ISMARA results: Plag1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Plag1

Z-value: 1.28

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Transcription factors associated with Plag1

Gene Symbol	Gene ID	Gene Info
Plag1 NCBI RGD Ensembl	ENSRNOG00000008846	PLAG1 zinc finger

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Plag1	rn6_v1_chr5_-_16799776_16799776	0.20	4.4e-04	Click!

Activity profile of Plag1 motif

Sorted Z-values of Plag1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_198232344 Show fit	40.83	ENSRNOT00000080988	Aldoa NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate A
chr10_+_57278307 Show fit	38.04	ENSRNOT00000005612	Eno3 NCBI RGD Ensembl Show fit	enolase 3
chr9_+_81821346 Show fit	36.53	ENSRNOT00000022234	Plcd4 NCBI RGD Ensembl Show fit	phospholipase C, delta 4
chr1_+_198655742 Show fit	35.05	ENSRNOT00000023944	Mylpf NCBI RGD Ensembl Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr1_-_220136470 Show fit	34.75	ENSRNOT00000026812	Actn3 NCBI RGD Ensembl Show fit	actinin alpha 3
chr1_-_215834704 Show fit	31.82	ENSRNOT00000073850	Igf2 NCBI RGD Ensembl Show fit	insulin-like growth factor 2
chr1_-_88066101 Show fit	31.17	ENSRNOT00000079473 ENSRNOT00000027893	Ryr1 NCBI RGD Ensembl Show fit	ryanodine receptor 1
chr1_+_101427195 Show fit	29.85	ENSRNOT00000028271	Gys1 NCBI RGD Ensembl Show fit	glycogen synthase 1
chrX_-_78496847 Show fit	28.28	ENSRNOT00000003265	Itm2a NCBI RGD Ensembl Show fit	integral membrane protein 2A
chr5_+_148528725 Show fit	26.86	ENSRNOT00000017325	Fabp3 NCBI RGD Ensembl Show fit	fatty acid binding protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Plag1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	61.8	GO:0006000	fructose metabolic process(GO:0006000)
17.5	52.4	GO:0031448	regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.5	42.4	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
6.0	41.9	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.9	34.2	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.3	33.3	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
2.2	31.4	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
4.5	31.2	GO:0071313	cellular response to caffeine(GO:0071313)
0.7	30.0	GO:0007340	acrosome reaction(GO:0007340)
0.7	29.8	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)

Showing 1 to 10 of 322 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	96.3	GO:0031430	M band(GO:0031430)
1.1	81.1	GO:0031594	neuromuscular junction(GO:0031594)
0.2	57.2	GO:0005635	nuclear envelope(GO:0005635)
0.4	39.6	GO:0030018	Z disc(GO:0030018)
6.3	38.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
3.1	37.7	GO:0005861	troponin complex(GO:0005861)
0.3	34.9	GO:0034705	potassium channel complex(GO:0034705)
3.4	33.7	GO:0008091	spectrin(GO:0008091)
1.1	31.9	GO:0002080	acrosomal membrane(GO:0002080)
0.3	31.8	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 149 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	102.9	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	85.6	GO:0005096	GTPase activator activity(GO:0005096)
0.5	82.4	GO:0044325	ion channel binding(GO:0044325)
0.2	49.0	GO:0015631	tubulin binding(GO:0015631)
2.1	47.0	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.3	43.7	GO:0003714	transcription corepressor activity(GO:0003714)
2.0	43.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
5.8	40.8	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
6.3	38.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
5.4	37.7	GO:0031014	troponin T binding(GO:0031014)

Showing 1 to 10 of 201 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	50.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.7	43.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.9	34.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.9	31.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	29.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	27.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.4	26.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.7	24.6	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.5	24.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.4	23.3	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	110.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.6	62.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.0	50.1	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
3.0	41.6	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.1	39.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	33.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
1.0	29.8	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.9	28.0	REACTOME KINESINS	Genes involved in Kinesins
0.7	27.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.5	21.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation

Showing 1 to 10 of 74 entries

Results for Plag1

Z-value: 1.28

Motif logo

Transcription factors associated with Plag1

Activity-expression correlation:

Activity profile of Plag1 motif

Sorted Z-values of Plag1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Plag1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: