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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pou2f2_Pou3f1

Z-value: 4.08

Motif logo

Transcription factors associated with Pou2f2_Pou3f1

Gene Symbol Gene ID Gene Info
ENSRNOG00000055650 POU class 2 homeobox 2
ENSRNOG00000047686 Pou3f1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou2f2rn6_v1_chr1_-_82004538_820045380.744.3e-56Click!

Activity profile of Pou2f2_Pou3f1 motif

Sorted Z-values of Pou2f2_Pou3f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_18315320 287.36 ENSRNOT00000006954

chr1_-_17378047 276.30 ENSRNOT00000020102
thymocyte selection associated
chr4_+_102489916 275.88 ENSRNOT00000082031

chr6_-_138662365 275.41 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr6_-_140102325 265.44 ENSRNOT00000072238

chr11_+_85532526 250.28 ENSRNOT00000036565

chr3_+_19274273 241.34 ENSRNOT00000040102

chr4_-_103258134 235.87 ENSRNOT00000086827

chr7_-_107634287 229.31 ENSRNOT00000093672
ENSRNOT00000087116
src-like adaptor
chr4_+_106323089 229.30 ENSRNOT00000091402

chr3_+_17889972 226.53 ENSRNOT00000073021

chr6_-_138632159 225.96 ENSRNOT00000082921
ENSRNOT00000040702
immunoglobulin heavy constant mu
chr11_+_85508300 213.35 ENSRNOT00000038646

chr6_+_139405966 205.68 ENSRNOT00000088974

chr6_-_140642221 199.79 ENSRNOT00000081996

chr6_-_142635763 199.58 ENSRNOT00000048908

chr4_+_98370797 195.93 ENSRNOT00000031991

chr11_+_85618714 195.25 ENSRNOT00000074614

chr6_+_139428999 194.13 ENSRNOT00000084482

chr4_-_102124609 193.07 ENSRNOT00000048263

chr6_-_140880070 191.58 ENSRNOT00000073779
uncharacterized LOC691828
chr2_+_223121410 189.09 ENSRNOT00000087559

chr7_-_18793289 185.42 ENSRNOT00000036375

chr6_-_143131118 181.93 ENSRNOT00000074930

chr6_-_142353308 178.90 ENSRNOT00000066416

chr6_-_138736203 178.74 ENSRNOT00000052021
rCG21044-like
chr11_+_85042348 170.00 ENSRNOT00000042220

chr17_+_43632397 162.15 ENSRNOT00000013790
histone cluster 1, H2ah
chr17_+_43423111 161.52 ENSRNOT00000022630
histone cluster 1 H2B family member a
chr3_+_16571602 160.75 ENSRNOT00000048351
rCG64259-like
chr4_+_102665529 160.56 ENSRNOT00000082333

chr17_+_44520537 160.46 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr10_-_94500591 155.34 ENSRNOT00000015976
CD79b molecule
chr11_+_85992696 153.70 ENSRNOT00000084433

chr6_-_141008427 153.48 ENSRNOT00000074472

chr3_+_17546566 152.55 ENSRNOT00000050825

chr6_-_138954577 148.59 ENSRNOT00000042728

chr10_-_45297385 147.49 ENSRNOT00000041187
histone cluster 3 H2B family member b
chr6_-_138954741 146.21 ENSRNOT00000083278

chr4_+_102068556 146.00 ENSRNOT00000077412

chr17_-_44520240 144.31 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr10_+_45289741 144.15 ENSRNOT00000066190
histone cluster 3, H2ba
chr17_+_44528125 142.03 ENSRNOT00000084538
similar to Histone H2A type 1
chr6_-_138931429 137.58 ENSRNOT00000090584
Ighg protein-like
chr2_+_198418691 136.09 ENSRNOT00000089409
histone cluster 1, H2bk
chr6_-_143065639 133.61 ENSRNOT00000070923

chr6_-_139660666 132.47 ENSRNOT00000086098

chr3_+_18706988 132.38 ENSRNOT00000074650

chr6_-_141198565 132.33 ENSRNOT00000064361

chr17_-_43422846 132.07 ENSRNOT00000050526
histone cluster 1 H2A family member a
chr6_-_139004980 131.91 ENSRNOT00000085427
ENSRNOT00000087351

chr6_-_142060032 129.99 ENSRNOT00000064717

chr6_-_138631997 126.51 ENSRNOT00000073304

chr17_-_44527801 125.04 ENSRNOT00000089643
histone cluster 1 H2B family member k
chr3_+_20303979 124.25 ENSRNOT00000058331

chr4_+_98481520 123.08 ENSRNOT00000078381
ENSRNOT00000048493

chrX_+_28593405 122.35 ENSRNOT00000071708
thymosin beta 4, X-linked
chr17_+_44758460 121.72 ENSRNOT00000089436
histone cluster 1, H2an
chr2_-_198382190 120.50 ENSRNOT00000044268
histone cluster 2, H2aa2
chr2_+_198388809 119.94 ENSRNOT00000083087
histone cluster 2, H2aa3
chr6_-_139637187 113.58 ENSRNOT00000089454
Ighg protein-like
chrX_+_96991658 112.84 ENSRNOT00000049969

chr11_+_85561460 111.50 ENSRNOT00000075455

chr6_-_139637354 111.19 ENSRNOT00000072900
Ighg protein-like
chr6_-_143702033 110.91 ENSRNOT00000051410

chr1_+_192233910 106.59 ENSRNOT00000016418
ENSRNOT00000016442
protein kinase C, beta
chr17_-_44748188 105.26 ENSRNOT00000081970
histone H2A type 1-E
chr4_+_101909389 102.85 ENSRNOT00000086458

chr17_+_44738643 102.80 ENSRNOT00000087643
histone H2A type 1-like
chr3_+_20375699 101.80 ENSRNOT00000088492

chr6_+_139560028 100.63 ENSRNOT00000072633
rCG58847-like
chr3_-_19320915 99.39 ENSRNOT00000043673
similar to Ig variable region, light chain
chr19_+_3325893 98.88 ENSRNOT00000048879
similar to Ig variable region, light chain
chr3_-_16441030 98.86 ENSRNOT00000047784

chr3_-_20419417 98.41 ENSRNOT00000077772

chr6_-_142933110 97.29 ENSRNOT00000046885

chr3_-_20479999 97.12 ENSRNOT00000050573

chr6_-_139033819 97.08 ENSRNOT00000091961

chr6_-_141321108 96.24 ENSRNOT00000040556

chr17_-_44738330 95.54 ENSRNOT00000072195
histone cluster 1, H2bd-like
chr6_-_142585188 94.78 ENSRNOT00000067437

chr6_-_141062581 90.83 ENSRNOT00000073446

chr17_+_44748482 90.81 ENSRNOT00000083765
histone cluster 1 H2B family member l
chr3_-_20695952 90.62 ENSRNOT00000072306

chr2_-_198360678 90.38 ENSRNOT00000051917
histone cluster 2 H2A family member c
chr18_+_44737154 90.29 ENSRNOT00000021972
TNF alpha induced protein 8
chr6_+_139531330 89.78 ENSRNOT00000083025

chr17_+_43627930 89.24 ENSRNOT00000081719
histone H2B type 1-N-like
chr4_+_93888502 87.19 ENSRNOT00000090783

chr4_+_101639641 87.15 ENSRNOT00000058282

chr6_-_142676432 85.55 ENSRNOT00000074947

chr3_+_17180411 85.27 ENSRNOT00000058260

chr4_+_102147211 83.50 ENSRNOT00000083239

chr6_-_139710905 83.00 ENSRNOT00000077430

chr3_+_16846412 82.20 ENSRNOT00000074266

chr19_+_50045020 81.78 ENSRNOT00000090165
phospholipase C, gamma 2
chr17_-_44758170 81.35 ENSRNOT00000091176
histone cluster 1 H2B family member o
chr6_-_138685656 80.98 ENSRNOT00000041706

chr2_+_264704769 80.28 ENSRNOT00000012667
DEP domain containing 1
chr17_-_43627629 79.67 ENSRNOT00000022965
histone cluster 1, H2af
chr2_+_55835151 78.60 ENSRNOT00000018634
FYN binding protein
chr6_-_141831632 77.60 ENSRNOT00000075526

chr3_-_20457554 76.70 ENSRNOT00000074237

chr3_+_19045214 76.33 ENSRNOT00000070878

chrX_+_96863891 74.00 ENSRNOT00000085665

chr4_-_95970666 73.97 ENSRNOT00000008826
hematopoietic prostaglandin D synthase
chr6_-_143206772 72.94 ENSRNOT00000073713

chr5_+_16526058 68.82 ENSRNOT00000011130
LYN proto-oncogene, Src family tyrosine kinase
chr1_-_118826977 68.48 ENSRNOT00000079274

chr6_+_139293294 67.99 ENSRNOT00000050297
ENSRNOT00000081817
Ighg protein-like
chr6_-_142880382 66.78 ENSRNOT00000074706
ENSRNOT00000072861

chr6_-_141957537 65.50 ENSRNOT00000090358
immunoglobulin heavy variable 13-2
chr4_-_103761881 63.62 ENSRNOT00000084103

chr1_-_265798167 58.50 ENSRNOT00000079483
LIM domain binding 1
chr4_-_119327822 58.47 ENSRNOT00000012645
Rho GTPase activating protein 25
chr4_-_28437676 56.75 ENSRNOT00000012995
HEPACAM family member 2
chr2_+_198359754 55.58 ENSRNOT00000048582
histone cluster 2 H2A family member b
chr3_+_17139670 55.32 ENSRNOT00000073316

chr3_-_92749121 55.00 ENSRNOT00000008760
CD44 molecule (Indian blood group)
chrX_-_62690806 53.27 ENSRNOT00000018147
DNA polymerase alpha 1, catalytic subunit
chr11_+_85633243 53.12 ENSRNOT00000045807
Ig lambda chain V-VI region AR-like
chr17_-_43689311 52.37 ENSRNOT00000028779
histone cluster 1, H2bc-like 1
chr6_-_141472746 48.30 ENSRNOT00000048010

chr2_+_198360998 47.55 ENSRNOT00000046129
histone cluster 2, H2be
chr6_-_143768985 47.52 ENSRNOT00000046694
immunoglobulin heavy variable V15-2
chr12_+_38160464 46.77 ENSRNOT00000032249
hydroxycarboxylic acid receptor 2
chr6_-_141365198 46.14 ENSRNOT00000040523

chr10_-_19652898 45.97 ENSRNOT00000009648
spindle apparatus coiled-coil protein 1
chr6_-_55524436 44.05 ENSRNOT00000006752
tetraspanin 13
chr9_-_54457753 43.17 ENSRNOT00000020032
signal transducer and activator of transcription 1
chr3_+_79918969 39.74 ENSRNOT00000016306
Spi-1 proto-oncogene
chr3_+_19071980 39.53 ENSRNOT00000079487
immunoglobulin kappa variable 4-81
chr6_-_125723732 38.70 ENSRNOT00000084815
fibulin 5
chr4_+_93959152 38.63 ENSRNOT00000058437

chr5_-_12172009 38.32 ENSRNOT00000061903
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr20_+_44680449 38.24 ENSRNOT00000000728
Traf3 interacting protein 2
chr2_-_250778269 37.95 ENSRNOT00000085670
ENSRNOT00000083535
ENSRNOT00000017824
chloride channel accessory 5
chr4_+_147333056 37.39 ENSRNOT00000012137
peroxisome proliferator-activated receptor gamma
chr10_-_108196217 37.34 ENSRNOT00000075440
chromobox 4
chr6_-_141866756 37.15 ENSRNOT00000068561

chr4_-_183424449 36.43 ENSRNOT00000071930
family with sequence similarity 60, member A
chr1_-_142183884 35.54 ENSRNOT00000016032
FES proto-oncogene, tyrosine kinase
chr6_-_142178771 34.68 ENSRNOT00000071577
immunoglobulin heavy variable V12-3
chr6_-_125723944 33.27 ENSRNOT00000007004
fibulin 5
chr14_-_86078954 32.51 ENSRNOT00000018319
DNA polymerase mu
chr1_-_57327379 31.70 ENSRNOT00000080429
delta like canonical Notch ligand 1
chr18_+_12008759 31.22 ENSRNOT00000022665
ENSRNOT00000061344
ENSRNOT00000038635
desmoglein 1
chr16_-_21017163 31.19 ENSRNOT00000027661
myocyte enhancer factor 2B
chr11_-_33003021 30.15 ENSRNOT00000084134
runt-related transcription factor 1
chr16_-_22561496 29.78 ENSRNOT00000016543
lipoprotein lipase
chr6_-_140587251 28.32 ENSRNOT00000090704

chr17_+_23116661 27.94 ENSRNOT00000067374
neural precursor cell expressed, developmentally down-regulated 9
chr4_+_102290338 27.31 ENSRNOT00000011067

chr10_-_13898855 27.04 ENSRNOT00000004249
RAB26, member RAS oncogene family
chr17_-_31916553 26.35 ENSRNOT00000074220
uncharacterized LOC100911032
chr4_-_183426439 25.94 ENSRNOT00000083310
family with sequence similarity 60, member A
chrX_+_104684676 25.77 ENSRNOT00000083229
tenomodulin
chr10_-_50402616 25.41 ENSRNOT00000004546
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr10_+_95642640 25.07 ENSRNOT00000029782
Ribosomal_L22 domain containing protein RGD1359290
chr18_-_12640716 25.07 ENSRNOT00000020697
kelch-like family member 14
chr10_-_78993045 24.17 ENSRNOT00000043005
ribosomal protein S24-like
chr3_-_94833406 24.14 ENSRNOT00000049695
similar to Ac2-210
chr1_-_179010257 24.00 ENSRNOT00000017199
related RAS viral (r-ras) oncogene homolog 2
chr4_+_155359921 23.86 ENSRNOT00000020762
activation-induced cytidine deaminase
chr20_-_22459025 22.83 ENSRNOT00000000792
early growth response 2
chr6_-_143537030 22.10 ENSRNOT00000071876
rCG64220-like
chr6_-_36876805 21.71 ENSRNOT00000006482
mesogenin 1
chr3_-_90751055 20.97 ENSRNOT00000040741
LRRGT00091
chr2_-_139528162 19.85 ENSRNOT00000014317
solute carrier family 7 member 11
chr17_-_15519060 19.54 ENSRNOT00000093624
asporin-like 1
chr3_-_20518105 19.01 ENSRNOT00000050435

chr11_-_60679555 18.98 ENSRNOT00000059735
coiled-coil domain containing 80
chr3_-_18244535 18.50 ENSRNOT00000040689

chr3_+_2396143 18.19 ENSRNOT00000012388
Notch-regulated ankyrin repeat protein
chr6_-_92527711 17.93 ENSRNOT00000007529
ninein
chr20_-_13657943 16.82 ENSRNOT00000032290
pre-B lymphocyte 3
chr16_-_7412150 16.40 ENSRNOT00000047252
similar to ribosomal protein S24
chr2_+_187893368 16.19 ENSRNOT00000092031
mex-3 RNA binding family member A
chr18_-_70924708 16.04 ENSRNOT00000025257
lipase G, endothelial type
chr17_+_15749978 15.47 ENSRNOT00000067311
FYVE, RhoGEF and PH domain containing 3
chr6_-_141715846 15.44 ENSRNOT00000044966

chrX_+_158835811 14.82 ENSRNOT00000071888
ENSRNOT00000080110
integrator complex subunit 6 like
chr7_+_144080614 12.32 ENSRNOT00000077687
poly(rC) binding protein 2
chr14_-_59735450 11.67 ENSRNOT00000071929
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_163112301 11.67 ENSRNOT00000087113
C-type lectin domain family 12, member A
chr1_+_273854248 11.17 ENSRNOT00000044827
ENSRNOT00000017600
ENSRNOT00000086496
adducin 3
chr1_-_264172729 10.21 ENSRNOT00000018447
stearoyl-CoA desaturase
chr20_+_5646097 9.82 ENSRNOT00000090925
inositol 1,4,5-trisphosphate receptor, type 3
chr3_-_3951025 9.81 ENSRNOT00000026212
notch 1
chr3_-_164964702 9.72 ENSRNOT00000014595
activity-dependent neuroprotector homeobox
chr6_-_141384305 9.50 ENSRNOT00000045320

chr5_+_157434481 9.43 ENSRNOT00000088556
transmembrane and coiled-coil domains 4
chr15_+_12827707 8.79 ENSRNOT00000012452
Fez family zinc finger 2
chr9_-_119321500 8.57 ENSRNOT00000048125
myosin light chain 12B
chr9_+_43049587 7.56 ENSRNOT00000021434
ENSRNOT00000079234
cyclin and CBS domain divalent metal cation transport mediator 4
chr20_+_9173127 7.42 ENSRNOT00000088409

chr14_+_86514214 7.27 ENSRNOT00000052002
zinc finger MIZ domain-containing protein 2
chr8_+_12823155 6.85 ENSRNOT00000011008
sestrin 3
chr12_+_25264192 6.84 ENSRNOT00000079392
GTF2I repeat domain containing 1
chr2_+_182723854 6.73 ENSRNOT00000012658
secreted frizzled-related protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou2f2_Pou3f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
35.5 106.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
26.9 161.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
22.9 68.8 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
18.5 74.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
17.5 122.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
17.1 308.7 GO:0002227 innate immune response in mucosa(GO:0002227)
14.6 58.5 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
14.5 276.3 GO:0043383 negative T cell selection(GO:0043383)
14.5 101.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
14.5 43.4 GO:0060846 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) blood vessel endothelial cell fate specification(GO:0097101)
13.3 53.3 GO:0006272 leading strand elongation(GO:0006272)
13.0 1274.4 GO:0006342 chromatin silencing(GO:0006342)
12.5 37.4 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
10.8 43.2 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
10.0 30.1 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
9.9 39.7 GO:0045347 hypermethylation of CpG island(GO:0044027) negative regulation of MHC class II biosynthetic process(GO:0045347)
8.2 81.8 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
7.6 22.8 GO:0021569 rhombomere 3 development(GO:0021569)
7.2 72.0 GO:0048251 elastic fiber assembly(GO:0048251)
6.4 598.0 GO:0006334 nucleosome assembly(GO:0006334)
5.3 16.0 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
4.9 9.8 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
4.3 25.8 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
4.3 29.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
3.6 25.4 GO:0006477 protein sulfation(GO:0006477)
3.5 257.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
3.4 10.2 GO:1903699 tarsal gland development(GO:1903699)
3.1 46.0 GO:0034501 protein localization to kinetochore(GO:0034501)
2.7 2.7 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production(GO:0032725)
2.7 32.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
2.7 106.8 GO:0050853 B cell receptor signaling pathway(GO:0050853)
2.2 6.7 GO:2000041 sclerotome development(GO:0061056) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
2.2 8.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.1 38.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
2.0 18.2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
2.0 9.8 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.8 17.9 GO:0021540 corpus callosum morphogenesis(GO:0021540)
1.6 1.6 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
1.4 9.7 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
1.4 12.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.2 82.9 GO:0032611 interleukin-1 beta production(GO:0032611)
1.2 19.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.1 6.9 GO:0038203 TORC2 signaling(GO:0038203)
1.1 78.6 GO:0045576 mast cell activation(GO:0045576)
1.1 7.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.0 12.9 GO:0007379 segment specification(GO:0007379)
0.8 4.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.7 33.1 GO:0016925 protein sumoylation(GO:0016925)
0.7 0.7 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.7 4.0 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.6 5.9 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6 24.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.5 7.6 GO:1903830 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.4 31.2 GO:0032570 response to progesterone(GO:0032570)
0.4 19.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.4 27.0 GO:0035272 exocrine system development(GO:0035272)
0.3 2.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.3 5.6 GO:0060746 parental behavior(GO:0060746)
0.2 1.4 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 38.3 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.2 16.8 GO:0002377 immunoglobulin production(GO:0002377)
0.2 6.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 3.6 GO:0016180 snRNA processing(GO:0016180)
0.1 19.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 2.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.8 GO:0048539 bone marrow development(GO:0048539)
0.1 1.2 GO:0051601 exocyst localization(GO:0051601)
0.1 1.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 2.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 13.0 GO:0007265 Ras protein signal transduction(GO:0007265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
38.8 155.3 GO:0019815 B cell receptor complex(GO:0019815)
24.4 2388.5 GO:0000786 nucleosome(GO:0000786)
22.9 68.8 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
18.3 55.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
14.4 72.0 GO:0071953 elastic fiber(GO:0071953)
7.1 276.3 GO:0008180 COP9 signalosome(GO:0008180)
6.7 53.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
5.4 21.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
4.2 62.4 GO:0016580 Sin3 complex(GO:0016580)
3.3 46.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.6 17.9 GO:0036449 microtubule minus-end(GO:0036449)
2.5 37.3 GO:0035102 PRC1 complex(GO:0035102)
2.3 29.8 GO:0042627 chylomicron(GO:0042627)
1.6 227.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.4 31.2 GO:0030057 desmosome(GO:0030057)
1.2 106.6 GO:0031526 brush border membrane(GO:0031526)
1.0 23.9 GO:0000178 exosome (RNase complex)(GO:0000178)
0.9 19.0 GO:0005614 interstitial matrix(GO:0005614)
0.8 6.9 GO:0061700 GATOR2 complex(GO:0061700)
0.7 59.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 25.1 GO:0016235 aggresome(GO:0016235)
0.5 19.5 GO:0046930 pore complex(GO:0046930)
0.4 8.6 GO:0016460 myosin II complex(GO:0016460)
0.4 9.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 37.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 50.3 GO:0030496 midbody(GO:0030496)
0.3 24.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 30.1 GO:0005604 basement membrane(GO:0005604)
0.3 79.2 GO:0000790 nuclear chromatin(GO:0000790)
0.2 1.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 3.6 GO:0032039 integrator complex(GO:0032039)
0.2 19.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 11.2 GO:0005903 brush border(GO:0005903)
0.2 25.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 1.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 8.0 GO:0000922 spindle pole(GO:0000922)
0.1 6.2 GO:0000776 kinetochore(GO:0000776)
0.0 2.4 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
35.5 106.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
9.6 38.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
7.6 68.8 GO:0043208 glycosphingolipid binding(GO:0043208)
7.6 53.3 GO:0003896 DNA primase activity(GO:0003896)
7.3 58.5 GO:0030274 LIM domain binding(GO:0030274)
6.8 27.0 GO:0019002 GMP binding(GO:0019002)
6.6 19.8 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
5.5 55.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
5.3 37.4 GO:0050692 DBD domain binding(GO:0050692)
5.1 46.0 GO:0043515 kinetochore binding(GO:0043515)
5.0 39.7 GO:0051525 NFAT protein binding(GO:0051525)
4.2 25.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
4.2 257.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
4.0 23.9 GO:0004126 cytidine deaminase activity(GO:0004126)
3.9 43.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
3.5 31.7 GO:0030957 Tat protein binding(GO:0030957)
3.3 69.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
2.9 90.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
2.7 16.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
2.6 31.2 GO:0045295 gamma-catenin binding(GO:0045295)
2.6 10.2 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
2.5 1679.1 GO:0046982 protein heterodimerization activity(GO:0046982)
2.5 12.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
2.5 9.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
2.2 46.8 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
2.1 37.3 GO:0032183 SUMO binding(GO:0032183)
2.1 74.0 GO:0004364 glutathione transferase activity(GO:0004364)
1.5 32.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.5 44.2 GO:0003785 actin monomer binding(GO:0003785)
1.2 8.6 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 22.8 GO:0071837 HMG box domain binding(GO:0071837)
1.0 6.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.9 31.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.9 6.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.8 19.5 GO:0015288 porin activity(GO:0015288)
0.8 5.9 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.7 19.0 GO:0001968 fibronectin binding(GO:0001968)
0.6 58.0 GO:0005178 integrin binding(GO:0005178)
0.5 2.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 9.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.5 7.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.4 9.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 9.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 11.2 GO:0005080 protein kinase C binding(GO:0005080)
0.2 49.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 15.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 31.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 15.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.4 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 106.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
4.0 68.8 PID IL5 PATHWAY IL5-mediated signaling events
3.6 43.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
3.4 237.1 PID BCR 5PATHWAY BCR signaling pathway
3.3 153.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
3.1 55.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.1 122.0 PID IL4 2PATHWAY IL4-mediated signaling events
1.8 32.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
1.6 78.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.3 149.3 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
1.2 37.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.9 32.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.5 9.8 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.5 30.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 39.2 PID CMYB PATHWAY C-MYB transcription factor network
0.3 4.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 52.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 4.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 6.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 6.2 PID P73PATHWAY p73 transcription factor network
0.1 9.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
44.0 1144.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
8.1 315.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
5.1 71.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
4.2 55.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
3.6 43.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
3.1 53.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
3.0 56.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.6 31.7 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
2.2 31.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
1.9 35.5 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
1.8 29.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.3 11.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
1.3 122.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.9 25.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.6 6.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.5 80.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.5 19.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 8.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 12.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 6.2 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3 2.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 46.8 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.2 2.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing