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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Pou2f2_Pou3f1
Z-value: 4.08
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Transcription factors associated with Pou2f2_Pou3f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou2f2 | rn6_v1_chr1_-_82004538_82004538 | 0.74 | 4.3e-56 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_18315320 Show fit | 287.36 |
ENSRNOT00000006954
|
|
|
| chr1_-_17378047 Show fit | 276.30 |
ENSRNOT00000020102
|
thymocyte selection associated |
|
| chr4_+_102489916 Show fit | 275.88 |
ENSRNOT00000082031
|
|
|
| chr6_-_138662365 Show fit | 275.41 |
ENSRNOT00000066209
ENSRNOT00000084892 |
immunoglobulin heavy constant mu |
|
| chr6_-_140102325 Show fit | 265.44 |
ENSRNOT00000072238
|
|
|
| chr11_+_85532526 Show fit | 250.28 |
ENSRNOT00000036565
|
|
|
| chr3_+_19274273 Show fit | 241.34 |
ENSRNOT00000040102
|
|
|
| chr4_-_103258134 Show fit | 235.87 |
ENSRNOT00000086827
|
|
|
| chr7_-_107634287 Show fit | 229.31 |
ENSRNOT00000093672
ENSRNOT00000087116 |
src-like adaptor |
|
| chr4_+_106323089 Show fit | 229.30 |
ENSRNOT00000091402
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou2f2_Pou3f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.0 | 1274.4 | GO:0006342 | chromatin silencing(GO:0006342) |
| 6.4 | 598.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 17.1 | 308.7 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 14.5 | 276.3 | GO:0043383 | negative T cell selection(GO:0043383) |
| 3.5 | 257.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 26.9 | 161.5 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 17.5 | 122.3 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 2.7 | 106.8 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 35.5 | 106.6 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 14.5 | 101.8 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.4 | 2388.5 | GO:0000786 | nucleosome(GO:0000786) |
| 7.1 | 276.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.6 | 227.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 38.8 | 155.3 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 1.2 | 106.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.3 | 79.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 14.4 | 72.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 22.9 | 68.8 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 4.2 | 62.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.7 | 59.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 1679.1 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 4.2 | 257.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 35.5 | 106.6 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 2.9 | 90.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 2.1 | 74.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 3.3 | 69.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 7.6 | 68.8 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 7.3 | 58.5 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.6 | 58.0 | GO:0005178 | integrin binding(GO:0005178) |
| 5.5 | 55.0 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 237.1 | PID BCR 5PATHWAY | BCR signaling pathway |
| 3.3 | 153.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.3 | 149.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 2.1 | 122.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 7.6 | 106.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 1.6 | 78.6 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 4.0 | 68.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 3.1 | 55.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 52.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 3.6 | 43.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 44.0 | 1144.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 8.1 | 315.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.3 | 122.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 80.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 5.1 | 71.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 3.0 | 56.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 4.2 | 55.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 3.1 | 53.3 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.2 | 46.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 3.6 | 43.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |