ISMARA results: Pbx2

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Pbx2

Z-value: 0.85

Motif logo

Transcription factors associated with Pbx2

Gene Symbol	Gene ID	Gene Info
Pbx2 NCBI RGD Ensembl	ENSRNOG00000000440	PBX homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pbx2	rn6_v1_chr20_+_4357733_4357733	0.24	1.8e-05	Click!

Activity profile of Pbx2 motif

Sorted Z-values of Pbx2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_201620642 Show fit	52.65	ENSRNOT00000093674	Dmbt1 NCBI RGD Ensembl Show fit	deleted in malignant brain tumors 1
chr7_+_125288081 Show fit	43.02	ENSRNOT00000085216	Parvg NCBI RGD Ensembl Show fit	parvin, gamma
chr4_+_98337367 Show fit	35.58	ENSRNOT00000042165	AABR07060872.1 NCBI RGD Ensembl Show fit
chr11_+_85430400 Show fit	32.84	ENSRNOT00000083198	AABR07034729.1 NCBI RGD Ensembl Show fit
chr9_-_14706557 Show fit	28.61	ENSRNOT00000048975	Treml4 NCBI RGD Ensembl Show fit	triggering receptor expressed on myeloid cells-like 4
chr11_+_85263536 Show fit	25.55	ENSRNOT00000046465	AABR07034729.1 NCBI RGD Ensembl Show fit
chr1_-_197821936 Show fit	24.93	ENSRNOT00000055027	Cd19 NCBI RGD Ensembl Show fit	CD19 molecule
chr4_+_101639641 Show fit	23.08	ENSRNOT00000058282	AABR07060952.1 NCBI RGD Ensembl Show fit
chr4_+_102489916 Show fit	22.80	ENSRNOT00000082031	AABR07061001.1 NCBI RGD Ensembl Show fit
chr9_-_23493081 Show fit	21.84	ENSRNOT00000072144	Rhag NCBI RGD Ensembl Show fit	Rh-associated glycoprotein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pbx2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.8	52.7	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.4	43.0	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
4.8	28.6	GO:0002457	T cell antigen processing and presentation(GO:0002457)
1.8	24.9	GO:0006968	cellular defense response(GO:0006968)
3.1	21.8	GO:0015670	carbon dioxide transport(GO:0015670)
6.9	20.8	GO:0045799	positive regulation of chromatin assembly or disassembly(GO:0045799)
6.7	20.0	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.6	20.0	GO:0006730	one-carbon metabolic process(GO:0006730)
0.1	19.9	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
1.3	18.9	GO:0051764	actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	88.7	GO:0009897	external side of plasma membrane(GO:0009897)
2.8	52.7	GO:0042589	zymogen granule membrane(GO:0042589)
0.3	22.2	GO:0000118	histone deacetylase complex(GO:0000118)
0.7	18.9	GO:0001891	phagocytic cup(GO:0001891)
0.5	18.8	GO:0001772	immunological synapse(GO:0001772)
0.2	15.4	GO:0005902	microvillus(GO:0005902)
0.3	15.1	GO:0008023	transcription elongation factor complex(GO:0008023)
0.4	13.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.5	13.0	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	12.6	GO:0005743	mitochondrial inner membrane(GO:0005743)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	75.6	GO:0030246	carbohydrate binding(GO:0030246)
7.5	52.7	GO:0035375	zymogen binding(GO:0035375)
0.1	46.0	GO:0003779	actin binding(GO:0003779)
0.1	24.8	GO:0005057	receptor signaling protein activity(GO:0005057)
2.7	21.8	GO:0022840	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
3.0	21.3	GO:0004064	arylesterase activity(GO:0004064)
0.4	20.8	GO:0070888	E-box binding(GO:0070888)
0.4	20.8	GO:0005044	scavenger receptor activity(GO:0005044)
2.2	20.0	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3	18.2	GO:0030971	receptor tyrosine kinase binding(GO:0030971)

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	50.8	PID ILK PATHWAY	Integrin-linked kinase signaling
1.0	45.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	40.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	25.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	18.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.3	15.6	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	13.1	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.7	13.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	11.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	11.7	PID ALK1 PATHWAY	ALK1 signaling events

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	24.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6	21.8	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
1.8	20.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.9	18.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.2	16.1	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
1.1	13.6	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5	13.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.9	13.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.5	11.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.1	11.7	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand

Showing 1 to 10 of 47 entries

Results for Pbx2

Z-value: 0.85

Motif logo

Transcription factors associated with Pbx2

Activity-expression correlation:

Activity profile of Pbx2 motif

Sorted Z-values of Pbx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pbx2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: