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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pou6f2_Pou4f2

Z-value: 1.09

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Transcription factors associated with Pou6f2_Pou4f2

Gene Symbol Gene ID Gene Info
Pou6f2
ENSRNOG00000013237 POU domain, class 6, transcription factor 2
Pou4f2
ENSRNOG00000012167 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou4f2rn6_v1_chr19_+_33160180_331601800.672.5e-43Click!
Pou6f2rn6_v1_chr17_+_49322205_493222050.381.3e-12Click!

Activity profile of Pou6f2_Pou4f2 motif

Sorted Z-values of Pou6f2_Pou4f2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_73378057 114.81 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
Map2
microtubule-associated protein 2
chrX_-_142164220 60.71 ENSRNOT00000064780
Fgf13
fibroblast growth factor 13
chr19_-_58735173 55.14 ENSRNOT00000030077
Pcnx2
pecanex homolog 2 (Drosophila)
chr6_+_8284878 48.62 ENSRNOT00000009581
Slc3a1
solute carrier family 3 member 1
chr1_+_234363994 42.68 ENSRNOT00000018137
Rorb
RAR-related orphan receptor B
chr16_+_23668595 39.35 ENSRNOT00000067886
Psd3
pleckstrin and Sec7 domain containing 3
chr15_+_1054937 38.25 ENSRNOT00000008154
AABR07016841.1

chr17_+_9109731 37.90 ENSRNOT00000016009
Cxcl14
C-X-C motif chemokine ligand 14
chr6_-_67084234 37.82 ENSRNOT00000050372
Nova1
NOVA alternative splicing regulator 1
chr4_+_172942020 37.76 ENSRNOT00000072450
Lmo3
LIM domain only 3
chr3_-_66417741 33.64 ENSRNOT00000007662
Neurod1
neuronal differentiation 1
chr13_+_71107465 33.56 ENSRNOT00000003239
Rgs8
regulator of G-protein signaling 8
chr3_+_48106099 33.22 ENSRNOT00000007218
Slc4a10
solute carrier family 4 member 10
chr5_-_68059933 32.26 ENSRNOT00000088716
Plppr1
phospholipid phosphatase related 1
chr6_+_73553210 31.87 ENSRNOT00000006562
Akap6
A-kinase anchoring protein 6
chr1_+_59156251 31.66 ENSRNOT00000017442
Lix1
limb and CNS expressed 1
chr5_-_109651730 31.01 ENSRNOT00000093032
Elavl2
ELAV like RNA binding protein 2
chr6_+_83083740 29.38 ENSRNOT00000007600
Lrfn5
leucine rich repeat and fibronectin type III domain containing 5
chr12_-_2174131 27.67 ENSRNOT00000001313
Pcp2
Purkinje cell protein 2
chr5_+_139790395 26.75 ENSRNOT00000015033
Rims3
regulating synaptic membrane exocytosis 3
chr2_+_235596907 25.57 ENSRNOT00000071463
ENSRNOT00000075728
Col25a1
collagen type XXV alpha 1 chain
chr3_-_81304181 24.15 ENSRNOT00000079746
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr8_-_132753145 22.73 ENSRNOT00000007467
ENSRNOT00000008172
RGD1566368
similar to Solute carrier family 6 (neurotransmitter transporter), member 20
chr4_+_108301129 22.41 ENSRNOT00000007993
LRRTM1
leucine rich repeat transmembrane neuronal 1
chrX_-_142248369 21.07 ENSRNOT00000091330
Fgf13
fibroblast growth factor 13
chr13_-_76049363 18.02 ENSRNOT00000075865
ENSRNOT00000007455
Brinp2
BMP/retinoic acid inducible neural specific 2
chr5_-_12526962 17.50 ENSRNOT00000092104
St18
suppression of tumorigenicity 18
chr1_+_157920786 16.92 ENSRNOT00000014284
Fam181b
family with sequence similarity 181, member B
chr2_+_145174876 16.56 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr13_+_90723092 16.51 ENSRNOT00000010146
Kcnj10
ATP-sensitive inward rectifier potassium channel 10
chr19_+_6046665 16.42 ENSRNOT00000084126
Cdh8
cadherin 8
chr17_-_84247038 15.81 ENSRNOT00000068553
Nebl
nebulette
chrX_+_84064427 15.27 ENSRNOT00000046364
Zfp711
zinc finger protein 711
chr13_-_60567882 14.95 ENSRNOT00000004701
Trove2
TROVE domain family, member 2
chr7_-_134722215 14.89 ENSRNOT00000036750
Prickle1
prickle planar cell polarity protein 1
chr2_+_116970344 14.57 ENSRNOT00000039603
Egfem1
EGF-like and EMI domain containing 1
chrX_-_6620722 13.77 ENSRNOT00000066674
Maoa
monoamine oxidase A
chr15_-_51485692 13.58 ENSRNOT00000023876
Rhobtb2
Rho-related BTB domain containing 2
chr15_+_67555835 13.26 ENSRNOT00000045882
Pcdh17
protocadherin 17
chrX_+_86126157 13.15 ENSRNOT00000006992
Klhl4
kelch-like family member 4
chr8_+_13796021 13.06 ENSRNOT00000013927
Vstm5
V-set and transmembrane domain containing 5
chr2_+_207930796 12.96 ENSRNOT00000047827
Kcnd3
potassium voltage-gated channel subfamily D member 3
chr2_+_113984646 12.87 ENSRNOT00000016799
Tnik
TRAF2 and NCK interacting kinase
chr13_-_74923402 12.84 ENSRNOT00000033324
Rasal2
RAS protein activator like 2
chr5_+_18901039 12.43 ENSRNOT00000012066
Fam110b
family with sequence similarity 110, member B
chr13_+_113373578 11.18 ENSRNOT00000009900
Plxna2
plexin A2
chr8_-_45137893 11.07 ENSRNOT00000010743
RGD1309108
similar to hypothetical protein FLJ23554
chr10_+_55927223 10.69 ENSRNOT00000011523
Kcnab3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
chr2_-_5577369 10.15 ENSRNOT00000093420
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr3_+_97349454 9.74 ENSRNOT00000089524
Dcdc5
doublecortin domain containing 5
chr1_-_87825333 9.62 ENSRNOT00000072689
Zfp74
zinc finger protein 74
chr19_-_24614019 9.30 ENSRNOT00000005124
Scoc
short coiled-coil protein
chr2_+_239415046 8.73 ENSRNOT00000072196
Cxxc4
CXXC finger protein 4
chr8_-_39551700 8.61 ENSRNOT00000091894
ENSRNOT00000076025
Pknox2
PBX/knotted 1 homeobox 2
chr1_+_190666149 8.32 ENSRNOT00000089361
LOC102547219
uncharacterized LOC102547219
chr5_-_7941822 8.24 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_40879747 8.03 ENSRNOT00000083702
Akap12
A-kinase anchoring protein 12
chr1_-_72311856 7.26 ENSRNOT00000021286
Epn1
Epsin 1
chr1_-_279277339 6.63 ENSRNOT00000023667
Gfra1
GDNF family receptor alpha 1
chr3_+_100770975 6.46 ENSRNOT00000089233
Bdnf
brain-derived neurotrophic factor
chr18_+_30880020 6.01 ENSRNOT00000060468
Pcdhgb5
protocadherin gamma subfamily B, 5
chr2_-_32518643 5.72 ENSRNOT00000061032
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_187786700 5.27 ENSRNOT00000092257
ENSRNOT00000092612
ENSRNOT00000068360
Slc25a44
solute carrier family 25, member 44
chr17_+_26808330 5.05 ENSRNOT00000022108
Bloc1s5
biogenesis of lysosomal organelles complex 1 subunit 5
chr5_+_152680407 4.86 ENSRNOT00000076864
Stmn1
stathmin 1
chr6_+_146784915 4.74 ENSRNOT00000008362
Sp8
Sp8 transcription factor
chr1_+_217345154 4.73 ENSRNOT00000092516
Shank2
SH3 and multiple ankyrin repeat domains 2
chr1_-_8038665 4.66 ENSRNOT00000046539
Aig1
androgen-induced 1
chr3_+_104816987 4.35 ENSRNOT00000042103
ENSRNOT00000044625
Fmn1
formin 1
chr15_+_4064706 4.04 ENSRNOT00000011956
Synpo2l
synaptopodin 2-like
chr5_-_144345531 4.04 ENSRNOT00000014721
Tekt2
tektin 2
chr8_-_43854765 3.83 ENSRNOT00000081506
Olr1335
olfactory receptor 1335
chr9_-_70787913 3.80 ENSRNOT00000072007
ENSRNOT00000017901
Klf7
Klf7
Kruppel like factor 7
Kruppel like factor 7
chr3_-_37803112 3.43 ENSRNOT00000059461
Neb
nebulin
chr14_-_18704059 3.30 ENSRNOT00000081455
Mthfd2l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr15_-_27819376 3.06 ENSRNOT00000067400
A930018M24Rik
RIKEN cDNA A930018M24 gene
chr20_+_45458558 2.93 ENSRNOT00000000713
Cdk19
cyclin-dependent kinase 19
chr1_-_44474674 2.69 ENSRNOT00000078768
Tfb1m
transcription factor B1, mitochondrial
chr10_+_53740841 2.40 ENSRNOT00000004295
Myh2
myosin heavy chain 2
chr3_+_75265525 2.35 ENSRNOT00000013319
Olr554
olfactory receptor 554
chr11_-_62067655 2.33 ENSRNOT00000093382
Zbtb20
zinc finger and BTB domain containing 20
chr12_+_10577068 2.13 ENSRNOT00000001282
Rnf6
ring finger protein 6
chr4_+_68656928 1.87 ENSRNOT00000016232
Tas2r108
taste receptor, type 2, member 108
chr11_-_86303453 1.80 ENSRNOT00000071453
LOC498122
similar to CG15908-PA
chr13_+_80464348 1.78 ENSRNOT00000076324
Vamp4
vesicle-associated membrane protein 4
chr12_-_17186679 1.46 ENSRNOT00000001730
Uncx
UNC homeobox
chr18_-_26656879 1.46 ENSRNOT00000086729
Epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr9_+_71915421 1.33 ENSRNOT00000020447
Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
chr4_+_181315444 1.32 ENSRNOT00000044147
Ppfibp1
PPFIA binding protein 1
chr7_+_15628665 0.44 ENSRNOT00000071081
Olr1091
olfactory receptor 1091
chr15_-_27485639 0.16 ENSRNOT00000041030
Olr1631
olfactory receptor 1631
chr1_-_14117021 0.02 ENSRNOT00000004344
RGD1560303
similar to hypothetical protein 4933423E17

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.7 81.8 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
8.0 31.9 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
6.7 33.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
6.3 37.9 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
5.5 16.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
5.3 15.8 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
4.7 37.8 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
3.9 42.7 GO:0035881 amacrine cell differentiation(GO:0035881)
3.1 114.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
2.8 22.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
2.7 21.3 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
2.6 33.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
2.3 25.6 GO:0060385 axonogenesis involved in innervation(GO:0060385)
2.2 24.1 GO:0007258 JUN phosphorylation(GO:0007258)
2.0 13.8 GO:0042420 dopamine catabolic process(GO:0042420)
1.7 33.2 GO:0021860 pyramidal neuron development(GO:0021860)
1.7 5.0 GO:0032474 otolith morphogenesis(GO:0032474)
1.7 14.9 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
1.6 39.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.6 11.2 GO:0060174 limb bud formation(GO:0060174)
1.2 4.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.2 13.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
1.1 13.3 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
1.1 3.3 GO:0000105 histidine biosynthetic process(GO:0000105)
1.1 4.4 GO:0072092 ureteric bud invasion(GO:0072092)
1.0 31.7 GO:0097352 autophagosome maturation(GO:0097352)
0.9 9.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.9 12.9 GO:0007256 activation of JNKK activity(GO:0007256)
0.8 6.5 GO:0061193 taste bud development(GO:0061193)
0.8 8.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.8 31.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.8 10.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 26.7 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.4 2.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 4.7 GO:0098880 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.3 48.6 GO:0006865 amino acid transport(GO:0006865)
0.2 16.4 GO:0009409 response to cold(GO:0009409)
0.2 4.0 GO:0060294 inner dynein arm assembly(GO:0036159) cilium movement involved in cell motility(GO:0060294)
0.2 33.9 GO:0050684 regulation of mRNA processing(GO:0050684)
0.2 2.4 GO:0001778 plasma membrane repair(GO:0001778)
0.2 1.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 2.7 GO:0031167 rRNA methylation(GO:0031167)
0.2 9.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 8.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 1.8 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1 10.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 14.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.1 2.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 8.7 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 4.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 6.6 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.1 16.6 GO:0043010 camera-type eye development(GO:0043010)
0.1 1.3 GO:0032288 myelin assembly(GO:0032288)
0.1 10.7 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 20.9 GO:0007409 axonogenesis(GO:0007409)
0.0 13.6 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 1.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 2.9 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 5.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 5.3 GO:0006839 mitochondrial transport(GO:0006839)
0.0 12.7 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
16.4 148.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
10.6 31.9 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
8.0 24.1 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
1.8 7.3 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
1.1 16.4 GO:0043083 synaptic cleft(GO:0043083)
1.0 69.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.9 12.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.8 16.5 GO:0097449 astrocyte projection(GO:0097449)
0.8 33.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 13.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.6 53.4 GO:0031526 brush border membrane(GO:0031526)
0.5 26.7 GO:0048786 presynaptic active zone(GO:0048786)
0.4 5.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.4 6.5 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 33.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 5.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 15.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 13.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 8.6 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.9 GO:0060170 ciliary membrane(GO:0060170)
0.1 22.4 GO:0030426 growth cone(GO:0030426)
0.1 13.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 7.5 GO:0030018 Z disc(GO:0030018)
0.1 52.3 GO:0043025 neuronal cell body(GO:0043025)
0.1 2.9 GO:0016592 mediator complex(GO:0016592)
0.1 2.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 9.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 49.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 13.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 4.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 18.0 GO:0009986 cell surface(GO:0009986)
0.0 9.3 GO:0005925 focal adhesion(GO:0005925)
0.0 4.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.9 GO:0005874 microtubule(GO:0005874)
0.0 22.8 GO:0005730 nucleolus(GO:0005730)
0.0 14.9 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 12.4 GO:0005815 microtubule organizing center(GO:0005815)
0.0 3.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 16.1 GO:0005794 Golgi apparatus(GO:0005794)
0.0 5.0 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 42.7 GO:0008502 melatonin receptor activity(GO:0008502)
5.0 114.8 GO:0002162 dystroglycan binding(GO:0002162)
4.1 16.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
3.5 31.9 GO:0043495 protein anchor(GO:0043495)
3.4 24.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
2.9 32.3 GO:0042577 lipid phosphatase activity(GO:0042577)
2.6 13.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
2.1 14.9 GO:0030620 U2 snRNA binding(GO:0030620)
1.8 81.8 GO:0048487 beta-tubulin binding(GO:0048487)
1.5 39.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.3 10.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.3 13.8 GO:0008131 primary amine oxidase activity(GO:0008131)
1.2 33.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.9 2.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.9 15.8 GO:0005523 tropomyosin binding(GO:0005523)
0.8 3.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.8 33.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.8 6.5 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.8 11.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.7 33.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 7.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.7 25.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.6 8.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 8.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 4.7 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.3 13.0 GO:0008009 chemokine activity(GO:0008009)
0.3 8.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 22.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 37.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 27.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 10.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 2.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 12.9 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 2.1 GO:0050681 androgen receptor binding(GO:0050681)
0.1 8.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 40.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 6.6 GO:0005178 integrin binding(GO:0005178)
0.1 5.9 GO:0044325 ion channel binding(GO:0044325)
0.1 64.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 13.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 8.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 16.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.9 GO:0015631 tubulin binding(GO:0015631)
0.0 6.1 GO:0003779 actin binding(GO:0003779)
0.0 4.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 114.8 PID LKB1 PATHWAY LKB1 signaling events
0.8 24.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5 25.6 NABA COLLAGENS Genes encoding collagen proteins
0.5 4.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 107.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 6.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 12.9 PID TNF PATHWAY TNF receptor signaling pathway
0.2 7.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 6.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 4.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 8.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 2.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 6.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 48.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.2 33.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.0 13.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.8 52.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.6 11.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.6 16.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.6 16.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 23.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 25.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 6.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 13.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events