ISMARA results: Pitx2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pitx2_Otx2

Z-value: 1.22

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Transcription factors associated with Pitx2_Otx2

Gene Symbol	Gene ID	Gene Info
Pitx2 NCBI RGD Ensembl	ENSRNOG00000010681	paired-like homeodomain 2
Otx2 NCBI RGD Ensembl	ENSRNOG00000056186	orthodenticle homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Otx2	rn6_v1_chr15_-_25521393_25521393	0.17	3.0e-03	Click!
Pitx2	rn6_v1_chr2_+_233602732_233602732	0.05	3.4e-01	Click!

Activity profile of Pitx2_Otx2 motif

Sorted Z-values of Pitx2_Otx2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_56591715 Show fit	42.98	ENSRNOT00000041207	Fam71f1 NCBI RGD Ensembl Show fit	family with sequence similarity 71, member F1
chr3_-_3266260 Show fit	39.65	ENSRNOT00000034538	Glt6d1 NCBI RGD Ensembl Show fit	glycosyltransferase 6 domain containing 1
chr7_-_145048283 Show fit	38.82	ENSRNOT00000055275	Gtsf1 NCBI RGD Ensembl Show fit	gametocyte specific factor 1
chr4_-_6062641 Show fit	37.67	ENSRNOT00000074846	Cct8l1 NCBI RGD Ensembl Show fit	chaperonin containing TCP1, subunit 8 (theta)-like 1
chr19_+_14835822 Show fit	37.25	ENSRNOT00000072804	1700007B14Rik NCBI RGD Ensembl Show fit	RIKEN cDNA 1700007B14 gene
chr1_-_88162583 Show fit	30.40	ENSRNOT00000087411	Catsperg NCBI RGD Ensembl Show fit	cation channel sperm associated auxiliary subunit gamma
chrX_+_78991223 Show fit	29.99	ENSRNOT00000031200	Fam46d NCBI RGD Ensembl Show fit	family with sequence similarity 46, member D
chr1_-_85317968 Show fit	29.97	ENSRNOT00000026891	Gmfg NCBI RGD Ensembl Show fit	glia maturation factor, gamma
chr14_+_81858737 Show fit	29.69	ENSRNOT00000029784 ENSRNOT00000058068 ENSRNOT00000058067	Poln NCBI RGD Ensembl Show fit	DNA polymerase nu
chr8_+_115213471 Show fit	29.36	ENSRNOT00000017570	Iqcf5 NCBI RGD Ensembl Show fit	IQ motif containing F5
chr8_-_67232298 Show fit	29.12	ENSRNOT00000049441	Spesp1 NCBI RGD Ensembl Show fit	sperm equatorial segment protein 1
chr3_+_170994038 Show fit	28.77	ENSRNOT00000081823	Spo11 NCBI RGD Ensembl Show fit	SPO11, initiator of meiotic double stranded breaks
chr20_+_30791422 Show fit	28.45	ENSRNOT00000047394 ENSRNOT00000000683	Tbata NCBI RGD Ensembl Show fit	thymus, brain and testes associated
chr5_+_159612762 Show fit	28.39	ENSRNOT00000012147	Spata21 NCBI RGD Ensembl Show fit	spermatogenesis associated 21
chr15_-_40428800 Show fit	27.07	ENSRNOT00000011451	Atp8a2 NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 8A2
chr6_-_47848026 Show fit	26.89	ENSRNOT00000011048 ENSRNOT00000090017	Allc NCBI RGD Ensembl Show fit	allantoicase
chr2_+_127549331 Show fit	26.02	ENSRNOT00000093416	Slc25a31 NCBI RGD Ensembl Show fit	solute carrier family 25 member 31
chr7_+_27620458 Show fit	25.17	ENSRNOT00000059532	RGD1560034 NCBI RGD Ensembl Show fit	similar to FLJ25323 protein
chr5_+_128190708 Show fit	23.85	ENSRNOT00000012492	Orc1 NCBI RGD Ensembl Show fit	origin recognition complex, subunit 1
chr8_+_22947152 Show fit	23.78	ENSRNOT00000016790	Plppr2 NCBI RGD Ensembl Show fit	phospholipid phosphatase related 2
chr18_+_25749098 Show fit	23.47	ENSRNOT00000027771	Camk4 NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase IV
chr3_+_170996193 Show fit	23.05	ENSRNOT00000008959	Spo11 NCBI RGD Ensembl Show fit	SPO11, initiator of meiotic double stranded breaks
chr14_+_8182383 Show fit	22.31	ENSRNOT00000092719	Mapk10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase 10
chr9_+_10760113 Show fit	21.72	ENSRNOT00000073054	Arrdc5 NCBI RGD Ensembl Show fit	arrestin domain containing 5
chr16_+_68633720 Show fit	21.58	ENSRNOT00000081838	LOC100911229 NCBI RGD Ensembl Show fit	sperm motility kinase-like
chr1_-_167005839 Show fit	21.57	ENSRNOT00000027261	Lrrc51 NCBI RGD Ensembl Show fit	leucine rich repeat containing 51
chr4_+_55720010 Show fit	21.33	ENSRNOT00000063987	Fscn3 NCBI RGD Ensembl Show fit	fascin actin-bundling protein 3
chr14_+_33247274 Show fit	21.15	ENSRNOT00000075226	Spink2 NCBI RGD Ensembl Show fit	serine peptidase inhibitor, Kazal type 2
chr4_-_157433467 Show fit	20.88	ENSRNOT00000028965	Lag3 NCBI RGD Ensembl Show fit	lymphocyte activating 3
chr1_+_99447561 Show fit	20.79	ENSRNOT00000070899 ENSRNOT00000073798	Izumo2 NCBI RGD Ensembl Show fit	IZUMO family member 2
chr20_-_3401273 Show fit	20.37	ENSRNOT00000089257 ENSRNOT00000078451 ENSRNOT00000001085	Nrm NCBI RGD Ensembl Show fit	nurim (nuclear envelope membrane protein)
chr11_-_87977368 Show fit	19.89	ENSRNOT00000002546	Tmem191c NCBI RGD Ensembl Show fit	transmembrane protein 191C
chr3_-_153042395 Show fit	19.84	ENSRNOT00000055232	Ndrg3 NCBI RGD Ensembl Show fit	NDRG family member 3
chr2_+_27905535 Show fit	19.81	ENSRNOT00000022120	Fam169a NCBI RGD Ensembl Show fit	family with sequence similarity 169, member A
chr5_-_17061361 Show fit	19.65	ENSRNOT00000089318	Penk NCBI RGD Ensembl Show fit	proenkephalin
chr3_+_177188044 Show fit	19.62	ENSRNOT00000022073	Tcea2 NCBI RGD Ensembl Show fit	transcription elongation factor A2
chr8_+_115193146 Show fit	19.34	ENSRNOT00000056391	Iqcf1 NCBI RGD Ensembl Show fit	IQ motif containing F1
chr17_+_44556039 Show fit	19.04	ENSRNOT00000086540	Prss16 NCBI RGD Ensembl Show fit	protease, serine 16
chr11_-_27971359 Show fit	19.01	ENSRNOT00000085629 ENSRNOT00000051060 ENSRNOT00000042581 ENSRNOT00000050073 ENSRNOT00000081066	Grik1 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor kainate type subunit 1
chr3_+_2438089 Show fit	18.98	ENSRNOT00000013335	Fam166a NCBI RGD Ensembl Show fit	family with sequence similarity 166, member A
chr11_-_1437732 Show fit	18.82	ENSRNOT00000037345	Csnka2ip NCBI RGD Ensembl Show fit	casein kinase 2, alpha prime interacting protein
chr16_+_71242470 Show fit	18.71	ENSRNOT00000030489	Letm2 NCBI RGD Ensembl Show fit	leucine zipper and EF-hand containing transmembrane protein 2
chr13_-_74005486 Show fit	18.56	ENSRNOT00000090173	AABR07021465.1 NCBI RGD Ensembl Show fit
chr5_-_17061837 Show fit	18.40	ENSRNOT00000011892	Penk NCBI RGD Ensembl Show fit	proenkephalin
chr10_-_82374171 Show fit	18.16	ENSRNOT00000032693	Eme1 NCBI RGD Ensembl Show fit	essential meiotic structure-specific endonuclease 1
chr1_+_102924059 Show fit	17.96	ENSRNOT00000078137	AC099150.1 NCBI RGD Ensembl Show fit
chr6_+_95205153 Show fit	17.93	ENSRNOT00000007339	Lrrc9 NCBI RGD Ensembl Show fit	leucine rich repeat containing 9
chr1_-_56982554 Show fit	17.84	ENSRNOT00000047157 ENSRNOT00000078312	Tcte3 NCBI RGD Ensembl Show fit	t-complex-associated testis expressed 3
chr5_-_144345531 Show fit	17.78	ENSRNOT00000014721	Tekt2 NCBI RGD Ensembl Show fit	tektin 2
chr12_+_14021727 Show fit	17.48	ENSRNOT00000060608	Mmd2 NCBI RGD Ensembl Show fit	monocyte to macrophage differentiation-associated 2
chr2_-_196415530 Show fit	17.35	ENSRNOT00000064238	RGD1359334 NCBI RGD Ensembl Show fit	similar to hypothetical protein FLJ20519
chr13_+_109646455 Show fit	17.15	ENSRNOT00000073985	LOC498316 NCBI RGD Ensembl Show fit	hypothetical LOC498316
chr14_-_1505085 Show fit	17.15	ENSRNOT00000090361	LOC102554799 NCBI RGD Ensembl Show fit	uncharacterized LOC102554799
chr6_-_26318568 Show fit	16.99	ENSRNOT00000072707	LOC102556504 NCBI RGD Ensembl Show fit	titin-like
chr10_+_55626741 Show fit	16.94	ENSRNOT00000008492	Aurkb NCBI RGD Ensembl Show fit	aurora kinase B
chr20_-_5927070 Show fit	16.81	ENSRNOT00000059264	Slc26a8 NCBI RGD Ensembl Show fit	solute carrier family 26 member 8
chr20_-_5865775 Show fit	16.64	ENSRNOT00000000612 ENSRNOT00000092641	Srpk1 NCBI RGD Ensembl Show fit	SRSF protein kinase 1
chr11_+_66316606 Show fit	16.48	ENSRNOT00000041715	Stxbp5l NCBI RGD Ensembl Show fit	syntaxin binding protein 5-like
chr3_-_63211842 Show fit	16.44	ENSRNOT00000008371 ENSRNOT00000050355	Pde11a NCBI RGD Ensembl Show fit	phosphodiesterase 11A
chr19_+_24545318 Show fit	16.24	ENSRNOT00000005071	Clgn NCBI RGD Ensembl Show fit	calmegin
chr4_+_124005280 Show fit	15.49	ENSRNOT00000014353	Nr2c2 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 2, group C, member 2
chr2_+_92573004 Show fit	15.28	ENSRNOT00000065774	tGap1 NCBI RGD Ensembl Show fit	GTPase activating protein testicular GAP1
chr19_+_9895121 Show fit	15.28	ENSRNOT00000033953	Prss54 NCBI RGD Ensembl Show fit	protease, serine, 54
chr11_-_88177448 Show fit	15.13	ENSRNOT00000085475	Ypel1 NCBI RGD Ensembl Show fit	yippee-like 1
chr4_-_100783750 Show fit	15.13	ENSRNOT00000078956	Kcmf1 NCBI RGD Ensembl Show fit	potassium channel modulatory factor 1
chr18_-_37096132 Show fit	15.09	ENSRNOT00000041188	Ppp2r2b NCBI RGD Ensembl Show fit	protein phosphatase 2, regulatory subunit B, beta
chr10_-_79097807 Show fit	15.08	ENSRNOT00000003421	Kif2b NCBI RGD Ensembl Show fit	kinesin family member 2B
chr2_+_54660722 Show fit	15.03	ENSRNOT00000060376	Mroh2b NCBI RGD Ensembl Show fit	maestro heat-like repeat family member 2B
chr10_+_54155876 Show fit	15.02	ENSRNOT00000072855	Gas7 NCBI RGD Ensembl Show fit	growth arrest specific 7
chr11_+_87522971 Show fit	14.84	ENSRNOT00000043545	Smpd4 NCBI RGD Ensembl Show fit	sphingomyelin phosphodiesterase 4
chr8_-_127871192 Show fit	14.83	ENSRNOT00000055928	Slc22a14 NCBI RGD Ensembl Show fit	solute carrier family 22, member 14
chr1_-_98490315 Show fit	14.71	ENSRNOT00000056490	Cldnd2 NCBI RGD Ensembl Show fit	claudin domain containing 2
chr4_+_123801174 Show fit	14.71	ENSRNOT00000029055	RGD1560289 NCBI RGD Ensembl Show fit	similar to chromosome 3 open reading frame 20
chr12_+_24158766 Show fit	14.66	ENSRNOT00000001963	Ccl26 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 26
chr4_-_156945126 Show fit	14.42	ENSRNOT00000064853	RGD1307916 NCBI RGD Ensembl Show fit	LOC362433
chr20_-_44220702 Show fit	14.24	ENSRNOT00000036853	Fam229b NCBI RGD Ensembl Show fit	family with sequence similarity 229, member B
chr9_+_24095751 Show fit	14.15	ENSRNOT00000018177	Pgk2 NCBI RGD Ensembl Show fit	phosphoglycerate kinase 2
chr2_+_127625683 Show fit	14.10	ENSRNOT00000015474	Hspa4l NCBI RGD Ensembl Show fit	heat shock protein 4-like
chr10_+_65454658 Show fit	13.94	ENSRNOT00000037048	Proca1 NCBI RGD Ensembl Show fit	protein interacting with cyclin A1
chr2_+_123790915 Show fit	13.93	ENSRNOT00000023282	Adad1 NCBI RGD Ensembl Show fit	adenosine deaminase domain containing 1
chr16_-_47163898 Show fit	13.89	ENSRNOT00000074490	Ccdc110 NCBI RGD Ensembl Show fit	coiled-coil domain containing 110
chr10_-_12469110 Show fit	13.86	ENSRNOT00000060991	AC129054.1 NCBI RGD Ensembl Show fit	olfactory receptor Olr1366
chr1_+_277641512 Show fit	13.70	ENSRNOT00000084861 ENSRNOT00000023024	Tdrd1 NCBI RGD Ensembl Show fit	tudor domain containing 1
chr15_-_24199341 Show fit	13.55	ENSRNOT00000015553	Dlgap5 NCBI RGD Ensembl Show fit	DLG associated protein 5
chr13_-_71276497 Show fit	13.45	ENSRNOT00000029773	Rgsl1 NCBI RGD Ensembl Show fit	regulator of G-protein signaling like 1
chr5_-_135472116 Show fit	13.45	ENSRNOT00000022170	Nasp NCBI RGD Ensembl Show fit	nuclear autoantigenic sperm protein
chr1_-_197568165 Show fit	13.43	ENSRNOT00000079044	Xpo6 NCBI RGD Ensembl Show fit	exportin 6
chr3_+_143151739 Show fit	13.43	ENSRNOT00000006850	Cst13 NCBI RGD Ensembl Show fit	cystatin 13
chr19_-_37528011 Show fit	13.41	ENSRNOT00000059628	Agrp NCBI RGD Ensembl Show fit	agouti related neuropeptide
chr16_+_52169450 Show fit	13.36	ENSRNOT00000019474	Triml1 NCBI RGD Ensembl Show fit	tripartite motif family-like 1
chr5_+_151413382 Show fit	13.34	ENSRNOT00000012626	Cd164l2 NCBI RGD Ensembl Show fit	CD164 molecule like 2
chr18_+_63098144 Show fit	13.31	ENSRNOT00000024968	Cidea NCBI RGD Ensembl Show fit	cell death-inducing DFFA-like effector a
chr1_+_129613497 Show fit	13.25	ENSRNOT00000074410	LOC102551255 NCBI RGD Ensembl Show fit	tetraspanin-7-like
chr9_+_10004805 Show fit	13.25	ENSRNOT00000074117	Slc25a41 NCBI RGD Ensembl Show fit	solute carrier family 25, member 41
chrX_-_105793306 Show fit	13.18	ENSRNOT00000015806	Nxf2 NCBI RGD Ensembl Show fit	nuclear RNA export factor 2
chr2_-_200762492 Show fit	13.17	ENSRNOT00000056172	Hsd3b2 NCBI RGD Ensembl Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr15_+_52148379 Show fit	13.13	ENSRNOT00000074912	Phyhip NCBI RGD Ensembl Show fit	phytanoyl-CoA 2-hydroxylase interacting protein
chr17_+_59697875 Show fit	13.07	ENSRNOT00000077324	RGD1560860 NCBI RGD Ensembl Show fit	similar to ankyrin repeat domain 26
chr1_-_100205147 Show fit	13.07	ENSRNOT00000046737	AABR07003250.1 NCBI RGD Ensembl Show fit
chr1_+_53531076 Show fit	13.01	ENSRNOT00000018015	Tcp10b NCBI RGD Ensembl Show fit	t-complex protein 10b
chr14_+_94776233 Show fit	12.98	ENSRNOT00000070839	AABR07016166.1 NCBI RGD Ensembl Show fit
chr20_-_6195463 Show fit	12.96	ENSRNOT00000092474	Pxt1 NCBI RGD Ensembl Show fit	peroxisomal, testis specific 1
chr15_+_47455690 Show fit	12.92	ENSRNOT00000075276	LOC100910401 NCBI RGD Ensembl Show fit	serine protease 55-like
chr4_-_174180729 Show fit	12.89	ENSRNOT00000011376	Plcz1 NCBI RGD Ensembl Show fit	phospholipase C, zeta 1
chr1_-_89132959 Show fit	12.87	ENSRNOT00000070888	Pmis2 NCBI RGD Ensembl Show fit	Pmis2, sperm specific protein
chr5_+_58937615 Show fit	12.85	ENSRNOT00000080909	Tesk1 NCBI RGD Ensembl Show fit	testis-specific kinase 1
chr17_-_78812111 Show fit	12.75	ENSRNOT00000021506	Dclre1c NCBI RGD Ensembl Show fit	DNA cross-link repair 1C
chr16_+_12955826 Show fit	12.64	ENSRNOT00000060751	4930596D02Rik NCBI RGD Ensembl Show fit	RIKEN cDNA 4930596D02 gene
chr14_+_33906821 Show fit	12.62	ENSRNOT00000051031	LOC100910138 NCBI RGD Ensembl Show fit	serine protease inhibitor Kazal-type 2-like
chr16_+_66230841 Show fit	12.61	ENSRNOT00000050464	LOC689479 NCBI RGD Ensembl Show fit	similar to Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg)
chr1_-_64350338 Show fit	12.54	ENSRNOT00000078444	Cacng8 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit gamma 8
chr1_+_100708693 Show fit	12.48	ENSRNOT00000071054 ENSRNOT00000071503	LOC100911976 NCBI RGD Ensembl Show fit	izumo sperm-egg fusion protein 2-like
chr3_+_170475831 Show fit	12.46	ENSRNOT00000006949	Fam209a NCBI RGD Ensembl Show fit	family with sequence similarity 209, member A
chr2_+_30666475 Show fit	12.46	ENSRNOT00000076061	Taf9 NCBI RGD Ensembl Show fit	TATA-box binding protein associated factor 9
chrX_+_74497262 Show fit	12.45	ENSRNOT00000003899	Zcchc13 NCBI RGD Ensembl Show fit	zinc finger CCHC-type containing 13
chr12_+_37709860 Show fit	12.44	ENSRNOT00000086244	Mphosph9 NCBI RGD Ensembl Show fit	M-phase phosphoprotein 9
chr1_+_101161252 Show fit	12.38	ENSRNOT00000028064 ENSRNOT00000064184	Slc17a7 NCBI RGD Ensembl Show fit	solute carrier family 17 member 7
chr19_-_33424955 Show fit	12.37	ENSRNOT00000016558 ENSRNOT00000089569	Ttc29 NCBI RGD Ensembl Show fit	tetratricopeptide repeat domain 29
chr12_+_37603986 Show fit	12.32	ENSRNOT00000088006	Sbno1 NCBI RGD Ensembl Show fit	strawberry notch homolog 1
chr1_-_279945557 Show fit	12.29	ENSRNOT00000039453	LOC681006 NCBI RGD Ensembl Show fit	hypothetical protein LOC681006
chr4_+_179905116 Show fit	12.26	ENSRNOT00000052352	Tuba3a NCBI RGD Ensembl Show fit	tubulin, alpha 3A
chr10_-_40489808 Show fit	12.21	ENSRNOT00000037274	Slc36a3 NCBI RGD Ensembl Show fit	solute carrier family 36, member 3
chr10_-_86930947 Show fit	12.18	ENSRNOT00000081440	Top2a NCBI RGD Ensembl Show fit	topoisomerase (DNA) II alpha
chr9_+_14951047 Show fit	12.16	ENSRNOT00000074267	LOC100911489 NCBI RGD Ensembl Show fit	uncharacterized LOC100911489
chr1_+_205911552 Show fit	12.13	ENSRNOT00000024751	Fank1 NCBI RGD Ensembl Show fit	fibronectin type 3 and ankyrin repeat domains 1
chr19_-_57192095 Show fit	12.11	ENSRNOT00000058080	Pgbd5 NCBI RGD Ensembl Show fit	piggyBac transposable element derived 5
chr19_+_10024947 Show fit	12.10	ENSRNOT00000061392	Cfap20 NCBI RGD Ensembl Show fit	cilia and flagella associated protein 20
chrX_-_73562046 Show fit	12.07	ENSRNOT00000080501	Gm14597 NCBI RGD Ensembl Show fit	predicted gene 14597
chr1_+_99532568 Show fit	12.03	ENSRNOT00000077073	Zfp819 NCBI RGD Ensembl Show fit	zinc finger protein 819
chr7_-_74901997 Show fit	11.98	ENSRNOT00000039378	Rgs22 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 22
chr10_-_10807079 Show fit	11.95	ENSRNOT00000087029	LOC360479 NCBI RGD Ensembl Show fit	similar to hypothetical protein
chr7_-_19088972 Show fit	11.94	ENSRNOT00000049266	Vom2r57 NCBI RGD Ensembl Show fit	vomeronasal 2 receptor, 57
chr3_+_143172686 Show fit	11.94	ENSRNOT00000006869	Cst9l NCBI RGD Ensembl Show fit	cystatin 9-like
chr8_-_13909061 Show fit	11.88	ENSRNOT00000078372 ENSRNOT00000083011	Cep295 NCBI RGD Ensembl Show fit	centrosomal protein 295
chr1_-_54854353 Show fit	11.81	ENSRNOT00000072895	Smok2a NCBI RGD Ensembl Show fit	sperm motility kinase 2A
chr3_+_143084563 Show fit	11.77	ENSRNOT00000006362	Cstl1 NCBI RGD Ensembl Show fit	cystatin-like 1
chr12_+_12756452 Show fit	11.75	ENSRNOT00000001382 ENSRNOT00000092462	Ankrd61 NCBI RGD Ensembl Show fit	ankyrin repeat domain 61
chr4_-_157304653 Show fit	11.74	ENSRNOT00000051613	Lrrc23 NCBI RGD Ensembl Show fit	leucine rich repeat containing 23
chr10_-_56506446 Show fit	11.68	ENSRNOT00000021357	Acap1 NCBI RGD Ensembl Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr2_+_92574038 Show fit	11.64	ENSRNOT00000089422	tGap1 NCBI RGD Ensembl Show fit	GTPase activating protein testicular GAP1
chr10_-_55515885 Show fit	11.64	ENSRNOT00000005667	Odf4 NCBI RGD Ensembl Show fit	outer dense fiber of sperm tails 4
chr10_+_70242874 Show fit	11.56	ENSRNOT00000010924	Fndc8 NCBI RGD Ensembl Show fit	fibronectin type III domain containing 8
chr9_+_16529579 Show fit	11.54	ENSRNOT00000067894	Ptcra NCBI RGD Ensembl Show fit	pre T-cell antigen receptor alpha
chr6_+_72092194 Show fit	11.43	ENSRNOT00000005670	G2e3 NCBI RGD Ensembl Show fit	G2/M-phase specific E3 ubiquitin protein ligase
chr9_+_16530074 Show fit	11.43	ENSRNOT00000091565	Ptcra NCBI RGD Ensembl Show fit	pre T-cell antigen receptor alpha
chr10_-_97750679 Show fit	11.43	ENSRNOT00000078059	Slc16a6 NCBI RGD Ensembl Show fit	solute carrier family 16, member 6
chr3_-_153321352 Show fit	11.33	ENSRNOT00000064824	Rbl1 NCBI RGD Ensembl Show fit	RB transcriptional corepressor like 1
chr1_+_162890475 Show fit	11.26	ENSRNOT00000034886	Gdpd4 NCBI RGD Ensembl Show fit	glycerophosphodiester phosphodiesterase domain containing 4
chr2_-_144323254 Show fit	11.23	ENSRNOT00000018780	Sertm1 NCBI RGD Ensembl Show fit	serine-rich and transmembrane domain containing 1
chr1_-_88723973 Show fit	11.19	ENSRNOT00000082555	NEWGENE_1306714 NCBI RGD Ensembl Show fit	WD repeat domain 62-like 1
chr4_+_57204944 Show fit	11.11	ENSRNOT00000085027	Strip2 NCBI RGD Ensembl Show fit	striatin interacting protein 2
chr2_+_92549479 Show fit	11.04	ENSRNOT00000082912	tGap1 NCBI RGD Ensembl Show fit	GTPase activating protein testicular GAP1
chr1_+_81683463 Show fit	11.03	ENSRNOT00000057600 ENSRNOT00000034553	Ceacam6 NCBI RGD Ensembl Show fit	carcinoembryonic antigen-related cell adhesion molecule 6
chr1_+_100832324 Show fit	11.02	ENSRNOT00000056364	Il4i1 NCBI RGD Ensembl Show fit	interleukin 4 induced 1
chr1_+_82169620 Show fit	11.02	ENSRNOT00000088955 ENSRNOT00000068251	Prr19 NCBI RGD Ensembl Show fit	proline rich 19
chr13_+_95887708 Show fit	11.01	ENSRNOT00000029081	LOC689766 NCBI RGD Ensembl Show fit	hypothetical protein LOC689766
chr1_+_253221812 Show fit	10.97	ENSRNOT00000085880 ENSRNOT00000054753	Kif20b NCBI RGD Ensembl Show fit	kinesin family member 20B
chr9_+_88964525 Show fit	10.95	ENSRNOT00000068236	Daw1 NCBI RGD Ensembl Show fit	dynein assembly factor with WD repeats 1
chr2_+_240527130 Show fit	10.94	ENSRNOT00000031348	Slc9b1 NCBI RGD Ensembl Show fit	solute carrier family 9 member B1
chr15_-_29548400 Show fit	10.91	ENSRNOT00000078176	AABR07017639.2 NCBI RGD Ensembl Show fit
chr2_-_220101791 Show fit	10.90	ENSRNOT00000022905	Plppr5 NCBI RGD Ensembl Show fit	phospholipid phosphatase related 5
chr7_-_129947991 Show fit	10.89	ENSRNOT00000064326	AABR07058658.1 NCBI RGD Ensembl Show fit
chr3_+_122928964 Show fit	10.86	ENSRNOT00000074724	LOC100365450 NCBI RGD Ensembl Show fit	rCG26795-like
chr8_-_111116014 Show fit	10.79	ENSRNOT00000056531	Cep63 NCBI RGD Ensembl Show fit	centrosomal protein 63
chr2_+_189454340 Show fit	10.78	ENSRNOT00000087063	Nup210l NCBI RGD Ensembl Show fit	nucleoporin 210-like
chr12_+_45319501 Show fit	10.73	ENSRNOT00000090630 ENSRNOT00000041732	RGD1561114 NCBI RGD Ensembl Show fit	similar to hypothetical protein 4930474N05
chr13_-_51955735 Show fit	10.71	ENSRNOT00000007597	Ptprv NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, V
chr3_-_123171875 Show fit	10.67	ENSRNOT00000028834	Ubox5 NCBI RGD Ensembl Show fit	U-box domain containing 5
chr6_+_43644830 Show fit	10.66	ENSRNOT00000086798	Taf1b NCBI RGD Ensembl Show fit	TATA-box binding protein associated factor, RNA polymerase I subunit B
chr3_-_9636058 Show fit	10.60	ENSRNOT00000024953	RGD1311084 NCBI RGD Ensembl Show fit	similar to 1700113K14Rik protein
chr9_+_20241062 Show fit	10.58	ENSRNOT00000071593	LOC100911585 NCBI RGD Ensembl Show fit	leucine-rich repeat-containing protein 23-like
chr2_+_197682000 Show fit	10.57	ENSRNOT00000066821	Hormad1 NCBI RGD Ensembl Show fit	HORMA domain containing 1
chr14_+_17534412 Show fit	10.55	ENSRNOT00000079304 ENSRNOT00000046771	Cdkl2 NCBI RGD Ensembl Show fit	cyclin dependent kinase like 2
chr4_+_61420009 Show fit	10.52	ENSRNOT00000082175 ENSRNOT00000011692	Lrguk NCBI RGD Ensembl Show fit	leucine-rich repeats and guanylate kinase domain containing
chr5_-_171327450 Show fit	10.52	ENSRNOT00000088710	Ccdc27 NCBI RGD Ensembl Show fit	coiled-coil domain containing 27
chr17_+_81798756 Show fit	10.52	ENSRNOT00000066826	Cacnb2 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit beta 2
chr6_+_22296128 Show fit	10.49	ENSRNOT00000087805	Dpy30 NCBI RGD Ensembl Show fit	dpy-30 histone methyltransferase complex regulatory subunit
chr1_+_219390523 Show fit	10.47	ENSRNOT00000054852	Gpr152 NCBI RGD Ensembl Show fit	G protein-coupled receptor 152
chr17_+_5311274 Show fit	10.44	ENSRNOT00000067020	LOC102547665 NCBI RGD Ensembl Show fit	spermatogenesis-associated protein 31D1-like
chr2_-_228665279 Show fit	10.42	ENSRNOT00000055648	RGD1306519 NCBI RGD Ensembl Show fit	similar to T-cell activation Rho GTPase-activating protein isoform b
chr2_-_265300868 Show fit	10.39	ENSRNOT00000066024 ENSRNOT00000016073 ENSRNOT00000033502	Lrrc7 NCBI RGD Ensembl Show fit	leucine rich repeat containing 7
chr3_+_148837814 Show fit	10.36	ENSRNOT00000091808	Asxl1 NCBI RGD Ensembl Show fit	additional sex combs like 1
chr8_+_23398030 Show fit	10.34	ENSRNOT00000031893	RGD1561444 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 9530077C05
chr10_-_55560422 Show fit	10.31	ENSRNOT00000006883	Rangrf NCBI RGD Ensembl Show fit	RAN guanine nucleotide release factor
chr10_-_12916784 Show fit	10.30	ENSRNOT00000004589	Zfp13 NCBI RGD Ensembl Show fit	zinc finger protein 13
chr1_-_81144024 Show fit	10.30	ENSRNOT00000088431	Zfp94 NCBI RGD Ensembl Show fit	zinc finger protein 94
chr1_+_101603222 Show fit	10.29	ENSRNOT00000033278	Izumo1 NCBI RGD Ensembl Show fit	izumo sperm-egg fusion 1
chr16_-_49453394 Show fit	10.27	ENSRNOT00000041617	Lrp2bp NCBI RGD Ensembl Show fit	Lrp2 binding protein
chr3_+_21555341 Show fit	10.23	ENSRNOT00000030332	AABR07051793.1 NCBI RGD Ensembl Show fit
chr10_+_57239993 Show fit	10.23	ENSRNOT00000067919	LOC687707 NCBI RGD Ensembl Show fit	hypothetical protein LOC687707
chr2_+_231884337 Show fit	10.22	ENSRNOT00000014695	Zgrf1 NCBI RGD Ensembl Show fit	zinc finger, GRF-type containing 1
chr1_-_66212418 Show fit	10.21	ENSRNOT00000026074	LOC691722 NCBI RGD Ensembl Show fit	hypothetical protein LOC691722
chr16_+_66230011 Show fit	10.21	ENSRNOT00000074550	LOC689479 NCBI RGD Ensembl Show fit	similar to Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg)
chr1_+_199019289 Show fit	10.20	ENSRNOT00000087142	Phkg2 NCBI RGD Ensembl Show fit	phosphorylase kinase catalytic subunit gamma 2
chr10_-_82492918 Show fit	10.20	ENSRNOT00000066895	LOC100364194 NCBI RGD Ensembl Show fit	transmembrane protein 92-like
chr5_+_8916633 Show fit	10.15	ENSRNOT00000066395	Ppp1r42 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 42
chr12_-_24365324 Show fit	10.06	ENSRNOT00000032250	Trim50 NCBI RGD Ensembl Show fit	tripartite motif-containing 50
chr3_+_161290391 Show fit	10.01	ENSRNOT00000021070	Zswim1 NCBI RGD Ensembl Show fit	zinc finger, SWIM-type containing 1
chr3_+_163552166 Show fit	10.01	ENSRNOT00000049082	Tp53rk NCBI RGD Ensembl Show fit	TP53 regulating kinase
chr10_+_62981297 Show fit	9.98	ENSRNOT00000031618	Efcab5 NCBI RGD Ensembl Show fit	EF-hand calcium binding domain 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx2_Otx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
12.7	38.0	GO:0051867	general adaptation syndrome, behavioral process(GO:0051867)
11.4	57.0	GO:1990918	double-strand break repair involved in meiotic recombination(GO:1990918)
9.0	27.1	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
9.0	26.9	GO:0043605	cellular amide catabolic process(GO:0043605)
7.0	35.2	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
5.3	21.2	GO:1904158	axonemal central apparatus assembly(GO:1904158)
4.8	19.3	GO:0060474	positive regulation of sperm motility involved in capacitation(GO:0060474)
4.8	23.9	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
4.5	18.2	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
4.4	13.2	GO:0021817	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix anchoring at nuclear membrane(GO:0090292)
4.2	16.9	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
3.7	11.0	GO:1902412	regulation of mitotic cytokinesis(GO:1902412)
3.6	18.2	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
3.6	39.7	GO:0030259	lipid glycosylation(GO:0030259)
3.6	28.7	GO:0051026	chiasma assembly(GO:0051026)
3.5	10.5	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
3.5	10.4	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
3.4	10.2	GO:0060468	prevention of polyspermy(GO:0060468)
3.2	9.7	GO:0032258	CVT pathway(GO:0032258)
3.2	9.6	GO:0006788	heme oxidation(GO:0006788)
3.2	25.5	GO:2000253	positive regulation of feeding behavior(GO:2000253)
3.1	12.4	GO:0097401	synaptic vesicle lumen acidification(GO:0097401)
3.0	39.4	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
2.9	8.8	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
2.9	8.7	GO:0060332	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
2.8	14.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
2.7	8.0	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
2.7	10.7	GO:0001180	transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
2.6	40.9	GO:0036297	interstrand cross-link repair(GO:0036297)
2.5	7.6	GO:0006529	asparagine biosynthetic process(GO:0006529)
2.4	7.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
2.3	9.4	GO:0051643	endoplasmic reticulum localization(GO:0051643)
2.3	6.9	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
2.3	6.9	GO:0014739	positive regulation of muscle hyperplasia(GO:0014739)
2.2	13.2	GO:0034757	negative regulation of iron ion transport(GO:0034757)
2.2	8.7	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
2.2	8.7	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
2.2	8.7	GO:0046462	monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
2.1	12.9	GO:0007343	egg activation(GO:0007343)
2.1	6.4	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
2.1	8.5	GO:0002125	maternal aggressive behavior(GO:0002125)
2.1	6.3	GO:0043366	beta selection(GO:0043366)
2.1	14.6	GO:0000492	box C/D snoRNP assembly(GO:0000492)
2.1	23.0	GO:0070244	negative regulation of thymocyte apoptotic process(GO:0070244)
2.1	33.4	GO:0035404	histone-serine phosphorylation(GO:0035404)
2.0	14.2	GO:0006685	sphingomyelin catabolic process(GO:0006685)
2.0	12.2	GO:0030263	apoptotic chromosome condensation(GO:0030263) single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
2.0	21.9	GO:0007258	JUN phosphorylation(GO:0007258)
1.9	5.8	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.9	7.7	GO:0002101	tRNA wobble cytosine modification(GO:0002101)
1.9	13.5	GO:0046959	habituation(GO:0046959)
1.9	11.3	GO:0061590	calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
1.8	7.2	GO:0034421	post-translational protein acetylation(GO:0034421)
1.8	21.1	GO:0002176	male germ cell proliferation(GO:0002176)
1.7	5.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
1.7	13.7	GO:0015808	L-alanine transport(GO:0015808)
1.7	8.5	GO:0072344	rescue of stalled ribosome(GO:0072344)
1.7	1.7	GO:1904815	negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
1.7	5.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
1.6	9.7	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
1.6	3.2	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
1.6	4.8	GO:0071224	cellular response to peptidoglycan(GO:0071224)
1.6	4.7	GO:0098971	anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
1.6	4.7	GO:0032289	central nervous system myelin formation(GO:0032289)
1.6	6.2	GO:0072092	ureteric bud invasion(GO:0072092)
1.5	10.8	GO:0098535	de novo centriole assembly(GO:0098535)
1.5	22.2	GO:0060294	cilium movement involved in cell motility(GO:0060294)
1.5	8.8	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.5	8.7	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.4	14.5	GO:0002371	dendritic cell cytokine production(GO:0002371)
1.4	2.8	GO:1990164	histone H2A phosphorylation(GO:1990164)
1.4	4.3	GO:0060392	negative regulation of SMAD protein import into nucleus(GO:0060392)
1.4	12.6	GO:0015866	ADP transport(GO:0015866)
1.4	9.8	GO:0070535	histone H2A K63-linked ubiquitination(GO:0070535)
1.4	5.6	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.4	8.3	GO:1904528	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
1.4	20.7	GO:0048733	sebaceous gland development(GO:0048733)
1.4	4.1	GO:0015692	nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444)
1.3	22.7	GO:0034587	piRNA metabolic process(GO:0034587)
1.3	2.7	GO:0002215	defense response to nematode(GO:0002215)
1.3	9.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.3	6.3	GO:0046600	negative regulation of centriole replication(GO:0046600)
1.3	16.4	GO:0046069	cGMP catabolic process(GO:0046069)
1.2	5.9	GO:0075525	viral translational termination-reinitiation(GO:0075525)
1.2	3.5	GO:0021997	neural plate axis specification(GO:0021997)
1.2	3.5	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
1.1	10.3	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
1.1	10.3	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
1.1	3.4	GO:0090172	microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
1.1	4.5	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
1.1	32.0	GO:0048266	behavioral response to pain(GO:0048266)
1.1	3.3	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.1	41.2	GO:0006458	'de novo' protein folding(GO:0006458)
1.1	3.2	GO:0070084	protein initiator methionine removal(GO:0070084)
1.1	5.3	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.1	5.3	GO:0032918	polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
1.0	10.5	GO:0006348	chromatin silencing at telomere(GO:0006348)
1.0	7.3	GO:1904798	positive regulation of core promoter binding(GO:1904798)
1.0	3.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
1.0	4.0	GO:0060620	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
1.0	15.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
1.0	16.9	GO:1902358	oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
1.0	2.0	GO:0046958	nonassociative learning(GO:0046958)
1.0	3.9	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
0.9	2.8	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.9	4.6	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.9	2.8	GO:0030186	melatonin metabolic process(GO:0030186)
0.9	7.4	GO:0070842	aggresome assembly(GO:0070842)
0.9	13.7	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.9	7.3	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.9	4.5	GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.9	10.8	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.9	4.4	GO:0019563	glycerol catabolic process(GO:0019563)
0.9	7.9	GO:2000676	positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.9	6.1	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.9	2.6	GO:0046061	dATP catabolic process(GO:0046061)
0.8	2.5	GO:0002644	negative regulation of tolerance induction(GO:0002644)
0.8	13.4	GO:0043486	histone exchange(GO:0043486)
0.8	7.5	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.8	3.2	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.8	2.4	GO:1900673	olefin metabolic process(GO:1900673)
0.8	15.2	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.8	5.6	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.8	9.4	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.8	7.0	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.8	3.1	GO:0050955	thermoception(GO:0050955)
0.8	1.5	GO:0035600	tRNA methylthiolation(GO:0035600)
0.8	2.3	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.8	3.8	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.7	15.0	GO:0060046	regulation of acrosome reaction(GO:0060046)
0.7	3.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.7	1.5	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.7	2.2	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.7	4.4	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.7	2.9	GO:0071763	nuclear membrane organization(GO:0071763)
0.7	5.8	GO:2000381	negative regulation of mesoderm development(GO:2000381)
0.7	7.8	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.7	3.5	GO:1902416	positive regulation of mRNA binding(GO:1902416)
0.7	2.8	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.7	2.8	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.7	3.4	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.7	6.9	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.7	4.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.7	6.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.7	2.0	GO:0071049	nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.7	2.0	GO:0044726	protection of DNA demethylation of female pronucleus(GO:0044726)
0.7	5.9	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.7	2.0	GO:0018343	protein farnesylation(GO:0018343)
0.6	7.7	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.6	0.6	GO:0046671	negative regulation of retinal cell programmed cell death(GO:0046671)
0.6	3.8	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.6	1.9	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.6	3.2	GO:0009838	abscission(GO:0009838)
0.6	13.9	GO:0048520	positive regulation of behavior(GO:0048520)
0.6	16.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.6	3.7	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.6	12.8	GO:0006089	lactate metabolic process(GO:0006089)
0.6	1.2	GO:0010265	SCF complex assembly(GO:0010265)
0.6	3.7	GO:0031120	snRNA pseudouridine synthesis(GO:0031120)
0.6	7.9	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6	4.2	GO:0003356	regulation of cilium beat frequency(GO:0003356)
0.6	3.0	GO:1903059	regulation of protein lipidation(GO:1903059)
0.6	3.6	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.6	3.0	GO:0008215	spermine metabolic process(GO:0008215)
0.6	12.5	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6	2.4	GO:0006272	leading strand elongation(GO:0006272)
0.6	2.4	GO:0018992	germ-line sex determination(GO:0018992)
0.6	4.2	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.6	3.5	GO:0070914	UV-damage excision repair(GO:0070914)
0.6	1.8	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.6	6.5	GO:0034389	lipid particle organization(GO:0034389)
0.6	2.3	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.6	8.5	GO:0048642	negative regulation of skeletal muscle tissue development(GO:0048642)
0.6	5.6	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.6	4.5	GO:0010649	regulation of cell communication by electrical coupling(GO:0010649)
0.6	12.9	GO:0006298	mismatch repair(GO:0006298)
0.6	3.9	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.6	9.4	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.6	6.6	GO:0006108	malate metabolic process(GO:0006108)
0.5	2.2	GO:0072139	glomerular parietal epithelial cell differentiation(GO:0072139)
0.5	3.3	GO:2001271	regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.5	4.9	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.5	3.2	GO:0002943	tRNA dihydrouridine synthesis(GO:0002943)
0.5	4.3	GO:0042748	circadian sleep/wake cycle, non-REM sleep(GO:0042748)
0.5	27.8	GO:0006405	RNA export from nucleus(GO:0006405)
0.5	2.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.5	8.9	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.5	9.4	GO:0010818	T cell chemotaxis(GO:0010818)
0.5	2.6	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.5	7.8	GO:0006020	inositol metabolic process(GO:0006020)
0.5	3.6	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.5	1.5	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.5	1.5	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.5	8.6	GO:0048853	forebrain morphogenesis(GO:0048853)
0.5	3.0	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.5	4.5	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.5	4.5	GO:0060213	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.5	6.3	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.5	8.7	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.5	7.8	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.5	1.4	GO:0021558	trochlear nerve development(GO:0021558)
0.5	6.7	GO:0046473	phosphatidic acid metabolic process(GO:0046473)
0.5	1.9	GO:0030221	basophil differentiation(GO:0030221)
0.5	7.6	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.5	3.8	GO:0046015	regulation of transcription by glucose(GO:0046015)
0.5	2.8	GO:0099526	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.5	11.8	GO:0060009	Sertoli cell development(GO:0060009)
0.5	4.6	GO:0045059	positive thymic T cell selection(GO:0045059)
0.4	3.1	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.4	2.2	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.4	5.7	GO:0060736	prostate gland growth(GO:0060736)
0.4	10.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.4	4.8	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.4	3.0	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.4	2.6	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.4	1.7	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.4	2.1	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) response to amino acid starvation(GO:1990928)
0.4	11.0	GO:0070528	protein kinase C signaling(GO:0070528)
0.4	1.3	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.4	1.2	GO:0097116	postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4	4.6	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.4	2.1	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4	1.2	GO:0009177	pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.4	2.8	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.4	2.8	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.4	0.4	GO:0014900	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4	15.0	GO:0010737	protein kinase A signaling(GO:0010737)
0.4	6.3	GO:0009437	carnitine metabolic process(GO:0009437)
0.4	2.0	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.4	4.7	GO:0003351	epithelial cilium movement(GO:0003351)
0.4	1.9	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.4	3.9	GO:0000338	protein deneddylation(GO:0000338)
0.4	8.5	GO:0045616	regulation of keratinocyte differentiation(GO:0045616)
0.4	0.4	GO:1900112	regulation of histone H3-K9 trimethylation(GO:1900112)
0.4	4.8	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.4	2.6	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.4	1.1	GO:0046099	guanine salvage(GO:0006178) GMP catabolic process(GO:0046038) guanine biosynthetic process(GO:0046099)
0.4	4.6	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.4	1.4	GO:2000293	regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.3	1.4	GO:2000354	regulation of ovarian follicle development(GO:2000354)
0.3	4.5	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.3	144.9	GO:0007283	spermatogenesis(GO:0007283)
0.3	21.2	GO:0007019	microtubule depolymerization(GO:0007019)
0.3	11.9	GO:0019730	antimicrobial humoral response(GO:0019730)
0.3	2.4	GO:0010587	miRNA catabolic process(GO:0010587)
0.3	1.0	GO:1902606	regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.3	1.0	GO:1990910	response to hypobaric hypoxia(GO:1990910)
0.3	19.9	GO:0030317	sperm motility(GO:0030317)
0.3	5.3	GO:0050832	defense response to fungus(GO:0050832)
0.3	4.6	GO:0045760	positive regulation of action potential(GO:0045760)
0.3	1.3	GO:0071955	recycling endosome to Golgi transport(GO:0071955)
0.3	4.2	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.3	7.4	GO:0045116	protein neddylation(GO:0045116)
0.3	1.9	GO:0030321	transepithelial chloride transport(GO:0030321)
0.3	2.2	GO:0034472	snRNA 3'-end processing(GO:0034472)
0.3	2.8	GO:1902224	ketone body metabolic process(GO:1902224)
0.3	3.7	GO:1902259	regulation of delayed rectifier potassium channel activity(GO:1902259)
0.3	2.7	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.3	1.5	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.3	5.3	GO:0008053	mitochondrial fusion(GO:0008053)
0.3	2.1	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.3	8.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3	0.8	GO:1903576	response to L-arginine(GO:1903576)
0.3	5.8	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.3	13.7	GO:0031023	microtubule organizing center organization(GO:0031023)
0.3	45.2	GO:0000209	protein polyubiquitination(GO:0000209)
0.3	5.9	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.3	0.5	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.3	2.9	GO:0006465	signal peptide processing(GO:0006465)
0.3	1.6	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.3	1.6	GO:0035878	nail development(GO:0035878)
0.3	11.2	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.3	2.1	GO:2000009	negative regulation of protein localization to cell surface(GO:2000009)
0.3	1.8	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.2	6.2	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.2	5.4	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.2	2.9	GO:1901642	nucleoside transmembrane transport(GO:1901642)
0.2	2.2	GO:0019336	phenol-containing compound catabolic process(GO:0019336)
0.2	2.4	GO:0007512	adult heart development(GO:0007512)
0.2	2.6	GO:0051593	response to folic acid(GO:0051593)
0.2	4.0	GO:0035855	megakaryocyte development(GO:0035855)
0.2	1.2	GO:0015705	iodide transport(GO:0015705)
0.2	4.6	GO:0009299	mRNA transcription(GO:0009299)
0.2	4.8	GO:0042073	intraciliary transport(GO:0042073)
0.2	1.6	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2	2.7	GO:0006301	postreplication repair(GO:0006301)
0.2	12.9	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
0.2	4.8	GO:1990126	retrograde transport, endosome to plasma membrane(GO:1990126)
0.2	1.7	GO:0048664	neuron fate determination(GO:0048664)
0.2	5.7	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.2	7.6	GO:0006611	protein export from nucleus(GO:0006611)
0.2	4.0	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2	2.7	GO:0044458	motile cilium assembly(GO:0044458)
0.2	3.6	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2	0.8	GO:0042780	tRNA 3'-end processing(GO:0042780)
0.2	2.3	GO:0015747	urate transport(GO:0015747)
0.2	6.6	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.2	1.9	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.2	3.5	GO:0006379	mRNA cleavage(GO:0006379)
0.2	5.5	GO:0050918	positive chemotaxis(GO:0050918)
0.2	5.3	GO:0031639	plasminogen activation(GO:0031639)
0.2	1.6	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2	3.0	GO:0015671	oxygen transport(GO:0015671)
0.2	3.5	GO:0009629	response to gravity(GO:0009629)
0.2	3.1	GO:0015701	bicarbonate transport(GO:0015701)
0.2	3.4	GO:0070166	enamel mineralization(GO:0070166)
0.2	1.1	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.2	3.2	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2	2.2	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.2	0.7	GO:0042376	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.2	2.4	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2	1.8	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.2	3.2	GO:0006098	pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2	5.3	GO:0016239	positive regulation of macroautophagy(GO:0016239)
0.2	6.0	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2	1.2	GO:0043686	co-translational protein modification(GO:0043686)
0.2	2.8	GO:0006895	Golgi to endosome transport(GO:0006895)
0.2	1.5	GO:0046185	aldehyde catabolic process(GO:0046185)
0.2	1.0	GO:0048318	axial mesoderm development(GO:0048318)
0.2	0.8	GO:0042256	mature ribosome assembly(GO:0042256)
0.2	3.5	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.2	1.8	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.2	5.0	GO:1902117	positive regulation of organelle assembly(GO:1902117)
0.2	1.6	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2	0.6	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.2	3.5	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.2	11.6	GO:0007368	determination of left/right symmetry(GO:0007368)
0.2	1.6	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2	2.2	GO:0006415	translational termination(GO:0006415)
0.2	1.9	GO:0007256	activation of JNKK activity(GO:0007256)
0.2	1.7	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.2	0.9	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.1	2.8	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.1	2.0	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	1.3	GO:1902969	mitotic DNA replication(GO:1902969)
0.1	4.8	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.1	1.8	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.1	3.5	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.1	1.9	GO:0045063	T-helper 1 cell differentiation(GO:0045063)
0.1	1.1	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.1	1.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.1	1.7	GO:0016322	neuron remodeling(GO:0016322)
0.1	2.1	GO:0032873	negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1	14.0	GO:0010921	regulation of phosphatase activity(GO:0010921)
0.1	0.4	GO:0015858	nucleoside transport(GO:0015858)
0.1	0.6	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.1	0.3	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.1	9.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.1	2.1	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.1	0.7	GO:0006102	isocitrate metabolic process(GO:0006102)
0.1	3.2	GO:0045740	positive regulation of DNA replication(GO:0045740)
0.1	2.8	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.1	0.3	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.1	18.5	GO:0006470	protein dephosphorylation(GO:0006470)
0.1	0.7	GO:0070200	establishment of protein localization to telomere(GO:0070200)
0.1	2.0	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.1	1.4	GO:0016180	snRNA processing(GO:0016180)
0.1	4.0	GO:0034605	cellular response to heat(GO:0034605)
0.1	2.6	GO:0006289	nucleotide-excision repair(GO:0006289)
0.1	5.0	GO:0043966	histone H3 acetylation(GO:0043966)
0.1	0.4	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.1	0.4	GO:0046512	sphingosine biosynthetic process(GO:0046512)
0.1	0.6	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.1	1.0	GO:0051546	keratinocyte migration(GO:0051546)
0.1	1.4	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1	6.7	GO:0006334	nucleosome assembly(GO:0006334)
0.1	3.6	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	1.0	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1	0.6	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1	1.5	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)
0.1	0.3	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.1	1.6	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.1	9.5	GO:0007018	microtubule-based movement(GO:0007018)
0.1	2.5	GO:0006360	transcription from RNA polymerase I promoter(GO:0006360)
0.1	3.6	GO:0009411	response to UV(GO:0009411)
0.1	0.6	GO:0044030	regulation of DNA methylation(GO:0044030)
0.1	1.4	GO:0071158	positive regulation of cell cycle arrest(GO:0071158)
0.1	2.0	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.1	1.8	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.1	3.6	GO:0000725	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.1	2.6	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1	0.3	GO:1902751	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1	0.5	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
0.1	7.4	GO:0008154	actin polymerization or depolymerization(GO:0008154)
0.1	1.4	GO:0048741	skeletal muscle fiber development(GO:0048741)
0.1	1.1	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.7	GO:0006833	water transport(GO:0006833)
0.0	1.5	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	1.2	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.0	0.3	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.3	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.2	GO:0035886	vascular smooth muscle cell differentiation(GO:0035886)
0.0	0.3	GO:0021860	pyramidal neuron development(GO:0021860)
0.0	4.3	GO:0006457	protein folding(GO:0006457)
0.0	1.4	GO:0021766	hippocampus development(GO:0021766)
0.0	0.6	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	1.1	GO:0014902	myotube differentiation(GO:0014902)
0.0	0.2	GO:0006000	fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.6	GO:0046785	microtubule polymerization(GO:0046785)
0.0	1.2	GO:0006352	DNA-templated transcription, initiation(GO:0006352)
0.0	0.2	GO:0031643	positive regulation of myelination(GO:0031643)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.1	GO:0071280	cellular response to copper ion(GO:0071280)
0.0	0.5	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0	0.7	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0	0.4	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:2000272	negative regulation of receptor activity(GO:2000272)
0.0	0.8	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	3.6	GO:0043547	positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.3	38.0	GO:0032280	symmetric synapse(GO:0032280)
5.3	15.8	GO:0005668	RNA polymerase transcription factor SL1 complex(GO:0005668)
4.9	29.7	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
4.5	4.5	GO:0044317	rod spherule(GO:0044317)
4.3	30.4	GO:0036128	CatSper complex(GO:0036128)
3.6	18.2	GO:0048476	Holliday junction resolvase complex(GO:0048476)
3.3	30.0	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
3.2	9.7	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
2.9	41.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
2.8	16.9	GO:0032133	chromosome passenger complex(GO:0032133)
2.6	17.9	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
2.5	10.0	GO:0000408	EKC/KEOPS complex(GO:0000408)
2.5	5.0	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
2.5	12.3	GO:1990716	axonemal central apparatus(GO:1990716)
2.3	7.0	GO:0032798	Swi5-Sfr1 complex(GO:0032798)
2.3	9.2	GO:0033503	HULC complex(GO:0033503)
2.1	6.4	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
2.1	10.6	GO:0099569	presynaptic cytoskeleton(GO:0099569)
2.1	6.4	GO:0032301	recombination nodule(GO:0005713) MutSalpha complex(GO:0032301)
2.1	12.7	GO:0000125	PCAF complex(GO:0000125)
2.1	20.7	GO:0044615	nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
2.0	8.1	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.9	7.7	GO:0072487	MSL complex(GO:0072487)
1.9	20.7	GO:0002177	manchette(GO:0002177)
1.9	33.4	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
1.8	5.5	GO:0042642	actomyosin, myosin complex part(GO:0042642)
1.6	4.8	GO:0045203	intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
1.5	13.7	GO:0071546	pi-body(GO:0071546)
1.5	8.9	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
1.5	4.5	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
1.5	4.4	GO:1990590	ATF1-ATF4 transcription factor complex(GO:1990590)
1.4	4.3	GO:0000802	transverse filament(GO:0000802)
1.4	4.1	GO:0070826	paraferritin complex(GO:0070826)
1.4	13.6	GO:0031616	spindle pole centrosome(GO:0031616)
1.3	6.4	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
1.3	10.2	GO:0005964	phosphorylase kinase complex(GO:0005964)
1.3	5.1	GO:0035339	SPOTS complex(GO:0035339)
1.2	12.4	GO:0044300	cerebellar mossy fiber(GO:0044300)
1.2	14.7	GO:0031597	cytosolic proteasome complex(GO:0031597)
1.1	6.8	GO:0008278	cohesin complex(GO:0008278)
1.1	50.4	GO:0000795	synaptonemal complex(GO:0000795)
1.1	11.1	GO:0031080	nuclear pore outer ring(GO:0031080)
1.1	10.8	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
1.0	7.3	GO:0030991	intraciliary transport particle A(GO:0030991)
1.0	4.1	GO:0005683	U7 snRNP(GO:0005683)
1.0	9.3	GO:0070419	nonhomologous end joining complex(GO:0070419)
1.0	2.9	GO:0000811	GINS complex(GO:0000811)
1.0	14.6	GO:0035253	ciliary rootlet(GO:0035253)
1.0	5.8	GO:1990696	USH2 complex(GO:1990696)
0.9	14.7	GO:0010369	chromocenter(GO:0010369)
0.9	4.4	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.9	2.6	GO:0031021	interphase microtubule organizing center(GO:0031021)
0.9	10.5	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.9	8.7	GO:0042555	MCM complex(GO:0042555)
0.9	11.3	GO:0032426	stereocilium tip(GO:0032426)
0.9	3.5	GO:1990584	cardiac Troponin complex(GO:1990584)
0.9	94.1	GO:0036126	sperm flagellum(GO:0036126)
0.8	11.0	GO:1990023	mitotic spindle midzone(GO:1990023)
0.8	3.3	GO:0002947	tumor necrosis factor receptor superfamily complex(GO:0002947)
0.8	4.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.8	10.5	GO:0044666	MLL3/4 complex(GO:0044666)
0.8	12.0	GO:0035102	PRC1 complex(GO:0035102)
0.8	2.4	GO:0044307	dendritic branch(GO:0044307)
0.8	12.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.7	2.2	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.7	6.5	GO:0031209	SCAR complex(GO:0031209)
0.7	7.8	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.7	4.2	GO:0000243	commitment complex(GO:0000243)
0.7	6.2	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.7	21.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.7	4.0	GO:0071203	WASH complex(GO:0071203)
0.6	5.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.6	3.8	GO:0072588	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.6	14.6	GO:0019013	viral nucleocapsid(GO:0019013)
0.6	76.2	GO:0001669	acrosomal vesicle(GO:0001669)
0.6	3.2	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.6	66.6	GO:0005814	centriole(GO:0005814)
0.6	5.6	GO:0071821	FANCM-MHF complex(GO:0071821)
0.6	5.4	GO:0030314	junctional membrane complex(GO:0030314)
0.6	6.0	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.6	3.5	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.6	2.8	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.5	2.2	GO:0071914	prominosome(GO:0071914)
0.5	10.9	GO:1990391	DNA repair complex(GO:1990391)
0.5	5.1	GO:0030891	VCB complex(GO:0030891)
0.5	21.2	GO:0031941	filamentous actin(GO:0031941)
0.5	4.0	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.5	5.9	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.5	3.9	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.5	2.4	GO:0005675	holo TFIIH complex(GO:0005675)
0.5	19.7	GO:0016235	aggresome(GO:0016235)
0.4	4.5	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.4	4.5	GO:0030992	intraciliary transport particle B(GO:0030992)
0.4	4.8	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.4	2.2	GO:0070761	pre-snoRNP complex(GO:0070761)
0.4	54.9	GO:0000781	chromosome, telomeric region(GO:0000781)
0.4	5.8	GO:0017119	Golgi transport complex(GO:0017119)
0.4	2.8	GO:0034709	methylosome(GO:0034709)
0.4	10.4	GO:0043194	axon initial segment(GO:0043194)
0.4	18.7	GO:0031514	motile cilium(GO:0031514)
0.4	3.1	GO:0016342	catenin complex(GO:0016342)
0.4	24.3	GO:0036064	ciliary basal body(GO:0036064)
0.4	1.1	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.4	15.1	GO:0005871	kinesin complex(GO:0005871)
0.4	5.6	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.4	2.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.4	5.6	GO:0033202	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.4	8.4	GO:0035371	microtubule plus-end(GO:0035371)
0.4	16.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.4	1.1	GO:0031510	SUMO activating enzyme complex(GO:0031510)
0.4	6.3	GO:0042101	T cell receptor complex(GO:0042101)
0.4	3.5	GO:0043020	NADPH oxidase complex(GO:0043020)
0.3	5.6	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3	1.4	GO:1990005	granular vesicle(GO:1990005)
0.3	5.2	GO:0005916	fascia adherens(GO:0005916)
0.3	1.7	GO:0072534	perineuronal net(GO:0072534)
0.3	2.0	GO:0001940	male pronucleus(GO:0001940)
0.3	2.6	GO:0000439	core TFIIH complex(GO:0000439)
0.3	2.6	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3	1.6	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.3	2.4	GO:0016272	prefoldin complex(GO:0016272)
0.3	2.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.3	5.7	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3	3.7	GO:0045120	pronucleus(GO:0045120)
0.3	6.0	GO:0031527	filopodium membrane(GO:0031527)
0.3	4.8	GO:0042581	specific granule(GO:0042581)
0.3	18.0	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.3	0.3	GO:0070876	SOSS complex(GO:0070876)
0.3	11.1	GO:0045171	intercellular bridge(GO:0045171)
0.3	4.8	GO:0030904	retromer complex(GO:0030904)
0.3	1.3	GO:0032156	septin cytoskeleton(GO:0032156)
0.3	3.1	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3	2.1	GO:0071141	SMAD protein complex(GO:0071141)
0.2	0.7	GO:0046691	intracellular canaliculus(GO:0046691)
0.2	1.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2	0.7	GO:0045242	mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
0.2	2.5	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.2	1.8	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.2	1.8	GO:0032593	insulin-responsive compartment(GO:0032593)
0.2	1.5	GO:0016589	NURF complex(GO:0016589)
0.2	2.6	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.2	3.6	GO:0032039	integrator complex(GO:0032039)
0.2	8.2	GO:0032809	neuronal cell body membrane(GO:0032809)
0.2	5.9	GO:0005921	gap junction(GO:0005921)
0.2	6.7	GO:0008180	COP9 signalosome(GO:0008180)
0.2	2.1	GO:0098984	neuron to neuron synapse(GO:0098984)
0.2	1.8	GO:0044294	dendritic growth cone(GO:0044294)
0.2	4.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.2	1.6	GO:0035097	histone methyltransferase complex(GO:0035097)
0.2	2.8	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.2	12.8	GO:0005884	actin filament(GO:0005884)
0.2	23.4	GO:0005923	bicellular tight junction(GO:0005923)
0.2	1.9	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2	5.4	GO:0030686	90S preribosome(GO:0030686)
0.2	14.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	4.5	GO:0031519	PcG protein complex(GO:0031519)
0.2	3.2	GO:1902711	GABA-A receptor complex(GO:1902711)
0.2	10.2	GO:0000776	kinetochore(GO:0000776)
0.2	3.4	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.2	1.7	GO:0032797	SMN complex(GO:0032797)
0.2	6.7	GO:0016592	mediator complex(GO:0016592)
0.2	2.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	2.5	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.1	2.7	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	4.7	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
0.1	2.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	3.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	9.6	GO:0005811	lipid particle(GO:0005811)
0.1	1.7	GO:0000178	exosome (RNase complex)(GO:0000178)
0.1	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.1	7.6	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	1.5	GO:0043218	compact myelin(GO:0043218)
0.1	33.4	GO:0005813	centrosome(GO:0005813)
0.1	1.3	GO:0030014	CCR4-NOT complex(GO:0030014)
0.1	0.5	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	1.8	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	21.3	GO:0014069	postsynaptic density(GO:0014069)
0.1	14.7	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.1	8.6	GO:0001650	fibrillar center(GO:0001650)
0.1	1.4	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	0.9	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.1	5.9	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	2.9	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	1.9	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	21.1	GO:0005635	nuclear envelope(GO:0005635)
0.1	2.1	GO:0015030	Cajal body(GO:0015030)
0.1	43.6	GO:0005730	nucleolus(GO:0005730)
0.1	2.2	GO:0005657	replication fork(GO:0005657)
0.1	0.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	1.7	GO:0014704	intercalated disc(GO:0014704)
0.1	1.4	GO:0060170	ciliary membrane(GO:0060170)
0.1	0.7	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	1.6	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.2	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0	0.5	GO:0046930	pore complex(GO:0046930)
0.0	1.4	GO:0005815	microtubule organizing center(GO:0005815)
0.0	1.1	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
16.0	64.0	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
5.9	35.3	GO:0001515	opioid peptide activity(GO:0001515)
4.9	14.7	GO:0031728	CCR3 chemokine receptor binding(GO:0031728)
4.7	14.2	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
4.4	13.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
4.2	29.7	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
3.7	11.0	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
3.5	20.9	GO:0042289	MHC class II protein binding(GO:0042289)
3.2	9.6	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
3.1	50.3	GO:0035174	histone serine kinase activity(GO:0035174)
2.8	8.5	GO:0031893	vasopressin receptor binding(GO:0031893)
2.7	13.7	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
2.7	8.0	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
2.7	42.4	GO:0008409	5'-3' exonuclease activity(GO:0008409)
2.6	7.8	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827)
2.6	10.3	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
2.5	7.6	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
2.4	9.6	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
2.3	16.4	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
2.3	35.2	GO:0071933	Arp2/3 complex binding(GO:0071933)
2.2	21.9	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.1	23.5	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
2.1	16.9	GO:0001164	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
2.0	7.8	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
1.9	5.6	GO:0005502	11-cis retinal binding(GO:0005502)
1.8	53.0	GO:0044183	protein binding involved in protein folding(GO:0044183)
1.8	5.3	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
1.8	10.5	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.8	5.3	GO:0019809	spermidine binding(GO:0019809)
1.7	8.7	GO:0019960	C-X3-C chemokine binding(GO:0019960)
1.7	19.0	GO:0046972	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
1.6	13.0	GO:0005095	GTPase inhibitor activity(GO:0005095)
1.6	6.3	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
1.6	12.5	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.5	7.6	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
1.5	4.4	GO:0052591	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
1.5	4.4	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
1.5	8.7	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
1.4	8.7	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.4	11.6	GO:0016151	nickel cation binding(GO:0016151)
1.4	11.3	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.4	12.6	GO:0005347	ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
1.4	4.1	GO:0071209	U7 snRNA binding(GO:0071209)
1.4	5.4	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
1.3	26.6	GO:0017056	structural constituent of nuclear pore(GO:0017056)
1.3	6.4	GO:0050816	phosphothreonine binding(GO:0050816)
1.3	10.2	GO:0004689	phosphorylase kinase activity(GO:0004689)
1.2	13.7	GO:0042577	lipid phosphatase activity(GO:0042577)
1.2	26.5	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
1.2	5.8	GO:0015616	DNA translocase activity(GO:0015616)
1.2	4.7	GO:0004948	calcitonin receptor activity(GO:0004948)
1.2	13.9	GO:0004000	adenosine deaminase activity(GO:0004000)
1.1	10.3	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
1.1	16.9	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
1.1	7.9	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
1.0	4.1	GO:0019237	centromeric DNA binding(GO:0019237)
1.0	3.0	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
1.0	5.0	GO:0070739	protein-glutamic acid ligase activity(GO:0070739)
1.0	4.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
1.0	3.9	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
1.0	15.7	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.0	3.9	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.9	2.8	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.9	7.5	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.9	4.7	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.9	3.7	GO:1990715	mRNA CDS binding(GO:1990715)
0.9	2.8	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.9	2.8	GO:0001221	transcription cofactor binding(GO:0001221) transcription corepressor binding(GO:0001222)
0.9	4.6	GO:0001032	RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.9	3.6	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.9	2.7	GO:0001565	phorbol ester receptor activity(GO:0001565)
0.9	10.7	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.9	5.3	GO:0004126	cytidine deaminase activity(GO:0004126)
0.9	9.4	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.9	2.6	GO:0035539	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.8	5.9	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.8	7.6	GO:0008494	translation activator activity(GO:0008494)
0.8	24.5	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.8	3.2	GO:0016608	growth hormone-releasing hormone activity(GO:0016608)
0.8	16.0	GO:0030332	cyclin binding(GO:0030332)
0.8	15.4	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.8	2.3	GO:0005135	erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135)
0.8	9.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.8	8.3	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.7	9.7	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7	16.1	GO:0005521	lamin binding(GO:0005521)
0.7	5.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.7	9.5	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.7	7.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.7	3.6	GO:0005042	netrin receptor activity(GO:0005042)
0.7	2.8	GO:0035184	histone threonine kinase activity(GO:0035184)
0.7	2.8	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.7	20.4	GO:0008536	Ran GTPase binding(GO:0008536)
0.7	8.7	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.7	5.3	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.7	2.0	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.6	7.7	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.6	6.4	GO:0030983	mismatched DNA binding(GO:0030983)
0.6	1.9	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.6	20.1	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.6	3.7	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.6	12.9	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.6	4.1	GO:0001595	angiotensin receptor activity(GO:0001595)
0.6	3.5	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.6	4.0	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.6	7.4	GO:0098879	structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.6	2.8	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.6	13.3	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.6	14.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.5	2.2	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.5	2.2	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.5	3.2	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.5	13.4	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.5	1.6	GO:0035596	methylthiotransferase activity(GO:0035596) transferase activity, transferring alkylthio groups(GO:0050497)
0.5	3.1	GO:0004144	2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
0.5	1.6	GO:0038132	neuregulin binding(GO:0038132)
0.5	9.4	GO:0070628	proteasome binding(GO:0070628)
0.5	2.0	GO:1990955	G-rich single-stranded DNA binding(GO:1990955)
0.5	12.0	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.5	8.3	GO:0070182	DNA polymerase binding(GO:0070182)
0.5	2.4	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.5	2.4	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.5	5.1	GO:0051011	microtubule minus-end binding(GO:0051011)
0.5	15.5	GO:0051879	Hsp90 protein binding(GO:0051879)
0.5	11.9	GO:0070840	dynein complex binding(GO:0070840)
0.5	7.7	GO:0030552	cAMP binding(GO:0030552)
0.5	1.4	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.4	1.3	GO:0000991	transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.4	6.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.4	8.7	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.4	13.4	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.4	6.8	GO:0003993	acid phosphatase activity(GO:0003993)
0.4	2.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4	29.2	GO:0003777	microtubule motor activity(GO:0003777)
0.4	2.9	GO:1901611	phosphatidylglycerol binding(GO:1901611)
0.4	3.7	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.4	3.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.4	4.7	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4	2.4	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.4	1.6	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.4	3.5	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.4	3.9	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4	10.1	GO:0043015	gamma-tubulin binding(GO:0043015)
0.4	1.5	GO:0036310	annealing helicase activity(GO:0036310)
0.4	22.6	GO:0043022	ribosome binding(GO:0043022)
0.4	1.5	GO:0035514	DNA demethylase activity(GO:0035514) oxidative RNA demethylase activity(GO:0035515)
0.4	6.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.4	6.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.4	4.5	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.4	0.7	GO:0034618	arginine binding(GO:0034618)
0.4	2.2	GO:0055104	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.4	2.9	GO:1990446	U1 snRNA binding(GO:0030619) U1 snRNP binding(GO:1990446)
0.4	12.9	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.4	24.3	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.4	2.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4	3.5	GO:0004526	ribonuclease P activity(GO:0004526)
0.4	1.4	GO:0043404	corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
0.3	2.4	GO:0003896	DNA primase activity(GO:0003896)
0.3	6.4	GO:0003746	translation elongation factor activity(GO:0003746)
0.3	4.0	GO:0019966	interleukin-1 binding(GO:0019966)
0.3	1.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.3	3.1	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3	19.8	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.3	3.3	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.3	7.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.3	6.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3	2.3	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.3	3.7	GO:0005522	profilin binding(GO:0005522)
0.3	5.7	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.3	2.8	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3	2.8	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3	3.0	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3	1.4	GO:0001729	ceramide kinase activity(GO:0001729)
0.3	1.8	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3	6.5	GO:0004016	adenylate cyclase activity(GO:0004016)
0.3	8.8	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.3	8.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.3	3.6	GO:0005243	gap junction channel activity(GO:0005243)
0.2	0.7	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.2	14.8	GO:0002039	p53 binding(GO:0002039)
0.2	2.9	GO:0043138	3'-5' DNA helicase activity(GO:0043138)
0.2	1.9	GO:0000182	rDNA binding(GO:0000182)
0.2	3.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.2	4.2	GO:0017081	chloride channel regulator activity(GO:0017081)
0.2	6.5	GO:0003785	actin monomer binding(GO:0003785)
0.2	2.3	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2	5.0	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	4.0	GO:0031005	filamin binding(GO:0031005)
0.2	2.0	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.2	13.5	GO:0051082	unfolded protein binding(GO:0051082)
0.2	25.3	GO:0017124	SH3 domain binding(GO:0017124)
0.2	6.3	GO:0052866	phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.2	3.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.2	4.3	GO:0005112	Notch binding(GO:0005112)
0.2	12.0	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.2	50.2	GO:0005096	GTPase activator activity(GO:0005096)
0.2	5.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	0.4	GO:0031493	nucleosomal histone binding(GO:0031493)
0.2	2.5	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2	6.4	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2	0.4	GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.2	3.0	GO:0005344	oxygen transporter activity(GO:0005344)
0.2	0.6	GO:0030626	U12 snRNA binding(GO:0030626)
0.2	2.7	GO:0008266	poly(U) RNA binding(GO:0008266)
0.2	0.6	GO:0010385	double-stranded methylated DNA binding(GO:0010385)
0.2	10.3	GO:0003727	single-stranded RNA binding(GO:0003727)
0.2	8.2	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.2	1.7	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.2	3.4	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.2	5.3	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.2	2.8	GO:0001056	RNA polymerase III activity(GO:0001056)
0.2	3.4	GO:0017069	snRNA binding(GO:0017069)
0.2	2.8	GO:0008327	methyl-CpG binding(GO:0008327)
0.2	17.6	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	4.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	0.4	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.2	3.8	GO:0051059	NF-kappaB binding(GO:0051059)
0.2	21.1	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.2	1.8	GO:0030507	spectrin binding(GO:0030507)
0.2	9.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.2	3.2	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.2	1.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.2	0.5	GO:0030348	syntaxin-3 binding(GO:0030348)
0.2	0.7	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2	0.7	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2	35.1	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.2	2.4	GO:0071889	14-3-3 protein binding(GO:0071889)
0.2	6.7	GO:0003714	transcription corepressor activity(GO:0003714)
0.2	1.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2	3.7	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.2	2.2	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.2	1.0	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.2	6.0	GO:0005109	frizzled binding(GO:0005109)
0.2	1.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.2	1.5	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2	3.6	GO:0042056	chemoattractant activity(GO:0042056)
0.1	1.9	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.9	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1	3.1	GO:0015301	anion:anion antiporter activity(GO:0015301)
0.1	1.0	GO:0004966	galanin receptor activity(GO:0004966)
0.1	3.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.1	2.6	GO:0015288	porin activity(GO:0015288)
0.1	1.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	4.2	GO:0003684	damaged DNA binding(GO:0003684)
0.1	2.9	GO:0004518	nuclease activity(GO:0004518)
0.1	5.0	GO:0004402	histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1	1.2	GO:0090079	translation regulator activity, nucleic acid binding(GO:0090079)
0.1	4.8	GO:0015459	potassium channel regulator activity(GO:0015459)
0.1	11.4	GO:0030674	protein binding, bridging(GO:0030674)
0.1	16.9	GO:0005516	calmodulin binding(GO:0005516)
0.1	0.9	GO:0019808	polyamine binding(GO:0019808)
0.1	3.2	GO:0004890	GABA-A receptor activity(GO:0004890)
0.1	1.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1	1.7	GO:0042162	telomeric DNA binding(GO:0042162)
0.1	26.4	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.1	0.3	GO:0047025	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1	1.9	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	3.3	GO:0051219	phosphoprotein binding(GO:0051219)
0.1	4.5	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1	1.5	GO:0016881	acid-amino acid ligase activity(GO:0016881)
0.1	0.6	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.1	0.8	GO:0019957	C-C chemokine binding(GO:0019957)
0.1	0.6	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.1	14.1	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	1.9	GO:0050699	WW domain binding(GO:0050699)
0.1	1.7	GO:0071837	HMG box domain binding(GO:0071837)
0.1	0.4	GO:0017040	ceramidase activity(GO:0017040)
0.1	0.6	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	3.6	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	2.0	GO:0004532	exoribonuclease activity(GO:0004532)
0.1	1.4	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.1	1.8	GO:0005080	protein kinase C binding(GO:0005080)
0.1	0.2	GO:0004977	melanocortin receptor activity(GO:0004977)
0.0	4.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	1.1	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	4.4	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.0	5.5	GO:0008017	microtubule binding(GO:0008017)
0.0	0.5	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.5	GO:0051400	BH domain binding(GO:0051400)
0.0	1.6	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	1.4	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.2	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.8	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	3.2	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.0	0.5	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.4	GO:0015299	solute:proton antiporter activity(GO:0015299)
0.0	64.9	GO:0003676	nucleic acid binding(GO:0003676)
0.0	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	1.4	GO:0051015	actin filament binding(GO:0051015)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	6.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.8	31.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.8	30.5	PID AURORA A PATHWAY	Aurora A signaling
0.7	8.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.7	20.8	PID FANCONI PATHWAY	Fanconi anemia pathway
0.7	22.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.7	30.6	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.7	5.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.7	20.4	PID MYC PATHWAY	C-MYC pathway
0.6	23.1	PID ATR PATHWAY	ATR signaling pathway
0.6	13.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	43.0	PID E2F PATHWAY	E2F transcription factor network
0.5	4.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.5	9.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.5	10.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.5	26.1	PID NOTCH PATHWAY	Notch signaling pathway
0.4	4.8	ST G ALPHA S PATHWAY	G alpha s Pathway
0.4	7.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.4	5.9	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4	17.2	PID LKB1 PATHWAY	LKB1 signaling events
0.4	14.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	5.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3	2.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.3	8.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	7.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.3	11.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	10.8	PID ARF6 PATHWAY	Arf6 signaling events
0.2	1.4	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	9.6	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.2	9.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	10.5	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	2.4	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	1.8	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	3.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	5.4	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	1.9	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	2.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	4.1	PID P53 REGULATION PATHWAY	p53 pathway
0.1	5.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	2.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	3.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	1.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	2.8	PID RHOA PATHWAY	RhoA signaling pathway
0.1	1.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	0.5	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	2.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	0.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	1.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.0	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	32.7	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.9	29.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
1.3	20.9	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.2	65.1	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
1.2	11.7	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
1.1	13.2	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
1.0	16.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.0	7.8	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
1.0	29.7	REACTOME KINESINS	Genes involved in Kinesins
0.9	20.7	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.9	31.6	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.8	8.5	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.8	23.7	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.8	6.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.7	20.4	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.7	3.4	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.7	21.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.7	11.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.6	13.6	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.6	28.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.6	6.3	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.6	4.5	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.5	12.4	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.5	8.0	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.5	13.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.5	4.1	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.5	11.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.5	8.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.5	8.7	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.5	14.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.5	6.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.4	13.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.4	27.5	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.4	32.0	REACTOME REGULATION OF MITOTIC CELL CYCLE	Genes involved in Regulation of mitotic cell cycle
0.4	4.7	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.4	8.6	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.4	13.9	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.4	8.8	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.3	9.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.3	4.6	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3	5.6	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.3	11.1	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.3	2.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.3	2.5	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.3	1.2	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.3	4.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3	5.5	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.2	3.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.2	39.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	3.0	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.2	7.9	REACTOME SPHINGOLIPID METABOLISM	Genes involved in Sphingolipid metabolism
0.2	3.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.2	8.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	2.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.2	4.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	2.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	3.6	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.1	2.6	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	1.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	10.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	2.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	1.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	22.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	0.4	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	3.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	9.4	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.1	1.9	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.1	2.4	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1	4.7	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	1.6	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	1.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	1.4	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	3.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	1.2	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	2.0	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	0.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	1.2	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.3	REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0	0.6	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events

Results for Pitx2_Otx2

Z-value: 1.22

Motif logo

Transcription factors associated with Pitx2_Otx2

Activity-expression correlation:

Activity profile of Pitx2_Otx2 motif

Sorted Z-values of Pitx2_Otx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx2_Otx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: