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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Pou5f1
Z-value: 4.67
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Transcription factors associated with Pou5f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou5f1 | rn6_v1_chr20_-_3751994_3751994 | 0.07 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_98370797 Show fit | 270.58 |
ENSRNOT00000031991
|
|
|
| chr10_-_94500591 Show fit | 235.84 |
ENSRNOT00000015976
|
CD79b molecule |
|
| chr11_+_85532526 Show fit | 229.38 |
ENSRNOT00000036565
|
|
|
| chr4_+_102489916 Show fit | 225.54 |
ENSRNOT00000082031
|
|
|
| chr3_+_16413080 Show fit | 224.36 |
ENSRNOT00000040386
|
Ig kappa chain V19-17-like |
|
| chr3_+_17546566 Show fit | 218.75 |
ENSRNOT00000050825
|
|
|
| chr3_+_18315320 Show fit | 217.00 |
ENSRNOT00000006954
|
|
|
| chr6_-_138662365 Show fit | 216.80 |
ENSRNOT00000066209
ENSRNOT00000084892 |
immunoglobulin heavy constant mu |
|
| chr3_-_16537433 Show fit | 215.43 |
ENSRNOT00000048523
|
|
|
| chr3_+_18706988 Show fit | 212.95 |
ENSRNOT00000074650
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou5f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 325.4 | GO:0006342 | chromatin silencing(GO:0006342) |
| 4.9 | 227.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 8.1 | 154.6 | GO:0043383 | negative T cell selection(GO:0043383) |
| 10.2 | 152.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 47.5 | 142.6 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 26.6 | 133.0 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.2 | 124.7 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 16.6 | 116.0 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 18.3 | 109.5 | GO:0071224 | cellular response to peptidoglycan(GO:0071224) |
| 35.8 | 107.4 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 640.4 | GO:0000786 | nucleosome(GO:0000786) |
| 59.0 | 235.8 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 4.0 | 154.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.6 | 142.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 6.4 | 109.5 | GO:0042581 | specific granule(GO:0042581) |
| 17.1 | 102.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.8 | 94.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.7 | 91.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 5.5 | 88.5 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.2 | 77.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 47.5 | 142.6 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 19.8 | 119.0 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 14.5 | 116.0 | GO:0022840 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.4 | 111.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 4.5 | 107.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 4.5 | 98.1 | GO:0001614 | purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) |
| 31.4 | 94.1 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 1.5 | 91.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 3.9 | 85.0 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 10.4 | 83.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.7 | 261.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 4.2 | 235.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 6.3 | 190.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 1.8 | 109.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 15.6 | 109.5 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 1.8 | 84.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.9 | 83.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.5 | 66.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 4.5 | 63.4 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 3.1 | 58.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.9 | 388.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 8.8 | 342.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.1 | 154.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 7.2 | 137.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 3.1 | 116.0 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 3.1 | 109.5 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 107.0 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.5 | 98.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 6.7 | 94.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 2.9 | 94.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |