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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ppard

Z-value: 0.49

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Transcription factors associated with Ppard

Gene Symbol Gene ID Gene Info
Ppard
ENSRNOG00000000503 peroxisome proliferator-activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ppardrn6_v1_chr20_+_7821755_7821755-0.311.1e-08Click!

Activity profile of Ppard motif

Sorted Z-values of Ppard motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_57372239 32.38 ENSRNOT00000012975
Aqp7
aquaporin 7
chr2_-_178389608 21.69 ENSRNOT00000013262
Etfdh
electron transfer flavoprotein dehydrogenase
chr12_-_48238887 21.28 ENSRNOT00000078868
Acacb
acetyl-CoA carboxylase beta
chr1_+_48273611 17.04 ENSRNOT00000022254
ENSRNOT00000022068
Slc22a1
solute carrier family 22 member 1
chr5_-_169301728 15.08 ENSRNOT00000013646
Espn
espin
chr7_+_11490852 14.34 ENSRNOT00000044484
Creb3l3
cAMP responsive element binding protein 3-like 3
chr14_+_22142364 12.69 ENSRNOT00000002699
Sult1b1
sulfotransferase family 1B member 1
chr2_+_198965685 11.23 ENSRNOT00000000107
ENSRNOT00000091578
Pdzk1
PDZ domain containing 1
chr14_-_79464770 10.86 ENSRNOT00000008932
Grpel1
GrpE-like 1, mitochondrial
chr8_+_117455262 10.20 ENSRNOT00000027520
Slc25a20
solute carrier family 25 member 20
chr10_-_56624526 9.49 ENSRNOT00000024973
Acadvl
acyl-CoA dehydrogenase, very long chain
chr12_+_47254484 9.11 ENSRNOT00000001556
Acads
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr5_+_76812931 8.45 ENSRNOT00000059458
Hsdl2
hydroxysteroid dehydrogenase like 2
chr20_+_14101659 6.68 ENSRNOT00000072696
Gucd1
guanylyl cyclase domain containing 1
chr2_+_200452624 6.56 ENSRNOT00000026121
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr14_-_84937725 6.42 ENSRNOT00000083839
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr10_+_71159869 6.12 ENSRNOT00000075977
ENSRNOT00000047427
Hnf1b
HNF1 homeobox B
chr11_-_24294179 5.23 ENSRNOT00000002116
Atp5j
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr6_+_26051396 5.07 ENSRNOT00000006452
Rbks
ribokinase
chr1_-_222178725 4.94 ENSRNOT00000028697
Esrra
estrogen related receptor, alpha
chr5_+_165415136 4.75 ENSRNOT00000016317
ENSRNOT00000079407
Masp2
mannan-binding lectin serine peptidase 2
chr2_+_95045034 4.74 ENSRNOT00000081305
Mrps28
mitochondrial ribosomal protein S28
chr8_+_117170620 4.56 ENSRNOT00000075271
LOC498675
hypothetical LOC498675
chr20_-_3819200 4.40 ENSRNOT00000000542
ENSRNOT00000081486
Hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_153096269 4.32 ENSRNOT00000022578
Tmem135
transmembrane protein 135
chr1_+_255842783 4.29 ENSRNOT00000023562
March5
membrane associated ring-CH-type finger 5
chr3_-_60813869 4.00 ENSRNOT00000058234
Atp5g3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr10_+_31508512 3.98 ENSRNOT00000031580
Fam71b
family with sequence similarity 71, member B
chr10_+_84871680 3.95 ENSRNOT00000073292
Prr15l
proline rich 15-like
chr1_+_212558257 3.31 ENSRNOT00000024912
Prap1
proline-rich acidic protein 1
chr7_-_143793774 3.09 ENSRNOT00000079678
Csad
cysteine sulfinic acid decarboxylase
chr2_+_244521699 2.81 ENSRNOT00000029382
Stpg2
sperm-tail PG-rich repeat containing 2
chr9_-_69953182 2.75 ENSRNOT00000015852
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr7_-_143793970 2.60 ENSRNOT00000016205
Csad
cysteine sulfinic acid decarboxylase
chr3_+_81287242 2.54 ENSRNOT00000086530
Pex16
peroxisomal biogenesis factor 16
chr3_-_120106697 2.47 ENSRNOT00000020354
Prom2
prominin 2
chr10_+_11146359 2.44 ENSRNOT00000006314
Pam16
presequence translocase associated motor 16 homolog
chr9_+_64095978 2.34 ENSRNOT00000021533
Maip1
matrix AAA peptidase interacting protein 1
chr10_-_88107232 2.13 ENSRNOT00000019330
ENSRNOT00000076770
Krt9
keratin 9
chr8_-_119265157 1.99 ENSRNOT00000056100
Rtp3
receptor (chemosensory) transporter protein 3
chr13_+_96219853 1.68 ENSRNOT00000006154
Cox20
COX20 cytochrome C oxidase assembly factor
chr8_+_59164572 1.63 ENSRNOT00000015102
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr6_+_108363485 1.16 ENSRNOT00000073962
Vrtn
vertebrae development associated
chr5_-_167244786 1.14 ENSRNOT00000051309
Car6
carbonic anhydrase 6
chr5_+_57738321 1.00 ENSRNOT00000063849
Ubap1
ubiquitin-associated protein 1
chr1_-_219853329 0.97 ENSRNOT00000026169
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr4_+_71836677 0.92 ENSRNOT00000024048
Tas2r126
taste receptor, type 2, member 126
chr5_+_150032999 0.79 ENSRNOT00000013301
Srsf4
serine and arginine rich splicing factor 4
chr1_-_222177421 0.77 ENSRNOT00000078393
Esrra
estrogen related receptor, alpha
chr1_+_144601410 0.53 ENSRNOT00000047408
Efl1
elongation factor like GTPase 1
chr2_+_211050360 0.08 ENSRNOT00000026928
Psma5
proteasome subunit alpha 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Ppard

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 32.4 GO:0015793 glycerol transport(GO:0015793)
5.4 21.4 GO:0015879 carnitine transport(GO:0015879)
5.3 21.3 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
3.7 40.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
2.8 17.0 GO:0015697 quaternary ammonium group transport(GO:0015697)
2.2 15.1 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
2.0 6.1 GO:0061228 mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
1.9 5.7 GO:0042412 taurine biosynthetic process(GO:0042412)
1.8 12.7 GO:0009812 flavonoid metabolic process(GO:0009812)
1.7 5.1 GO:0019303 D-ribose catabolic process(GO:0019303)
1.6 6.6 GO:0034696 response to prostaglandin F(GO:0034696) ketone body biosynthetic process(GO:0046951)
1.0 14.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.8 13.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.8 2.3 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.5 2.5 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.5 2.5 GO:0048550 negative regulation of pinocytosis(GO:0048550)
0.5 4.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.3 4.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 9.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 8.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.3 1.6 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 5.7 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 4.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.7 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 2.1 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.5 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 1.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 2.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
1.1 15.1 GO:0032426 stereocilium tip(GO:0032426)
0.7 9.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.7 21.7 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.6 2.5 GO:0071914 microspike(GO:0044393) prominosome(GO:0071914)
0.5 1.6 GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
0.5 11.2 GO:0031528 microvillus membrane(GO:0031528)
0.4 32.4 GO:0031526 brush border membrane(GO:0031526)
0.2 9.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 4.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 5.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.1 22.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 17.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 4.3 GO:0005811 lipid particle(GO:0005811)
0.1 2.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 16.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 21.4 GO:0005739 mitochondrion(GO:0005739)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 32.4 GO:0015254 glycerol channel activity(GO:0015254)
5.7 17.0 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
5.3 21.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
3.6 21.7 GO:0048039 ubiquinone binding(GO:0048039)
3.4 10.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
3.2 9.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
1.8 12.7 GO:0004062 aryl sulfotransferase activity(GO:0004062)
1.5 4.4 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
1.3 6.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.1 10.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.9 14.3 GO:0035497 cAMP response element binding(GO:0035497)
0.7 9.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.4 4.8 GO:0001846 opsonin binding(GO:0001846)
0.4 1.6 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.4 2.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 4.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 5.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 5.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 15.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 8.2 GO:0005496 steroid binding(GO:0005496)
0.1 11.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 6.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 5.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.9 GO:0043022 ribosome binding(GO:0043022)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.5 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 15.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 32.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.9 17.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.4 31.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.3 18.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
1.0 12.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 4.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 24.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 5.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 13.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 5.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 6.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 12.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing