ISMARA results: Rfx2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rfx2_Rfx7

Z-value: 3.61

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Transcription factors associated with Rfx2_Rfx7

Gene Symbol	Gene ID	Gene Info
Rfx2 NCBI RGD Ensembl	ENSRNOG00000045846	regulatory factor X2
Rfx7 NCBI RGD Ensembl	ENSRNOG00000060367	regulatory factor X, 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rfx2	rn6_v1_chr9_+_10216205_10216293	0.71	3.3e-51	Click!
Rfx7	rn6_v1_chr8_+_79159370_79159370	0.01	8.5e-01	Click!

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_84976170 Show fit	237.93	ENSRNOT00000013542	Lrrc46 NCBI RGD Ensembl Show fit	leucine rich repeat containing 46
chr6_-_27460038 Show fit	204.70	ENSRNOT00000036815	Drc1 NCBI RGD Ensembl Show fit	dynein regulatory complex subunit 1
chr6_+_52702544 Show fit	200.83	ENSRNOT00000014252	Efcab10 NCBI RGD Ensembl Show fit	EF-hand calcium binding domain 10
chr16_+_56248331 Show fit	196.79	ENSRNOT00000085300	Tusc3 NCBI RGD Ensembl Show fit	tumor suppressor candidate 3
chr10_+_14828597 Show fit	186.42	ENSRNOT00000025434	Tekt4 NCBI RGD Ensembl Show fit	tektin 4
chr1_-_226526959 Show fit	177.68	ENSRNOT00000028003	Ppp1r32 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 32
chr7_+_126028350 Show fit	170.86	ENSRNOT00000042412	Ribc2 NCBI RGD Ensembl Show fit	RIB43A domain with coiled-coils 2
chr3_+_56802714 Show fit	168.74	ENSRNOT00000077551	Erich2 NCBI RGD Ensembl Show fit	glutamate-rich 2
chr1_-_72632185 Show fit	151.51	ENSRNOT00000066383	Tmem190 NCBI RGD Ensembl Show fit	transmembrane protein 190
chr4_+_10020349 Show fit	151.04	ENSRNOT00000065039	Fbxl13 NCBI RGD Ensembl Show fit	F-box and leucine-rich repeat protein 13

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
26.0	571.3	GO:0060285	cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
23.1	415.2	GO:0036158	outer dynein arm assembly(GO:0036158)
63.7	318.4	GO:0080154	regulation of fertilization(GO:0080154)
3.0	312.5	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
18.5	277.1	GO:0003351	epithelial cilium movement(GO:0003351)
2.6	274.8	GO:0044782	cilium organization(GO:0044782)
14.1	196.8	GO:0015693	magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
1.1	161.9	GO:0007018	microtubule-based movement(GO:0007018)
6.4	133.5	GO:0045724	positive regulation of cilium assembly(GO:0045724)
1.1	133.4	GO:0060271	cilium morphogenesis(GO:0060271)

Showing 1 to 10 of 155 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.7	727.2	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
12.1	374.5	GO:0097228	sperm principal piece(GO:0097228)
10.0	239.3	GO:0002080	acrosomal membrane(GO:0002080)
11.6	196.8	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
4.1	196.0	GO:0036126	sperm flagellum(GO:0036126)
30.0	180.1	GO:0036157	outer dynein arm(GO:0036157)
37.9	151.5	GO:0002079	inner acrosomal membrane(GO:0002079)
0.4	143.7	GO:0005813	centrosome(GO:0005813)
4.1	142.8	GO:0030286	dynein complex(GO:0030286)
0.7	125.2	GO:0005929	cilium(GO:0005929)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	357.8	GO:0003777	microtubule motor activity(GO:0003777)
0.5	223.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
14.1	196.8	GO:0004579	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
2.1	164.6	GO:0043621	protein self-association(GO:0043621)
0.2	155.0	GO:0005509	calcium ion binding(GO:0005509)
0.5	144.7	GO:0030695	GTPase regulator activity(GO:0030695)
0.4	137.1	GO:0005525	GTP binding(GO:0005525)
32.9	131.8	GO:0004127	cytidylate kinase activity(GO:0004127)
0.8	121.6	GO:0005516	calmodulin binding(GO:0005516)
16.1	112.7	GO:0005432	calcium:sodium antiporter activity(GO:0005432)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	83.1	PID PLK1 PATHWAY	PLK1 signaling events
1.2	62.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
1.8	56.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
1.0	50.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.4	44.0	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.5	37.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
1.1	32.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.8	28.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.7	27.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.9	27.2	PID TRAIL PATHWAY	TRAIL signaling pathway

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	122.1	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
2.1	116.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
1.5	86.0	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
1.8	58.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
3.0	56.8	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.9	56.3	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.2	52.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7	49.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
2.3	49.6	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.5	47.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors

Showing 1 to 10 of 35 entries

Results for Rfx2_Rfx7

Z-value: 3.61

Motif logo

Transcription factors associated with Rfx2_Rfx7

Activity-expression correlation:

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: