ISMARA results: Pou4f1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pou4f1_Pou6f1

Z-value: 0.94

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Transcription factors associated with Pou4f1_Pou6f1

Gene Symbol	Gene ID	Gene Info
Pou4f1 NCBI RGD Ensembl	ENSRNOG00000060662	POU class 4 homeobox 1
Pou6f1 NCBI RGD Ensembl	ENSRNOG00000004595	POU class 6 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pou4f1	rn6_v1_chr15_-_88622413_88622413	0.37	1.3e-11	Click!
Pou6f1	rn6_v1_chr7_-_142210738_142210738	0.25	6.0e-06	Click!

Activity profile of Pou4f1_Pou6f1 motif

Sorted Z-values of Pou4f1_Pou6f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_133400485 Show fit	47.56	ENSRNOT00000006219	Cntn1 NCBI RGD Ensembl Show fit	contactin 1
chr3_-_26056818 Show fit	37.22	ENSRNOT00000044209	Lrp1b NCBI RGD Ensembl Show fit	LDL receptor related protein 1B
chr14_+_60764409 Show fit	33.95	ENSRNOT00000005168	Lgi2 NCBI RGD Ensembl Show fit	leucine-rich repeat LGI family, member 2
chr1_-_93949187 Show fit	33.12	ENSRNOT00000018956	Zfp536 NCBI RGD Ensembl Show fit	zinc finger protein 536
chr6_+_64789940 Show fit	32.40	ENSRNOT00000085979 ENSRNOT00000059739 ENSRNOT00000051908 ENSRNOT00000082793 ENSRNOT00000078583 ENSRNOT00000091677 ENSRNOT00000093241	Nrcam NCBI RGD Ensembl Show fit	neuronal cell adhesion molecule
chr13_+_57243877 Show fit	31.18	ENSRNOT00000083693	Kcnt2 NCBI RGD Ensembl Show fit	potassium sodium-activated channel subfamily T member 2
chrX_-_142164220 Show fit	29.54	ENSRNOT00000064780	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr5_+_57947716 Show fit	29.28	ENSRNOT00000067657	Dnai1 NCBI RGD Ensembl Show fit	dynein, axonemal, intermediate chain 1
chr6_-_23291568 Show fit	28.95	ENSRNOT00000085708	Clip4 NCBI RGD Ensembl Show fit	CAP-GLY domain containing linker protein family, member 4
chr2_-_196402106 Show fit	28.36	ENSRNOT00000028664	Mllt11 NCBI RGD Ensembl Show fit	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou4f1_Pou6f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	66.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9	47.6	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
2.1	38.2	GO:0036158	outer dynein arm assembly(GO:0036158)
3.7	33.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.6	32.4	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.9	32.2	GO:0035036	sperm-egg recognition(GO:0035036)
4.2	29.5	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
2.2	28.4	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.3	25.6	GO:0008344	adult locomotory behavior(GO:0008344)
0.9	25.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)

Showing 1 to 10 of 168 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	58.7	GO:0031225	anchored component of membrane(GO:0031225)
0.5	43.6	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
1.2	32.4	GO:0043194	axon initial segment(GO:0043194)
0.6	29.5	GO:0014704	intercalated disc(GO:0014704)
4.9	29.3	GO:0036157	outer dynein arm(GO:0036157)
0.3	25.5	GO:0000786	nucleosome(GO:0000786)
0.7	25.4	GO:0034707	chloride channel complex(GO:0034707)
4.0	24.1	GO:0042584	chromaffin granule membrane(GO:0042584)
0.3	23.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	21.8	GO:0045211	postsynaptic membrane(GO:0045211)

Showing 1 to 10 of 103 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.9	53.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
2.0	45.9	GO:0002162	dystroglycan binding(GO:0002162)
0.9	43.5	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	36.8	GO:0005509	calcium ion binding(GO:0005509)
4.1	33.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
1.1	31.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	26.2	GO:0008270	zinc ion binding(GO:0008270)
0.2	25.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.5	25.4	GO:0050811	GABA receptor binding(GO:0050811)
4.8	24.1	GO:0030348	syntaxin-3 binding(GO:0030348)

Showing 1 to 10 of 113 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	47.6	PID NOTCH PATHWAY	Notch signaling pathway
0.4	32.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	31.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	31.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	26.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.6	22.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	20.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.3	17.0	PID LKB1 PATHWAY	LKB1 signaling events
0.3	14.7	PID BMP PATHWAY	BMP receptor signaling
0.3	11.0	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	47.6	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.0	40.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.9	32.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.9	24.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.7	24.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.2	20.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.1	18.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.2	16.3	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.5	14.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.5	13.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 42 entries

Results for Pou4f1_Pou6f1

Z-value: 0.94

Motif logo

Transcription factors associated with Pou4f1_Pou6f1

Activity-expression correlation:

Activity profile of Pou4f1_Pou6f1 motif

Sorted Z-values of Pou4f1_Pou6f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou4f1_Pou6f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: