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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pou5f1

Z-value: 4.67

Motif logo

Transcription factors associated with Pou5f1

Gene Symbol Gene ID Gene Info
ENSRNOG00000046487 POU class 5 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou5f1rn6_v1_chr20_-_3751994_37519940.072.3e-01Click!

Activity profile of Pou5f1 motif

Sorted Z-values of Pou5f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_98370797 270.58 ENSRNOT00000031991

chr10_-_94500591 235.84 ENSRNOT00000015976
CD79b molecule
chr11_+_85532526 229.38 ENSRNOT00000036565

chr4_+_102489916 225.54 ENSRNOT00000082031

chr3_+_16413080 224.36 ENSRNOT00000040386
Ig kappa chain V19-17-like
chr3_+_17546566 218.75 ENSRNOT00000050825

chr3_+_18315320 217.00 ENSRNOT00000006954

chr6_-_138662365 216.80 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr3_-_16537433 215.43 ENSRNOT00000048523

chr3_+_18706988 212.95 ENSRNOT00000074650

chr6_-_140102325 205.26 ENSRNOT00000072238

chr17_-_31780120 203.18 ENSRNOT00000058388

chr3_+_16846412 196.08 ENSRNOT00000074266

chr11_+_85508300 194.76 ENSRNOT00000038646

chr4_-_103258134 194.30 ENSRNOT00000086827

chr3_-_17081510 193.60 ENSRNOT00000063862

chrX_+_96991658 192.59 ENSRNOT00000049969

chr4_+_106323089 192.41 ENSRNOT00000091402

chr4_+_98481520 192.09 ENSRNOT00000078381
ENSRNOT00000048493

chr6_-_138632159 187.49 ENSRNOT00000082921
ENSRNOT00000040702
immunoglobulin heavy constant mu
chr6_+_139158334 183.11 ENSRNOT00000089227

chr6_-_138744480 181.50 ENSRNOT00000089387

chr3_+_17107861 179.71 ENSRNOT00000043097

chr4_+_102351036 177.89 ENSRNOT00000079277

chr6_+_139551751 176.87 ENSRNOT00000081684

chr3_-_20419417 175.56 ENSRNOT00000077772

chr3_+_20375699 175.03 ENSRNOT00000088492

chr6_-_141147264 174.72 ENSRNOT00000042900
Igh protein-like
chr6_+_139405966 174.69 ENSRNOT00000088974

chr3_+_16610086 171.71 ENSRNOT00000046231
rCG64257-like
chr4_+_93791054 170.89 ENSRNOT00000042300

chr3_+_17889972 170.49 ENSRNOT00000073021

chr6_-_140880070 169.60 ENSRNOT00000073779
uncharacterized LOC691828
chr6_-_139102378 169.38 ENSRNOT00000086423

chr6_-_141321108 158.47 ENSRNOT00000040556

chr11_+_85618714 157.82 ENSRNOT00000074614

chr2_+_223121410 157.12 ENSRNOT00000087559

chr3_-_19320915 155.74 ENSRNOT00000043673
similar to Ig variable region, light chain
chr19_+_3325893 155.45 ENSRNOT00000048879
similar to Ig variable region, light chain
chr1_-_17378047 154.59 ENSRNOT00000020102
thymocyte selection associated
chr6_+_139428999 153.21 ENSRNOT00000084482

chr6_-_138565245 153.04 ENSRNOT00000070980

chr11_+_85561460 152.84 ENSRNOT00000075455

chr4_+_102665529 152.59 ENSRNOT00000082333

chr6_-_140642221 150.84 ENSRNOT00000081996

chr3_-_20479999 150.65 ENSRNOT00000050573

chr17_+_43627930 147.68 ENSRNOT00000081719
histone H2B type 1-N-like
chr6_-_142353308 145.26 ENSRNOT00000066416

chr6_-_141062581 144.90 ENSRNOT00000073446

chr6_+_139560028 144.70 ENSRNOT00000072633
rCG58847-like
chr6_-_138736203 143.38 ENSRNOT00000052021
rCG21044-like
chr1_+_192233910 142.62 ENSRNOT00000016418
ENSRNOT00000016442
protein kinase C, beta
chr4_+_102147211 140.69 ENSRNOT00000083239

chr6_+_139345486 140.51 ENSRNOT00000081540

chr6_-_139911839 140.03 ENSRNOT00000077113
ENSRNOT00000084547

chr3_+_17180411 138.44 ENSRNOT00000058260

chr3_+_16817051 136.94 ENSRNOT00000071666

chr4_+_101639641 136.02 ENSRNOT00000058282

chr3_+_16571602 135.40 ENSRNOT00000048351
rCG64259-like
chr3_+_17139670 134.72 ENSRNOT00000073316

chr6_+_139486775 133.81 ENSRNOT00000077771

chr6_-_138565404 133.11 ENSRNOT00000079420

chr2_+_32820322 132.96 ENSRNOT00000013768
CD180 molecule
chr6_-_141008427 132.59 ENSRNOT00000074472

chr3_+_16495748 132.45 ENSRNOT00000045492

chr4_-_102124609 132.21 ENSRNOT00000048263

chr3_-_20457554 130.66 ENSRNOT00000074237

chr6_-_138536321 128.68 ENSRNOT00000077743

chr6_-_139710905 128.60 ENSRNOT00000077430

chr6_-_138772894 127.66 ENSRNOT00000080779

chr7_-_18793289 126.88 ENSRNOT00000036375

chr4_+_93888502 125.98 ENSRNOT00000090783

chr6_-_139004980 124.43 ENSRNOT00000085427
ENSRNOT00000087351

chr3_-_16441030 123.67 ENSRNOT00000047784

chr6_-_138536162 122.76 ENSRNOT00000083031

chr3_-_16753987 121.99 ENSRNOT00000091257

chr6_-_138954741 121.90 ENSRNOT00000083278

chr1_+_87938042 119.03 ENSRNOT00000027837
mitogen activated protein kinase kinase kinase kinase 1
chr6_-_138640187 118.96 ENSRNOT00000087983

chr6_-_138954577 117.07 ENSRNOT00000042728

chr4_-_103569159 116.81 ENSRNOT00000084036

chr9_-_23493081 116.02 ENSRNOT00000072144
Rh-associated glycoprotein
chr6_-_143131118 115.53 ENSRNOT00000074930

chr11_+_85042348 115.40 ENSRNOT00000042220

chr6_-_139660666 114.83 ENSRNOT00000086098

chr6_-_139719323 113.31 ENSRNOT00000090133

chr11_+_85992696 111.84 ENSRNOT00000084433

chr6_-_138631997 110.38 ENSRNOT00000073304

chr8_-_117932518 109.53 ENSRNOT00000028130
cathelicidin antimicrobial peptide
chr6_-_142060032 109.41 ENSRNOT00000064717

chr6_-_140485913 107.44 ENSRNOT00000048463

chr12_+_9360672 107.40 ENSRNOT00000088957
fms-related tyrosine kinase 3
chr7_-_107634287 107.33 ENSRNOT00000093672
ENSRNOT00000087116
src-like adaptor
chr6_-_140715174 106.60 ENSRNOT00000085345

chr6_-_141198565 105.22 ENSRNOT00000064361

chr10_-_104628676 102.89 ENSRNOT00000010466
unc-13 homolog D
chr4_+_102068556 101.91 ENSRNOT00000077412

chr6_+_139293294 101.17 ENSRNOT00000050297
ENSRNOT00000081817
Ighg protein-like
chr4_-_119327822 101.17 ENSRNOT00000012645
Rho GTPase activating protein 25
chr6_-_138931429 99.90 ENSRNOT00000090584
Ighg protein-like
chr12_+_38160464 98.08 ENSRNOT00000032249
hydroxycarboxylic acid receptor 2
chr6_-_139637187 95.56 ENSRNOT00000089454
Ighg protein-like
chr3_+_16590244 94.18 ENSRNOT00000073229

chr2_-_139528162 94.11 ENSRNOT00000014317
solute carrier family 7 member 11
chr2_+_55835151 94.11 ENSRNOT00000018634
FYN binding protein
chr17_+_43423111 93.14 ENSRNOT00000022630
histone cluster 1 H2B family member a
chr6_-_139637354 92.77 ENSRNOT00000072900
Ighg protein-like
chr6_+_139523337 89.15 ENSRNOT00000090711

chr7_-_107391184 88.60 ENSRNOT00000056793
transmembrane protein 71
chr4_+_102290338 87.62 ENSRNOT00000011067

chr11_+_85633243 86.32 ENSRNOT00000045807
Ig lambda chain V-VI region AR-like
chr3_+_19174027 85.04 ENSRNOT00000074445

chr5_-_169658875 85.02 ENSRNOT00000015840
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr6_-_139654508 83.60 ENSRNOT00000082576

chr20_+_7788084 83.48 ENSRNOT00000000597
DEF6 guanine nucleotide exchange factor
chr6_+_139531330 83.27 ENSRNOT00000083025

chr17_-_31916553 83.26 ENSRNOT00000074220
uncharacterized LOC100911032
chr1_-_260254600 83.01 ENSRNOT00000019014
B-cell linker
chr3_+_17009089 82.76 ENSRNOT00000048829
rCG64257-like
chr6_+_139293130 82.57 ENSRNOT00000071714
Ighg protein-like
chr6_+_139523495 82.34 ENSRNOT00000075467

chr4_+_101909389 82.03 ENSRNOT00000086458

chr3_+_79918969 81.93 ENSRNOT00000016306
Spi-1 proto-oncogene
chr6_-_140418831 80.50 ENSRNOT00000086301

chr17_+_43632397 80.43 ENSRNOT00000013790
histone cluster 1, H2ah
chr6_-_141365198 79.93 ENSRNOT00000040523

chr17_+_44738643 78.83 ENSRNOT00000087643
histone H2A type 1-like
chr17_-_43627629 78.62 ENSRNOT00000022965
histone cluster 1, H2af
chr6_-_139033819 78.35 ENSRNOT00000091961

chr2_+_198418691 78.33 ENSRNOT00000089409
histone cluster 1, H2bk
chr6_-_138685656 77.01 ENSRNOT00000041706

chr6_-_138550417 75.51 ENSRNOT00000071945

chr17_-_44738330 74.34 ENSRNOT00000072195
histone cluster 1, H2bd-like
chr17_+_44528125 74.06 ENSRNOT00000084538
similar to Histone H2A type 1
chr6_-_141831632 71.14 ENSRNOT00000075526

chr4_-_103761881 70.92 ENSRNOT00000084103

chr1_-_57327379 68.53 ENSRNOT00000080429
delta like canonical Notch ligand 1
chr6_-_142178771 67.61 ENSRNOT00000071577
immunoglobulin heavy variable V12-3
chr9_-_54457753 63.45 ENSRNOT00000020032
signal transducer and activator of transcription 1
chr10_-_45297385 62.36 ENSRNOT00000041187
histone cluster 3 H2B family member b
chr17_-_44527801 61.29 ENSRNOT00000089643
histone cluster 1 H2B family member k
chr15_-_95514259 59.19 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr8_+_54993859 58.89 ENSRNOT00000013093
interleukin 18
chr2_+_212247451 58.34 ENSRNOT00000027813
vav guanine nucleotide exchange factor 3
chrX_+_96863891 57.48 ENSRNOT00000085665

chr18_-_12640716 56.16 ENSRNOT00000020697
kelch-like family member 14
chr17_+_44520537 53.74 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr3_+_124088157 52.28 ENSRNOT00000028876
spermine oxidase
chr1_-_118826977 51.46 ENSRNOT00000079274

chr5_+_16526058 48.92 ENSRNOT00000011130
LYN proto-oncogene, Src family tyrosine kinase
chr3_+_19071980 48.73 ENSRNOT00000079487
immunoglobulin kappa variable 4-81
chr6_-_141957537 47.95 ENSRNOT00000090358
immunoglobulin heavy variable 13-2
chr6_-_140805551 47.08 ENSRNOT00000080018

chr17_-_44520240 46.79 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr12_+_37544918 46.06 ENSRNOT00000001403
Rab interacting lysosomal protein-like 2
chr4_+_147333056 45.98 ENSRNOT00000012137
peroxisome proliferator-activated receptor gamma
chr2_-_250778269 44.64 ENSRNOT00000085670
ENSRNOT00000083535
ENSRNOT00000017824
chloride channel accessory 5
chr6_-_55524436 43.96 ENSRNOT00000006752
tetraspanin 13
chr10_-_108196217 42.81 ENSRNOT00000075440
chromobox 4
chr10_-_37311625 41.70 ENSRNOT00000043343
jade family PHD finger 2
chr17_-_67904674 38.46 ENSRNOT00000078532
Kruppel-like factor 6
chr13_-_26769374 36.82 ENSRNOT00000003768
BCL2, apoptosis regulator
chr3_-_2411544 36.29 ENSRNOT00000012406
torsin family 4, member A
chr8_-_78397123 35.47 ENSRNOT00000087270
ENSRNOT00000084925
transcription factor 12
chr2_-_222935973 35.38 ENSRNOT00000071934

chr6_-_141472746 35.31 ENSRNOT00000048010

chr18_+_44737154 34.68 ENSRNOT00000021972
TNF alpha induced protein 8
chr2_-_198360678 33.75 ENSRNOT00000051917
histone cluster 2 H2A family member c
chr7_-_104541392 33.49 ENSRNOT00000078116
family with sequence similarity 49, member B
chr10_-_50402616 33.39 ENSRNOT00000004546
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr6_-_125723732 32.43 ENSRNOT00000084815
fibulin 5
chr20_-_13657943 31.96 ENSRNOT00000032290
pre-B lymphocyte 3
chr17_+_23116661 31.77 ENSRNOT00000067374
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_141866756 31.26 ENSRNOT00000068561

chr18_-_86279680 30.76 ENSRNOT00000006169
hypothetical protein LOC689166
chr6_-_140587251 29.99 ENSRNOT00000090704

chr13_-_89874008 29.72 ENSRNOT00000051368
prothymosin alpha
chr6_-_125723944 28.80 ENSRNOT00000007004
fibulin 5
chr17_+_15749978 28.72 ENSRNOT00000067311
FYVE, RhoGEF and PH domain containing 3
chr20_-_22459025 27.64 ENSRNOT00000000792
early growth response 2
chr14_-_86078954 26.51 ENSRNOT00000018319
DNA polymerase mu
chr9_+_93545396 26.35 ENSRNOT00000025093
hypothetical protein LOC100359583
chr6_-_141715846 25.97 ENSRNOT00000044966

chr14_-_45165207 25.61 ENSRNOT00000002960
Kruppel like factor 3
chr14_+_48740190 24.96 ENSRNOT00000031638
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_141384305 23.47 ENSRNOT00000045320

chr14_-_59980586 21.48 ENSRNOT00000064713
60S ribosomal protein L13-like
chr16_-_21017163 20.76 ENSRNOT00000027661
myocyte enhancer factor 2B
chr20_+_47596575 19.73 ENSRNOT00000087230
ENSRNOT00000064905
sex comb on midleg-like 4 (Drosophila)
chr4_-_183424449 19.71 ENSRNOT00000071930
family with sequence similarity 60, member A
chr3_-_152179193 19.52 ENSRNOT00000026700
RNA binding motif protein 12
chr3_-_18244535 18.58 ENSRNOT00000040689

chr17_+_52938980 17.40 ENSRNOT00000081052
GA binding protein transcription factor, beta subunit 1-like
chr15_+_12827707 15.59 ENSRNOT00000012452
Fez family zinc finger 2
chr4_+_106289816 14.80 ENSRNOT00000040075

chr10_-_78993045 13.00 ENSRNOT00000043005
ribosomal protein S24-like
chr13_-_60849094 12.97 ENSRNOT00000005156
regulator of G-protein signaling 2
chr9_-_94495333 12.96 ENSRNOT00000021507
potassium voltage-gated channel subfamily J member 13
chr8_+_114916122 12.88 ENSRNOT00000074194
toll-like receptor 9
chr8_-_112648880 12.81 ENSRNOT00000015265
atypical chemokine receptor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou5f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
47.5 142.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
35.8 107.4 GO:0002572 pro-T cell differentiation(GO:0002572)
34.3 102.9 GO:0002432 granuloma formation(GO:0002432)
26.6 133.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
25.5 76.4 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
24.5 48.9 GO:0034136 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
20.5 81.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
18.3 109.5 GO:0071224 cellular response to peptidoglycan(GO:0071224)
16.6 116.0 GO:0015670 carbon dioxide transport(GO:0015670)
15.9 63.4 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
15.5 93.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
15.4 46.1 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
15.3 46.0 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
14.7 58.9 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
12.3 36.8 GO:0046671 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671)
12.3 98.1 GO:0070163 positive regulation of neutrophil apoptotic process(GO:0033031) adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
11.8 59.2 GO:0060005 vestibular reflex(GO:0060005)
11.2 33.5 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
10.2 152.3 GO:0002227 innate immune response in mucosa(GO:0002227)
9.2 27.6 GO:0021569 rhombomere 3 development(GO:0021569)
8.7 52.3 GO:0046208 spermine catabolic process(GO:0046208)
8.5 85.0 GO:0070995 NADPH oxidation(GO:0070995)
8.1 154.6 GO:0043383 negative T cell selection(GO:0043383)
6.4 12.9 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
6.1 61.2 GO:0048251 elastic fiber assembly(GO:0048251)
5.5 94.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
4.9 227.0 GO:0050853 B cell receptor signaling pathway(GO:0050853)
4.8 38.5 GO:0071409 cellular response to cycloheximide(GO:0071409)
4.8 33.4 GO:0006477 protein sulfation(GO:0006477)
3.9 15.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.8 41.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
3.3 325.4 GO:0006342 chromatin silencing(GO:0006342)
3.2 13.0 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
2.3 29.7 GO:0043486 histone exchange(GO:0043486)
2.2 26.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
1.9 5.6 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
1.6 6.5 GO:0097167 circadian regulation of translation(GO:0097167)
1.6 107.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.3 94.1 GO:0045576 mast cell activation(GO:0045576)
1.2 30.4 GO:0002377 immunoglobulin production(GO:0002377)
1.0 8.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
1.0 3.8 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.9 8.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.8 69.6 GO:0006334 nucleosome assembly(GO:0006334)
0.7 34.1 GO:0016925 protein sumoylation(GO:0016925)
0.6 3.5 GO:0021633 optic nerve structural organization(GO:0021633)
0.6 8.6 GO:0042118 endothelial cell activation(GO:0042118)
0.5 3.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.4 25.7 GO:0032611 interleukin-1 beta production(GO:0032611)
0.4 83.0 GO:0042113 B cell activation(GO:0042113)
0.3 66.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.3 26.4 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.3 13.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 2.7 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.3 34.3 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.2 12.8 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.2 124.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 7.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 4.6 GO:0016574 histone ubiquitination(GO:0016574)
0.1 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.9 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.5 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.3 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
59.0 235.8 GO:0019815 B cell receptor complex(GO:0019815)
17.1 102.9 GO:0033093 Weibel-Palade body(GO:0033093)
16.3 48.9 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
12.2 61.2 GO:0071953 elastic fiber(GO:0071953)
6.5 640.4 GO:0000786 nucleosome(GO:0000786)
6.4 109.5 GO:0042581 specific granule(GO:0042581)
5.5 88.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
4.0 154.6 GO:0008180 COP9 signalosome(GO:0008180)
3.2 47.4 GO:0035102 PRC1 complex(GO:0035102)
2.0 7.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
1.8 26.9 GO:0016580 Sin3 complex(GO:0016580)
1.6 142.6 GO:0031526 brush border membrane(GO:0031526)
1.3 12.9 GO:0032009 early phagosome(GO:0032009)
1.1 56.2 GO:0016235 aggresome(GO:0016235)
1.1 7.6 GO:0042382 paraspeckles(GO:0042382)
1.0 36.8 GO:0046930 pore complex(GO:0046930)
0.8 94.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.7 91.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 41.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.5 64.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 51.5 GO:0072562 blood microparticle(GO:0072562)
0.3 8.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 77.7 GO:0016324 apical plasma membrane(GO:0016324)
0.2 21.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 13.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 13.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 11.7 GO:0015934 large ribosomal subunit(GO:0015934)
0.2 42.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 41.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 16.0 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
47.5 142.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
31.4 94.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
19.8 119.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
17.4 52.3 GO:0046592 polyamine oxidase activity(GO:0046592)
14.5 116.0 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
11.2 33.5 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
10.4 83.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
10.2 81.9 GO:0051525 NFAT protein binding(GO:0051525)
7.6 68.5 GO:0030957 Tat protein binding(GO:0030957)
6.6 46.0 GO:0050692 DBD domain binding(GO:0050692)
6.1 36.8 GO:0051434 BH3 domain binding(GO:0051434)
5.6 33.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
5.4 48.9 GO:0043208 glycosphingolipid binding(GO:0043208)
5.3 63.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
4.6 46.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
4.5 107.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
4.5 98.1 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
3.9 85.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
2.9 8.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.7 58.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
2.6 12.9 GO:0045322 unmethylated CpG binding(GO:0045322)
2.4 42.8 GO:0019789 SUMO transferase activity(GO:0019789)
2.2 35.5 GO:0035497 cAMP response element binding(GO:0035497)
1.7 8.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.5 91.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.3 3.8 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
1.2 34.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.9 26.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.7 57.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 13.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.5 25.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 12.8 GO:0019956 chemokine binding(GO:0019956)
0.5 28.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 48.9 GO:0005178 integrin binding(GO:0005178)
0.4 111.6 GO:0005096 GTPase activator activity(GO:0005096)
0.4 11.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 12.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 3.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 46.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 7.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 3.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 21.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.9 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
18.7 261.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
15.6 109.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
6.3 190.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
4.5 63.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
4.2 235.8 PID BCR 5PATHWAY BCR signaling pathway
3.3 36.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
3.1 58.9 PID IL27 PATHWAY IL27-mediated signaling events
1.9 83.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.8 109.6 PID IL4 2PATHWAY IL4-mediated signaling events
1.8 84.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.5 26.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
1.5 66.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
1.4 38.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
1.2 46.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
1.1 42.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.6 25.0 PID ARF6 PATHWAY Arf6 signaling events
0.6 42.8 PID CMYB PATHWAY C-MYB transcription factor network
0.3 8.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 28.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
14.9 388.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
8.8 342.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
7.2 137.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
6.7 94.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
5.7 68.5 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
5.3 63.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
3.1 109.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
3.1 116.0 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
2.9 94.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
2.9 52.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.9 36.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
1.9 58.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
1.4 12.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.1 154.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.1 31.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.0 28.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.9 58.9 REACTOME SIGNALING BY ILS Genes involved in Signaling by Interleukins
0.9 107.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.7 7.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.6 6.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 98.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.4 9.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 7.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions