ISMARA results: Prop1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Prop1

Z-value: 1.25

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Transcription factors associated with Prop1

Gene Symbol	Gene ID	Gene Info
Prop1 NCBI RGD Ensembl	ENSRNOG00000003671	PROP paired-like homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Prop1	rn6_v1_chr10_-_36452378_36452378	-0.07	2.0e-01	Click!

Activity profile of Prop1 motif

Sorted Z-values of Prop1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_40086870 Show fit	53.89	ENSRNOT00000010027	Smpx NCBI RGD Ensembl Show fit	small muscle protein, X-linked
chr5_-_119564846 Show fit	48.08	ENSRNOT00000012977	Cyp2j4 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily j, polypeptide 4
chrX_-_142164220 Show fit	39.06	ENSRNOT00000064780	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr11_+_7265828 Show fit	36.57	ENSRNOT00000084765	Gbe1 NCBI RGD Ensembl Show fit	1,4-alpha-glucan branching enzyme 1
chr1_+_248428099 Show fit	32.11	ENSRNOT00000050984	Mbl2 NCBI RGD Ensembl Show fit	mannose binding lectin 2
chr2_-_227207584 Show fit	31.89	ENSRNOT00000065361 ENSRNOT00000080215	Myoz2 NCBI RGD Ensembl Show fit	myozenin 2
chr9_+_37727942 Show fit	30.68	ENSRNOT00000016511 ENSRNOT00000074276	LOC100912306 NCBI RGD Ensembl Show fit	myotilin-like
chr8_+_84945444 Show fit	30.51	ENSRNOT00000008244	Klhl31 NCBI RGD Ensembl Show fit	kelch-like family member 31
chr18_+_35574002 Show fit	30.00	ENSRNOT00000093442 ENSRNOT00000070817 ENSRNOT00000093356	Myot NCBI RGD Ensembl Show fit	myotilin
chr9_+_95501778 Show fit	29.91	ENSRNOT00000086805	Spp2 NCBI RGD Ensembl Show fit	secreted phosphoprotein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Prop1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	276.8	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
2.9	54.2	GO:0046415	urate metabolic process(GO:0046415)
3.2	53.9	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
3.3	53.3	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.3	48.7	GO:0006941	striated muscle contraction(GO:0006941)
4.3	46.8	GO:0006068	ethanol catabolic process(GO:0006068)
0.3	45.9	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.0	41.7	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
5.6	39.1	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.7	36.6	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	376.3	GO:0031224	intrinsic component of membrane(GO:0031224)
2.1	88.7	GO:0043034	costamere(GO:0043034)
1.5	75.3	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	74.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.5	57.2	GO:0030018	Z disc(GO:0030018)
10.8	53.9	GO:0005927	muscle tendon junction(GO:0005927)
0.7	41.1	GO:0014704	intercalated disc(GO:0014704)
1.0	39.5	GO:0060077	inhibitory synapse(GO:0060077)
0.4	32.1	GO:0005581	collagen trimer(GO:0005581)
2.8	30.9	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	147.5	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	85.9	GO:0005549	odorant binding(GO:0005549)
2.8	75.3	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
4.5	54.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
16.0	48.1	GO:0008405	arachidonic acid 11,12-epoxygenase activity(GO:0008405)
9.3	46.3	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.9	42.6	GO:0030507	spectrin binding(GO:0030507)
0.4	40.9	GO:0016503	pheromone receptor activity(GO:0016503)
0.3	40.5	GO:0042626	ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
12.2	36.6	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)

Showing 1 to 10 of 115 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	26.1	PID FGF PATHWAY	FGF signaling pathway
0.3	25.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	23.8	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	17.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	16.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.3	15.7	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.4	15.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	14.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	11.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	54.2	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
1.1	43.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
3.6	39.5	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.7	35.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.4	29.6	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
2.2	28.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
2.6	26.4	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
3.0	24.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.5	23.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
2.8	22.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Showing 1 to 10 of 50 entries

Results for Prop1

Z-value: 1.25

Motif logo

Transcription factors associated with Prop1

Activity-expression correlation:

Activity profile of Prop1 motif

Sorted Z-values of Prop1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prop1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: