ISMARA results: Pparg

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pparg_Rxrg

Z-value: 3.01

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Transcription factors associated with Pparg_Rxrg

Gene Symbol	Gene ID	Gene Info
Pparg NCBI RGD Ensembl	ENSRNOG00000008839	peroxisome proliferator-activated receptor gamma
Rxrg NCBI RGD Ensembl	ENSRNOG00000004537	retinoid X receptor gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rxrg	rn6_v1_chr13_+_85818427_85818473	0.32	6.5e-09	Click!
Pparg	rn6_v1_chr4_+_147275334_147275334	-0.22	7.9e-05	Click!

Activity profile of Pparg_Rxrg motif

Sorted Z-values of Pparg_Rxrg motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_123638702 Show fit	245.22	ENSRNOT00000082473 ENSRNOT00000044470 ENSRNOT00000092017	Cyp2d1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily d, polypeptide 1
chr7_+_11490852 Show fit	183.16	ENSRNOT00000044484	Creb3l3 NCBI RGD Ensembl Show fit	cAMP responsive element binding protein 3-like 3
chr2_-_243407608 Show fit	180.65	ENSRNOT00000014631	Mttp NCBI RGD Ensembl Show fit	microsomal triglyceride transfer protein
chr4_+_99063181 Show fit	172.98	ENSRNOT00000008840	Fabp1 NCBI RGD Ensembl Show fit	fatty acid binding protein 1
chr2_+_20857202 Show fit	164.85	ENSRNOT00000078919	Acot12 NCBI RGD Ensembl Show fit	acyl-CoA thioesterase 12
chr8_-_50531423 Show fit	164.14	ENSRNOT00000090985 ENSRNOT00000074942	Apoc3 NCBI RGD Ensembl Show fit	apolipoprotein C3
chr7_-_123621102 Show fit	154.80	ENSRNOT00000046024	Cyp2d5 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily d, polypeptide 5
chr14_+_22142364 Show fit	154.74	ENSRNOT00000002699	Sult1b1 NCBI RGD Ensembl Show fit	sulfotransferase family 1B member 1
chr9_+_16924520 Show fit	152.52	ENSRNOT00000025094	Slc22a7 NCBI RGD Ensembl Show fit	solute carrier family 22 member 7
chr11_+_65022100 Show fit	145.77	ENSRNOT00000003934	Nr1i2 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 1, group I, member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pparg_Rxrg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
50.7	608.6	GO:0042738	exogenous drug catabolic process(GO:0042738)
46.8	514.5	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
16.2	372.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
8.8	309.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
79.2	237.7	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
29.1	232.5	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
13.6	204.0	GO:0035634	response to stilbenoid(GO:0035634)
7.6	197.6	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
63.4	190.2	GO:0010133	proline catabolic process to glutamate(GO:0010133)
12.2	183.2	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)

Showing 1 to 10 of 396 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	1643.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
3.9	1056.1	GO:0005759	mitochondrial matrix(GO:0005759)
0.6	659.8	GO:0005739	mitochondrion(GO:0005739)
2.0	626.3	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.3	372.4	GO:0005615	extracellular space(GO:0005615)
4.9	256.0	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
28.3	254.5	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
22.6	225.9	GO:0045179	apical cortex(GO:0045179)
0.1	215.3	GO:0005576	extracellular region(GO:0005576)
8.0	199.0	GO:0031528	microvillus membrane(GO:0031528)

Showing 1 to 10 of 127 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
25.5	1047.5	GO:0070330	aromatase activity(GO:0070330)
2.7	541.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
33.4	301.0	GO:0032052	bile acid binding(GO:0032052)
13.9	292.3	GO:0034185	apolipoprotein binding(GO:0034185)
4.0	271.1	GO:0038024	cargo receptor activity(GO:0038024)
79.2	237.7	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
29.3	205.3	GO:0004062	aryl sulfotransferase activity(GO:0004062)
11.9	190.7	GO:0035497	cAMP response element binding(GO:0035497)
63.4	190.2	GO:0004657	proline dehydrogenase activity(GO:0004657)
2.9	177.3	GO:0009055	electron carrier activity(GO:0009055)

Showing 1 to 10 of 286 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	599.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
10.6	581.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
5.3	163.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
2.1	159.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
3.1	134.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
4.7	121.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
2.4	112.8	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
2.7	98.9	PID IGF1 PATHWAY	IGF1 pathway
2.6	62.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.8	55.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.3	463.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
2.6	389.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
3.2	371.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
5.4	353.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
29.2	292.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
19.5	273.5	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
5.9	229.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
7.1	205.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
15.7	188.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
14.4	187.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 96 entries

Results for Pparg_Rxrg

Z-value: 3.01

Motif logo

Transcription factors associated with Pparg_Rxrg

Activity-expression correlation:

Activity profile of Pparg_Rxrg motif

Sorted Z-values of Pparg_Rxrg motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pparg_Rxrg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: