ISMARA results: Rela_Rel

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rela_Rel_Nfkb1

Z-value: 2.66

Motif logo

Transcription factors associated with Rela_Rel_Nfkb1

Gene Symbol	Gene ID	Gene Info
Rela NCBI RGD Ensembl	ENSRNOG00000030888	RELA proto-oncogene, NF-kB subunit
Rel NCBI RGD Ensembl	ENSRNOG00000054437	REL proto-oncogene, NF-kB subunit
Nfkb1 NCBI RGD Ensembl	ENSRNOG00000023258	nuclear factor kappa B subunit 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rel	rn6_v1_chr14_-_108509892_108509892	0.79	1.1e-70	Click!
Nfkb1	rn6_v1_chr2_-_240866689_240866689	0.65	1.5e-39	Click!
Rela	rn6_v1_chr1_+_220992770_220992770	0.39	5.2e-13	Click!

Activity profile of Rela_Rel_Nfkb1 motif

Sorted Z-values of Rela_Rel_Nfkb1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_163049084 Show fit	214.19	ENSRNOT00000091644	Cd69 NCBI RGD Ensembl Show fit	Cd69 molecule
chr18_+_56071478 Show fit	163.29	ENSRNOT00000025344 ENSRNOT00000025354	Cd74 NCBI RGD Ensembl Show fit	CD74 molecule
chr20_-_1878126 Show fit	160.23	ENSRNOT00000000995	Ubd NCBI RGD Ensembl Show fit	ubiquitin D
chr4_+_69384145 Show fit	143.51	ENSRNOT00000084834	Trbv13-2 NCBI RGD Ensembl Show fit	T cell receptor beta, variable 13-2
chr10_-_85947938 Show fit	142.42	ENSRNOT00000037318 ENSRNOT00000082427	Arl5c NCBI RGD Ensembl Show fit	ADP-ribosylation factor like GTPase 5C
chr20_-_4863198 Show fit	138.91	ENSRNOT00000001108	Ltb NCBI RGD Ensembl Show fit	lymphotoxin beta
chr20_+_5184515 Show fit	134.41	ENSRNOT00000089411	LOC103694381 NCBI RGD Ensembl Show fit	lymphotoxin-beta
chr20_-_4863011 Show fit	134.24	ENSRNOT00000079503	Ltb NCBI RGD Ensembl Show fit	lymphotoxin beta
chr13_+_112031594 Show fit	113.96	ENSRNOT00000008440	Lamb3 NCBI RGD Ensembl Show fit	laminin subunit beta 3
chr1_+_266053002 Show fit	106.99	ENSRNOT00000026235	Nfkb2 NCBI RGD Ensembl Show fit	nuclear factor kappa B subunit 2
chr20_-_4070721 Show fit	105.84	ENSRNOT00000000523	RT1-Ba NCBI RGD Ensembl Show fit	RT1 class II, locus Ba
chr6_+_109562587 Show fit	104.34	ENSRNOT00000011563	Batf NCBI RGD Ensembl Show fit	basic leucine zipper ATF-like transcription factor
chr8_-_48850671 Show fit	96.74	ENSRNOT00000016580	Cxcr5 NCBI RGD Ensembl Show fit	C-X-C motif chemokine receptor 5
chr20_+_9948908 Show fit	94.46	ENSRNOT00000001541	Ubash3a NCBI RGD Ensembl Show fit	ubiquitin associated and SH3 domain containing, A
chr17_+_56109549 Show fit	89.67	ENSRNOT00000022190	Map3k8 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 8
chr1_-_80544825 Show fit	86.13	ENSRNOT00000057802 ENSRNOT00000040060 ENSRNOT00000067049 ENSRNOT00000052387 ENSRNOT00000073352	Relb NCBI RGD Ensembl Show fit	RELB proto-oncogene, NF-kB subunit
chr10_-_70744315 Show fit	76.64	ENSRNOT00000014865	Ccl5 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 5
chr2_+_189955836 Show fit	71.87	ENSRNOT00000078351	S100a3 NCBI RGD Ensembl Show fit	S100 calcium binding protein A3
chr20_-_4921348 Show fit	70.25	ENSRNOT00000082497 ENSRNOT00000041151	RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE4
chr1_-_89269930 Show fit	68.40	ENSRNOT00000028532	Ffar2 NCBI RGD Ensembl Show fit	free fatty acid receptor 2
chr14_-_18745457 Show fit	66.42	ENSRNOT00000003778	Cxcl1 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 1
chr6_+_135866739 Show fit	66.03	ENSRNOT00000013460	Exoc3l4 NCBI RGD Ensembl Show fit	exocyst complex component 3-like 4
chr8_-_6076598 Show fit	63.83	ENSRNOT00000090774	Birc3 NCBI RGD Ensembl Show fit	baculoviral IAP repeat-containing 3
chr8_+_132828091 Show fit	62.80	ENSRNOT00000008269	Ccr9 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 9
chr14_-_18839420 Show fit	60.50	ENSRNOT00000034090	Cxcl3 NCBI RGD Ensembl Show fit	chemokine (C-X-C motif) ligand 3
chr1_-_7064870 Show fit	59.71	ENSRNOT00000019983	Stx11 NCBI RGD Ensembl Show fit	syntaxin 11
chr11_+_47243342 Show fit	59.49	ENSRNOT00000041116	Nfkbiz NCBI RGD Ensembl Show fit	NFKB inhibitor zeta
chr1_-_82580761 Show fit	59.34	ENSRNOT00000028131 ENSRNOT00000028132	Axl NCBI RGD Ensembl Show fit	Axl receptor tyrosine kinase
chr10_-_87067456 Show fit	58.24	ENSRNOT00000014163	Ccr7 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 7
chr5_+_168019058 Show fit	54.93	ENSRNOT00000077202	Tnfrsf9 NCBI RGD Ensembl Show fit	TNF receptor superfamily member 9
chr5_+_5866897 Show fit	51.96	ENSRNOT00000011940	Slco5a1 NCBI RGD Ensembl Show fit	solute carrier organic anion transporter family, member 5A1
chr6_-_76270457 Show fit	51.28	ENSRNOT00000009894	Nfkbia NCBI RGD Ensembl Show fit	NFKB inhibitor alpha
chr10_+_56187020 Show fit	49.76	ENSRNOT00000046490	Tp53 NCBI RGD Ensembl Show fit	tumor protein p53
chr7_-_11648322 Show fit	49.74	ENSRNOT00000026871	Gadd45b NCBI RGD Ensembl Show fit	growth arrest and DNA-damage-inducible, beta
chr3_+_2643610 Show fit	48.74	ENSRNOT00000037169	Fut7 NCBI RGD Ensembl Show fit	fucosyltransferase 7
chr9_+_88918433 Show fit	48.17	ENSRNOT00000021730	Ccl20 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 20
chr9_-_42839837 Show fit	45.46	ENSRNOT00000038610	Neurl3 NCBI RGD Ensembl Show fit	neuralized E3 ubiquitin protein ligase 3
chr4_+_101882994 Show fit	44.97	ENSRNOT00000087773	AABR07060963.1 NCBI RGD Ensembl Show fit
chr13_+_47539231 Show fit	44.71	ENSRNOT00000029694	Fcamr NCBI RGD Ensembl Show fit	Fc fragment of IgA and IgM receptor
chr5_-_143120165 Show fit	42.96	ENSRNOT00000012314	Zc3h12a NCBI RGD Ensembl Show fit	zinc finger CCCH type containing 12A
chr3_+_177164359 Show fit	42.59	ENSRNOT00000066837	RGD1561282 NCBI RGD Ensembl Show fit	RGD1561282
chr14_+_17195014 Show fit	42.15	ENSRNOT00000031667	Cxcl11 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 11
chr3_+_18315320 Show fit	41.89	ENSRNOT00000006954	AABR07051626.2 NCBI RGD Ensembl Show fit
chr8_+_133029625 Show fit	41.10	ENSRNOT00000008809	Ccr3 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 3
chr1_+_164502389 Show fit	40.86	ENSRNOT00000043554	Arrb1 NCBI RGD Ensembl Show fit	arrestin, beta 1
chr3_+_20375699 Show fit	40.05	ENSRNOT00000088492	AABR07051731.1 NCBI RGD Ensembl Show fit
chrX_+_96991658 Show fit	40.02	ENSRNOT00000049969	AABR07040288.1 NCBI RGD Ensembl Show fit
chr19_-_55257876 Show fit	40.02	ENSRNOT00000017564	Cyba NCBI RGD Ensembl Show fit	cytochrome b-245 alpha chain
chr13_-_113927745 Show fit	37.56	ENSRNOT00000010910 ENSRNOT00000080616	Cr2 NCBI RGD Ensembl Show fit	complement C3d receptor 2
chr1_+_165295847 Show fit	37.50	ENSRNOT00000046943	P4ha3 NCBI RGD Ensembl Show fit	prolyl 4-hydroxylase subunit alpha 3
chr4_+_102876038 Show fit	37.06	ENSRNOT00000085205	AABR07061022.3 NCBI RGD Ensembl Show fit
chr10_-_86509454 Show fit	36.91	ENSRNOT00000009454	Ikzf3 NCBI RGD Ensembl Show fit	IKAROS family zinc finger 3
chr9_+_71230108 Show fit	36.54	ENSRNOT00000018326	Creb1 NCBI RGD Ensembl Show fit	cAMP responsive element binding protein 1
chr15_+_57241968 Show fit	35.40	ENSRNOT00000082191	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr14_+_77067503 Show fit	35.36	ENSRNOT00000085275	Slc2a9 NCBI RGD Ensembl Show fit	solute carrier family 2 member 9
chr20_-_1339488 Show fit	34.94	ENSRNOT00000041074	RT1-M2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus M2
chr1_+_252589785 Show fit	34.45	ENSRNOT00000025928	Fas NCBI RGD Ensembl Show fit	Fas cell surface death receptor
chr1_+_137014272 Show fit	34.13	ENSRNOT00000014802	Akap13 NCBI RGD Ensembl Show fit	A-kinase anchoring protein 13
chr2_-_219097619 Show fit	34.06	ENSRNOT00000078806	Vcam1 NCBI RGD Ensembl Show fit	vascular cell adhesion molecule 1
chr3_-_20695952 Show fit	33.91	ENSRNOT00000072306	AABR07051746.1 NCBI RGD Ensembl Show fit
chr3_+_161519743 Show fit	33.41	ENSRNOT00000055148	Cd40 NCBI RGD Ensembl Show fit	CD40 molecule
chrX_+_134979646 Show fit	32.59	ENSRNOT00000006035	Sash3 NCBI RGD Ensembl Show fit	SAM and SH3 domain containing 3
chr13_+_92167643 Show fit	32.53	ENSRNOT00000030794	Olr1589 NCBI RGD Ensembl Show fit	olfactory receptor 1589
chr3_+_161413298 Show fit	32.38	ENSRNOT00000023965 ENSRNOT00000088776	Mmp9 NCBI RGD Ensembl Show fit	matrix metallopeptidase 9
chr14_+_17228856 Show fit	32.10	ENSRNOT00000003082	Cxcl9 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 9
chr20_+_4852671 Show fit	31.98	ENSRNOT00000001111	Lta NCBI RGD Ensembl Show fit	lymphotoxin alpha
chr8_+_33816386 Show fit	31.90	ENSRNOT00000011925	Ets1 NCBI RGD Ensembl Show fit	ETS proto-oncogene 1, transcription factor
chr2_-_182846061 Show fit	31.05	ENSRNOT00000013025	Tlr2 NCBI RGD Ensembl Show fit	toll-like receptor 2
chr9_-_17835240 Show fit	30.73	ENSRNOT00000026988	Nfkbie NCBI RGD Ensembl Show fit	NFKB inhibitor epsilon
chr10_-_13081136 Show fit	30.40	ENSRNOT00000005718	Kremen2 NCBI RGD Ensembl Show fit	kringle containing transmembrane protein 2
chr17_+_24416651 Show fit	30.18	ENSRNOT00000024458	Cd83 NCBI RGD Ensembl Show fit	CD83 molecule
chr4_+_71740532 Show fit	30.15	ENSRNOT00000023537	Zyx NCBI RGD Ensembl Show fit	zyxin
chr3_-_20457554 Show fit	29.32	ENSRNOT00000074237	AABR07051733.1 NCBI RGD Ensembl Show fit
chr3_-_20479999 Show fit	29.16	ENSRNOT00000050573	AABR07051733.2 NCBI RGD Ensembl Show fit
chr4_+_157612536 Show fit	28.69	ENSRNOT00000055970	Chd4 NCBI RGD Ensembl Show fit	chromodomain helicase DNA binding protein 4
chr2_+_223121410 Show fit	28.32	ENSRNOT00000087559	AABR07013116.1 NCBI RGD Ensembl Show fit
chr17_-_10004321 Show fit	28.27	ENSRNOT00000042394	Fgfr4 NCBI RGD Ensembl Show fit	fibroblast growth factor receptor 4
chr4_+_93888502 Show fit	28.27	ENSRNOT00000090783	AABR07060792.1 NCBI RGD Ensembl Show fit
chr20_-_157665 Show fit	27.98	ENSRNOT00000048858 ENSRNOT00000079494	RT1-CE10 NCBI RGD Ensembl Show fit	RT1 class I, locus CE10
chr13_-_50916982 Show fit	27.37	ENSRNOT00000004408	Btg2 NCBI RGD Ensembl Show fit	BTG anti-proliferation factor 2
chr3_-_20419417 Show fit	27.09	ENSRNOT00000077772	AABR07051733.3 NCBI RGD Ensembl Show fit
chr4_+_93791054 Show fit	26.94	ENSRNOT00000042300	AABR07060788.1 NCBI RGD Ensembl Show fit
chr1_-_100537377 Show fit	26.71	ENSRNOT00000026599	Spib NCBI RGD Ensembl Show fit	Spi-B transcription factor
chr7_-_28932641 Show fit	26.64	ENSRNOT00000059487	Dram1 NCBI RGD Ensembl Show fit	DNA-damage regulated autophagy modulator 1
chr20_+_4852496 Show fit	26.59	ENSRNOT00000088936	Lta NCBI RGD Ensembl Show fit	lymphotoxin alpha
chr9_+_2190915 Show fit	25.88	ENSRNOT00000077417	Satb1 NCBI RGD Ensembl Show fit	SATB homeobox 1
chr3_-_2853272 Show fit	25.25	ENSRNOT00000023022	Fcna NCBI RGD Ensembl Show fit	ficolin A
chr4_+_3043231 Show fit	24.91	ENSRNOT00000013732	Il6 NCBI RGD Ensembl Show fit	interleukin 6
chr10_+_88764732 Show fit	24.89	ENSRNOT00000026662	Stat5a NCBI RGD Ensembl Show fit	signal transducer and activator of transcription 5A
chr1_-_259357056 Show fit	24.75	ENSRNOT00000022000	Pdlim1 NCBI RGD Ensembl Show fit	PDZ and LIM domain 1
chr3_-_118959850 Show fit	24.63	ENSRNOT00000092750	Atp8b4 NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 8B4 (putative)
chr2_+_248178389 Show fit	24.10	ENSRNOT00000037339	Gbp5 NCBI RGD Ensembl Show fit	guanylate binding protein 5
chr6_-_107678156 Show fit	24.06	ENSRNOT00000014158	Elmsan1 NCBI RGD Ensembl Show fit	ELM2 and Myb/SANT domain containing 1
chr8_+_23113048 Show fit	23.98	ENSRNOT00000029577	Cnn1 NCBI RGD Ensembl Show fit	calponin 1
chr1_-_14412807 Show fit	23.48	ENSRNOT00000074583	Tnfaip3 NCBI RGD Ensembl Show fit	TNF alpha induced protein 3
chr11_+_31694339 Show fit	23.28	ENSRNOT00000002779	Ifngr2 NCBI RGD Ensembl Show fit	interferon gamma receptor 2
chr3_+_47453821 Show fit	23.18	ENSRNOT00000081682	Tank NCBI RGD Ensembl Show fit	TRAF family member-associated NFKB activator
chr5_+_131915382 Show fit	22.84	ENSRNOT00000087012	Skint1 NCBI RGD Ensembl Show fit	selection and upkeep of intraepithelial T cells 1
chr17_-_55346279 Show fit	22.71	ENSRNOT00000025037	Svil NCBI RGD Ensembl Show fit	supervillin
chr6_+_139405966 Show fit	22.33	ENSRNOT00000088974	AABR07065693.3 NCBI RGD Ensembl Show fit
chr13_+_51958834 Show fit	22.20	ENSRNOT00000007833	Ptpn7 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 7
chr4_-_157252104 Show fit	22.12	ENSRNOT00000082739	Ptpn6 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 6
chr10_+_104952458 Show fit	22.06	ENSRNOT00000074082	RGD1559482 NCBI RGD Ensembl Show fit	similar to immunoglobulin superfamily, member 7
chr4_-_10517832 Show fit	22.00	ENSRNOT00000039953 ENSRNOT00000083964	Gsap NCBI RGD Ensembl Show fit	gamma-secretase activating protein
chr5_-_153924896 Show fit	21.98	ENSRNOT00000065247	Grhl3 NCBI RGD Ensembl Show fit	grainyhead-like transcription factor 3
chr2_-_219458271 Show fit	21.91	ENSRNOT00000064735	Cdc14a NCBI RGD Ensembl Show fit	cell division cycle 14A
chr9_+_81427730 Show fit	21.86	ENSRNOT00000019109 ENSRNOT00000081711	Cxcr2 NCBI RGD Ensembl Show fit	C-X-C motif chemokine receptor 2
chr17_+_80882666 Show fit	21.78	ENSRNOT00000024430	Vim NCBI RGD Ensembl Show fit	vimentin
chr10_+_104997205 Show fit	21.77	ENSRNOT00000074003	RGD1561778 NCBI RGD Ensembl Show fit	similar to dendritic cell-derived immunoglobulin(Ig)-like receptor 1, DIgR1 - mouse
chr6_+_135890931 Show fit	21.21	ENSRNOT00000042973	Tnfaip2 NCBI RGD Ensembl Show fit	TNF alpha induced protein 2
chr3_+_120728688 Show fit	21.18	ENSRNOT00000022596	Bcl2l11 NCBI RGD Ensembl Show fit	BCL2 like 11
chr14_-_18839595 Show fit	21.13	ENSRNOT00000078746	Cxcl3 NCBI RGD Ensembl Show fit	chemokine (C-X-C motif) ligand 3
chrX_+_54390733 Show fit	21.04	ENSRNOT00000004977	RGD1565785 NCBI RGD Ensembl Show fit	similar to chromosome X open reading frame 21
chr13_-_85443727 Show fit	21.01	ENSRNOT00000090668 ENSRNOT00000076125	Uck2 NCBI RGD Ensembl Show fit	uridine-cytidine kinase 2
chr20_-_11815647 Show fit	20.53	ENSRNOT00000001639	Itgb2 NCBI RGD Ensembl Show fit	integrin subunit beta 2
chr14_-_59735450 Show fit	20.51	ENSRNOT00000071929	Rbpj NCBI RGD Ensembl Show fit	recombination signal binding protein for immunoglobulin kappa J region
chr4_-_157155609 Show fit	20.36	ENSRNOT00000016330	C1s NCBI RGD Ensembl Show fit	complement C1s
chr7_+_119482272 Show fit	20.33	ENSRNOT00000009544	Ncf4 NCBI RGD Ensembl Show fit	neutrophil cytosolic factor 4
chr13_-_85443976 Show fit	20.12	ENSRNOT00000005213	Uck2 NCBI RGD Ensembl Show fit	uridine-cytidine kinase 2
chr13_-_52088780 Show fit	19.85	ENSRNOT00000008754	Elf3 NCBI RGD Ensembl Show fit	E74-like factor 3
chr5_-_146795866 Show fit	19.52	ENSRNOT00000065640	Tlr12 NCBI RGD Ensembl Show fit	toll-like receptor 12
chr3_+_77047466 Show fit	19.18	ENSRNOT00000089424	Olr648 NCBI RGD Ensembl Show fit	olfactory receptor 648
chr7_+_54247460 Show fit	18.97	ENSRNOT00000005361	Phlda1 NCBI RGD Ensembl Show fit	pleckstrin homology-like domain, family A, member 1
chr20_+_4363508 Show fit	18.92	ENSRNOT00000077205	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr2_-_157759819 Show fit	18.77	ENSRNOT00000015763 ENSRNOT00000016016	LOC100909712 NCBI RGD Ensembl Show fit	cyclin-L1-like
chr10_-_40296470 Show fit	18.58	ENSRNOT00000086456	Tnip1 NCBI RGD Ensembl Show fit	TNFAIP3 interacting protein 1
chr9_+_42871950 Show fit	18.56	ENSRNOT00000089673	Arid5a NCBI RGD Ensembl Show fit	AT-rich interaction domain 5A
chr7_+_116632506 Show fit	18.54	ENSRNOT00000009811	Gpihbp1 NCBI RGD Ensembl Show fit	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr20_-_49486550 Show fit	18.50	ENSRNOT00000048270 ENSRNOT00000076541	Prdm1 NCBI RGD Ensembl Show fit	PR/SET domain 1
chr8_-_132919110 Show fit	18.43	ENSRNOT00000008747	Xcr1 NCBI RGD Ensembl Show fit	X-C motif chemokine receptor 1
chr14_+_17210733 Show fit	18.37	ENSRNOT00000003075	Cxcl10 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 10
chr20_+_3156170 Show fit	18.35	ENSRNOT00000082880	RT1-S2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus S2
chr1_-_80178708 Show fit	18.18	ENSRNOT00000088676	Vasp NCBI RGD Ensembl Show fit	vasodilator-stimulated phosphoprotein
chr1_+_221710670 Show fit	18.13	ENSRNOT00000064798	Map4k2 NCBI RGD Ensembl Show fit	mitogen activated protein kinase kinase kinase kinase 2
chr11_+_67082193 Show fit	17.91	ENSRNOT00000003129	Cd86 NCBI RGD Ensembl Show fit	CD86 molecule
chr3_-_125533600 Show fit	17.90	ENSRNOT00000040802	Lrrn4 NCBI RGD Ensembl Show fit	leucine rich repeat neuronal 4
chr6_+_96479430 Show fit	17.88	ENSRNOT00000006729	Prkch NCBI RGD Ensembl Show fit	protein kinase C, eta
chr20_+_29897594 Show fit	17.67	ENSRNOT00000057752	Vsir NCBI RGD Ensembl Show fit	V-set immunoregulatory receptor
chr1_+_78739930 Show fit	17.61	ENSRNOT00000021976	Strn4 NCBI RGD Ensembl Show fit	striatin 4
chr10_+_74959285 Show fit	17.56	ENSRNOT00000010296	Rnf43 NCBI RGD Ensembl Show fit	ring finger protein 43
chr9_+_11064605 Show fit	17.56	ENSRNOT00000075121	Stap2 NCBI RGD Ensembl Show fit	signal transducing adaptor family member 2
chr17_-_18028808 Show fit	17.40	ENSRNOT00000022244	Kdm1b NCBI RGD Ensembl Show fit	lysine demethylase 1B
chr3_-_110324084 Show fit	17.37	ENSRNOT00000010381	Bmf NCBI RGD Ensembl Show fit	Bcl2 modifying factor
chr15_+_62406873 Show fit	16.75	ENSRNOT00000047572	Olfm4 NCBI RGD Ensembl Show fit	olfactomedin 4
chr2_-_219090874 Show fit	16.52	ENSRNOT00000019377	Vcam1 NCBI RGD Ensembl Show fit	vascular cell adhesion molecule 1
chrX_+_28486869 Show fit	16.44	ENSRNOT00000005620	Tlr7 NCBI RGD Ensembl Show fit	toll-like receptor 7
chr1_-_3849080 Show fit	16.34	ENSRNOT00000045301	RGD1560633 NCBI RGD Ensembl Show fit	similar to ribosomal protein L27a
chr3_-_176958880 Show fit	16.27	ENSRNOT00000078661	Zbtb46 NCBI RGD Ensembl Show fit	zinc finger and BTB domain containing 46
chrX_+_156463953 Show fit	16.25	ENSRNOT00000079889	Flna NCBI RGD Ensembl Show fit	filamin A
chr1_-_87174530 Show fit	16.00	ENSRNOT00000089578	Kcnk6 NCBI RGD Ensembl Show fit	potassium two pore domain channel subfamily K member 6
chr4_-_23135354 Show fit	15.82	ENSRNOT00000011432	Steap4 NCBI RGD Ensembl Show fit	STEAP4 metalloreductase
chr3_+_80676820 Show fit	15.75	ENSRNOT00000084809	Ambra1 NCBI RGD Ensembl Show fit	autophagy and beclin 1 regulator 1
chr6_-_41039437 Show fit	15.68	ENSRNOT00000005774	Trib2 NCBI RGD Ensembl Show fit	tribbles pseudokinase 2
chr10_-_83655182 Show fit	15.50	ENSRNOT00000007897	Abi3 NCBI RGD Ensembl Show fit	ABI family, member 3
chr6_+_139428999 Show fit	15.49	ENSRNOT00000084482	AABR07065693.2 NCBI RGD Ensembl Show fit
chr12_+_48403797 Show fit	15.45	ENSRNOT00000044751	Ssh1 NCBI RGD Ensembl Show fit	slingshot protein phosphatase 1
chr7_+_142912316 Show fit	15.44	ENSRNOT00000010171	Nr4a1 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 4, group A, member 1
chr10_-_88172910 Show fit	15.28	ENSRNOT00000046956	Krt42 NCBI RGD Ensembl Show fit	keratin 42
chr20_+_27975549 Show fit	15.28	ENSRNOT00000092075	Lims1 NCBI RGD Ensembl Show fit	LIM zinc finger domain containing 1
chr1_-_213811901 Show fit	15.13	ENSRNOT00000020265	Ifitm3 NCBI RGD Ensembl Show fit	interferon induced transmembrane protein 3
chr13_-_90814119 Show fit	15.06	ENSRNOT00000011208	Tagln2 NCBI RGD Ensembl Show fit	transgelin 2
chr16_-_20148867 Show fit	15.05	ENSRNOT00000040464	Fcho1 NCBI RGD Ensembl Show fit	FCH domain only 1
chr13_-_90977734 Show fit	14.96	ENSRNOT00000011869	Slamf8 NCBI RGD Ensembl Show fit	SLAM family member 8
chr18_-_63488027 Show fit	14.89	ENSRNOT00000023763	Ptpn2 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 2
chr2_-_232245319 Show fit	14.87	ENSRNOT00000014510	LOC691931 NCBI RGD Ensembl Show fit	hypothetical protein LOC691931
chr13_+_74456487 Show fit	14.70	ENSRNOT00000065801	Angptl1 NCBI RGD Ensembl Show fit	angiopoietin-like 1
chr3_-_13978224 Show fit	14.63	ENSRNOT00000025528	Phf19 NCBI RGD Ensembl Show fit	PHD finger protein 19
chr20_+_2057878 Show fit	14.53	ENSRNOT00000051480	RT1-M6-1 NCBI RGD Ensembl Show fit	RT1 class I, locus M6, gene 1
chr1_+_141120166 Show fit	14.41	ENSRNOT00000050759	Fanci NCBI RGD Ensembl Show fit	Fanconi anemia, complementation group I
chr6_-_128727374 Show fit	14.24	ENSRNOT00000082152	Syne3 NCBI RGD Ensembl Show fit	spectrin repeat containing, nuclear envelope family member 3
chr1_-_86948845 Show fit	14.17	ENSRNOT00000027212	Nfkbib NCBI RGD Ensembl Show fit	NFKB inhibitor beta
chr20_+_3979035 Show fit	14.02	ENSRNOT00000000529	Tap1 NCBI RGD Ensembl Show fit	transporter 1, ATP binding cassette subfamily B member
chr7_-_2353875 Show fit	13.94	ENSRNOT00000074873	LOC100911319 NCBI RGD Ensembl Show fit	zinc finger protein 36, C3H1 type-like 2-like
chr8_-_78655856 Show fit	13.88	ENSRNOT00000081185	Tcf12 NCBI RGD Ensembl Show fit	transcription factor 12
chr20_-_4698718 Show fit	13.81	ENSRNOT00000047527	RT1-CE7 NCBI RGD Ensembl Show fit	RT1 class I, locus CE7
chr1_-_80744831 Show fit	13.81	ENSRNOT00000025913	Bcl3 NCBI RGD Ensembl Show fit	B-cell CLL/lymphoma 3
chr2_+_31378743 Show fit	13.69	ENSRNOT00000050384	AABR07007853.1 NCBI RGD Ensembl Show fit
chr20_-_3299580 Show fit	13.48	ENSRNOT00000050373	Gnl1 NCBI RGD Ensembl Show fit	G protein nucleolar 1
chr2_-_186333805 Show fit	13.27	ENSRNOT00000022150	Cd1d1 NCBI RGD Ensembl Show fit	CD1d1 molecule
chr4_-_103636632 Show fit	13.22	ENSRNOT00000086523	AABR07061077.1 NCBI RGD Ensembl Show fit
chr4_-_22307453 Show fit	13.19	ENSRNOT00000047126	Abcb1a NCBI RGD Ensembl Show fit	ATP binding cassette subfamily B member 1A
chrX_+_156429585 Show fit	13.11	ENSRNOT00000083203 ENSRNOT00000077322	Dnase1l1 NCBI RGD Ensembl Show fit	deoxyribonuclease 1-like 1
chr1_-_166413564 Show fit	13.04	ENSRNOT00000026286	Atg16l2 NCBI RGD Ensembl Show fit	autophagy related 16-like 2
chr1_+_166141954 Show fit	12.94	ENSRNOT00000042524	Fchsd2 NCBI RGD Ensembl Show fit	FCH and double SH3 domains 2
chr2_-_235852708 Show fit	12.81	ENSRNOT00000009046 ENSRNOT00000005772	Rpl34 NCBI RGD Ensembl Show fit	ribosomal protein L34
chr10_+_34149717 Show fit	12.75	ENSRNOT00000084232 ENSRNOT00000089829	Rack1 NCBI RGD Ensembl Show fit	receptor for activated C kinase 1
chr20_-_4390436 Show fit	12.72	ENSRNOT00000000497 ENSRNOT00000077655	Ppt2 NCBI RGD Ensembl Show fit	palmitoyl-protein thioesterase 2
chr13_+_49870976 Show fit	12.72	ENSRNOT00000090170	Pik3c2b NCBI RGD Ensembl Show fit	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr4_-_82141385 Show fit	12.69	ENSRNOT00000008447	Hoxa3 NCBI RGD Ensembl Show fit	homeobox A3
chr2_+_185524774 Show fit	12.67	ENSRNOT00000089338	Lrba NCBI RGD Ensembl Show fit	LPS responsive beige-like anchor protein
chr4_+_70755795 Show fit	12.53	ENSRNOT00000043527	LOC683849 NCBI RGD Ensembl Show fit	similar to Anionic trypsin II precursor (Pretrypsinogen II)
chr1_-_82580007 Show fit	12.49	ENSRNOT00000078668	Axl NCBI RGD Ensembl Show fit	Axl receptor tyrosine kinase
chr5_-_76756140 Show fit	12.48	ENSRNOT00000022107 ENSRNOT00000089251	Ptbp3 NCBI RGD Ensembl Show fit	polypyrimidine tract binding protein 3
chr5_-_29870735 Show fit	12.47	ENSRNOT00000012963	Ripk2 NCBI RGD Ensembl Show fit	receptor-interacting serine-threonine kinase 2
chr6_-_103470427 Show fit	12.46	ENSRNOT00000091560 ENSRNOT00000088795 ENSRNOT00000079824	Actn1 NCBI RGD Ensembl Show fit	actinin, alpha 1
chr1_+_198932870 Show fit	12.38	ENSRNOT00000055003	Fbrs NCBI RGD Ensembl Show fit	fibrosin
chr1_-_64446818 Show fit	12.36	ENSRNOT00000081980	Myadm NCBI RGD Ensembl Show fit	myeloid-associated differentiation marker
chr3_+_113415774 Show fit	12.35	ENSRNOT00000056151	Serf2 NCBI RGD Ensembl Show fit	small EDRK-rich factor 2
chr8_+_52729003 Show fit	12.32	ENSRNOT00000081738	Nxpe4 NCBI RGD Ensembl Show fit	neurexophilin and PC-esterase domain family, member 4
chr10_-_50402616 Show fit	12.31	ENSRNOT00000004546	Hs3st3b1 NCBI RGD Ensembl Show fit	heparan sulfate-glucosamine 3-sulfotransferase 3B1

Network of associatons between targets according to the STRING database.

First level regulatory network of Rela_Rel_Nfkb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
35.9	71.8	GO:2000669	negative regulation of dendritic cell apoptotic process(GO:2000669)
32.7	163.3	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
31.2	124.7	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
24.6	73.9	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
20.0	160.2	GO:0070842	aggresome assembly(GO:0070842)
19.9	59.7	GO:0043316	cytotoxic T cell degranulation(GO:0043316)
19.5	234.6	GO:0001867	complement activation, lectin pathway(GO:0001867)
19.5	58.6	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
19.2	134.4	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
19.2	76.6	GO:0071307	CD8-positive, alpha-beta T cell extravasation(GO:0035697) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)
18.4	73.7	GO:1903003	positive regulation of protein deubiquitination(GO:1903003)
18.3	54.9	GO:2001183	negative regulation of interleukin-12 secretion(GO:2001183)
17.4	87.2	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
16.3	65.2	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
16.1	48.2	GO:0042222	interleukin-1 biosynthetic process(GO:0042222)
14.7	29.5	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
13.3	40.0	GO:1904845	positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
12.4	49.8	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
12.2	36.5	GO:0032916	positive regulation of transforming growth factor beta3 production(GO:0032916)
12.0	131.9	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
10.8	32.4	GO:0009644	response to high light intensity(GO:0009644)
10.7	53.6	GO:0030820	regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820)
10.3	41.1	GO:0044211	CTP salvage(GO:0044211)
9.0	108.0	GO:0002467	germinal center formation(GO:0002467)
8.5	34.1	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
8.0	31.9	GO:0030578	PML body organization(GO:0030578)
7.9	7.9	GO:2001198	regulation of dendritic cell differentiation(GO:2001198) positive regulation of dendritic cell differentiation(GO:2001200)
7.5	15.0	GO:1902623	negative regulation of neutrophil migration(GO:1902623)
7.3	73.0	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
7.3	29.2	GO:0060375	regulation of mast cell differentiation(GO:0060375)
7.3	21.9	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
7.1	28.3	GO:0007037	vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
6.8	20.5	GO:0097101	arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
6.8	115.7	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
6.6	13.3	GO:0045402	interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
6.5	420.1	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
6.4	90.1	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
6.4	25.7	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
6.4	89.0	GO:0051601	exocyst localization(GO:0051601)
6.3	63.4	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
6.3	19.0	GO:0045210	FasL biosynthetic process(GO:0045210)
6.3	18.9	GO:1905204	response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
6.2	18.7	GO:1902226	regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
6.2	18.5	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
6.0	17.9	GO:0002644	negative regulation of tolerance induction(GO:0002644)
5.9	17.7	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
5.5	22.1	GO:0033277	abortive mitotic cell cycle(GO:0033277)
5.4	21.8	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
5.4	5.4	GO:0060932	His-Purkinje system cell differentiation(GO:0060932)
5.2	30.9	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
5.1	50.6	GO:0022614	membrane to membrane docking(GO:0022614)
4.9	48.7	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
4.7	14.0	GO:0046968	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
4.5	31.8	GO:0033590	response to cobalamin(GO:0033590)
4.4	30.7	GO:0042940	D-amino acid transport(GO:0042940)
4.4	17.5	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
4.3	21.7	GO:0021943	formation of radial glial scaffolds(GO:0021943)
4.3	94.5	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
4.2	8.4	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
4.2	175.1	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
4.1	12.4	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
4.1	16.4	GO:0045356	toll-like receptor 7 signaling pathway(GO:0034154) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356) positive regulation of interleukin-8 biosynthetic process(GO:0045416)
4.1	28.7	GO:0072553	terminal button organization(GO:0072553)
4.1	20.5	GO:0032621	interleukin-18 production(GO:0032621)
4.1	32.6	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
4.1	12.2	GO:0061341	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
3.8	11.5	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
3.7	3.7	GO:0072683	T cell extravasation(GO:0072683)
3.6	28.6	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
3.6	17.9	GO:0034351	negative regulation of glial cell apoptotic process(GO:0034351)
3.5	17.3	GO:0010159	specification of organ position(GO:0010159)
3.4	33.6	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
3.3	6.7	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
3.3	13.2	GO:1905235	carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) response to cyclosporin A(GO:1905237) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
3.2	158.1	GO:0035987	endodermal cell differentiation(GO:0035987)
3.1	15.5	GO:1904717	regulation of AMPA glutamate receptor clustering(GO:1904717)
3.0	48.4	GO:0000185	activation of MAPKKK activity(GO:0000185)
3.0	12.0	GO:2000814	positive regulation of barbed-end actin filament capping(GO:2000814)
3.0	11.8	GO:0002386	immune response in mucosal-associated lymphoid tissue(GO:0002386)
2.9	8.8	GO:1903699	tarsal gland development(GO:1903699)
2.9	37.5	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
2.8	42.2	GO:0051639	actin filament network formation(GO:0051639)
2.6	18.5	GO:0051136	regulation of NK T cell differentiation(GO:0051136)
2.6	7.8	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
2.6	25.9	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.6	7.7	GO:0070268	cornification(GO:0070268)
2.6	15.4	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
2.4	22.0	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
2.4	7.2	GO:1903445	protein transport from ciliary membrane to plasma membrane(GO:1903445)
2.4	11.9	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
2.3	16.0	GO:0060075	regulation of resting membrane potential(GO:0060075)
2.3	27.4	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
2.2	11.2	GO:1903899	positive regulation of PERK-mediated unfolded protein response(GO:1903899)
2.2	22.0	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)
2.2	15.3	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
2.2	24.0	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
2.2	13.0	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
2.1	6.4	GO:0071298	cellular response to L-ascorbic acid(GO:0071298)
2.1	2.1	GO:0060921	sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
2.1	8.4	GO:1901423	response to benzene(GO:1901423)
2.1	16.8	GO:2000389	regulation of neutrophil extravasation(GO:2000389)
2.1	35.4	GO:0046415	urate metabolic process(GO:0046415)
2.1	8.3	GO:0072709	cellular response to sorbitol(GO:0072709)
2.1	10.3	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
2.0	4.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
2.0	15.8	GO:0033216	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.9	7.7	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
1.9	18.9	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
1.9	5.6	GO:2000872	positive regulation of progesterone secretion(GO:2000872)
1.9	7.5	GO:0035772	interleukin-13-mediated signaling pathway(GO:0035772)
1.8	9.0	GO:0090131	mesenchyme migration(GO:0090131)
1.8	14.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.8	14.2	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
1.8	12.3	GO:0006477	protein sulfation(GO:0006477)
1.7	9.9	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.6	8.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
1.6	6.4	GO:0098501	DNA damage response, detection of DNA damage(GO:0042769) polynucleotide dephosphorylation(GO:0098501)
1.6	12.7	GO:0098734	macromolecule depalmitoylation(GO:0098734)
1.6	38.1	GO:0045577	regulation of B cell differentiation(GO:0045577)
1.6	7.9	GO:0006564	L-serine biosynthetic process(GO:0006564)
1.6	4.7	GO:1905225	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
1.6	7.8	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
1.5	6.2	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.5	21.6	GO:0044068	modulation by symbiont of host cellular process(GO:0044068)
1.5	19.9	GO:0060056	mammary gland involution(GO:0060056)
1.5	12.2	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
1.5	13.5	GO:0008228	opsonization(GO:0008228)
1.5	5.8	GO:0071802	negative regulation of podosome assembly(GO:0071802)
1.4	101.4	GO:0000186	activation of MAPKK activity(GO:0000186)
1.4	12.5	GO:0043249	erythrocyte maturation(GO:0043249)
1.4	6.8	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.3	17.4	GO:0034720	histone H3-K4 demethylation(GO:0034720)
1.2	4.9	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
1.2	3.7	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
1.2	20.6	GO:0042832	defense response to protozoan(GO:0042832)
1.2	7.2	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
1.2	4.8	GO:1901662	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
1.2	3.5	GO:0018992	germ-line sex determination(GO:0018992)
1.2	3.5	GO:1903281	positive regulation of calcium:sodium antiporter activity(GO:1903281)
1.1	32.1	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
1.1	10.3	GO:0000012	single strand break repair(GO:0000012)
1.1	11.4	GO:0019372	lipoxygenase pathway(GO:0019372)
1.1	27.4	GO:0032801	receptor catabolic process(GO:0032801)
1.1	9.0	GO:0006021	inositol biosynthetic process(GO:0006021)
1.1	26.7	GO:0030225	macrophage differentiation(GO:0030225)
1.1	6.6	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
1.1	2.2	GO:1902527	positive regulation of protein monoubiquitination(GO:1902527)
1.1	3.2	GO:0006409	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
1.1	11.8	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
1.1	4.2	GO:0007296	vitellogenesis(GO:0007296)
1.0	7.3	GO:0070269	pyroptosis(GO:0070269)
1.0	3.1	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
1.0	4.1	GO:1903413	cellular response to bile acid(GO:1903413)
1.0	3.1	GO:1903595	positive regulation of histamine secretion by mast cell(GO:1903595)
1.0	6.1	GO:1901223	leptin-mediated signaling pathway(GO:0033210) negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.0	7.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
1.0	3.0	GO:0014908	myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
1.0	14.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
1.0	9.0	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
1.0	3.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
1.0	7.8	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
1.0	7.8	GO:0046015	regulation of transcription by glucose(GO:0046015)
0.9	2.7	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.9	15.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.9	6.1	GO:2000254	regulation of male germ cell proliferation(GO:2000254)
0.9	3.4	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.8	15.9	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.8	5.6	GO:0014050	negative regulation of glutamate secretion(GO:0014050)
0.8	5.5	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.8	16.9	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.8	9.1	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.8	6.0	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.8	4.5	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.7	3.6	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.7	12.7	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.7	7.7	GO:0006013	mannose metabolic process(GO:0006013)
0.7	8.7	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.7	7.2	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.6	2.5	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.6	11.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.6	12.2	GO:0006855	drug transmembrane transport(GO:0006855)
0.6	1.8	GO:1900060	negative regulation of sphingolipid biosynthetic process(GO:0090155) cellular sphingolipid homeostasis(GO:0090156) negative regulation of ceramide biosynthetic process(GO:1900060)
0.6	10.5	GO:1990845	adaptive thermogenesis(GO:1990845)
0.5	3.8	GO:0060591	chondroblast differentiation(GO:0060591)
0.5	3.2	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.5	9.1	GO:0006691	leukotriene metabolic process(GO:0006691)
0.5	8.0	GO:0008340	determination of adult lifespan(GO:0008340)
0.5	3.2	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.5	13.1	GO:0006308	DNA catabolic process(GO:0006308)
0.5	1.6	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.5	18.5	GO:0019882	antigen processing and presentation(GO:0019882)
0.5	23.3	GO:0051607	defense response to virus(GO:0051607)
0.5	6.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.5	6.0	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313)
0.5	2.0	GO:0031642	negative regulation of myelination(GO:0031642)
0.5	7.5	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.5	17.9	GO:0007616	long-term memory(GO:0007616)
0.5	6.9	GO:0031167	rRNA methylation(GO:0031167)
0.5	5.4	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.5	4.2	GO:0035879	plasma membrane lactate transport(GO:0035879)
0.5	1.9	GO:0002325	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.5	1.9	GO:0002101	tRNA wobble cytosine modification(GO:0002101)
0.5	4.2	GO:0045622	regulation of T-helper cell differentiation(GO:0045622)
0.5	1.4	GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.4	27.1	GO:0030279	negative regulation of ossification(GO:0030279)
0.4	6.9	GO:0001553	luteinization(GO:0001553)
0.4	9.5	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.4	4.2	GO:0046085	adenosine metabolic process(GO:0046085)
0.4	2.5	GO:0033572	transferrin transport(GO:0033572) iron ion import(GO:0097286)
0.4	1.7	GO:0021564	vagus nerve development(GO:0021564)
0.4	10.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.4	6.7	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.4	8.6	GO:1900027	regulation of ruffle assembly(GO:1900027)
0.4	1.9	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.4	6.4	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.4	2.7	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.4	3.7	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.4	12.2	GO:0010165	response to X-ray(GO:0010165)
0.4	8.9	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.4	15.9	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.4	22.3	GO:0030183	B cell differentiation(GO:0030183)
0.4	0.7	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.4	3.3	GO:0097178	ruffle assembly(GO:0097178)
0.4	7.5	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.4	2.9	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3	3.5	GO:0002544	chronic inflammatory response(GO:0002544)
0.3	2.1	GO:0002943	tRNA dihydrouridine synthesis(GO:0002943)
0.3	2.7	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.3	24.7	GO:0030038	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.3	2.5	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.3	2.5	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.3	0.6	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.3	3.9	GO:0007210	serotonin receptor signaling pathway(GO:0007210)
0.3	0.5	GO:0030091	protein repair(GO:0030091)
0.3	1.4	GO:0009115	xanthine catabolic process(GO:0009115) xanthine metabolic process(GO:0046110)
0.3	4.3	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.3	1.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.3	1.8	GO:0019348	dolichol metabolic process(GO:0019348)
0.3	2.3	GO:0080009	mRNA methylation(GO:0080009)
0.2	14.9	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.2	1.7	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.2	10.9	GO:0030833	regulation of actin filament polymerization(GO:0030833)
0.2	23.5	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2	7.3	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.2	3.8	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2	3.5	GO:0007398	ectoderm development(GO:0007398)
0.2	0.7	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.2	1.5	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2	1.1	GO:1904751	positive regulation of protein localization to nucleolus(GO:1904751)
0.2	6.9	GO:0042058	regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2	2.1	GO:0016926	protein desumoylation(GO:0016926)
0.2	1.2	GO:0038169	somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2	3.6	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.2	2.0	GO:0090070	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2	2.0	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.2	1.2	GO:0033233	regulation of protein sumoylation(GO:0033233) negative regulation of protein sumoylation(GO:0033234)
0.2	1.9	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.2	0.5	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.2	1.7	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.2	7.1	GO:0048146	positive regulation of fibroblast proliferation(GO:0048146)
0.2	10.3	GO:0090630	activation of GTPase activity(GO:0090630)
0.1	3.6	GO:0032042	mitochondrial DNA metabolic process(GO:0032042)
0.1	1.0	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	1.6	GO:0032274	gonadotropin secretion(GO:0032274)
0.1	3.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1	12.5	GO:0007586	digestion(GO:0007586)
0.1	0.7	GO:0007097	nuclear migration(GO:0007097)
0.1	2.0	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.1	1.6	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.1	0.4	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1	77.0	GO:0006955	immune response(GO:0006955)
0.1	3.6	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.1	2.0	GO:0034453	microtubule anchoring(GO:0034453)
0.1	1.6	GO:1903963	arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1	1.6	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.1	2.9	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.1	1.7	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.1	0.4	GO:0034627	tryptophan catabolic process to kynurenine(GO:0019441) 'de novo' NAD biosynthetic process(GO:0034627)
0.1	5.8	GO:0031334	positive regulation of protein complex assembly(GO:0031334)
0.1	0.5	GO:0042100	B cell proliferation(GO:0042100)
0.1	1.0	GO:0070918	dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.1	0.9	GO:0042438	melanin biosynthetic process(GO:0042438)
0.1	1.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.1	1.6	GO:0000460	maturation of 5.8S rRNA(GO:0000460)
0.1	1.8	GO:0018345	protein palmitoylation(GO:0018345)
0.1	9.0	GO:0042254	ribosome biogenesis(GO:0042254)
0.0	0.3	GO:0000103	sulfate assimilation(GO:0000103)
0.0	3.6	GO:0048754	branching morphogenesis of an epithelial tube(GO:0048754)
0.0	4.0	GO:0018108	peptidyl-tyrosine phosphorylation(GO:0018108) peptidyl-tyrosine modification(GO:0018212)
0.0	1.4	GO:0042398	cellular modified amino acid biosynthetic process(GO:0042398)
0.0	2.7	GO:0046777	protein autophosphorylation(GO:0046777)
0.0	5.1	GO:1901653	cellular response to peptide(GO:1901653)
0.0	0.3	GO:0015671	oxygen transport(GO:0015671)
0.0	0.8	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.6	GO:0080171	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	0.3	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	1.1	GO:0030308	negative regulation of cell growth(GO:0030308)
0.0	5.5	GO:0006412	translation(GO:0006412)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
54.4	163.3	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
30.3	272.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
12.7	114.0	GO:0005610	laminin-5 complex(GO:0005610)
12.6	50.6	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
12.2	36.5	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
10.3	31.0	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
9.4	37.5	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
8.3	24.9	GO:0005896	interleukin-6 receptor complex(GO:0005896)
7.1	105.8	GO:0042613	MHC class II protein complex(GO:0042613)
6.9	34.5	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
6.1	98.2	GO:0042612	MHC class I protein complex(GO:0042612)
6.1	43.0	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
5.5	71.8	GO:0033643	host cell part(GO:0033643)
5.1	20.5	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
5.0	50.2	GO:0043020	NADPH oxidase complex(GO:0043020)
4.7	14.0	GO:0043657	host(GO:0018995) host cell(GO:0043657)
4.4	21.8	GO:0045098	type III intermediate filament(GO:0045098)
4.3	21.5	GO:0030485	smooth muscle contractile fiber(GO:0030485)
4.1	12.2	GO:0060187	cell pole(GO:0060187)
3.7	92.4	GO:0000145	exocyst(GO:0000145)
3.7	25.8	GO:0097136	Bcl-2 family protein complex(GO:0097136)
3.2	12.7	GO:1990630	IRE1-RACK1-PP2A complex(GO:1990630)
3.1	40.9	GO:0031143	pseudopodium(GO:0031143)
3.0	35.9	GO:0035631	CD40 receptor complex(GO:0035631)
2.8	8.4	GO:0008537	proteasome activator complex(GO:0008537)
2.8	137.0	GO:0016235	aggresome(GO:0016235)
2.8	22.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
2.3	13.8	GO:1990111	spermatoproteasome complex(GO:1990111)
2.1	25.3	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
2.0	14.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
2.0	12.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
2.0	618.9	GO:0009897	external side of plasma membrane(GO:0009897)
1.9	11.5	GO:0035189	Rb-E2F complex(GO:0035189)
1.8	44.2	GO:0001891	phagocytic cup(GO:0001891)
1.8	9.0	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
1.7	8.6	GO:0042824	MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
1.7	64.5	GO:0035861	site of double-strand break(GO:0035861)
1.6	16.4	GO:0032009	early phagosome(GO:0032009)
1.6	7.9	GO:0070552	BRISC complex(GO:0070552)
1.6	7.8	GO:0033553	rDNA heterochromatin(GO:0033553)
1.3	6.4	GO:0071953	elastic fiber(GO:0071953)
1.3	3.8	GO:1990682	CSF1-CSF1R complex(GO:1990682)
1.2	28.7	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.2	62.8	GO:0031201	SNARE complex(GO:0031201)
1.2	14.6	GO:0035098	ESC/E(Z) complex(GO:0035098)
1.2	16.8	GO:0042581	specific granule(GO:0042581)
1.1	3.4	GO:0097543	ciliary inversin compartment(GO:0097543)
1.1	20.5	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
1.0	7.3	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
1.0	21.9	GO:0042629	mast cell granule(GO:0042629)
0.9	2.7	GO:0044326	dendritic spine neck(GO:0044326)
0.9	3.6	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.9	6.0	GO:0001651	dense fibrillar component(GO:0001651)
0.8	53.7	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.8	3.8	GO:0072534	perineuronal net(GO:0072534)
0.7	64.6	GO:0032432	actin filament bundle(GO:0032432)
0.7	3.6	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.7	46.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.7	66.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.7	3.4	GO:0005641	nuclear envelope lumen(GO:0005641)
0.7	3.4	GO:0016035	zeta DNA polymerase complex(GO:0016035)
0.7	17.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.6	11.1	GO:0031528	microvillus membrane(GO:0031528)
0.6	12.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.6	11.3	GO:0005614	interstitial matrix(GO:0005614)
0.6	12.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.5	26.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5	3.7	GO:0042382	paraspeckles(GO:0042382)
0.5	54.0	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.5	2.0	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.5	671.5	GO:0005615	extracellular space(GO:0005615)
0.5	6.2	GO:0031258	lamellipodium membrane(GO:0031258)
0.5	1.8	GO:0035339	SPOTS complex(GO:0035339)
0.5	3.2	GO:0031415	NatA complex(GO:0031415)
0.4	0.9	GO:0000125	PCAF complex(GO:0000125)
0.4	2.9	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.4	15.7	GO:0045335	phagocytic vesicle(GO:0045335)
0.4	5.5	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.4	2.3	GO:0036396	MIS complex(GO:0036396)
0.4	2.7	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.4	7.5	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287)
0.3	10.4	GO:0002102	podosome(GO:0002102)
0.3	3.8	GO:0005686	U2 snRNP(GO:0005686)
0.3	3.7	GO:0002177	manchette(GO:0002177)
0.3	103.7	GO:0005925	focal adhesion(GO:0005925)
0.3	2.9	GO:0046581	intercellular canaliculus(GO:0046581)
0.3	7.1	GO:0005685	U1 snRNP(GO:0005685)
0.3	9.6	GO:0031519	PcG protein complex(GO:0031519)
0.3	1.4	GO:0035976	AP1 complex(GO:0035976)
0.3	5.5	GO:0000421	autophagosome membrane(GO:0000421)
0.3	15.1	GO:0031902	late endosome membrane(GO:0031902)
0.3	5.9	GO:0090544	BAF-type complex(GO:0090544)
0.3	15.4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2	2.4	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2	4.8	GO:0035145	exon-exon junction complex(GO:0035145)
0.2	29.4	GO:0005882	intermediate filament(GO:0005882)
0.2	17.3	GO:0016363	nuclear matrix(GO:0016363)
0.2	11.4	GO:0031225	anchored component of membrane(GO:0031225)
0.2	67.3	GO:0005667	transcription factor complex(GO:0005667)
0.2	25.8	GO:0001650	fibrillar center(GO:0001650)
0.2	0.8	GO:0042788	polysomal ribosome(GO:0042788)
0.2	3.2	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.2	8.9	GO:0000786	nucleosome(GO:0000786)
0.2	1.6	GO:0000178	exosome (RNase complex)(GO:0000178)
0.2	66.0	GO:0005730	nucleolus(GO:0005730)
0.2	1.7	GO:0030014	CCR4-NOT complex(GO:0030014)
0.2	2.5	GO:0034399	nuclear periphery(GO:0034399)
0.1	53.1	GO:0005635	nuclear envelope(GO:0005635)
0.1	5.1	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.1	6.7	GO:0016459	myosin complex(GO:0016459)
0.1	3.4	GO:0030686	90S preribosome(GO:0030686)
0.1	4.0	GO:0016328	lateral plasma membrane(GO:0016328)
0.1	1.8	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.1	9.9	GO:0030027	lamellipodium(GO:0030027)
0.1	2.4	GO:0001533	cornified envelope(GO:0001533)
0.1	4.0	GO:0031901	early endosome membrane(GO:0031901)
0.1	7.0	GO:0005770	late endosome(GO:0005770)
0.1	1.5	GO:0042575	DNA polymerase complex(GO:0042575)
0.1	1.1	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1	6.6	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	202.8	GO:0005654	nucleoplasm(GO:0005654)
0.1	2.5	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	7.1	GO:0036064	ciliary basal body(GO:0036064)
0.1	1.8	GO:0032587	ruffle membrane(GO:0032587)
0.1	8.2	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.1	11.7	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0	3.4	GO:0010008	endosome membrane(GO:0010008)
0.0	9.6	GO:0005911	cell-cell junction(GO:0005911)
0.0	0.3	GO:0005833	hemoglobin complex(GO:0005833)
0.0	4.5	GO:0098552	side of membrane(GO:0098552)
0.0	0.9	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	1.6	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	4.8	GO:0009986	cell surface(GO:0009986)
0.0	0.2	GO:0035371	microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
61.5	307.6	GO:0043120	tumor necrosis factor binding(GO:0043120)
27.2	163.3	GO:0042289	MHC class II protein binding(GO:0042289)
18.5	92.6	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
18.1	163.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
14.4	129.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
13.6	40.9	GO:0031762	follicle-stimulating hormone receptor binding(GO:0031762) vasopressin receptor binding(GO:0031893)
13.3	13.3	GO:0030881	beta-2-microglobulin binding(GO:0030881)
12.8	76.6	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
12.2	36.5	GO:1990763	arrestin family protein binding(GO:1990763)
12.0	48.2	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
11.7	164.5	GO:0016493	C-C chemokine receptor activity(GO:0016493)
10.3	31.0	GO:0042498	diacyl lipopeptide binding(GO:0042498)
10.3	30.8	GO:0035800	deubiquitinase activator activity(GO:0035800)
9.4	37.5	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
9.3	166.5	GO:0070628	proteasome binding(GO:0070628)
8.9	44.7	GO:0019862	IgA binding(GO:0019862)
8.5	34.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
8.3	41.6	GO:0004849	uridine kinase activity(GO:0004849)
8.1	48.7	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
7.4	29.8	GO:0004950	chemokine receptor activity(GO:0004950)
6.2	49.8	GO:0035033	histone deacetylase regulator activity(GO:0035033)
6.2	68.0	GO:0032036	myosin heavy chain binding(GO:0032036)
5.4	16.3	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
5.1	212.5	GO:0042605	peptide antigen binding(GO:0042605)
5.0	14.9	GO:0097677	STAT family protein binding(GO:0097677)
4.7	23.3	GO:0004920	interleukin-10 receptor activity(GO:0004920)
4.6	88.3	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
4.6	50.6	GO:0008131	primary amine oxidase activity(GO:0008131)
4.5	50.0	GO:0035613	RNA stem-loop binding(GO:0035613)
4.5	17.9	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
4.4	21.8	GO:1990254	keratin filament binding(GO:1990254)
4.3	8.6	GO:0046979	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
4.2	173.9	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
4.2	24.9	GO:0005138	interleukin-6 receptor binding(GO:0005138)
4.1	12.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
3.9	23.5	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
3.9	101.6	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
3.8	18.9	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
3.7	41.2	GO:0019864	IgG binding(GO:0019864)
3.7	11.1	GO:0070573	metallodipeptidase activity(GO:0070573)
3.5	35.4	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
3.5	28.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
3.4	37.6	GO:0004875	complement receptor activity(GO:0004875)
3.3	29.9	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
3.1	18.5	GO:0035473	lipase binding(GO:0035473)
2.9	17.4	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
2.9	11.4	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
2.7	8.0	GO:0001605	adrenomedullin receptor activity(GO:0001605)
2.6	13.2	GO:0090555	phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
2.6	15.8	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.6	10.5	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
2.6	7.9	GO:0048030	disaccharide binding(GO:0048030)
2.6	7.9	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
2.6	68.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
2.5	20.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
2.5	22.1	GO:0046703	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) natural killer cell lectin-like receptor binding(GO:0046703)
2.4	19.6	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
2.3	16.4	GO:0035197	siRNA binding(GO:0035197)
2.3	4.7	GO:0070053	thrombospondin receptor activity(GO:0070053)
2.3	11.5	GO:0061676	importin-alpha family protein binding(GO:0061676)
2.2	9.0	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
2.2	8.9	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.1	6.4	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023)
2.1	6.4	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
2.1	12.3	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
2.0	12.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
2.0	17.6	GO:0070016	armadillo repeat domain binding(GO:0070016)
1.8	75.7	GO:0051059	NF-kappaB binding(GO:0051059)
1.8	12.7	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.8	10.6	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
1.7	8.4	GO:0061133	endopeptidase activator activity(GO:0061133)
1.6	4.8	GO:0000253	3-keto sterol reductase activity(GO:0000253)
1.6	27.1	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
1.6	8.0	GO:0015616	DNA translocase activity(GO:0015616)
1.6	12.7	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
1.6	12.5	GO:0030274	LIM domain binding(GO:0030274)
1.5	49.2	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
1.5	6.1	GO:0055100	adiponectin binding(GO:0055100)
1.5	15.1	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
1.5	6.0	GO:0042134	rRNA primary transcript binding(GO:0042134)
1.5	4.5	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
1.4	59.7	GO:0005484	SNAP receptor activity(GO:0005484)
1.4	5.4	GO:0019960	C-X3-C chemokine binding(GO:0019960)
1.3	39.6	GO:0001968	fibronectin binding(GO:0001968)
1.3	9.0	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832)
1.3	3.8	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
1.3	3.8	GO:0031708	endothelin B receptor binding(GO:0031708)
1.2	31.2	GO:0071837	HMG box domain binding(GO:0071837)
1.2	3.7	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
1.2	7.3	GO:1901612	cardiolipin binding(GO:1901612)
1.2	25.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
1.2	3.5	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
1.1	5.6	GO:0004969	histamine receptor activity(GO:0004969)
1.1	7.8	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.1	8.5	GO:0031386	protein tag(GO:0031386)
1.0	15.7	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
1.0	3.1	GO:1990460	leptin receptor binding(GO:1990460)
1.0	5.0	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
1.0	8.8	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.9	9.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.9	16.3	GO:0070182	DNA polymerase binding(GO:0070182)
0.9	21.2	GO:0070840	dynein complex binding(GO:0070840)
0.9	8.7	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.9	6.9	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.9	275.1	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9	3.4	GO:0048408	epidermal growth factor binding(GO:0048408)
0.8	44.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.8	5.8	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.8	29.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.8	3.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.8	19.2	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.8	7.2	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.8	1.5	GO:0001635	calcitonin gene-related peptide receptor activity(GO:0001635)
0.8	8.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.7	13.5	GO:0017049	GTP-Rho binding(GO:0017049)
0.7	229.0	GO:0030246	carbohydrate binding(GO:0030246)
0.7	5.0	GO:0030957	Tat protein binding(GO:0030957)
0.7	7.7	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.7	13.9	GO:0008009	chemokine activity(GO:0008009)
0.7	6.2	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7	6.0	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.6	17.3	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6	10.8	GO:0002162	dystroglycan binding(GO:0002162)
0.6	12.0	GO:0017166	vinculin binding(GO:0017166)
0.6	1.8	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.6	1.7	GO:0052724	inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.6	16.5	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5	4.4	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.5	50.1	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5	6.9	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.5	6.8	GO:0031432	titin binding(GO:0031432)
0.5	61.5	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.5	24.0	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5	5.4	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.5	4.6	GO:0039706	co-receptor binding(GO:0039706)
0.4	21.2	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.4	1.7	GO:0071532	ankyrin repeat binding(GO:0071532)
0.4	4.6	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.4	2.7	GO:0003896	DNA primase activity(GO:0003896)
0.4	3.4	GO:0008432	JUN kinase binding(GO:0008432)
0.4	0.8	GO:0051525	NFAT protein binding(GO:0051525)
0.4	7.6	GO:0017127	cholesterol transporter activity(GO:0017127)
0.4	8.9	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.4	3.2	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.4	4.6	GO:0017160	Ral GTPase binding(GO:0017160)
0.4	59.6	GO:0051015	actin filament binding(GO:0051015)
0.3	2.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.3	7.6	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.3	3.3	GO:0070888	E-box binding(GO:0070888)
0.3	1.6	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.3	5.6	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.3	3.5	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.3	2.5	GO:0005381	iron ion transmembrane transporter activity(GO:0005381) P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3	17.2	GO:0035064	methylated histone binding(GO:0035064)
0.3	2.5	GO:0097100	supercoiled DNA binding(GO:0097100)
0.3	8.8	GO:0001540	beta-amyloid binding(GO:0001540)
0.3	11.8	GO:0003823	antigen binding(GO:0003823)
0.3	33.8	GO:0000149	SNARE binding(GO:0000149)
0.3	4.6	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.3	1.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.3	0.5	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3	1.4	GO:0004031	aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.3	5.8	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3	66.4	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	17.0	GO:0003724	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2	8.4	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.2	4.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.2	12.1	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2	0.9	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2	7.0	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.2	3.2	GO:0033038	bitter taste receptor activity(GO:0033038)
0.2	49.9	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.2	3.2	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2	25.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	2.9	GO:0008327	methyl-CpG binding(GO:0008327)
0.2	4.0	GO:0003993	acid phosphatase activity(GO:0003993)
0.2	3.7	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2	13.9	GO:0004536	deoxyribonuclease activity(GO:0004536)
0.2	1.1	GO:0043995	G-quadruplex RNA binding(GO:0002151) histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2	2.1	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.2	1.2	GO:0004994	somatostatin receptor activity(GO:0004994)
0.2	3.0	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.2	2.0	GO:0051787	misfolded protein binding(GO:0051787)
0.2	76.1	GO:0005525	GTP binding(GO:0005525)
0.2	7.4	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.2	11.8	GO:0001948	glycoprotein binding(GO:0001948)
0.2	42.2	GO:0003779	actin binding(GO:0003779)
0.2	5.2	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2	3.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.2	8.5	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	1.2	GO:0000400	four-way junction DNA binding(GO:0000400)
0.1	7.7	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	2.9	GO:0042169	SH2 domain binding(GO:0042169)
0.1	7.9	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	11.2	GO:0008201	heparin binding(GO:0008201)
0.1	0.3	GO:0004781	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1	2.6	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	0.8	GO:0001055	RNA polymerase II activity(GO:0001055)
0.1	19.5	GO:0045296	cadherin binding(GO:0045296)
0.1	1.3	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	6.6	GO:0004497	monooxygenase activity(GO:0004497)
0.1	2.7	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	3.9	GO:0022824	transmitter-gated ion channel activity(GO:0022824) transmitter-gated channel activity(GO:0022835)
0.1	19.5	GO:0000989	transcription factor activity, transcription factor binding(GO:0000989)
0.1	1.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	1.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	3.3	GO:0019838	growth factor binding(GO:0019838)
0.0	0.7	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	7.5	GO:0044212	transcription regulatory region DNA binding(GO:0044212)
0.0	0.6	GO:0050699	WW domain binding(GO:0050699)
0.0	0.5	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	2.6	GO:0008168	methyltransferase activity(GO:0008168)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.8	291.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
8.4	92.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
6.9	13.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
6.7	114.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
4.2	58.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
3.8	34.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
3.7	26.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
3.7	148.3	PID IL23 PATHWAY	IL23-mediated signaling events
3.6	132.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
3.3	36.5	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
3.3	82.8	PID CD40 PATHWAY	CD40/CD40L signaling
3.3	141.6	PID IL12 2PATHWAY	IL12-mediated signaling events
3.2	100.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
3.1	82.5	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
2.7	54.9	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
2.7	62.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
2.4	48.5	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
2.3	36.9	PID IL2 1PATHWAY	IL2-mediated signaling events
2.0	43.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.9	21.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.9	36.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
1.9	70.7	PID BCR 5PATHWAY	BCR signaling pathway
1.9	7.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.8	37.6	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
1.5	16.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
1.5	79.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.4	409.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.4	21.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.3	43.7	PID FGF PATHWAY	FGF signaling pathway
1.2	17.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.1	19.3	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
1.0	33.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
1.0	14.9	PID IFNG PATHWAY	IFN-gamma pathway
1.0	10.8	PID CERAMIDE PATHWAY	Ceramide signaling pathway
1.0	41.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.9	18.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.9	20.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.8	29.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.8	9.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.8	22.7	PID TNF PATHWAY	TNF receptor signaling pathway
0.7	28.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.7	19.9	PID INSULIN PATHWAY	Insulin Pathway
0.6	61.4	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.6	6.9	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.5	26.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.5	7.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.5	20.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.5	6.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.4	17.1	PID P73PATHWAY	p73 transcription factor network
0.4	3.5	PID MYC PATHWAY	C-MYC pathway
0.4	7.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.4	8.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.3	6.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3	3.7	PID AURORA A PATHWAY	Aurora A signaling
0.3	5.8	PID REELIN PATHWAY	Reelin signaling pathway
0.3	6.6	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	5.0	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	5.4	PID RAS PATHWAY	Regulation of Ras family activation
0.2	5.4	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	4.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	3.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	1.5	ST ADRENERGIC	Adrenergic Pathway
0.1	15.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	1.2	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.5	31.0	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
13.7	686.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
11.3	191.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
4.2	24.9	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
4.0	88.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
3.8	107.6	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
3.5	58.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
3.4	40.9	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
3.3	60.3	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
3.1	59.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
2.9	34.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
2.8	96.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
2.8	8.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
2.7	16.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
2.6	52.0	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
2.5	24.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
2.3	114.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.1	35.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
2.0	28.3	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
2.0	14.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.9	20.4	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.7	26.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
1.7	20.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
1.5	41.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
1.5	25.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.5	130.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.4	25.8	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
1.4	49.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.2	16.0	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
1.2	32.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.1	14.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
1.1	11.9	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
1.0	81.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
1.0	16.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.9	25.9	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.8	45.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.8	24.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.8	48.0	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.8	24.9	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.7	16.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.6	2.5	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.6	13.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.6	8.6	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.6	8.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5	9.0	REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.5	3.7	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.5	2.5	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4	4.6	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.4	41.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.4	7.7	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.3	60.8	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.3	3.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.3	3.4	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.3	4.6	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.3	4.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.2	7.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.2	6.2	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.2	13.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	4.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	3.9	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.2	1.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	13.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	3.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	3.9	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.1	2.9	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.1	7.2	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.1	3.3	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.1	0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	1.7	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	1.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	1.0	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	1.8	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1	9.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	3.8	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0	2.7	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	3.7	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.0	1.1	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0	0.9	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	1.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.7	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Results for Rela_Rel_Nfkb1

Z-value: 2.66

Motif logo

Transcription factors associated with Rela_Rel_Nfkb1

Activity-expression correlation:

Activity profile of Rela_Rel_Nfkb1 motif

Sorted Z-values of Rela_Rel_Nfkb1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rela_Rel_Nfkb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: