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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rfx2_Rfx7

Z-value: 3.61

Motif logo

Transcription factors associated with Rfx2_Rfx7

Gene Symbol Gene ID Gene Info
ENSRNOG00000045846 regulatory factor X2
ENSRNOG00000060367 regulatory factor X, 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx2rn6_v1_chr9_+_10216205_102162930.713.3e-51Click!
Rfx7rn6_v1_chr8_+_79159370_791593700.018.5e-01Click!

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_84976170 237.93 ENSRNOT00000013542
leucine rich repeat containing 46
chr6_-_27460038 204.70 ENSRNOT00000036815
dynein regulatory complex subunit 1
chr6_+_52702544 200.83 ENSRNOT00000014252
EF-hand calcium binding domain 10
chr16_+_56248331 196.79 ENSRNOT00000085300
tumor suppressor candidate 3
chr10_+_14828597 186.42 ENSRNOT00000025434
tektin 4
chr1_-_226526959 177.68 ENSRNOT00000028003
protein phosphatase 1, regulatory subunit 32
chr7_+_126028350 170.86 ENSRNOT00000042412
RIB43A domain with coiled-coils 2
chr3_+_56802714 168.74 ENSRNOT00000077551
glutamate-rich 2
chr1_-_72632185 151.51 ENSRNOT00000066383
transmembrane protein 190
chr4_+_10020349 151.04 ENSRNOT00000065039
F-box and leucine-rich repeat protein 13
chr14_-_114868328 149.77 ENSRNOT00000034584
similar to hypothetical protein FLJ40298
chr12_+_46042413 145.80 ENSRNOT00000046882
coiled-coil domain containing 60
chr17_+_78817529 145.11 ENSRNOT00000021918
meiosis/spermiogenesis associated 1
chr7_-_33916338 142.42 ENSRNOT00000005492
cilia and flagella associated protein 54
chr10_+_49472460 131.95 ENSRNOT00000038276
tektin 3
chr17_-_88095729 129.77 ENSRNOT00000025140
enkurin, TRPC channel interacting protein
chr1_-_154111725 128.78 ENSRNOT00000055488
coiled-coil domain containing 81
chr3_-_7051953 128.01 ENSRNOT00000013473
similar to hypothetical protein MGC29761
chr10_+_1834518 126.70 ENSRNOT00000061709
predicted gene 1758
chr8_-_23014499 126.07 ENSRNOT00000017820
coiled-coil domain containing 151
chr1_+_267689328 122.85 ENSRNOT00000077738
cilia and flagella associated protein 58
chr6_+_137386422 119.83 ENSRNOT00000018568
LOC362793
chr4_+_114854458 119.22 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr19_-_53754602 118.58 ENSRNOT00000035651
family with sequence similarity 92, member B
chr15_-_47338976 118.20 ENSRNOT00000016562
similar to 4930578I06Rik protein
chr20_+_14577166 117.56 ENSRNOT00000085583
rhabdoid tumor deletion region gene 1
chr17_+_85914410 117.02 ENSRNOT00000075188
armadillo repeat containing 3
chr7_-_126028279 116.69 ENSRNOT00000044883
structural maintenance of chromosomes 1B
chr10_+_88459490 115.89 ENSRNOT00000080231
ENSRNOT00000067559
tetratricopeptide repeat domain 25
chr5_-_78324278 115.42 ENSRNOT00000082642
ENSRNOT00000048904
WD repeat domain 31
chr6_+_78567970 114.68 ENSRNOT00000032743
tetratricopeptide repeat domain 6
chr3_+_171597241 113.85 ENSRNOT00000029558
similar to Protein C20orf85 homolog
chr10_-_44746549 113.27 ENSRNOT00000003841
family with sequence similarity 183, member B
chr5_+_118574801 112.85 ENSRNOT00000035949
ubiquitin-conjugating enzyme E2U (putative)
chr2_-_243475639 112.74 ENSRNOT00000089222
similar to hypothetical protein DKFZp434G072
chr4_+_25538497 109.02 ENSRNOT00000009264
cilia and flagella associated protein 69
chr10_+_55169282 106.00 ENSRNOT00000005423
coiled-coil domain containing 42
chr3_-_56030744 105.13 ENSRNOT00000089637
coiled-coil domain containing 173
chr2_-_29248174 104.65 ENSRNOT00000071167
similar to HIStone family member (his-41)
chr10_+_103266296 99.00 ENSRNOT00000038852
dynein, axonemal, intermediate chain 2
chr14_+_107785029 98.63 ENSRNOT00000013097
ENSRNOT00000087091
family with sequence similarity 161, member A
chr4_-_4473307 98.06 ENSRNOT00000045773
dipeptidyl peptidase like 6
chr10_+_90984227 96.92 ENSRNOT00000003890
ENSRNOT00000093707
coiled-coil domain containing 103
chr5_-_136112344 96.53 ENSRNOT00000050195
RGD1563714
chr7_-_130350570 95.07 ENSRNOT00000055805
outer dense fiber of sperm tails 3B
chr1_-_37726151 93.60 ENSRNOT00000071842
LOC361192
chr7_-_74901997 93.25 ENSRNOT00000039378
regulator of G-protein signaling 22
chr6_-_27323992 89.05 ENSRNOT00000013198
similar to RIKEN cDNA 1700001C02
chr3_+_92640752 88.49 ENSRNOT00000007604
solute carrier family 1 member 2
chr2_-_251970768 87.77 ENSRNOT00000020141
WD repeat domain 63
chr4_-_145555748 86.99 ENSRNOT00000013503
FANCD2 opposite strand
chr11_+_60073383 85.90 ENSRNOT00000087508
transgelin 3
chr6_-_135259603 84.31 ENSRNOT00000010529
MOK protein kinase
chrX_+_20351486 83.45 ENSRNOT00000093675
ENSRNOT00000047444
WNK lysine deficient protein kinase 3
chr6_+_111223026 82.39 ENSRNOT00000074634
sterile alpha motif domain containing 15
chr3_-_11820549 82.28 ENSRNOT00000020660
cilia and flagella associated protein 157
chr1_-_156327352 82.13 ENSRNOT00000074282
coiled-coil domain-containing protein 89-like
chr13_-_47916877 81.96 ENSRNOT00000006502
dual specificity tyrosine phosphorylation regulated kinase 3
chr6_+_34094306 81.62 ENSRNOT00000051970
WD repeat domain 35
chr5_+_57947716 81.08 ENSRNOT00000067657
dynein, axonemal, intermediate chain 1
chr3_-_102430151 81.00 ENSRNOT00000006507
ankyrin repeat domain 30A
chr18_+_70263359 80.71 ENSRNOT00000019573
cilia and flagella associated protein 53
chr7_+_140383397 79.50 ENSRNOT00000090760
coiled-coil domain containing 65
chr1_+_154606490 79.46 ENSRNOT00000024095
coiled-coil domain containing 89
chr5_-_144345531 77.95 ENSRNOT00000014721
tektin 2
chr1_-_267598639 77.51 ENSRNOT00000031925
cilia and flagella associated protein 43
chr1_+_214182830 76.58 ENSRNOT00000022867
leucine rich repeat containing 56
chr20_-_7654428 76.56 ENSRNOT00000045044
t-complex 11
chr1_-_145931583 75.85 ENSRNOT00000016433
cilia and flagella associated protein 161
chr6_+_129538982 72.19 ENSRNOT00000083626
ENSRNOT00000082522
adenylate kinase 7
chr1_+_164849974 71.73 ENSRNOT00000031908
X-ray radiation resistance associated 1
chr10_-_107158997 70.25 ENSRNOT00000004047
dynein, axonemal, heavy chain 17
chr8_+_79054237 69.59 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr6_-_11063073 69.47 ENSRNOT00000086010
ENSRNOT00000061746
hypothetical protein LOC681766
chr14_-_81725181 68.73 ENSRNOT00000078252
cilia and flagella associated protein 99
chr16_-_68832862 67.01 ENSRNOT00000016348
POTE ankyrin domain family, member G
chr5_+_140870140 66.13 ENSRNOT00000074347
hippocalcin-like 4
chr10_+_5352933 66.03 ENSRNOT00000003465
tektin 5
chr8_+_79638696 64.75 ENSRNOT00000085959
dyslexia susceptibility 1 candidate 1
chr5_+_113592919 64.50 ENSRNOT00000011336
intraflagellar transport 74
chr1_-_212022212 64.36 ENSRNOT00000074298
cilia and flagella associated protein 46
chr7_+_91588458 64.10 ENSRNOT00000006257
alanine and arginine rich domain containing protein
chr19_-_20508711 63.82 ENSRNOT00000032408
hypothetical protein LOC680913
chr18_-_27374603 63.45 ENSRNOT00000027244
NME/NM23 family member 5
chr7_+_54859104 63.31 ENSRNOT00000087341
calcyphosine 2
chr7_+_117420788 62.51 ENSRNOT00000049198
WD repeat domain 97
chr19_+_49016891 62.47 ENSRNOT00000016713
dynein light chain roadblock-type 2
chr8_-_58542844 62.35 ENSRNOT00000012041
ELMO domain containing 1
chr3_+_56030915 61.90 ENSRNOT00000010489
phosphatase, orphan 2
chr14_+_91557601 61.12 ENSRNOT00000038733
hypothetical LOC289778
chr14_-_66771750 60.00 ENSRNOT00000005587
PARK2 co-regulated-like
chr3_+_7279340 59.61 ENSRNOT00000017029
adenylate kinase 8
chr5_+_78384444 59.14 ENSRNOT00000034978
similar to hypothetical protein 4933430I17
chr1_+_280103695 58.33 ENSRNOT00000065289
enolase family member 4
chr1_-_72464492 58.05 ENSRNOT00000068550
N-acetyltransferase 14
chr9_-_44456554 58.03 ENSRNOT00000080011
testis specific 10
chr10_+_90622992 57.52 ENSRNOT00000032856
meiosis specific with coiled-coil domain
chr10_-_40201992 56.88 ENSRNOT00000075311
LYR motif containing 7
chr5_-_172769421 56.79 ENSRNOT00000021285
protein kinase C, zeta
chr16_-_39970532 56.53 ENSRNOT00000071331
spermatogenesis associated 4
chr6_+_122603269 56.52 ENSRNOT00000005297
spermatogenesis associated 7
chr3_-_177205836 56.40 ENSRNOT00000034209
LKAAEAR motif containing 1
chr1_+_78893271 55.84 ENSRNOT00000029825
paraneoplastic Ma antigen family-like 1
chr17_+_6701315 55.30 ENSRNOT00000026054
ENSRNOT00000080683
kinesin family member 27
chr16_+_18648866 55.06 ENSRNOT00000014862
DPY30 domain containing 1
chr2_-_208633945 54.52 ENSRNOT00000049155
primary cilia formation
chr9_+_27068443 54.27 ENSRNOT00000017393
EF-hand domain containing 1
chr4_-_113988246 52.96 ENSRNOT00000013128
WD repeat-containing protein 54
chr6_+_122920317 52.83 ENSRNOT00000068595
ENSRNOT00000082856
tetratricopeptide repeat domain 8
chr6_+_109110534 51.99 ENSRNOT00000009156
zinc finger, C2HC-type containing 1C
chr10_+_91710495 51.22 ENSRNOT00000033276
reprimo-like
chr19_+_32344078 51.15 ENSRNOT00000015541
LOC498933
chr4_-_184096806 50.67 ENSRNOT00000055433
mKIAA1238 protein-like
chr16_+_51748970 49.83 ENSRNOT00000059182
a disintegrin and metallopeptidase domain 26A
chr1_+_267618248 49.70 ENSRNOT00000017186
glutathione S-transferase omega 2
chr4_+_21317695 49.62 ENSRNOT00000007572
glutamate metabotropic receptor 3
chr1_+_78876205 49.59 ENSRNOT00000022610
paraneoplastic Ma antigen family-like 2
chr7_+_54859326 49.34 ENSRNOT00000039141
calcyphosine 2
chr8_-_132790778 49.19 ENSRNOT00000008255
ENSRNOT00000091431
leucine zipper transcription factor-like 1
chr3_-_147487170 48.68 ENSRNOT00000077580
family with sequence similarity 110, member A
chr19_+_56010085 48.32 ENSRNOT00000058216
spermatogenesis associated 33
chr17_+_27452638 48.24 ENSRNOT00000038349
cancer antigen 1
chr1_-_107373807 48.05 ENSRNOT00000056024
small VCP interacting protein
chr4_+_120156659 47.90 ENSRNOT00000050584
DnaJ heat shock protein family (Hsp40) member B8
chr5_-_138462864 47.85 ENSRNOT00000011325
coiled-coil domain containing 30
chr1_-_212317244 47.24 ENSRNOT00000068604
sperm flagellar protein 1-like
chr7_+_12247498 46.80 ENSRNOT00000022358
proprotein convertase subtilisin/kexin type 4
chr5_+_172488708 46.52 ENSRNOT00000019930
MORN repeat containing 1
chr11_-_90234286 46.39 ENSRNOT00000071986
EF hand calcium binding domain 1
chrX_+_45965301 46.17 ENSRNOT00000005141
family with sequence similarity 47, member A
chr1_-_199037267 46.06 ENSRNOT00000078779
coiled-coil domain containing 189
chrX_+_148421627 45.33 ENSRNOT00000016754
cancer/testis antigen 2
chr5_-_77294735 45.16 ENSRNOT00000018209
ENSRNOT00000056900
zinc finger protein 37
chrX_+_5825711 44.90 ENSRNOT00000037360
EF-hand domain containing 2
chr3_-_2434257 44.86 ENSRNOT00000013278
sperm-tail PG-rich repeat containing 3
chr6_-_59950586 44.24 ENSRNOT00000005800
ADP-ribosylation factor like GTPase 4A
chr18_-_37132223 44.24 ENSRNOT00000091634
protein phosphatase 2, regulatory subunit B, beta
chr1_+_190462327 43.98 ENSRNOT00000030732
similar to ankyrin repeat domain 26
chr8_-_47094352 43.80 ENSRNOT00000048347
glutamate ionotropic receptor kainate type subunit 4
chr3_+_8450612 43.77 ENSRNOT00000040457
outer dense fiber of sperm tails 2
chr6_-_144123596 43.38 ENSRNOT00000006144
ENSRNOT00000087845
WD repeat domain 60
chr9_-_13311924 43.37 ENSRNOT00000015584
kinesin family member 6
chr3_-_9326993 43.08 ENSRNOT00000090137
laminin subunit gamma 3
chr5_-_25721072 42.87 ENSRNOT00000021839
transmembrane protein 67
chr14_-_43584343 42.84 ENSRNOT00000039835
NOP2/Sun RNA methyltransferase family member 7
chr9_+_66335492 42.69 ENSRNOT00000037555
similar to KIAA2012 protein
chr15_+_18920373 41.20 ENSRNOT00000036754
mCG11429-like
chr1_+_23977688 41.17 ENSRNOT00000014805
TATA-box binding protein like 1
chr20_+_3351303 41.15 ENSRNOT00000080419
ENSRNOT00000001065
ENSRNOT00000086503
alpha tubulin acetyltransferase 1
chr3_-_52212412 40.92 ENSRNOT00000007615
polypeptide N-acetylgalactosaminyltransferase 3
chr12_+_17614632 40.92 ENSRNOT00000031896
protein kinase cAMP-dependent type 1 regulatory subunit beta
chr1_-_189666440 40.55 ENSRNOT00000019167
defective in cullin neddylation 1 domain containing 3
chr9_+_81880177 40.47 ENSRNOT00000022839
serine/threonine kinase 36
chr9_-_82410904 40.30 ENSRNOT00000026081
galactosidase, beta 1-like
chr20_+_20236151 40.28 ENSRNOT00000079630
ankyrin 3
chr14_-_114484127 40.08 ENSRNOT00000056706
echinoderm microtubule associated protein like 6
chr12_-_48286352 39.99 ENSRNOT00000030891
ubiquitin specific peptidase 30
chr1_-_88516129 39.67 ENSRNOT00000087232

chr3_+_8450275 39.38 ENSRNOT00000020073
outer dense fiber of sperm tails 2
chr13_+_82574966 39.28 ENSRNOT00000003844
coiled-coil domain containing 181
chr1_+_188278469 38.86 ENSRNOT00000065601
transmembrane channel-like 5
chr6_+_7900972 38.84 ENSRNOT00000006953
ENSRNOT00000068030
dynein cytoplasmic 2 light intermediate chain 1
chr6_-_99274269 38.63 ENSRNOT00000058675
testis expressed 21
chr6_-_94932806 38.52 ENSRNOT00000006346
coiled-coil domain containing 175
chr8_-_68525911 38.36 ENSRNOT00000080588
ENSRNOT00000011109
IQ motif containing H
chrX_-_61029298 38.34 ENSRNOT00000043817
similar to MAGEB3
chr7_-_130564719 38.23 ENSRNOT00000044262
RAB, member of RAS oncogene family-like 2A
chr8_+_117221367 38.22 ENSRNOT00000073445
hypothetical protein LOC680045
chr3_+_177310753 37.85 ENSRNOT00000031448
myelin transcription factor 1
chr16_-_7406951 37.78 ENSRNOT00000066508
dynein, axonemal, heavy chain 1
chr10_+_37458452 37.39 ENSRNOT00000079411
cyclin-dependent kinase-like 3
chr20_-_14573519 37.13 ENSRNOT00000001772
RAB36, member RAS oncogene family
chr1_-_47477524 37.13 ENSRNOT00000067916
radial spoke 3 homolog
chr16_-_49453394 36.68 ENSRNOT00000041617
Lrp2 binding protein
chr2_-_60538088 36.65 ENSRNOT00000086809
tetratricopeptide repeat domain 23-like
chr18_-_15167311 35.93 ENSRNOT00000021061
ring finger protein 138
chr1_-_247088012 35.91 ENSRNOT00000020464
spermatogenesis associated 6-like
chr17_+_15194262 35.75 ENSRNOT00000073070

chr14_+_85814824 35.65 ENSRNOT00000090046
ENSRNOT00000083756
ankyrin repeat domain 36
chr3_-_134406576 35.58 ENSRNOT00000081589
SEL1L2 ERAD E3 ligase adaptor subunit
chr1_-_206417143 35.41 ENSRNOT00000091863
ENSRNOT00000073836
hypothetical LOC100302465
chr1_-_259106948 35.27 ENSRNOT00000074429
tectonic-3-like
chr1_+_220096422 34.74 ENSRNOT00000034771
coiled-coil domain containing 87
chr12_+_16030788 34.50 ENSRNOT00000051565
IQ motif containing E
chr7_-_72328128 34.32 ENSRNOT00000008227
TSPY-like 5
chr1_-_81534140 33.99 ENSRNOT00000027202
testis expressed 101
chr4_+_57823411 33.97 ENSRNOT00000030462
ENSRNOT00000088235
serine-rich single-pass membrane protein 1
chr1_-_205669760 33.65 ENSRNOT00000086703
testis expressed 36
chr4_+_147756553 32.77 ENSRNOT00000086549
ENSRNOT00000014733
intraflagellar transport 122
chr10_-_82252720 32.58 ENSRNOT00000066132
ENSRNOT00000075795
Mycbp associated protein
chr6_+_107596782 32.55 ENSRNOT00000076882
dynein, axonemal, light chain 1
chr5_-_50221095 32.36 ENSRNOT00000012164
similar to hypothetical protein
chrX_+_32495809 32.03 ENSRNOT00000020999
similar to RIKEN cDNA 1700045I19
chr12_+_23954574 31.87 ENSRNOT00000046343
serine/threonine/tyrosine interacting-like 1
chr2_-_246737997 31.73 ENSRNOT00000021719
pyruvate dehydrogenase (lipoamide) alpha 2
chr11_+_64488194 31.70 ENSRNOT00000030268
similar to hypothetical protein FLJ32859
chr10_-_82252963 31.56 ENSRNOT00000086261
Mycbp associated protein
chr4_+_55720010 31.01 ENSRNOT00000063987
fascin actin-bundling protein 3
chr14_+_106393959 30.99 ENSRNOT00000092168
WD repeat containing planar cell polarity effector
chr13_-_100189778 30.97 ENSRNOT00000071062
uncharacterized LOC100912759

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
63.7 318.4 GO:0080154 regulation of fertilization(GO:0080154)
27.8 83.4 GO:2000688 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
26.0 571.3 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
23.1 415.2 GO:0036158 outer dynein arm assembly(GO:0036158)
18.5 277.1 GO:0003351 epithelial cilium movement(GO:0003351)
17.7 88.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
17.6 52.8 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
16.4 82.0 GO:0035617 stress granule disassembly(GO:0035617)
16.0 48.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
15.0 105.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
14.1 196.8 GO:0015693 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
13.7 41.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
12.3 49.2 GO:1903564 regulation of protein localization to cilium(GO:1903564)
11.6 69.5 GO:0090116 C-5 methylation of cytosine(GO:0090116)
11.4 114.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
11.4 56.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
10.7 32.0 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
10.3 31.0 GO:0016476 regulation of embryonic cell shape(GO:0016476)
10.3 41.2 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
10.1 40.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
10.0 40.0 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
9.6 57.5 GO:0007144 female meiosis I(GO:0007144)
9.1 18.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
8.9 26.6 GO:0036334 epidermal stem cell homeostasis(GO:0036334)
8.6 42.8 GO:0030382 sperm mitochondrion organization(GO:0030382)
8.2 40.9 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
8.1 56.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
7.5 22.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)
7.3 29.0 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
6.4 83.7 GO:0003341 cilium movement(GO:0003341)
6.4 133.5 GO:0045724 positive regulation of cilium assembly(GO:0045724)
6.3 19.0 GO:1905218 cellular response to astaxanthin(GO:1905218)
6.1 24.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
5.9 29.5 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
5.6 16.9 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
5.6 39.2 GO:0071500 cellular response to nitrosative stress(GO:0071500)
5.5 49.7 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
5.4 123.4 GO:0048240 sperm capacitation(GO:0048240)
5.3 16.0 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
4.7 46.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
4.5 49.6 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
4.4 47.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
4.1 58.0 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
3.9 7.8 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
3.9 23.4 GO:0021943 formation of radial glial scaffolds(GO:0021943)
3.7 18.6 GO:0061741 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
3.7 18.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
3.6 21.8 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
3.6 82.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
3.6 67.5 GO:0045116 protein neddylation(GO:0045116)
3.3 35.9 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
3.3 26.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
3.2 12.8 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
3.0 312.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
2.9 44.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
2.8 17.0 GO:1905232 cellular response to L-glutamate(GO:1905232)
2.8 16.9 GO:0006681 galactosylceramide metabolic process(GO:0006681)
2.8 5.6 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
2.7 16.3 GO:1904117 cellular response to vasopressin(GO:1904117)
2.6 26.2 GO:0046548 retinal rod cell development(GO:0046548)
2.6 59.6 GO:0021591 ventricular system development(GO:0021591)
2.6 7.7 GO:0032875 regulation of DNA endoreduplication(GO:0032875)
2.6 28.3 GO:0002934 desmosome organization(GO:0002934)
2.6 274.8 GO:0044782 cilium organization(GO:0044782)
2.3 28.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.3 13.7 GO:0033564 anterior/posterior axon guidance(GO:0033564)
2.2 15.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
2.1 84.0 GO:0016574 histone ubiquitination(GO:0016574)
2.0 116.7 GO:0007062 sister chromatid cohesion(GO:0007062)
2.0 13.8 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
2.0 68.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.9 46.2 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
1.9 19.0 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
1.8 72.9 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
1.8 27.2 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.7 20.1 GO:0060539 diaphragm development(GO:0060539)
1.7 43.0 GO:0014002 astrocyte development(GO:0014002)
1.6 11.5 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.5 6.0 GO:0097681 double-strand break repair via alternative nonhomologous end joining(GO:0097681)
1.4 16.6 GO:0051013 microtubule severing(GO:0051013)
1.4 70.0 GO:0010165 response to X-ray(GO:0010165)
1.4 4.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.3 14.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.3 19.8 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
1.3 7.7 GO:1990928 response to amino acid starvation(GO:1990928)
1.3 1.3 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
1.2 25.7 GO:0043084 penile erection(GO:0043084)
1.2 6.1 GO:1901525 negative regulation of macromitophagy(GO:1901525)
1.2 6.0 GO:1903817 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
1.2 3.5 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
1.1 37.4 GO:0030517 negative regulation of axon extension(GO:0030517)
1.1 133.4 GO:0060271 cilium morphogenesis(GO:0060271)
1.1 161.9 GO:0007018 microtubule-based movement(GO:0007018)
1.1 4.3 GO:1902534 single-organism membrane invagination(GO:1902534)
1.0 8.3 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.0 54.3 GO:0021795 cerebral cortex cell migration(GO:0021795)
1.0 34.0 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
1.0 9.9 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
1.0 6.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
1.0 17.3 GO:0001573 ganglioside metabolic process(GO:0001573)
0.9 91.3 GO:0006334 nucleosome assembly(GO:0006334)
0.9 9.2 GO:0070995 NADPH oxidation(GO:0070995)
0.9 12.8 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.8 4.9 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.8 1.6 GO:0032423 regulation of mismatch repair(GO:0032423)
0.8 122.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.8 16.6 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.7 7.4 GO:0006266 DNA ligation(GO:0006266)
0.7 101.7 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.7 9.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.7 9.8 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.7 28.3 GO:1901998 toxin transport(GO:1901998)
0.6 1.3 GO:0046066 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside diphosphate biosynthetic process(GO:0009189) glycoprotein transport(GO:0034436) dGDP metabolic process(GO:0046066)
0.6 3.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.6 6.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.5 17.3 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.5 12.4 GO:0030252 growth hormone secretion(GO:0030252)
0.5 15.3 GO:0071625 vocalization behavior(GO:0071625)
0.5 55.3 GO:0007286 spermatid development(GO:0007286)
0.5 9.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.5 5.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.5 7.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.4 22.3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.4 44.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 9.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.4 124.2 GO:0007283 spermatogenesis(GO:0007283)
0.4 11.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.4 4.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 13.7 GO:0007032 endosome organization(GO:0007032)
0.3 13.4 GO:0007520 myoblast fusion(GO:0007520)
0.3 14.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.3 9.3 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.3 2.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 6.9 GO:0006301 postreplication repair(GO:0006301)
0.3 12.1 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.3 5.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.2 16.8 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.2 22.1 GO:0018210 peptidyl-threonine modification(GO:0018210)
0.2 5.1 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.2 23.5 GO:0007631 feeding behavior(GO:0007631)
0.2 18.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.2 8.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 0.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 46.1 GO:0016311 dephosphorylation(GO:0016311)
0.1 3.4 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 3.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 9.2 GO:0007416 synapse assembly(GO:0007416)
0.1 1.8 GO:0010761 fibroblast migration(GO:0010761)
0.1 4.7 GO:0001824 blastocyst development(GO:0001824)
0.1 3.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 15.8 GO:0031344 regulation of cell projection organization(GO:0031344)
0.0 8.8 GO:0198738 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.0 0.8 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 3.2 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
37.9 151.5 GO:0002079 inner acrosomal membrane(GO:0002079)
30.0 180.1 GO:0036157 outer dynein arm(GO:0036157)
28.2 112.8 GO:0033503 HULC complex(GO:0033503)
17.4 69.5 GO:0042585 germinal vesicle(GO:0042585)
16.7 116.7 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
16.3 114.4 GO:0030991 intraciliary transport particle A(GO:0030991)
14.9 59.5 GO:0036156 inner dynein arm(GO:0036156)
13.2 26.4 GO:0016939 kinesin II complex(GO:0016939)
12.1 374.5 GO:0097228 sperm principal piece(GO:0097228)
11.6 196.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
10.8 43.4 GO:0031021 interphase microtubule organizing center(GO:0031021)
10.3 41.2 GO:0097427 microtubule bundle(GO:0097427)
10.0 239.3 GO:0002080 acrosomal membrane(GO:0002080)
9.8 68.7 GO:0034464 BBSome(GO:0034464)
9.6 48.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
8.1 56.8 GO:0043203 axon hillock(GO:0043203)
7.7 727.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
7.3 43.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
7.0 28.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
6.9 83.1 GO:0097539 ciliary transition fiber(GO:0097539)
6.9 41.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
6.6 106.1 GO:0030990 intraciliary transport particle(GO:0030990)
5.8 17.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
5.4 16.3 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
4.5 76.6 GO:0097225 sperm midpiece(GO:0097225)
4.5 103.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
4.4 84.3 GO:0097546 ciliary base(GO:0097546)
4.1 196.0 GO:0036126 sperm flagellum(GO:0036126)
4.1 142.8 GO:0030286 dynein complex(GO:0030286)
4.0 40.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
3.8 19.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
3.4 50.7 GO:0036038 MKS complex(GO:0036038)
3.2 32.0 GO:0035748 myelin sheath abaxonal region(GO:0035748)
3.2 31.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
3.1 55.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
3.0 8.9 GO:0033165 interphotoreceptor matrix(GO:0033165)
2.9 88.5 GO:0030673 axolemma(GO:0030673)
2.7 13.7 GO:0070695 FHF complex(GO:0070695)
2.4 11.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
2.3 27.9 GO:0098839 postsynaptic density membrane(GO:0098839)
2.2 47.1 GO:0097449 astrocyte projection(GO:0097449)
2.2 43.4 GO:0001673 male germ cell nucleus(GO:0001673)
2.2 62.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
2.1 25.0 GO:0002199 zona pellucida receptor complex(GO:0002199)
2.0 16.2 GO:0035869 ciliary transition zone(GO:0035869)
1.6 4.9 GO:0070939 Dsl1p complex(GO:0070939)
1.5 9.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.5 53.8 GO:0031514 motile cilium(GO:0031514)
1.5 4.4 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
1.4 27.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.4 7.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.3 6.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
1.1 7.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.1 66.8 GO:0036064 ciliary basal body(GO:0036064)
1.0 24.8 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.9 16.0 GO:0070938 lamellipodium membrane(GO:0031258) contractile ring(GO:0070938)
0.9 7.3 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.9 86.1 GO:0000786 nucleosome(GO:0000786)
0.9 6.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.8 28.7 GO:0035861 site of double-strand break(GO:0035861)
0.8 75.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.8 16.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.7 3.6 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.7 32.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 125.2 GO:0005929 cilium(GO:0005929)
0.6 28.3 GO:0031594 neuromuscular junction(GO:0031594)
0.6 9.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.6 29.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 18.3 GO:0016235 aggresome(GO:0016235)
0.4 13.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.4 10.2 GO:0097440 apical dendrite(GO:0097440)
0.4 5.9 GO:0017119 Golgi transport complex(GO:0017119)
0.4 43.1 GO:0005604 basement membrane(GO:0005604)
0.4 6.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.4 5.1 GO:0031045 dense core granule(GO:0031045)
0.4 143.7 GO:0005813 centrosome(GO:0005813)
0.3 31.6 GO:0030175 filopodium(GO:0030175)
0.3 49.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.3 3.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.3 9.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 2.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 17.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.3 23.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 6.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 22.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 3.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 16.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 12.6 GO:0031901 early endosome membrane(GO:0031901)
0.2 8.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 18.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 7.7 GO:0016605 PML body(GO:0016605)
0.1 10.6 GO:0030426 growth cone(GO:0030426)
0.1 4.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 12.8 GO:0043235 receptor complex(GO:0043235)
0.0 2.1 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.1 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
32.9 131.8 GO:0004127 cytidylate kinase activity(GO:0004127)
17.7 88.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
16.9 50.7 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
16.5 49.6 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
16.1 112.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
14.1 196.8 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
12.4 49.7 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
10.7 32.0 GO:0042903 tubulin deacetylase activity(GO:0042903)
10.2 71.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
9.8 98.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
9.7 58.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
9.7 38.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
7.9 31.7 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
7.5 74.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
7.0 83.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
6.6 39.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
6.2 43.4 GO:0045503 dynein light chain binding(GO:0045503)
5.9 41.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
5.3 16.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
5.2 26.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
5.0 40.3 GO:0004565 beta-galactosidase activity(GO:0004565)
4.8 58.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
4.5 27.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
4.3 357.8 GO:0003777 microtubule motor activity(GO:0003777)
4.0 28.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
3.7 40.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
3.6 10.7 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
3.4 17.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
3.3 52.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
3.2 12.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
3.2 19.0 GO:0051434 BH3 domain binding(GO:0051434)
2.9 17.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
2.9 14.6 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
2.9 58.4 GO:0004697 protein kinase C activity(GO:0004697)
2.8 13.8 GO:0046923 ER retention sequence binding(GO:0046923)
2.7 13.7 GO:0005042 netrin receptor activity(GO:0005042)
2.7 45.3 GO:0097602 cullin family protein binding(GO:0097602)
2.4 9.6 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
2.2 55.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
2.2 17.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
2.1 42.9 GO:0031005 filamin binding(GO:0031005)
2.1 82.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
2.1 18.6 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
2.1 82.6 GO:0048487 beta-tubulin binding(GO:0048487)
2.1 164.6 GO:0043621 protein self-association(GO:0043621)
2.0 6.1 GO:0005135 erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135)
1.9 20.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.7 49.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
1.7 47.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
1.7 66.1 GO:0005246 calcium channel regulator activity(GO:0005246)
1.6 54.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.5 7.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
1.4 29.5 GO:0032183 SUMO binding(GO:0032183)
1.4 35.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
1.4 8.3 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.3 14.8 GO:0051011 microtubule minus-end binding(GO:0051011)
1.2 28.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
1.2 18.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.2 16.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
1.2 19.0 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
1.2 60.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.2 46.3 GO:0051393 alpha-actinin binding(GO:0051393)
1.1 56.8 GO:0003774 motor activity(GO:0003774)
1.1 9.8 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.1 40.3 GO:0030507 spectrin binding(GO:0030507)
1.1 9.5 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.0 18.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.9 11.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.9 49.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.8 121.6 GO:0005516 calmodulin binding(GO:0005516)
0.7 16.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 12.8 GO:0015026 coreceptor activity(GO:0015026)
0.7 20.0 GO:0030552 cAMP binding(GO:0030552)
0.7 66.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 87.4 GO:0051015 actin filament binding(GO:0051015)
0.6 9.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.6 10.8 GO:0070628 proteasome binding(GO:0070628)
0.6 13.0 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.6 26.6 GO:0019894 kinesin binding(GO:0019894)
0.6 20.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.5 2.7 GO:0004673 phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673)
0.5 19.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.5 9.3 GO:0008199 ferric iron binding(GO:0008199)
0.5 144.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.5 4.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.5 45.9 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.5 223.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 9.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 32.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.5 6.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.4 76.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.4 9.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.4 22.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 5.0 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.4 3.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4 137.1 GO:0005525 GTP binding(GO:0005525)
0.4 36.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.3 60.6 GO:0016791 phosphatase activity(GO:0016791)
0.3 22.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 16.0 GO:0000049 tRNA binding(GO:0000049)
0.3 1.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 7.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 30.7 GO:0008017 microtubule binding(GO:0008017)
0.2 155.0 GO:0005509 calcium ion binding(GO:0005509)
0.2 4.0 GO:0030276 clathrin binding(GO:0030276)
0.2 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 3.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 12.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 5.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 6.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 8.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 17.8 GO:0005125 cytokine activity(GO:0005125)
0.1 12.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 56.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
1.6 26.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
1.5 83.1 PID PLK1 PATHWAY PLK1 signaling events
1.3 16.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
1.2 19.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.2 62.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
1.1 32.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.0 50.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
1.0 12.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.9 27.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.8 17.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.8 28.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.7 13.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.7 27.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.5 10.9 PID ARF 3PATHWAY Arf1 pathway
0.5 37.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 10.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.4 15.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 7.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.4 44.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.3 6.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 7.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 4.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 5.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 21.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.2 ST GAQ PATHWAY G alpha q Pathway
0.1 4.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 2.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 56.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2.7 43.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
2.5 47.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.3 49.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.1 116.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.8 27.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.8 58.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
1.7 49.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
1.6 7.8 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
1.5 86.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
1.3 122.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
1.3 28.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
1.2 24.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.2 40.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.0 17.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
1.0 19.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
1.0 24.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.9 40.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.9 56.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.8 10.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.5 8.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.4 16.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.4 6.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 9.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 4.1 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.3 25.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 6.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 52.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 16.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 2.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.2 10.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 4.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.3 REACTOME KINESINS Genes involved in Kinesins