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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Pou6f2_Pou4f2
Z-value: 1.09
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Transcription factors associated with Pou6f2_Pou4f2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou4f2 | rn6_v1_chr19_+_33160180_33160180 | 0.67 | 2.5e-43 | Click! |
| Pou6f2 | rn6_v1_chr17_+_49322205_49322205 | 0.38 | 1.3e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_73378057 Show fit | 114.81 |
ENSRNOT00000043627
ENSRNOT00000045766 ENSRNOT00000092445 ENSRNOT00000037974 |
microtubule-associated protein 2 |
|
| chrX_-_142164220 Show fit | 60.71 |
ENSRNOT00000064780
|
fibroblast growth factor 13 |
|
| chr19_-_58735173 Show fit | 55.14 |
ENSRNOT00000030077
|
pecanex homolog 2 (Drosophila) |
|
| chr6_+_8284878 Show fit | 48.62 |
ENSRNOT00000009581
|
solute carrier family 3 member 1 |
|
| chr1_+_234363994 Show fit | 42.68 |
ENSRNOT00000018137
|
RAR-related orphan receptor B |
|
| chr16_+_23668595 Show fit | 39.35 |
ENSRNOT00000067886
|
pleckstrin and Sec7 domain containing 3 |
|
| chr15_+_1054937 Show fit | 38.25 |
ENSRNOT00000008154
|
|
|
| chr17_+_9109731 Show fit | 37.90 |
ENSRNOT00000016009
|
C-X-C motif chemokine ligand 14 |
|
| chr6_-_67084234 Show fit | 37.82 |
ENSRNOT00000050372
|
NOVA alternative splicing regulator 1 |
|
| chr4_+_172942020 Show fit | 37.76 |
ENSRNOT00000072450
|
LIM domain only 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou6f2_Pou4f2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 114.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 11.7 | 81.8 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.3 | 48.6 | GO:0006865 | amino acid transport(GO:0006865) |
| 3.9 | 42.7 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 1.6 | 39.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 6.3 | 37.9 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 4.7 | 37.8 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.2 | 33.9 | GO:0050684 | regulation of mRNA processing(GO:0050684) |
| 6.7 | 33.6 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 2.6 | 33.6 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.4 | 148.0 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 1.0 | 69.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.6 | 53.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 52.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 49.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.8 | 33.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.2 | 33.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 10.6 | 31.9 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.5 | 26.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 8.0 | 24.1 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 114.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.8 | 81.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 64.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 8.5 | 42.7 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 40.1 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 1.5 | 39.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 37.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.8 | 33.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.7 | 33.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 1.2 | 33.2 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 114.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 107.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 25.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.8 | 24.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 12.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 8.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 7.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 6.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 6.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 52.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.2 | 48.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.2 | 33.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.4 | 25.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 23.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.6 | 16.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.6 | 16.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 1.0 | 13.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 13.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 11.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |