ISMARA results: Prrx1_Isx

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Prrx1_Isx_Prrxl1

Z-value: 0.81

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Transcription factors associated with Prrx1_Isx_Prrxl1

Gene Symbol	Gene ID	Gene Info
Prrx1 NCBI RGD Ensembl	ENSRNOG00000003720	paired related homeobox 1
Isx NCBI RGD Ensembl	ENSRNOG00000039808	intestine-specific homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Drgx	rn6_v1_chr16_+_8823872_8823872	0.33	1.9e-09	Click!
Prrx1	rn6_v1_chr13_-_81214494_81214546	0.31	2.4e-08	Click!
Isx	rn6_v1_chr19_+_14198899_14198899	0.03	6.3e-01	Click!

Activity profile of Prrx1_Isx_Prrxl1 motif

Sorted Z-values of Prrx1_Isx_Prrxl1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_198303168 Show fit	21.79	ENSRNOT00000056262	Mtmr11 NCBI RGD Ensembl Show fit	myotubularin related protein 11
chr5_+_118574801 Show fit	20.31	ENSRNOT00000035949	Ube2u NCBI RGD Ensembl Show fit	ubiquitin-conjugating enzyme E2U (putative)
chr18_-_24057917 Show fit	20.30	ENSRNOT00000023874	Rit2 NCBI RGD Ensembl Show fit	Ras-like without CAAX 2
chr4_-_55011415 Show fit	19.23	ENSRNOT00000056996	Grm8 NCBI RGD Ensembl Show fit	glutamate metabotropic receptor 8
chr4_-_61720956 Show fit	18.38	ENSRNOT00000012879	Akr1b1 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1 member B
chr20_+_31339787 Show fit	17.96	ENSRNOT00000082463	Aifm2 NCBI RGD Ensembl Show fit	apoptosis inducing factor, mitochondria associated 2
chr7_+_59200918 Show fit	17.63	ENSRNOT00000085073	Ptprr NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, R
chr8_-_6305033 Show fit	16.74	ENSRNOT00000029887	Cep126 NCBI RGD Ensembl Show fit	centrosomal protein 126
chr4_+_70252366 Show fit	16.33	ENSRNOT00000073039	Chl1 NCBI RGD Ensembl Show fit	cell adhesion molecule L1-like
chr17_+_63635086 Show fit	16.25	ENSRNOT00000020634	Dip2c NCBI RGD Ensembl Show fit	disco-interacting protein 2 homolog C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Prrx1_Isx_Prrxl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	39.0	GO:0007416	synapse assembly(GO:0007416)
0.7	23.6	GO:0035640	exploration behavior(GO:0035640)
0.2	20.8	GO:0008637	apoptotic mitochondrial changes(GO:0008637)
2.9	20.3	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.4	20.1	GO:0016574	histone ubiquitination(GO:0016574)
1.7	19.2	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
3.8	19.1	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
6.1	18.4	GO:0006059	hexitol metabolic process(GO:0006059)
0.6	17.8	GO:0007413	axonal fasciculation(GO:0007413)
4.4	17.6	GO:0038128	ERBB2 signaling pathway(GO:0038128)

Showing 1 to 10 of 262 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	33.4	GO:0044295	axonal growth cone(GO:0044295)
0.1	32.1	GO:0030425	dendrite(GO:0030425)
0.5	25.4	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
2.6	23.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.1	23.3	GO:0005635	nuclear envelope(GO:0005635)
1.8	21.8	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.3	20.8	GO:0042734	presynaptic membrane(GO:0042734)
5.1	20.3	GO:0033503	HULC complex(GO:0033503)
0.3	19.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	19.2	GO:0005814	centriole(GO:0005814)

Showing 1 to 10 of 127 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	52.4	GO:0016503	pheromone receptor activity(GO:0016503)
2.5	33.1	GO:0030215	semaphorin receptor binding(GO:0030215)
1.1	28.9	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	22.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.4	20.5	GO:0030507	spectrin binding(GO:0030507)
4.8	19.2	GO:0001642	group III metabotropic glutamate receptor activity(GO:0001642)
1.5	18.4	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4	18.3	GO:0070330	aromatase activity(GO:0070330)
0.6	18.0	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.7	17.8	GO:0008157	protein phosphatase 1 binding(GO:0008157)

Showing 1 to 10 of 177 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	20.3	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.3	17.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.3	16.5	PID LKB1 PATHWAY	LKB1 signaling events
0.2	15.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	15.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	11.3	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.3	10.4	PID RHOA PATHWAY	RhoA signaling pathway
0.2	9.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	7.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	7.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	22.7	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
1.0	20.3	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.9	19.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.7	18.4	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.4	17.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.6	16.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.9	16.1	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.9	15.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	13.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7	12.0	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs

Showing 1 to 10 of 70 entries

Results for Prrx1_Isx_Prrxl1

Z-value: 0.81

Motif logo

Transcription factors associated with Prrx1_Isx_Prrxl1

Activity-expression correlation:

Activity profile of Prrx1_Isx_Prrxl1 motif

Sorted Z-values of Prrx1_Isx_Prrxl1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prrx1_Isx_Prrxl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: