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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ptf1a

Z-value: 0.89

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Transcription factors associated with Ptf1a

Gene Symbol Gene ID Gene Info
Ptf1a
ENSRNOG00000016902 pancreas specific transcription factor, 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ptf1arn6_v1_chr17_+_86199623_861996230.496.8e-21Click!

Activity profile of Ptf1a motif

Sorted Z-values of Ptf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_43911057 59.92 ENSRNOT00000026017
Ctrb1
chymotrypsinogen B1
chr4_+_70755795 46.48 ENSRNOT00000043527
LOC683849
similar to Anionic trypsin II precursor (Pretrypsinogen II)
chr4_+_70689737 44.54 ENSRNOT00000018852
Prss2
protease, serine, 2
chr4_+_70614524 36.92 ENSRNOT00000041100
Prss3
protease, serine 3
chr7_+_70807867 33.90 ENSRNOT00000010639
Stac3
SH3 and cysteine rich domain 3
chr1_-_255376833 31.06 ENSRNOT00000024941
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
chr10_-_95934345 30.16 ENSRNOT00000004349
Cacng1
calcium voltage-gated channel auxiliary subunit gamma 1
chr4_-_70747226 29.38 ENSRNOT00000044960
LOC102554637
anionic trypsin-2-like
chr2_-_173668555 29.26 ENSRNOT00000013452
Serpini2
serpin family I member 2
chr4_-_70628470 26.15 ENSRNOT00000029319
Try5
trypsin 5
chr8_-_111777602 18.50 ENSRNOT00000052317
ENSRNOT00000083855
RGD1310507
similar to RIKEN cDNA 1300017J02
chr4_-_30338679 17.25 ENSRNOT00000012050
Pon3
paraoxonase 3
chr18_+_25163561 14.91 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
Bin1
bridging integrator 1
chr10_+_70262361 14.78 ENSRNOT00000064625
ENSRNOT00000076973
Unc45b
unc-45 myosin chaperone B
chr7_-_71226150 14.59 ENSRNOT00000005875
RGD1561812
similar to Retinol dehydrogenase type II (RODH II) (29 k-protein)
chr18_-_25314047 13.49 ENSRNOT00000079778
AABR07031674.4

chr18_+_24708115 13.07 ENSRNOT00000061054
Lims2
LIM zinc finger domain containing 2
chr4_+_115712850 12.87 ENSRNOT00000085765
Dysf
dysferlin
chr4_+_115713004 12.79 ENSRNOT00000064536
Dysf
dysferlin
chr4_+_100166863 12.64 ENSRNOT00000014505
Sftpb
surfactant protein B
chr20_-_5754773 12.45 ENSRNOT00000035977
Ip6k3
inositol hexakisphosphate kinase 3
chr11_-_64952687 12.00 ENSRNOT00000087892
Popdc2
popeye domain containing 2
chr16_-_75637789 11.29 ENSRNOT00000058029
Defb4
defensin beta 4
chr3_+_58632476 10.57 ENSRNOT00000010630
Rapgef4
Rap guanine nucleotide exchange factor 4
chr10_+_47412582 9.95 ENSRNOT00000003139
Tnfrsf13b
TNF receptor superfamily member 13B
chr9_+_100156154 9.31 ENSRNOT00000005935
Aqp12a
aquaporin 12A
chr10_-_97896525 8.64 ENSRNOT00000005172
Wipi1
WD repeat domain, phosphoinositide interacting 1
chr1_+_201055644 8.56 ENSRNOT00000054937
ENSRNOT00000047161
Tacc2
transforming, acidic coiled-coil containing protein 2
chr7_-_113228439 8.49 ENSRNOT00000034672
Col22a1
collagen type XXII alpha 1 chain
chr19_+_487723 7.91 ENSRNOT00000061734
Ces2j
carboxylesterase 2J
chr6_-_141291347 7.80 ENSRNOT00000008333
AABR07065789.1

chr14_+_17228856 7.61 ENSRNOT00000003082
Cxcl9
C-X-C motif chemokine ligand 9
chr4_+_102876038 7.53 ENSRNOT00000085205
AABR07061022.3

chr6_+_127946686 7.47 ENSRNOT00000082680
LOC500712
Ab1-233
chr14_-_86706626 7.34 ENSRNOT00000082893
H2afv
H2A histone family, member V
chr4_+_93888502 7.05 ENSRNOT00000090783
AABR07060792.1

chr8_+_116332796 6.38 ENSRNOT00000021408
Hyal1
hyaluronoglucosaminidase 1
chr4_-_156276304 6.27 ENSRNOT00000078725
Clec4e
C-type lectin domain family 4, member E
chrX_+_16946207 6.22 ENSRNOT00000003981
RGD1563606
similar to cysteine-rich protein 2
chr17_-_77304530 6.19 ENSRNOT00000024362
Phyh
phytanoyl-CoA 2-hydroxylase
chr16_-_88347369 6.03 ENSRNOT00000019797
Pdha1l1
pyruvate dehydrogenase (lipoamide) alpha 1-like 1
chr4_-_119927705 5.50 ENSRNOT00000077624
Rab7a
RAB7A, member RAS oncogene family
chr16_-_8350067 5.33 ENSRNOT00000026932
LOC100362432
mitochondrial import inner membrane translocase subunit Tim23-like
chr6_-_140572023 5.14 ENSRNOT00000072338
AABR07065772.1

chr8_-_22874637 5.02 ENSRNOT00000064551
ENSRNOT00000090424
Dock6
dedicator of cytokinesis 6
chr5_-_164747083 4.96 ENSRNOT00000010433
Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr7_-_139483997 4.89 ENSRNOT00000086062
Col2a1
collagen type II alpha 1 chain
chr20_-_7943575 4.71 ENSRNOT00000066897
Tulp1
tubby like protein 1
chr9_+_94928489 4.70 ENSRNOT00000087366
ENSRNOT00000085770
ENSRNOT00000024733
Sag
S-antigen visual arrestin
chr4_-_148690998 4.66 ENSRNOT00000052024
Olr831
olfactory receptor 831
chr1_-_282251257 4.61 ENSRNOT00000015186
Prdx3
peroxiredoxin 3
chr2_+_95320283 4.60 ENSRNOT00000015537
Hey1
hes-related family bHLH transcription factor with YRPW motif 1
chr11_+_28724341 4.46 ENSRNOT00000049858
LOC100363287
RIKEN cDNA 2310034C09-like
chr17_-_42927704 4.39 ENSRNOT00000087291
Prl3d4
prolactin family 3, subfamily d, member 4
chr5_+_113725717 4.34 ENSRNOT00000032248
Tek
TEK receptor tyrosine kinase
chr10_+_89251370 4.26 ENSRNOT00000076820
Aoc3
amine oxidase, copper containing 3
chr8_+_20265891 4.24 ENSRNOT00000048326
Olr1166
olfactory receptor 1166
chr8_-_126495347 4.24 ENSRNOT00000013467
Cmc1
C-x(9)-C motif containing 1
chr7_-_143552588 4.23 ENSRNOT00000086317
ENSRNOT00000092619
ENSRNOT00000092138
Krt78
keratin 78
chr17_-_39278695 4.14 ENSRNOT00000082821
LOC103689989
prolactin-3D4
chr4_-_162025090 4.00 ENSRNOT00000085887
ENSRNOT00000009904
Klrb1a
killer cell lectin-like receptor subfamily B, member 1A
chr3_+_19174027 3.99 ENSRNOT00000074445
AABR07051678.1

chr6_+_128152343 3.97 ENSRNOT00000085867
Gm1000
predicted gene 10000
chr3_+_67849966 3.79 ENSRNOT00000057826
Dusp19
dual specificity phosphatase 19
chr1_+_226030938 3.77 ENSRNOT00000030919
Fth1
ferritin heavy chain 1
chr16_-_64716224 3.76 ENSRNOT00000071166
Fut10
fucosyltransferase 10
chr4_-_103636632 3.70 ENSRNOT00000086523
AABR07061077.1

chr16_-_9430743 3.53 ENSRNOT00000043811
Wdfy4
WDFY family member 4
chr1_+_170887363 3.23 ENSRNOT00000036261
Olr215
olfactory receptor 215
chr19_+_25946979 3.23 ENSRNOT00000004027
Gadd45gip1
GADD45G interacting protein 1
chr20_+_5008508 3.21 ENSRNOT00000001153
Vwa7
von Willebrand factor A domain containing 7
chr12_+_19680712 3.10 ENSRNOT00000081310
AABR07035561.2

chr10_+_103349172 3.01 ENSRNOT00000035963
Gpr142
G protein-coupled receptor 142
chr3_+_43293185 2.93 ENSRNOT00000090323
Gpd2
glycerol-3-phosphate dehydrogenase 2
chr4_+_148664950 2.91 ENSRNOT00000017843
Olr830
olfactory receptor 830
chr8_+_43733545 2.83 ENSRNOT00000082000
Olr1326
olfactory receptor 1326
chr12_-_41625403 2.70 ENSRNOT00000001876
Sds
serine dehydratase
chr1_-_213981317 2.69 ENSRNOT00000086238
ENSRNOT00000054869
Slc25a22
solute carrier family 25 member 22
chr9_+_43259709 2.68 ENSRNOT00000022487
Cox5b
cytochrome c oxidase subunit 5B
chr15_+_28319136 2.57 ENSRNOT00000048723
Tppp2
tubulin polymerization-promoting protein family member 2
chr5_+_69784806 2.57 ENSRNOT00000024722
Olr853
olfactory receptor 853
chr4_-_115516296 2.54 ENSRNOT00000019399
Paip2b
poly(A) binding protein interacting protein 2B
chr7_-_60294796 2.47 ENSRNOT00000007580
Yeats4
YEATS domain containing 4
chr3_+_103192683 2.46 ENSRNOT00000037551
LOC100363452
ribosomal protein S8-like
chr1_-_98046770 2.38 ENSRNOT00000056528
Grb2
growth factor receptor bound protein 2
chr5_-_128333805 2.38 ENSRNOT00000037523
Zfyve9
zinc finger FYVE-type containing 9
chr1_-_215330492 2.33 ENSRNOT00000068147
ENSRNOT00000042047
AABR07006049.1

chr1_+_80973739 2.29 ENSRNOT00000026088
ENSRNOT00000081983
AC118165.1

chr10_+_44958544 2.12 ENSRNOT00000072282
Olr1439
olfactory receptor 1439
chr11_-_28736000 2.12 ENSRNOT00000064058
Krtap14l
keratin associated protein 14 like
chr1_+_229722768 2.11 ENSRNOT00000017126
Olr339
olfactory receptor 339
chr1_-_82580007 2.10 ENSRNOT00000078668
Axl
Axl receptor tyrosine kinase
chr14_-_18634309 2.06 ENSRNOT00000003720
Epgn
epithelial mitogen
chr15_-_27077160 1.99 ENSRNOT00000016721
Olr1611
olfactory receptor 1611
chr5_-_148444188 1.87 ENSRNOT00000033929
RGD1562036
similar to ornithine decarboxylase
chr16_-_52127591 1.86 ENSRNOT00000033652
Triml2
tripartite motif family-like 2
chr3_-_77170085 1.77 ENSRNOT00000042667
Olr654
olfactory receptor 654
chr1_-_215350161 1.69 ENSRNOT00000081144
ENSRNOT00000064050
AABR07006049.1

chr3_-_101547478 1.63 ENSRNOT00000006203
Fibin
fin bud initiation factor homolog (zebrafish)
chr8_+_64531594 1.49 ENSRNOT00000036798
Gramd2
GRAM domain containing 2
chr8_+_22035256 1.41 ENSRNOT00000028066
Icam1
intercellular adhesion molecule 1
chr19_-_54761670 1.39 ENSRNOT00000025848
Ca5a
carbonic anhydrase 5A
chr18_+_15738809 1.38 ENSRNOT00000075444
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr10_-_12571316 1.37 ENSRNOT00000074440
Olr1372
olfactory receptor 1372
chr1_-_99632845 1.36 ENSRNOT00000049123
LOC103691107
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene
chr4_-_148437961 1.30 ENSRNOT00000082907
Alox5
arachidonate 5-lipoxygenase
chr1_-_98501249 1.18 ENSRNOT00000023858
Lim2
lens intrinsic membrane protein 2
chr7_+_130357643 1.14 ENSRNOT00000040769
Klhdc7b
kelch domain containing 7B
chr7_-_130405347 1.09 ENSRNOT00000013985
Cpt1b
carnitine palmitoyltransferase 1B
chr20_-_848229 1.08 ENSRNOT00000000974
Olr1694
olfactory receptor 1694
chr1_+_77541359 1.07 ENSRNOT00000049028
LOC103690015
40S ribosomal protein S19-like
chr1_+_170796271 1.06 ENSRNOT00000042820
Olr210
olfactory receptor 210
chr16_-_38063821 1.06 ENSRNOT00000077452
ENSRNOT00000089533
Glra3
glycine receptor, alpha 3
chr1_+_79396578 1.03 ENSRNOT00000023686
Ceacam11
carcinoembryonic antigen-related cell adhesion molecule 11
chr3_+_153402548 0.97 ENSRNOT00000091273
Rpn2
ribophorin II
chr10_+_54126486 0.97 ENSRNOT00000078820
Gas7
growth arrest specific 7
chr10_+_87788458 0.95 ENSRNOT00000042020
LOC100910814
keratin-associated protein 9-1-like
chr17_-_62299655 0.94 ENSRNOT00000024855
Gjd4
gap junction protein, delta 4
chr6_+_38474804 0.93 ENSRNOT00000009779
Nbas
neuroblastoma amplified sequence
chr1_-_167971151 0.92 ENSRNOT00000043023
Olr53
olfactory receptor 53
chr4_-_103403976 0.91 ENSRNOT00000088153
AABR07061057.3

chr1_-_170927957 0.90 ENSRNOT00000049686
Olr218
olfactory receptor 218
chr19_+_27464937 0.83 ENSRNOT00000024020
Vps35
VPS35 retromer complex component
chr20_+_1944801 0.80 ENSRNOT00000075060
Olr1750
olfactory receptor 1750
chr5_+_137757938 0.80 ENSRNOT00000073594
LOC100912491
olfactory receptor 2A2-like
chr20_-_11644166 0.79 ENSRNOT00000073009
LOC100361739
keratin associated protein 12-1-like
chr5_-_6083083 0.77 ENSRNOT00000072411
Sulf1
sulfatase 1
chr8_+_56451240 0.73 ENSRNOT00000085278
LOC100359687
mitochondrial ribosomal protein L1-like
chr7_+_136037230 0.72 ENSRNOT00000071423
AABR07058745.1

chr3_+_20893187 0.71 ENSRNOT00000070947
Olr415
olfactory receptor 415
chr19_-_10581842 0.68 ENSRNOT00000021639
Polr2c
RNA polymerase II subunit C
chr11_+_74834050 0.57 ENSRNOT00000002333
Atp13a4
ATPase 13A4
chr5_-_137515690 0.56 ENSRNOT00000049593
LOC100912421
olfactory receptor 2D2-like
chr1_-_73961432 0.55 ENSRNOT00000035435
Nlrp4b
NLR family, pyrin domain containing 4B
chr1_-_54748763 0.50 ENSRNOT00000074549
LOC100911027
protein MAL2-like
chr7_+_141702038 0.47 ENSRNOT00000086577
Dip2b
disco-interacting protein 2 homolog B
chr3_+_160852164 0.43 ENSRNOT00000019127
Rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr13_+_96111800 0.41 ENSRNOT00000005967
Desi2
desumoylating isopeptidase 2
chr20_+_3367208 0.39 ENSRNOT00000091149
RGD1302996
hypothetical protein MGC:15854
chr1_-_170763377 0.35 ENSRNOT00000041335
Olr209
olfactory receptor 209
chr2_+_112868707 0.30 ENSRNOT00000017805
Nceh1
neutral cholesterol ester hydrolase 1
chr15_-_41316203 0.30 ENSRNOT00000065261
Tnfrsf19
TNF receptor superfamily member 19
chr9_+_16302578 0.28 ENSRNOT00000021762
Gltscr1l
GLTSCR1-like
chr1_-_167698263 0.26 ENSRNOT00000093046
Trim21
tripartite motif-containing 21
chr3_-_78409263 0.23 ENSRNOT00000041001
Olr704
olfactory receptor 704
chr1_+_259739955 0.21 ENSRNOT00000054719
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr16_-_37908173 0.16 ENSRNOT00000075026
Glra3
glycine receptor, alpha 3
chr10_-_45579029 0.13 ENSRNOT00000080028
Arf1
ADP-ribosylation factor 1
chr10_+_87819150 0.13 ENSRNOT00000073764
ENSRNOT00000064626
LOC680442
hypothetical protein LOC680442
chr2_+_87957363 0.06 ENSRNOT00000047881
LOC499565
LRRGT00038
chr10_-_87753668 0.06 ENSRNOT00000066758
ENSRNOT00000047104
Krtap4-3
keratin associated protein 4-3
chr10_-_12674077 0.02 ENSRNOT00000041353
Olr1376
olfactory receptor 1376
chr10_-_60275762 0.02 ENSRNOT00000074380
Olr1498
olfactory receptor 1498
chr7_-_11724843 0.01 ENSRNOT00000084144
Sppl2b
signal peptide peptidase-like 2B

Network of associatons between targets according to the STRING database.

First level regulatory network of Ptf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 14.9 GO:0060988 lipid tube assembly(GO:0060988)
4.0 12.0 GO:0060931 sinoatrial node cell development(GO:0060931)
3.5 10.6 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
2.9 17.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
2.6 31.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
2.5 12.6 GO:0050828 regulation of liquid surface tension(GO:0050828)
2.1 6.2 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
2.0 25.7 GO:0001778 plasma membrane repair(GO:0001778)
1.8 5.5 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
1.7 5.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.6 13.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.6 6.4 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.5 4.6 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
1.4 4.3 GO:0048014 Tie signaling pathway(GO:0048014)
1.2 187.9 GO:0007586 digestion(GO:0007586)
1.0 4.9 GO:0071306 cellular response to vitamin E(GO:0071306)
0.9 4.6 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.8 33.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.8 30.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.8 4.7 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.7 2.7 GO:0006565 L-serine catabolic process(GO:0006565)
0.7 2.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.7 8.6 GO:0030953 astral microtubule organization(GO:0030953)
0.6 2.9 GO:0019563 glycerol catabolic process(GO:0019563)
0.6 8.6 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.5 2.1 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.5 7.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.5 10.0 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.4 6.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.4 12.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.4 3.2 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.4 4.4 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.4 1.4 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.3 1.3 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.3 1.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.3 3.8 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 0.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of protein catabolic process in the vacuole(GO:1904350) lysosomal protein catabolic process(GO:1905146)
0.3 0.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 3.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.3 4.3 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.2 11.3 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 14.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 0.9 GO:0014901 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.2 0.9 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 2.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 3.8 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 2.4 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.1 2.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 2.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 7.3 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.2 GO:1903576 response to L-arginine(GO:1903576)
0.1 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 3.9 GO:0071806 protein transmembrane transport(GO:0071806)
0.1 2.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 8.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.0 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 22.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 1.9 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.6 GO:0007601 visual perception(GO:0007601)
0.0 1.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 5.9 GO:0043086 negative regulation of catalytic activity(GO:0043086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 31.1 GO:0042587 glycogen granule(GO:0042587)
2.1 6.4 GO:0036117 hyaluranon cable(GO:0036117)
2.1 10.6 GO:0044316 cone cell pedicle(GO:0044316)
1.5 14.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.3 18.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.8 8.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.7 30.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 2.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.6 2.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 5.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.4 4.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 1.2 GO:0098982 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.4 4.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 25.7 GO:0030315 T-tubule(GO:0030315)
0.3 3.8 GO:0044754 autolysosome(GO:0044754)
0.3 0.9 GO:0070939 Dsl1p complex(GO:0070939)
0.2 0.8 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 9.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 5.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 2.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 2.1 GO:0033643 host cell part(GO:0033643)
0.2 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 236.8 GO:0005615 extracellular space(GO:0005615)
0.1 12.0 GO:0042383 sarcolemma(GO:0042383)
0.1 2.5 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.7 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 7.3 GO:0000786 nucleosome(GO:0000786)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 1.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 9.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 6.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.2 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.6 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
2.8 11.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.7 5.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
1.5 4.6 GO:0035939 microsatellite binding(GO:0035939)
1.5 7.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.4 12.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.3 6.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.3 3.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.2 4.7 GO:0002046 opsin binding(GO:0002046)
1.2 4.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.0 2.9 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.9 2.7 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.8 4.9 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 180.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 4.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.7 14.9 GO:0048156 tau protein binding(GO:0048156)
0.6 3.8 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 22.6 GO:0030552 cAMP binding(GO:0030552)
0.5 30.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 2.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.5 4.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.4 3.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.4 1.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.4 31.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.4 1.2 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.4 4.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 14.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.4 1.9 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.4 25.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 8.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 6.2 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.3 1.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.3 2.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.3 29.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 2.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 2.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 5.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 4.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 2.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.0 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 18.5 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.8 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.1 8.2 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 4.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 8.1 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 8.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 4.1 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 22.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)
0.0 3.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 100.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 14.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.3 13.4 NABA COLLAGENS Genes encoding collagen proteins
0.3 10.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.3 13.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 2.4 PID IL5 PATHWAY IL5-mediated signaling events
0.2 7.6 PID IL23 PATHWAY IL23-mediated signaling events
0.2 4.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 5.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 5.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 18.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 3.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 2.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 3.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 44.5 REACTOME DEFENSINS Genes involved in Defensins
1.4 38.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 10.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.5 6.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 6.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 18.3 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.3 6.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 8.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 7.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 5.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 5.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 2.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.9 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 1.0 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation