ISMARA results: Pitx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pitx1

Z-value: 0.90

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Transcription factors associated with Pitx1

Gene Symbol	Gene ID	Gene Info
Pitx1 NCBI RGD Ensembl	ENSRNOG00000011423	paired-like homeodomain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pitx1	rn6_v1_chr17_+_8878270_8878270	0.49	7.0e-21	Click!

Activity profile of Pitx1 motif

Sorted Z-values of Pitx1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_224824799 Show fit	44.24	ENSRNOT00000024757	Slc22a6 NCBI RGD Ensembl Show fit	solute carrier family 22 member 6
chr10_+_53818818 Show fit	29.09	ENSRNOT00000057260	Myh8 NCBI RGD Ensembl Show fit	myosin heavy chain 8
chr20_+_20378861 Show fit	25.44	ENSRNOT00000091044	Ank3 NCBI RGD Ensembl Show fit	ankyrin 3
chrX_+_159158194 Show fit	24.12	ENSRNOT00000043820 ENSRNOT00000001169 ENSRNOT00000083502	Fhl1 NCBI RGD Ensembl Show fit	four and a half LIM domains 1
chr3_+_55910177 Show fit	23.41	ENSRNOT00000009969	Klhl41 NCBI RGD Ensembl Show fit	kelch-like family member 41
chr3_+_113318563 Show fit	22.44	ENSRNOT00000089230	Ckmt1 NCBI RGD Ensembl Show fit	creatine kinase, mitochondrial 1
chr3_+_80075991 Show fit	21.39	ENSRNOT00000080266	Pacsin3 NCBI RGD Ensembl Show fit	protein kinase C and casein kinase substrate in neurons 3
chr4_-_51199570 Show fit	20.89	ENSRNOT00000010788	Slc13a1 NCBI RGD Ensembl Show fit	solute carrier family 13 member 1
chr8_+_33514042 Show fit	18.03	ENSRNOT00000081614 ENSRNOT00000081525	Kcnj1 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 1
chr3_+_56355431 Show fit	17.88	ENSRNOT00000037188	Myo3b NCBI RGD Ensembl Show fit	myosin IIIB

Showing 1 to 10 of 153 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.4	44.2	GO:0031427	response to methotrexate(GO:0031427)
2.6	29.1	GO:0030049	muscle filament sliding(GO:0030049)
6.4	25.4	GO:1900827	positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5	24.1	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
1.7	23.4	GO:0031272	regulation of pseudopodium assembly(GO:0031272) regulation of myoblast proliferation(GO:2000291)
1.1	21.4	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
6.3	19.0	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
6.0	18.0	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979)
2.9	17.3	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.1	16.8	GO:0021549	cerebellum development(GO:0021549)

Showing 1 to 10 of 88 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	48.2	GO:0005794	Golgi apparatus(GO:0005794)
0.4	46.3	GO:0005901	caveola(GO:0005901)
1.9	29.1	GO:0032982	myosin filament(GO:0032982)
0.1	26.7	GO:0014069	postsynaptic density(GO:0014069)
2.5	25.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	24.8	GO:0005925	focal adhesion(GO:0005925)
0.3	24.4	GO:0045095	keratin filament(GO:0045095)
1.8	23.4	GO:0031143	pseudopodium(GO:0031143)
0.1	22.4	GO:0043209	myelin sheath(GO:0043209)
0.1	19.5	GO:0005802	trans-Golgi network(GO:0005802)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	47.0	GO:0000146	microfilament motor activity(GO:0000146)
5.5	44.2	GO:0031404	chloride ion binding(GO:0031404)
0.1	25.4	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
3.2	22.4	GO:0004111	creatine kinase activity(GO:0004111)
0.3	22.0	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.9	21.4	GO:0019855	calcium channel inhibitor activity(GO:0019855)
4.5	18.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6	17.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.4	16.5	GO:0030507	spectrin binding(GO:0030507)
5.3	15.9	GO:0008511	sodium:potassium:chloride symporter activity(GO:0008511)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	15.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	14.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	14.9	PID MTOR 4PATHWAY	mTOR signaling pathway
0.3	14.6	NABA COLLAGENS	Genes encoding collagen proteins
0.5	14.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	13.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	11.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.5	10.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	9.6	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	44.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
1.0	37.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	25.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.5	20.9	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
1.4	14.4	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4	12.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.7	11.5	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	11.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.5	10.9	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.7	10.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis

Showing 1 to 10 of 27 entries

Results for Pitx1

Z-value: 0.90

Motif logo

Transcription factors associated with Pitx1

Activity-expression correlation:

Activity profile of Pitx1 motif

Sorted Z-values of Pitx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pitx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: