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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rfx5

Z-value: 1.15

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
Rfx5
ENSRNOG00000021012 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5rn6_v1_chr2_+_196120580_1961205800.342.3e-10Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_4043741 85.20 ENSRNOT00000000525
RT1-Bb
RT1 class II, locus Bb
chr20_+_4087618 85.19 ENSRNOT00000000522
ENSRNOT00000060327
ENSRNOT00000080590
RT1-Db1
RT1 class II, locus Db1
chr20_+_4039413 76.79 ENSRNOT00000082136
RT1-Bb
RT1 class II, locus Bb
chr18_+_56071478 75.94 ENSRNOT00000025344
ENSRNOT00000025354
Cd74
CD74 molecule
chr20_+_4020317 56.78 ENSRNOT00000000526
RT1-DOb
RT1 class II, locus DOb
chr20_-_4896970 42.69 ENSRNOT00000061114
ENSRNOT00000060980
RT1-CE7
RT1-CE5
RT1 class I, locus CE7
RT1 class I, locus CE5
chr20_-_5234290 41.50 ENSRNOT00000073474
RT1-DMb
RT1 class II, locus DMb
chr1_+_256035866 41.42 ENSRNOT00000079726
Kif11
kinesin family member 11
chr20_+_3945601 40.18 ENSRNOT00000075342
RT1-DMb
RT1 class II, locus DMb
chr20_-_5227620 40.18 ENSRNOT00000086240
RT1-DMb
RT1 class II, locus DMb
chr20_-_157861 36.91 ENSRNOT00000084461
RT1-CE10
RT1 class I, locus CE10
chr20_-_157665 36.04 ENSRNOT00000048858
ENSRNOT00000079494
RT1-CE10
RT1 class I, locus CE10
chr20_+_3979035 32.83 ENSRNOT00000000529
Tap1
transporter 1, ATP binding cassette subfamily B member
chr20_+_4106189 32.75 ENSRNOT00000042571
RT1-Db2
RT1 class II, locus Db2
chr20_-_5244386 28.28 ENSRNOT00000070886
RT1-DMa
RT1 class II, locus DMa
chr20_-_3978845 27.69 ENSRNOT00000000532
Psmb9
proteasome subunit beta 9
chr20_+_5414448 25.92 ENSRNOT00000078972
ENSRNOT00000080900
RT1-A1
RT1 class Ia, locus A1
chr13_-_72789841 25.81 ENSRNOT00000004694
Mr1
major histocompatibility complex, class I-related
chr20_+_3935529 25.59 ENSRNOT00000072458
LOC108348072
class II histocompatibility antigen, M alpha chain
chr20_+_3146856 24.14 ENSRNOT00000050159
RT1-N2
RT1 class Ib, locus N2
chr20_+_5374985 23.73 ENSRNOT00000052270
RT1-A2
RT1 class Ia, locus A2
chr20_-_1818800 21.32 ENSRNOT00000000990
RT1-M3-1
RT1 class Ib, locus M3, gene 1
chr20_-_3401273 21.13 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
Nrm
nurim (nuclear envelope membrane protein)
chr10_-_65634666 19.25 ENSRNOT00000014672
Foxn1
forkhead box N1
chr3_-_7141522 18.03 ENSRNOT00000014572
Cel
carboxyl ester lipase
chr20_+_3167079 16.62 ENSRNOT00000001035
RT1-N3
RT1 class Ib, locus N3
chr20_-_3166569 16.17 ENSRNOT00000091390
AABR07044362.1

chr1_+_142951094 13.98 ENSRNOT00000077441
Slc28a1
solute carrier family 28 member 1
chr11_+_47243342 13.91 ENSRNOT00000041116
Nfkbiz
NFKB inhibitor zeta
chr10_-_14247886 12.20 ENSRNOT00000020504
Nubp2
nucleotide binding protein 2
chr1_+_101265272 11.89 ENSRNOT00000051280
RGD1562492
similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16)
chr13_-_50761306 10.33 ENSRNOT00000076610
ENSRNOT00000004241
Prelp
proline and arginine rich end leucine rich repeat protein
chr15_-_29761117 9.90 ENSRNOT00000075194
AABR07017658.2

chr16_-_23975061 9.83 ENSRNOT00000090726
Nat1
N-acetyltransferase 1
chr7_-_70577147 8.94 ENSRNOT00000008854
Mbd6
methyl-CpG binding domain protein 6
chr4_-_66380734 8.48 ENSRNOT00000009194
Klrg2
killer cell lectin like receptor G2
chr1_+_189550354 7.91 ENSRNOT00000083153
Exnef
exonuclease NEF-sp
chr1_-_170594168 7.84 ENSRNOT00000026280
Tpp1
tripeptidyl peptidase 1
chr3_+_117853999 7.37 ENSRNOT00000042949
LOC100911847
40S ribosomal protein S14-like
chr1_-_89124132 6.88 ENSRNOT00000031044
Haus5
HAUS augmin-like complex, subunit 5
chr12_-_17584466 6.68 ENSRNOT00000035545
Dnaaf5
dynein, axonemal, assembly factor 5
chr10_-_72196437 6.49 ENSRNOT00000029769
Pigw
phosphatidylinositol glycan anchor biosynthesis, class W
chr19_-_37528011 6.13 ENSRNOT00000059628
Agrp
agouti related neuropeptide
chr7_+_117420788 5.99 ENSRNOT00000049198
Wdr97
WD repeat domain 97
chr10_+_94466523 5.59 ENSRNOT00000014867
Tcam1
testicular cell adhesion molecule 1
chr19_-_25955371 5.39 ENSRNOT00000004042
ENSRNOT00000084123
Rad23a
RAD23 homolog A, nucleotide excision repair protein
chr3_+_114087287 4.61 ENSRNOT00000023017
B2m
beta-2 microglobulin
chr10_+_71217966 4.44 ENSRNOT00000076192
Hnf1b
HNF1 homeobox B
chr8_-_55491152 4.36 ENSRNOT00000014965
LOC100359479
rCG58364-like
chr1_+_85112834 4.13 ENSRNOT00000026107
Dyrk1b
dual specificity tyrosine phosphorylation regulated kinase 1B
chr2_+_100677411 4.04 ENSRNOT00000067556
Ythdf3
YTH N(6)-methyladenosine RNA binding protein 3
chr7_+_72985495 3.48 ENSRNOT00000008361
Matn2
matrilin 2
chr10_-_15306515 3.13 ENSRNOT00000060150
Nhlrc4
NHL repeat containing 4
chr4_+_181428664 3.10 ENSRNOT00000002518
Rep15
RAB15 effector protein
chr15_-_20032191 3.03 ENSRNOT00000032704
Ddhd1
DDHD domain containing 1
chr2_-_149333597 2.92 ENSRNOT00000066948
P2ry14
purinergic receptor P2Y14
chrX_+_10964067 2.49 ENSRNOT00000093181
ENSRNOT00000066480
Med14
mediator complex subunit 14
chr3_-_78271875 2.48 ENSRNOT00000008475
Olr701
olfactory receptor 701
chr11_-_67618704 1.96 ENSRNOT00000042208
Ccdc58
coiled-coil domain containing 58
chr1_-_22452301 1.59 ENSRNOT00000043436
Taar7h
trace amine-associated receptor 7h
chr14_+_73889213 1.09 ENSRNOT00000041310
ENSRNOT00000081033
Rab28
RAB28, member RAS oncogene family
chr13_-_71282802 0.82 ENSRNOT00000025544
Rgsl2h
regulator of G-protein signaling like 2 homolog (mouse)
chr1_-_89944752 0.32 ENSRNOT00000029680
Scgb2b24
secretoglobin, family 2B, member 24
chr12_+_37829579 0.31 ENSRNOT00000084587
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
40.5 162.0 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
39.2 235.3 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
18.9 56.8 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
15.2 75.9 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
13.0 25.9 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
10.9 32.8 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
8.6 25.9 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
6.9 27.7 GO:1901423 response to benzene(GO:1901423)
6.9 41.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
5.1 205.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
3.6 58.3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
3.5 14.0 GO:1904823 purine nucleobase transmembrane transport(GO:1904823)
2.1 19.2 GO:0035878 nail development(GO:0035878)
1.5 4.4 GO:0061296 mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
1.3 18.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.8 6.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.7 9.8 GO:0097068 response to thyroxine(GO:0097068)
0.6 3.0 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.6 12.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.4 6.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 3.1 GO:0033572 transferrin transport(GO:0033572)
0.2 2.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 7.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 7.8 GO:0043171 peptide catabolic process(GO:0043171)
0.2 6.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 5.4 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.1 4.1 GO:0007520 myoblast fusion(GO:0007520)
0.1 4.4 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 10.3 GO:0007569 cell aging(GO:0007569)
0.1 3.5 GO:0008347 glial cell migration(GO:0008347)
0.0 2.5 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 11.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.1 GO:1901998 toxin transport(GO:1901998)
0.0 4.8 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
36.8 588.4 GO:0042613 MHC class II protein complex(GO:0042613)
12.8 217.0 GO:0042611 MHC protein complex(GO:0042611)
4.7 32.8 GO:0042825 TAP complex(GO:0042825)
4.6 27.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.9 12.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 6.9 GO:0070652 HAUS complex(GO:0070652)
0.7 41.4 GO:0005876 spindle microtubule(GO:0005876)
0.6 18.0 GO:0042588 zymogen granule(GO:0042588)
0.6 6.1 GO:0005796 Golgi lumen(GO:0005796)
0.4 8.9 GO:0010369 chromocenter(GO:0010369)
0.4 2.5 GO:0070847 core mediator complex(GO:0070847)
0.3 18.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 13.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 7.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 7.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 13.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 14.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.1 GO:0055037 recycling endosome(GO:0055037)
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.5 368.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
12.6 75.5 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
12.5 162.0 GO:1990405 protein antigen binding(GO:1990405)
6.0 18.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
5.4 184.7 GO:0042605 peptide antigen binding(GO:0042605)
4.7 14.0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
3.3 9.8 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
2.6 41.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
2.0 7.8 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.5 27.7 GO:0070628 proteasome binding(GO:0070628)
1.0 25.8 GO:0003823 antigen binding(GO:0003823)
0.7 6.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.5 4.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 5.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 11.9 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.3 12.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 7.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 2.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 10.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 7.9 GO:0004527 exonuclease activity(GO:0004527)
0.1 19.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 5.6 GO:0005178 integrin binding(GO:0005178)
0.0 4.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 20.5 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 4.6 GO:0001948 glycoprotein binding(GO:0001948)
0.0 3.0 GO:0004620 phospholipase activity(GO:0004620)
0.0 8.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 6.5 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 8.9 GO:0003682 chromatin binding(GO:0003682)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 10.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 23.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 23.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 37.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.4 117.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.7 10.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.5 26.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.4 14.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 6.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 2.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 7.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 4.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 2.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation