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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Pitx2_Otx2
Z-value: 1.22
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Transcription factors associated with Pitx2_Otx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Otx2 | rn6_v1_chr15_-_25521393_25521393 | 0.17 | 3.0e-03 | Click! |
| Pitx2 | rn6_v1_chr2_+_233602732_233602732 | 0.05 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_56591715 Show fit | 42.98 |
ENSRNOT00000041207
|
family with sequence similarity 71, member F1 |
|
| chr3_-_3266260 Show fit | 39.65 |
ENSRNOT00000034538
|
glycosyltransferase 6 domain containing 1 |
|
| chr7_-_145048283 Show fit | 38.82 |
ENSRNOT00000055275
|
gametocyte specific factor 1 |
|
| chr4_-_6062641 Show fit | 37.67 |
ENSRNOT00000074846
|
chaperonin containing TCP1, subunit 8 (theta)-like 1 |
|
| chr19_+_14835822 Show fit | 37.25 |
ENSRNOT00000072804
|
RIKEN cDNA 1700007B14 gene |
|
| chr1_-_88162583 Show fit | 30.40 |
ENSRNOT00000087411
|
cation channel sperm associated auxiliary subunit gamma |
|
| chrX_+_78991223 Show fit | 29.99 |
ENSRNOT00000031200
|
family with sequence similarity 46, member D |
|
| chr1_-_85317968 Show fit | 29.97 |
ENSRNOT00000026891
|
glia maturation factor, gamma |
|
| chr14_+_81858737 Show fit | 29.69 |
ENSRNOT00000029784
ENSRNOT00000058068 ENSRNOT00000058067 |
DNA polymerase nu |
|
| chr8_+_115213471 Show fit | 29.36 |
ENSRNOT00000017570
|
IQ motif containing F5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pitx2_Otx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 144.9 | GO:0007283 | spermatogenesis(GO:0007283) |
| 11.4 | 57.0 | GO:1990918 | double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.3 | 45.2 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.1 | 41.2 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 2.6 | 40.9 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 3.6 | 39.7 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 3.0 | 39.4 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 12.7 | 38.0 | GO:0051867 | general adaptation syndrome, behavioral process(GO:0051867) |
| 7.0 | 35.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 2.1 | 33.4 | GO:0035404 | histone-serine phosphorylation(GO:0035404) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 94.1 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.6 | 76.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.6 | 66.6 | GO:0005814 | centriole(GO:0005814) |
| 0.4 | 54.9 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 1.1 | 50.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 43.6 | GO:0005730 | nucleolus(GO:0005730) |
| 2.9 | 41.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 6.3 | 38.0 | GO:0032280 | symmetric synapse(GO:0032280) |
| 1.9 | 33.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 33.4 | GO:0005813 | centrosome(GO:0005813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 64.9 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 16.0 | 64.0 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 1.8 | 53.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 3.1 | 50.3 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.2 | 50.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.7 | 42.4 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 5.9 | 35.3 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 2.3 | 35.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.2 | 35.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 4.2 | 29.7 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 43.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.8 | 31.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.7 | 30.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.8 | 30.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 26.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.6 | 23.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.7 | 22.3 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.7 | 20.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.7 | 20.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 17.2 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 65.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 39.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.7 | 32.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.4 | 32.0 | REACTOME REGULATION OF MITOTIC CELL CYCLE | Genes involved in Regulation of mitotic cell cycle |
| 0.9 | 31.6 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 1.9 | 29.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 1.0 | 29.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 28.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 27.5 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.8 | 23.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |