO:0097502 mannosylation(GO:0097502)
0.1 0.3 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.1 1.6 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 3.2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 9.3 GO:0050807 regulation of synapse organization(GO:0050807)
0.1 2.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 5.6 GO:0000045 autophagosome assembly(GO:0000045)
0.1 2.5 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.1 7.0 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 8.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 0.9 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.7 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.1 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 3.1 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 3.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.6 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.7 GO:0019228 neuronal action potential(GO:0019228)
0.0 3.4 GO:0009408 response to heat(GO:0009408)
0.0 2.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0009642 response to light intensity(GO:0009642)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 3.0 GO:0006006 glucose metabolic process(GO:0006006)
0.0 1.2 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 30.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
4.4 62.2 GO:0097208 alveolar lamellar body(GO:0097208)
3.1 31.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.4 28.5 GO:0005861 troponin complex(GO:0005861)
2.3 9.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.9 5.8 GO:0005899 insulin receptor complex(GO:0005899)
1.9 13.2 GO:1990357 terminal web(GO:1990357)
1.5 8.7 GO:0033093 Weibel-Palade body(GO:0033093) rough endoplasmic reticulum lumen(GO:0048237)
0.9 10.0 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.8 17.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.8 4.1 GO:0005927 muscle tendon junction(GO:0005927)
0.7 3.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.7 16.7 GO:0034706 sodium channel complex(GO:0034706)
0.6 5.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 4.5 GO:0042599 lamellar body(GO:0042599)
0.5 30.9 GO:0009925 basal plasma membrane(GO:0009925)
0.5 4.9 GO:0031209 SCAR complex(GO:0031209)
0.5 7.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 3.8 GO:0042825 TAP complex(GO:0042825)
0.5 4.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.5 4.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.4 2.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.4 8.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 5.3 GO:0016342 catenin complex(GO:0016342)
0.4 16.0 GO:0044295 axonal growth cone(GO:0044295)
0.3 1.9 GO:0097512 cardiac myofibril(GO:0097512)
0.3 4.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 2.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.7 GO:0070821 tertiary granule membrane(GO:0070821)
0.2 21.8 GO:0005902 microvillus(GO:0005902)
0.2 2.0 GO:0032437 cuticular plate(GO:0032437)
0.2 0.8 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 5.7 GO:0042588 zymogen granule(GO:0042588)
0.2 3.8 GO:0030673 axolemma(GO:0030673)
0.2 0.8 GO:0018444 translation release factor complex(GO:0018444)
0.2 11.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 15.5 GO:0005604 basement membrane(GO:0005604)
0.2 0.6 GO:0070876 SOSS complex(GO:0070876)
0.2 3.6 GO:0000145 exocyst(GO:0000145)
0.1 5.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 9.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 2.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 13.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 6.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 24.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.1 11.3 GO:0072562 blood microparticle(GO:0072562)
0.1 10.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 9.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.3 GO:0045252 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 3.0 GO:0001772 immunological synapse(GO:0001772)
0.1 1.0 GO:0008278 cohesin complex(GO:0008278)
0.1 4.2 GO:0016459 myosin complex(GO:0016459)
0.1 20.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 3.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 4.6 GO:0045095 keratin filament(GO:0045095)
0.1 5.6 GO:0005776 autophagosome(GO:0005776)
0.1 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 2.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.7 GO:0042641 actomyosin(GO:0042641)
0.1 37.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 6.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 47.4 GO:0005615 extracellular space(GO:0005615)
0.0 4.3 GO:0005769 early endosome(GO:0005769)
0.0 1.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 6.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.4 GO:0005903 brush border(GO:0005903)
0.0 3.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 9.2 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0030027 lamellipodium(GO:0030027)
0.0 2.4 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 25.6 GO:1903561 extracellular vesicle(GO:1903561)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 29.9 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
5.8 51.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
5.1 15.2 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
4.2 20.9 GO:0004977 melanocortin receptor activity(GO:0004977)
4.1 28.5 GO:0031014 troponin T binding(GO:0031014)
3.7 11.0 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
3.5 10.6 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
3.2 16.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
2.9 11.6 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
2.9 8.7 GO:0031708 endothelin B receptor binding(GO:0031708)
2.9 22.9 GO:0008430 selenium binding(GO:0008430)
2.5 65.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
2.3 9.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
2.3 9.1 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
2.3 9.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
2.3 18.2 GO:0008172 S-methyltransferase activity(GO:0008172)
2.2 17.6 GO:0016936 galactoside binding(GO:0016936)
2.2 17.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
1.9 21.3 GO:0008242 omega peptidase activity(GO:0008242)
1.9 21.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.8 7.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.8 8.9 GO:0048495 Roundabout binding(GO:0048495)
1.7 8.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.6 3.2 GO:0048030 disaccharide binding(GO:0048030)
1.6 14.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
1.4 12.5 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
1.4 4.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.3 3.9 GO:0016403 dimethylargininase activity(GO:0016403)
1.3 6.4 GO:0050816 phosphothreonine binding(GO:0050816)
1.2 15.3 GO:0019841 retinol binding(GO:0019841)
1.2 3.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
1.1 15.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.1 5.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.1 21.0 GO:0010181 FMN binding(GO:0010181)
1.0 6.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.0 6.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.0 13.6 GO:0005542 folic acid binding(GO:0005542)
1.0 18.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.9 2.8 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.9 3.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.9 2.8 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.9 31.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.9 25.6 GO:0003785 actin monomer binding(GO:0003785)
0.8 2.5 GO:0031694 beta-adrenergic receptor activity(GO:0004939) alpha-2A adrenergic receptor binding(GO:0031694)
0.8 18.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.8 2.3 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.8 13.5 GO:0016854 racemase and epimerase activity(GO:0016854)
0.6 7.0 GO:0001972 retinoic acid binding(GO:0001972)
0.6 5.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.5 2.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.5 5.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.5 7.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 5.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 1.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.4 15.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 4.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.4 9.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.4 1.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4 3.0 GO:1990459 transferrin receptor binding(GO:1990459)
0.4 10.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 3.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.4 1.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.3 5.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 4.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 17.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 9.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 5.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 6.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 1.3 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.3 5.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 4.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 2.7 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 4.6 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.2 9.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.1 GO:0097016 L27 domain binding(GO:0097016)
0.2 11.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 2.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 4.7 GO:0071837 HMG box domain binding(GO:0071837)
0.2 4.8 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 13.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 5.8 GO:0050681 androgen receptor binding(GO:0050681)
0.2 11.3 GO:0051213 dioxygenase activity(GO:0051213)
0.2 5.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 4.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 1.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 2.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 2.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.4 GO:0016805 dipeptidase activity(GO:0016805)
0.1 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 7.9 GO:0017022 myosin binding(GO:0017022)
0.1 1.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 22.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 7.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 2.1 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 17.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 3.2 GO:0019003 GDP binding(GO:0019003)
0.1 6.0 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.0 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 5.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 11.9 GO:0008017 microtubule binding(GO:0008017)
0.0 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.8 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 3.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.9 GO:0003774 motor activity(GO:0003774)
0.0 1.5 GO:0017046 peptide hormone binding(GO:0017046)
0.0 1.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 3.1 GO:0015293 symporter activity(GO:0015293)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.8 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0008200 ion channel inhibitor activity(GO:0008200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 46.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.9 50.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.6 9.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.6 10.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6 26.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.5 10.9 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 24.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.5 18.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.5 17.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 17.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.4 13.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.4 17.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 14.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 5.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 13.1 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 18.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 43.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 9.0 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.2 4.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 2.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 6.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 3.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 5.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 4.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.0 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 17.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.1 PID ARF 3PATHWAY Arf1 pathway
0.1 6.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.0 PID BMP PATHWAY BMP receptor signaling
0.1 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 3.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 2.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 9.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.2 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
2.7 55.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.1 29.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.4 31.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.3 21.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.2 17.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.2 17.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.2 15.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.1 13.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.9 9.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.7 28.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 9.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 10.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.6 5.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.5 4.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.5 8.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 17.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 3.8 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.4 3.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 5.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.4 3.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 10.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 5.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.4 4.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 10.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 5.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 5.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 3.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 5.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 2.6 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 2.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 1.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 16.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 24.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.2 2.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 8.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 10.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 13.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 10.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 6.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 4.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 16.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 4.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.0 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.1 3.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.1 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.1 6.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 8.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.7 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import