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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pknox2_Pknox1

Z-value: 0.76

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Transcription factors associated with Pknox2_Pknox1

Gene Symbol Gene ID Gene Info
Pknox2
ENSRNOG00000028856 PBX/knotted 1 homeobox 2
Pknox1
ENSRNOG00000001184 PBX/knotted 1 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pknox1rn6_v1_chr20_+_10334308_103343080.411.0e-14Click!
Pknox2rn6_v1_chr8_-_39551700_39551700-0.072.1e-01Click!

Activity profile of Pknox2_Pknox1 motif

Sorted Z-values of Pknox2_Pknox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_73958480 52.35 ENSRNOT00000017838
Myl1
myosin, light chain 1
chr13_+_52889737 46.66 ENSRNOT00000074366
Cacna1s
calcium voltage-gated channel subunit alpha1 S
chr10_+_4945911 30.25 ENSRNOT00000003420
Prm1
protamine 1
chr17_-_43614844 29.51 ENSRNOT00000023054
Hist1h1a
histone cluster 1 H1 family member a
chr10_-_85974644 18.24 ENSRNOT00000006098
ENSRNOT00000082974
Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
chr2_-_140618405 15.86 ENSRNOT00000017736
Setd7
SET domain containing (lysine methyltransferase) 7
chr8_-_33017854 15.35 ENSRNOT00000011386
Barx2
BARX homeobox 2
chr3_+_148386189 15.12 ENSRNOT00000011255
Mylk2
myosin light chain kinase 2
chr4_+_69138525 14.82 ENSRNOT00000073589
Trbv1
T cell receptor beta, variable 1
chr9_+_14529218 14.49 ENSRNOT00000016893
Apobec2
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr7_+_66595742 12.97 ENSRNOT00000031191
Usp15
ubiquitin specific peptidase 15
chr20_+_46667121 10.04 ENSRNOT00000089611
Sesn1
sestrin 1
chr20_+_46667454 9.72 ENSRNOT00000065890
Sesn1
sestrin 1
chr15_+_34251606 9.57 ENSRNOT00000025725
Fitm1
fat storage-inducing transmembrane protein 1
chr12_-_17904254 9.41 ENSRNOT00000060192
LOC680273
similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)
chr4_-_62526724 8.47 ENSRNOT00000038950
RGD1565367
similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2)
chr16_+_72086878 8.39 ENSRNOT00000023756
ENSRNOT00000078085
Adam3a
ADAM metallopeptidase domain 3A
chr1_+_264893162 8.10 ENSRNOT00000021714
Tlx1
T-cell leukemia, homeobox 1
chr4_+_127164453 7.71 ENSRNOT00000017889
Kbtbd8
kelch repeat and BTB domain containing 8
chr6_-_103605256 7.41 ENSRNOT00000006005
Dcaf5
DDB1 and CUL4 associated factor 5
chr2_-_105047984 7.09 ENSRNOT00000014970
Cpa3
carboxypeptidase A3
chr20_-_3728844 6.98 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr20_-_5212624 6.78 ENSRNOT00000074261
LOC103689996
antigen peptide transporter 2
chr20_+_3995544 6.33 ENSRNOT00000000527
Tap2
transporter 2, ATP binding cassette subfamily B member
chr8_-_67869019 6.25 ENSRNOT00000066009
Pias1
protein inhibitor of activated STAT, 1
chrX_-_138435391 5.80 ENSRNOT00000043258
Mbnl3
muscleblind-like splicing regulator 3
chr13_+_97838361 5.76 ENSRNOT00000003641
Cnst
consortin, connexin sorting protein
chr4_-_99125111 5.49 ENSRNOT00000009184
Smyd1
SET and MYND domain containing 1
chr10_+_105498728 5.41 ENSRNOT00000032163
Sphk1
sphingosine kinase 1
chr5_-_146446227 5.34 ENSRNOT00000044868
Hmgb4
high-mobility group box 4
chr1_+_75693232 4.85 ENSRNOT00000020090
Cabp5
calcium binding protein 5
chr9_+_81518176 4.68 ENSRNOT00000078317
ENSRNOT00000019265
ENSRNOT00000088246
ENSRNOT00000084682
Arpc2
actin related protein 2/3 complex, subunit 2
chr5_+_126511350 4.49 ENSRNOT00000011408
Ssbp3
single stranded DNA binding protein 3
chr6_+_129052503 4.44 ENSRNOT00000044152
RGD1565462
similar to BC049975 protein
chr3_+_175144495 4.40 ENSRNOT00000082601
ENSRNOT00000088026
Cdh4
cadherin 4
chr7_-_120967490 4.40 ENSRNOT00000046399
Sun2
Sad1 and UNC84 domain containing 2
chr3_-_125213607 4.34 ENSRNOT00000078070
Gpcpd1
glycerophosphocholine phosphodiesterase 1
chr7_-_27136652 4.30 ENSRNOT00000086905
Hcfc2
host cell factor C2
chr11_+_80358211 4.06 ENSRNOT00000002519
Sst
somatostatin
chr7_-_60743328 3.98 ENSRNOT00000066767
Mdm2
MDM2 proto-oncogene
chr9_-_45206427 3.84 ENSRNOT00000042227
Aff3
AF4/FMR2 family, member 3
chr8_-_76239995 3.75 ENSRNOT00000071321
LOC100912027
60S ribosomal protein L27-like
chr8_+_94122728 3.66 ENSRNOT00000014783
Dopey1
dopey family member 1
chr11_+_84745904 3.65 ENSRNOT00000002617
Klhl6
kelch-like family member 6
chr9_-_94201084 3.65 ENSRNOT00000026190
Alpi
alkaline phosphatase, intestinal
chr9_+_94228960 3.30 ENSRNOT00000083137
ENSRNOT00000080897
Akp3
alkaline phosphatase 3, intestine, not Mn requiring
chr10_-_87928251 3.19 ENSRNOT00000064120
Krtap17-1
keratin associated protein 17-1
chr1_-_201981229 3.17 ENSRNOT00000077246
ENSRNOT00000035531
Ikzf5
IKAROS family zinc finger 5
chr6_+_42947334 3.16 ENSRNOT00000041376
RGD1563157
similar to 60S ribosomal protein L35
chr15_-_88670349 3.16 ENSRNOT00000012881
Rnf219
ring finger protein 219
chr9_+_17163354 2.97 ENSRNOT00000026049
Polh
DNA polymerase eta
chr10_+_105393072 2.95 ENSRNOT00000013359
Ubald2
UBA-like domain containing 2
chr14_+_83412968 2.84 ENSRNOT00000024993
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr20_+_31035729 2.81 ENSRNOT00000000672
Nodal
nodal growth differentiation factor
chr10_-_46969406 2.52 ENSRNOT00000006753
Flii
FLII, actin remodeling protein
chr3_-_13978224 2.52 ENSRNOT00000025528
Phf19
PHD finger protein 19
chr4_-_80313411 2.48 ENSRNOT00000041621
RGD1565415
similar to ribosomal protein L27a
chr15_-_32925673 2.47 ENSRNOT00000081045
Olr1646
olfactory receptor 1646
chr18_+_44468784 2.40 ENSRNOT00000031812
Dmxl1
Dmx-like 1
chrX_+_136460215 2.33 ENSRNOT00000093538
Arhgap36
Rho GTPase activating protein 36
chr11_-_82366505 2.29 ENSRNOT00000041326
RGD1559972
similar to ribosomal protein L27a
chr2_+_140471690 2.28 ENSRNOT00000017379
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr10_+_66099531 2.27 ENSRNOT00000056192
Lyrm9
LYR motif containing 9
chr10_+_90731148 2.25 ENSRNOT00000093604
Adam11
ADAM metallopeptidase domain 11
chr10_+_90731865 2.20 ENSRNOT00000064429
Adam11
ADAM metallopeptidase domain 11
chr12_+_660011 2.17 ENSRNOT00000040830
Pds5b
PDS5 cohesin associated factor B
chr2_-_43999107 2.14 ENSRNOT00000065473
LOC100912399
mitogen-activated protein kinase kinase kinase 1-like
chr10_+_88245532 2.13 ENSRNOT00000019863
Gast
gastrin
chr17_-_10208360 1.99 ENSRNOT00000087397
Unc5a
unc-5 netrin receptor A
chr10_-_97647822 1.97 ENSRNOT00000065781
AC106648.1

chr4_+_178617401 1.95 ENSRNOT00000042619
AABR07062466.1

chr1_-_80073223 1.89 ENSRNOT00000021456
Gipr
gastric inhibitory polypeptide receptor
chr14_+_5928737 1.87 ENSRNOT00000071877
ENSRNOT00000040985
ENSRNOT00000074889
Mpa2l
macrophage activation 2 like
chr17_+_6786348 1.83 ENSRNOT00000083408
Gkap1
G kinase anchoring protein 1
chr1_+_15180328 1.81 ENSRNOT00000050656
Il20ra
interleukin 20 receptor subunit alpha
chr4_+_129574264 1.79 ENSRNOT00000010185
Arl6ip5
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr6_+_52265930 1.60 ENSRNOT00000087513
ENSRNOT00000067849
Sypl1
synaptophysin-like 1
chr5_-_77749613 1.55 ENSRNOT00000075988
Mup5
major urinary protein 5
chr14_+_42401706 1.53 ENSRNOT00000090148
Bend4
BEN domain containing 4
chr13_-_95250235 1.51 ENSRNOT00000085648
Akt3
AKT serine/threonine kinase 3
chr6_+_132090218 1.47 ENSRNOT00000083208
Ccnk
cyclin K
chr1_+_93242050 1.46 ENSRNOT00000013741
RGD1562402
similar to 60S ribosomal protein L27a
chr2_+_198797159 1.45 ENSRNOT00000056225
Ankrd35
ankyrin repeat domain 35
chr2_-_188727670 1.42 ENSRNOT00000074920
Lenep
lens epithelial protein
chr20_+_46428124 1.41 ENSRNOT00000000327
Foxo3
forkhead box O3
chr7_+_12146642 1.40 ENSRNOT00000085899
Tcf3
transcription factor 3
chr2_+_155555840 1.38 ENSRNOT00000080951
AABR07010944.1

chr3_-_23297774 1.33 ENSRNOT00000019162
Rpl35
ribosomal protein L35
chr6_+_132090633 1.32 ENSRNOT00000057171
Ccnk
cyclin K
chr6_-_137733026 1.25 ENSRNOT00000019213
Jag2
jagged 2
chr10_+_84214358 1.21 ENSRNOT00000011416
Hoxb1
homeo box B1
chr3_-_8979889 1.20 ENSRNOT00000065128
Crat
carnitine O-acetyltransferase
chrX_+_18998532 1.20 ENSRNOT00000004213
AABR07037343.1

chr18_-_24312950 1.18 ENSRNOT00000051911
LOC686074
similar to 60S ribosomal protein L35
chr3_+_65816569 1.17 ENSRNOT00000079672
Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr15_+_51222954 1.17 ENSRNOT00000064428
ENSRNOT00000088928
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr14_-_105055421 1.15 ENSRNOT00000008274
Lgalsl
galectin-like
chr10_+_87774552 1.12 ENSRNOT00000044342
Krtap9-1
keratin associated protein 9-1
chr7_-_105592804 1.09 ENSRNOT00000006789
Adcy8
adenylate cyclase 8
chr5_+_155649217 1.08 ENSRNOT00000018064
Wnt4
wingless-type MMTV integration site family, member 4
chr7_+_108613739 0.99 ENSRNOT00000007564
Phf20l1
PHD finger protein 20-like 1
chr15_-_28081465 0.98 ENSRNOT00000033739
Rnase6
ribonuclease, RNase A family, 6
chr7_+_5324469 0.91 ENSRNOT00000071164
Olr901
olfactory receptor 901
chr12_-_17186679 0.90 ENSRNOT00000001730
Uncx
UNC homeobox
chr12_+_7464155 0.80 ENSRNOT00000078798
LOC100910196
katanin p60 ATPase-containing subunit A-like 1-like
chr20_-_41209728 0.78 ENSRNOT00000000657
Nt5dc1
5'-nucleotidase domain containing 1
chr13_-_104156454 0.71 ENSRNOT00000031419
AABR07022046.1

chr7_-_3752134 0.63 ENSRNOT00000067319
Olr880
olfactory receptor 880
chr7_+_123531682 0.60 ENSRNOT00000010606
Wbp2nl
WBP2 N-terminal like
chr10_+_11595044 0.57 ENSRNOT00000007079
Crebbp
CREB binding protein
chrX_-_80142902 0.48 ENSRNOT00000071650
Hmgn5
high mobility group nucleosome binding domain 5
chr14_-_81254637 0.46 ENSRNOT00000058166
Htt
huntingtin
chr7_-_11266630 0.45 ENSRNOT00000027926
Cactin
cactin, spliceosome C complex subunit
chr1_+_230030914 0.43 ENSRNOT00000075730
Olr354
olfactory receptor 354
chr17_+_3385851 0.43 ENSRNOT00000061486
Cts8
cathepsin 8
chr14_+_83897117 0.42 ENSRNOT00000026569
Morc2
MORC family CW-type zinc finger 2
chr2_-_118989127 0.27 ENSRNOT00000014871
Gnb4
G protein subunit beta 4
chr9_-_17163170 0.24 ENSRNOT00000025921
Xpo5
exportin 5
chr14_-_84820415 0.21 ENSRNOT00000057501
Mtmr3
myotubularin related protein 3
chr5_-_159371313 0.18 ENSRNOT00000009921
Padi1
peptidyl arginine deiminase 1
chr10_+_36715565 0.14 ENSRNOT00000005048
Clk4
CDC-like kinase 4
chr14_-_1461543 0.12 ENSRNOT00000075656
Crlf2
cytokine receptor-like factor 2
chr1_-_198320075 0.06 ENSRNOT00000081291
Taok2
TAO kinase 2
chr2_+_211337271 0.06 ENSRNOT00000045155
Cox6b1
cytochrome c oxidase subunit 6B1
chr14_+_79261092 0.02 ENSRNOT00000029191
LOC680039
hypothetical protein LOC680039

Network of associatons between targets according to the STRING database.

First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 46.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
5.0 15.1 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
3.6 14.5 GO:0016554 cytidine to uridine editing(GO:0016554)
3.2 13.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.1 6.3 GO:0002585 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
1.6 15.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
1.5 4.4 GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix anchoring at nuclear membrane(GO:0090292)
1.4 5.8 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
1.4 2.8 GO:0060460 left lung morphogenesis(GO:0060460)
1.4 9.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.4 6.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.3 4.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089) response to formaldehyde(GO:1904404)
1.3 19.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
1.2 4.7 GO:2000814 positive regulation of barbed-end actin filament capping(GO:2000814)
1.1 5.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.9 30.2 GO:0030261 chromosome condensation(GO:0030261)
0.8 7.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.7 4.5 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.7 7.7 GO:0014029 neural crest formation(GO:0014029)
0.6 16.3 GO:0001502 cartilage condensation(GO:0001502)
0.6 6.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.5 1.1 GO:0030237 female sex determination(GO:0030237)
0.4 3.0 GO:0071494 cellular response to UV-C(GO:0071494)
0.4 1.2 GO:0021570 rhombomere 4 development(GO:0021570)
0.4 18.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.4 4.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 2.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.4 1.8 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.3 2.8 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.3 47.7 GO:0060048 cardiac muscle contraction(GO:0060048)
0.3 22.8 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.3 2.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 2.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.3 1.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.3 1.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 3.7 GO:0002467 germinal center formation(GO:0002467)
0.2 1.4 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.2 1.4 GO:0002326 B cell lineage commitment(GO:0002326)
0.2 8.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.2 5.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 5.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 1.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 3.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.2 7.2 GO:0048536 spleen development(GO:0048536)
0.2 4.1 GO:0010447 response to acidic pH(GO:0010447)
0.2 3.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 0.5 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 1.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 3.8 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 0.6 GO:0007343 egg activation(GO:0007343)
0.1 1.2 GO:0051014 actin filament severing(GO:0051014)
0.1 1.9 GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.1 0.4 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 0.2 GO:1900368 regulation of RNA interference(GO:1900368)
0.1 2.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 4.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.8 GO:0051013 microtubule severing(GO:0051013)
0.0 4.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.8 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 0.1 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.5 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 2.1 GO:0032094 response to food(GO:0032094)
0.0 1.1 GO:0007616 long-term memory(GO:0007616)
0.0 0.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 3.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.8 GO:0019827 stem cell population maintenance(GO:0019827)
0.0 7.9 GO:0016311 dephosphorylation(GO:0016311)
0.0 3.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 19.8 GO:0061700 GATOR2 complex(GO:0061700)
1.9 13.1 GO:0042825 TAP complex(GO:0042825)
1.4 64.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.9 2.8 GO:0002945 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.9 29.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.8 4.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.8 52.3 GO:0016459 myosin complex(GO:0016459)
0.6 4.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4 1.2 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 31.7 GO:0000786 nucleosome(GO:0000786)
0.3 2.3 GO:0031415 NatA complex(GO:0031415)
0.3 7.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 2.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 7.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 12.9 GO:0043195 terminal bouton(GO:0043195)
0.1 0.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 6.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 6.2 GO:0016605 PML body(GO:0016605)
0.1 6.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 15.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 16.6 GO:0005694 chromosome(GO:0005694)
0.0 7.2 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
3.4 64.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
3.3 19.8 GO:0070728 leucine binding(GO:0070728)
2.6 13.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
2.4 14.5 GO:0004126 cytidine deaminase activity(GO:0004126)
1.8 5.4 GO:0008481 sphinganine kinase activity(GO:0008481)
1.6 6.2 GO:0061665 SUMO ligase activity(GO:0061665)
1.4 4.3 GO:2001070 starch binding(GO:2001070)
0.9 2.8 GO:0070698 type I activin receptor binding(GO:0070698)
0.9 6.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.8 4.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.7 5.8 GO:0071253 connexin binding(GO:0071253)
0.7 4.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.6 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.4 2.0 GO:0005042 netrin receptor activity(GO:0005042)
0.4 1.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 1.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.3 31.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 13.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.3 7.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 10.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 1.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 2.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 3.4 GO:0005521 lamin binding(GO:0005521)
0.2 1.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 2.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 12.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.6 GO:0043426 MRF binding(GO:0043426)
0.1 0.5 GO:0034452 dynactin binding(GO:0034452)
0.1 0.2 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 1.3 GO:0005112 Notch binding(GO:0005112)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 21.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 35.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 6.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 57.6 GO:0003677 DNA binding(GO:0003677)
0.0 4.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.9 GO:0017046 peptide hormone binding(GO:0017046)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 4.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 7.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.1 GO:0005179 hormone activity(GO:0005179)
0.0 1.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.8 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 10.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 15.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 2.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.2 5.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 16.4 PID P53 REGULATION PATHWAY p53 pathway
0.1 22.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.5 PID S1P S1P3 PATHWAY S1P3 pathway
0.1 4.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 1.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.3 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 29.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.5 64.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
1.3 52.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.4 6.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 6.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.3 5.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 2.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 5.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 5.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 4.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 4.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 6.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.0 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation