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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pbx2

Z-value: 0.85

Motif logo

Transcription factors associated with Pbx2

Gene Symbol Gene ID Gene Info
ENSRNOG00000000440 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pbx2rn6_v1_chr20_+_4357733_43577330.241.8e-05Click!

Activity profile of Pbx2 motif

Sorted Z-values of Pbx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_201620642 52.65 ENSRNOT00000093674
deleted in malignant brain tumors 1
chr7_+_125288081 43.02 ENSRNOT00000085216
parvin, gamma
chr4_+_98337367 35.58 ENSRNOT00000042165

chr11_+_85430400 32.84 ENSRNOT00000083198

chr9_-_14706557 28.61 ENSRNOT00000048975
triggering receptor expressed on myeloid cells-like 4
chr11_+_85263536 25.55 ENSRNOT00000046465

chr1_-_197821936 24.93 ENSRNOT00000055027
CD19 molecule
chr4_+_101639641 23.08 ENSRNOT00000058282

chr4_+_102489916 22.80 ENSRNOT00000082031

chr9_-_23493081 21.84 ENSRNOT00000072144
Rh-associated glycoprotein
chr4_+_156752082 20.77 ENSRNOT00000084588
ENSRNOT00000068407
CD163 molecule
chr13_-_55173692 20.04 ENSRNOT00000064785
ENSRNOT00000029878
ENSRNOT00000029865
ENSRNOT00000060292
ENSRNOT00000000814
protein tyrosine phosphatase, receptor type, C
chr2_+_88217188 20.03 ENSRNOT00000014267
carbonic anhydrase I
chrX_+_80359555 19.53 ENSRNOT00000030692
hypothetical protein LOC681325
chr4_-_163849618 19.28 ENSRNOT00000086363
ENSRNOT00000077637
immunoreceptor Ly49si1
chr15_+_57241968 18.95 ENSRNOT00000082191
lymphocyte cytosolic protein 1
chr2_-_209537087 18.82 ENSRNOT00000024344
Cd53 molecule
chr4_-_163762434 16.59 ENSRNOT00000081854
immunoreceptor Ly49si1
chr10_-_34242985 16.47 ENSRNOT00000046438
similar to novel protein
chr4_+_69138525 16.19 ENSRNOT00000073589
T cell receptor beta, variable 1
chr13_+_101381510 16.09 ENSRNOT00000004821
toll-like receptor 5
chr3_-_113405829 15.07 ENSRNOT00000036823
elongation factor for RNA polymerase II 3
chr2_+_183674522 14.44 ENSRNOT00000014433
transmembrane protein 154
chr4_+_102403451 14.24 ENSRNOT00000071605

chr4_-_102124609 13.90 ENSRNOT00000048263

chr5_+_133865331 13.82 ENSRNOT00000035409
TAL bHLH transcription factor 1, erythroid differentiation factor
chr11_+_85992696 13.50 ENSRNOT00000084433

chr2_-_218658761 13.39 ENSRNOT00000018318
sphingosine-1-phosphate receptor 1
chr4_+_163174487 13.25 ENSRNOT00000088108
C-type lectin domain family 9, member A
chr9_+_67699379 13.10 ENSRNOT00000091237
ENSRNOT00000088183
cytotoxic T-lymphocyte-associated protein 4
chr1_-_98521551 13.06 ENSRNOT00000081922
sialic acid binding Ig-like lectin 10
chr19_-_19727081 13.01 ENSRNOT00000020700
adenylate cyclase 7
chr1_+_219390523 12.88 ENSRNOT00000054852
G protein-coupled receptor 152
chr7_-_81592206 12.87 ENSRNOT00000007979
angiopoietin 1
chr2_+_188449210 11.93 ENSRNOT00000027700
pyruvate kinase, liver and RBC
chr4_-_34282351 11.74 ENSRNOT00000011123
replication protein A3
chr8_-_124399494 11.72 ENSRNOT00000037883
transforming growth factor, beta receptor 2
chr1_-_133559975 11.51 ENSRNOT00000046645
multiple C2 and transmembrane domain containing 2
chr4_-_163214678 10.53 ENSRNOT00000091602
C-type lectin domain family 1, member A
chr2_-_203350736 10.36 ENSRNOT00000090115
ENSRNOT00000084516
transcription termination factor 2
chr8_+_130538651 10.27 ENSRNOT00000026343
atypical chemokine receptor 2
chr6_+_137323713 10.01 ENSRNOT00000029017
phospholipase D family, member 4
chr4_-_164691405 9.60 ENSRNOT00000090979
ENSRNOT00000091932
ENSRNOT00000078219
Ly49 stimulatory receptor 4
Ly49 inhibitory receptor 2
chr3_-_46457201 9.32 ENSRNOT00000010683
lymphocyte antigen 75
chr7_-_14189688 9.32 ENSRNOT00000037456
notch 3
chr18_+_55666027 9.17 ENSRNOT00000045950
similar to CDNA sequence BC023105
chr17_-_43614844 9.07 ENSRNOT00000023054
histone cluster 1 H1 family member a
chr13_+_82496022 9.06 ENSRNOT00000080759
coagulation factor V
chr9_-_20154077 8.57 ENSRNOT00000082904
adhesion G protein-coupled receptor F5
chr1_+_84280945 8.52 ENSRNOT00000057190
SERTA domain containing 3
chr4_+_34282625 8.27 ENSRNOT00000011138
ENSRNOT00000086735
glucocorticoid induced 1
chr7_+_144064931 7.65 ENSRNOT00000048504
proline rich 13
chr1_-_218810118 7.54 ENSRNOT00000065950
ENSRNOT00000020886
protein phosphatase 6, regulatory subunit 3
chr8_+_2635851 7.34 ENSRNOT00000061973
caspase 4
chrX_+_124894466 7.28 ENSRNOT00000080894
MCTS1, re-initiation and release factor
chr15_-_24199341 7.02 ENSRNOT00000015553
DLG associated protein 5
chr5_+_133864798 6.95 ENSRNOT00000091977
TAL bHLH transcription factor 1, erythroid differentiation factor
chr17_+_43673294 6.62 ENSRNOT00000074109
histone cluster 2, H4
chr6_-_131914028 6.20 ENSRNOT00000007602
B-cell CLL/lymphoma 11B
chr3_+_114772603 6.13 ENSRNOT00000073569
hypothetical LOC302884
chr2_+_208738132 5.98 ENSRNOT00000023972

chr19_-_29968424 5.86 ENSRNOT00000024981
inositol polyphosphate-4-phosphatase type II B
chr17_+_10137974 5.82 ENSRNOT00000031935
hexokinase 3
chr1_+_88955135 5.81 ENSRNOT00000083550
proline dehydrogenase 2
chr5_+_163773509 5.73 ENSRNOT00000072167
60S ribosomal protein L9 pseudogene
chr6_+_99282850 5.70 ENSRNOT00000008374
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr16_+_8302950 5.65 ENSRNOT00000066062
nuclear receptor coactivator 4
chr16_+_75966352 5.36 ENSRNOT00000022774
angiopoietin 2
chr1_-_222224910 5.34 ENSRNOT00000028720
phospholipase C beta 3
chrX_-_15504165 5.30 ENSRNOT00000006233
OTU deubiquitinase 5
chr12_+_47590154 5.06 ENSRNOT00000045946
GIT ArfGAP 2
chr8_-_119523964 5.01 ENSRNOT00000081718
mutL homolog 1
chr1_+_88955440 4.97 ENSRNOT00000091101
proline dehydrogenase 2
chr6_-_115616766 4.94 ENSRNOT00000006143
ENSRNOT00000045870
SEL1L ERAD E3 ligase adaptor subunit
chrX_-_123486814 4.87 ENSRNOT00000016993
similar to hypothetical protein FLJ22965
chr2_+_150013327 4.78 ENSRNOT00000075623

chr4_+_148782479 4.77 ENSRNOT00000018133
similar to hypothetical protein MGC6835
chr6_+_93461713 4.76 ENSRNOT00000031595
AT-rich interaction domain 4A
chr3_+_122662086 4.76 ENSRNOT00000009097
transglutaminase 6
chrX_-_2116483 4.71 ENSRNOT00000055077
retinitis pigmentosa 2 (X-linked recessive)
chr3_-_9936352 4.69 ENSRNOT00000011224
ENSRNOT00000042798
formin binding protein 1
chr1_+_227743612 4.67 ENSRNOT00000028476
predicted gene 8369
chr9_+_112360419 4.64 ENSRNOT00000086682
mannosidase, alpha, class 2A, member 1
chr16_-_23991570 4.59 ENSRNOT00000044198
ENSRNOT00000018854
N-acetyltransferase 2
N-acetyltransferase 1
chr12_+_51878153 4.43 ENSRNOT00000056798
HscB mitochondrial iron-sulfur cluster co-chaperone
chr20_+_8312792 4.36 ENSRNOT00000083108
cap methyltransferase 1
chr8_-_119523716 4.35 ENSRNOT00000064581
mutL homolog 1
chr8_+_77107536 4.28 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr11_+_60140130 4.13 ENSRNOT00000033595
similar to TPA-induced transmembrane protein
chr20_-_10968432 4.09 ENSRNOT00000001593
cystatin B
chr17_-_4454701 4.09 ENSRNOT00000080750
ENSRNOT00000066950
death associated protein kinase 1
chr7_+_144865608 3.92 ENSRNOT00000091596
ENSRNOT00000055285
heterogeneous nuclear ribonucleoprotein A1
chr3_-_76518601 3.89 ENSRNOT00000071021
olfactory receptor 623
chr10_+_40812858 3.88 ENSRNOT00000018149
G3BP stress granule assembly factor 1
chr20_+_29831314 3.87 ENSRNOT00000000696
prosaposin
chr5_+_58144705 3.79 ENSRNOT00000019886
galactose-1-phosphate uridylyltransferase
chr11_-_35749464 3.75 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr1_-_129776276 3.72 ENSRNOT00000051402
arrestin domain containing 4
chrX_-_2116656 3.69 ENSRNOT00000081913
retinitis pigmentosa 2 (X-linked recessive)
chr3_+_160908769 3.65 ENSRNOT00000030054
Sys1 golgi trafficking protein
chr1_+_48273611 3.64 ENSRNOT00000022254
ENSRNOT00000022068
solute carrier family 22 member 1
chr19_+_24849356 3.45 ENSRNOT00000090312
DExD-box helicase 39A
chr2_+_104854572 3.45 ENSRNOT00000064828
ENSRNOT00000090912
helicase-like transcription factor
chr9_+_95202632 3.42 ENSRNOT00000025652
UDP glucuronosyltransferase family 1 member A5
chr7_-_29949603 3.39 ENSRNOT00000009419
60S ribosomal protein L9 pseudogene
chr1_+_260798239 3.39 ENSRNOT00000036791
ligand dependent nuclear receptor corepressor
chr5_-_73986373 3.29 ENSRNOT00000064043
ENSRNOT00000032299
transmembrane protein 245
chr3_+_75322884 3.25 ENSRNOT00000066249
olfactory receptor 556
chr16_+_50179458 3.21 ENSRNOT00000041946
coagulation factor XI
chr3_-_119405453 3.19 ENSRNOT00000090355
signal peptide peptidase-like 2A
chr5_-_100970043 3.05 ENSRNOT00000013950
zinc finger, DHHC-type containing 21
chr3_-_76346196 3.04 ENSRNOT00000047702
olfactory receptor 613
chr3_-_3890758 2.96 ENSRNOT00000064083
SEC16 homolog A, endoplasmic reticulum export factor
chr4_-_40136061 2.94 ENSRNOT00000009752
base methyltransferase of 25S rRNA 2 homolog
chr3_-_103203299 2.87 ENSRNOT00000047208
olfactory receptor 783
chr13_-_74520634 2.82 ENSRNOT00000077169
Ral GEF with PH domain and SH3 binding motif 2
chr17_+_69960160 2.81 ENSRNOT00000023887
urocortin 3
chr5_-_155709215 2.76 ENSRNOT00000018118
cell division cycle 42
chr20_+_44220840 2.75 ENSRNOT00000047194
tubulin, epsilon 1
chrX_+_112311251 2.73 ENSRNOT00000086698

chr5_-_56536772 2.65 ENSRNOT00000060765
DEXD/H-box helicase 58
chr17_-_32015071 2.60 ENSRNOT00000070876
leukocyte elastase inhibitor A-like
chr5_+_121952977 2.58 ENSRNOT00000008278
phosphodiesterase 4B
chr3_-_75752501 2.56 ENSRNOT00000042725
olfactory receptor 578
chr8_-_77398156 2.54 ENSRNOT00000091858
ENSRNOT00000085349
ENSRNOT00000082763
lipase C, hepatic type
chr11_+_81796891 2.53 ENSRNOT00000058402
crystallin, gamma S
chrX_-_36884748 2.51 ENSRNOT00000065678
phosphorylase kinase, alpha 2
chr5_+_35991068 2.49 ENSRNOT00000061139
PNN interacting serine and arginine rich protein
chr9_-_52238564 2.44 ENSRNOT00000005073
collagen type V alpha 2 chain
chr6_+_8220228 2.32 ENSRNOT00000079279
ENSRNOT00000048656
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr1_+_168204985 2.31 ENSRNOT00000049036
olfactory receptor 75
chr2_+_208373154 2.27 ENSRNOT00000082943
ENSRNOT00000050538
adenosine receptor A3-like
chr20_-_6864387 2.26 ENSRNOT00000068527
peptidylprolyl isomerase like 1
chr5_+_159734838 2.22 ENSRNOT00000079905
REM2 and RAB-like small GTPase 1
chrX_+_1787266 2.20 ENSRNOT00000011183
NADH:ubiquinone oxidoreductase subunit B11
chr13_-_91735361 2.18 ENSRNOT00000058090
Fc fragment of IgE receptor Ia
chr2_+_222021103 2.16 ENSRNOT00000086125
dihydropyrimidine dehydrogenase
chr6_+_49852130 2.15 ENSRNOT00000068208
SH3 and SYLF domain containing 1
chr17_+_57906050 2.12 ENSRNOT00000077338

chr13_+_27032048 2.12 ENSRNOT00000031789
serpin family B member 13
chr8_-_43970394 2.11 ENSRNOT00000079362
olfactory receptor 1340
chr17_+_6909728 2.08 ENSRNOT00000061231
hypothetical protein LOC681410
chr16_-_75208230 2.07 ENSRNOT00000058059
defensin beta 10
chr11_+_31893489 2.07 ENSRNOT00000042750
intersectin 1
chr10_+_34489940 2.00 ENSRNOT00000085975
zinc finger protein 62
chr2_+_243656579 1.98 ENSRNOT00000036993
alcohol dehydrogenase 1 (class I)
chr3_+_75518280 1.97 ENSRNOT00000079476
olfactory receptor 566
chr10_-_98390384 1.86 ENSRNOT00000065947
ATP-binding cassette, subfamily A (ABC1), member 8a
chr15_-_70349983 1.80 ENSRNOT00000012167
diaphanous-related formin 3
chr5_-_120743748 1.75 ENSRNOT00000057774

chr1_-_88428685 1.75 ENSRNOT00000074582
zinc finger protein 566
chr9_-_14502933 1.74 ENSRNOT00000078464
unc-5 family C-terminal like
chr17_-_39824299 1.73 ENSRNOT00000023412
prolactin
chr2_+_127525285 1.71 ENSRNOT00000093247
inturned planar cell polarity protein
chr7_-_115979298 1.69 ENSRNOT00000075883
similar to secreted Ly6/uPAR related protein 2
chr10_-_43998533 1.69 ENSRNOT00000047037
olfactory receptor 1417
chr7_-_58365313 1.67 ENSRNOT00000005443
THAP domain containing 2
chr14_-_46054022 1.67 ENSRNOT00000002982
similar to RIKEN cDNA 0610040J01
chr2_+_226563050 1.59 ENSRNOT00000065111
breast cancer anti-estrogen resistance 3
chr10_-_13892997 1.59 ENSRNOT00000004192
TNF receptor associated factor 7
chr3_+_75809445 1.56 ENSRNOT00000049950
olfactory receptor 581
chr3_+_158887412 1.49 ENSRNOT00000075772
olfactory receptor 1261
chr1_+_261291870 1.46 ENSRNOT00000049914
4-hydroxy-2-oxoglutarate aldolase 1
chrX_+_44907521 1.45 ENSRNOT00000004901
transducin (beta)-like 1 X-linked
chr16_+_18716019 1.43 ENSRNOT00000047870
surfactant protein A1
chr20_+_27173213 1.41 ENSRNOT00000073617
heterogeneous nuclear ribonucleoprotein H3
chr20_+_47395014 1.37 ENSRNOT00000057116
osteopetrosis associated transmembrane protein 1
chr3_-_77402579 1.37 ENSRNOT00000043801
olfactory receptor 658
chr10_-_62361963 1.33 ENSRNOT00000072702
olfactory receptor 1
chr5_-_69171311 1.33 ENSRNOT00000072957
olfactory receptor 13C3-like
chr3_-_431933 1.31 ENSRNOT00000033653
speckle type BTB/POZ protein like
chr7_+_6215743 1.31 ENSRNOT00000050967
olfactory receptor 1002
chr3_-_146396299 1.26 ENSRNOT00000040188
ENSRNOT00000008931
adipocyte plasma membrane associated protein
chr3_+_154437571 1.26 ENSRNOT00000019331

chrX_-_105417323 1.21 ENSRNOT00000015494
galactosidase, alpha
chr1_-_55895636 1.21 ENSRNOT00000029537
vomeronasal 2 receptor, 9
chr3_+_20965751 1.21 ENSRNOT00000010450
olfactory receptor 417
chr12_-_38916237 1.16 ENSRNOT00000074517
transmembrane protein 120B
chr10_-_44659707 1.14 ENSRNOT00000002064
similar to Alpha enolase (2-phospho-D-glycerate hydro-lyase)
chr1_-_7443863 1.12 ENSRNOT00000088558
phosphatase and actin regulator 2
chr2_+_165805144 1.11 ENSRNOT00000073716
RAB interacting factor
chr2_+_257568613 1.11 ENSRNOT00000066125
ubiquitin specific peptidase 33
chr11_-_33801999 1.08 ENSRNOT00000002308
SET domain containing 4
chr1_+_172860797 1.07 ENSRNOT00000081313
similar to olfactory receptor 508
chr18_+_3887419 1.05 ENSRNOT00000093089
laminin subunit alpha 3
chr10_-_44026578 1.05 ENSRNOT00000050448
olfactory receptor 1418
chr2_+_208323882 1.04 ENSRNOT00000085178
transmembrane and immunoglobulin domain containing 3
chr3_-_71012860 1.03 ENSRNOT00000078440

chrM_+_11736 1.02 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr20_+_572454 1.01 ENSRNOT00000061839
olfactory receptor 1684
chr17_-_63879166 1.01 ENSRNOT00000049391
ENSRNOT00000045183
zinc finger, MYND-type containing 11
chr11_-_67551211 0.99 ENSRNOT00000049463
stefin A3-like 1
chr6_+_11644578 0.99 ENSRNOT00000021923
ENSRNOT00000093689
mutS homolog 6
chr6_+_136380990 0.98 ENSRNOT00000063865
ENSRNOT00000082914
zinc finger FYVE-type containing 21
chr2_+_243018975 0.97 ENSRNOT00000081989
DnaJ heat shock protein family (Hsp40) member B14
chr6_+_76079880 0.97 ENSRNOT00000009304
similar to 1110008L16Rik protein
chr4_-_66062089 0.95 ENSRNOT00000018782
zinc finger CCCH-type containing, antiviral 1
chr15_-_18521161 0.94 ENSRNOT00000051556
LRRGT00055
chr5_-_100977902 0.93 ENSRNOT00000077429
zinc finger, DHHC-type containing 21
chr1_-_169032157 0.82 ENSRNOT00000034624
olfactory receptor 129

Network of associatons between targets according to the STRING database.

First level regulatory network of Pbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
6.7 20.0 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
6.1 18.2 GO:0048014 Tie signaling pathway(GO:0048014)
5.4 16.1 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
4.8 28.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
3.9 11.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
3.6 10.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
3.1 9.4 GO:0043060 meiotic metaphase I plate congression(GO:0043060)
3.1 21.8 GO:0015670 carbon dioxide transport(GO:0015670)
2.8 52.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
2.7 13.4 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
2.6 13.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
2.0 8.0 GO:0002188 translation reinitiation(GO:0002188)
1.9 5.7 GO:0000105 histidine biosynthetic process(GO:0000105)
1.9 15.1 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
1.8 24.9 GO:0006968 cellular defense response(GO:0006968)
1.8 5.3 GO:1905076 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
1.5 4.4 GO:0036451 cap mRNA methylation(GO:0036451)
1.4 4.3 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
1.3 13.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
1.3 5.3 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
1.3 18.9 GO:0051764 actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
1.3 3.8 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
1.2 9.3 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
1.1 8.6 GO:0043031 negative regulation of macrophage activation(GO:0043031)
1.0 7.3 GO:0070269 pyroptosis(GO:0070269)
1.0 6.2 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
1.0 9.1 GO:0032571 response to vitamin K(GO:0032571)
1.0 3.9 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.9 8.4 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.9 2.8 GO:0060661 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.8 2.5 GO:0010034 response to acetate(GO:0010034)
0.8 16.9 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.8 2.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 2.2 GO:0032752 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.7 2.2 GO:0046127 thymidine catabolic process(GO:0006214) pyrimidine deoxyribonucleoside catabolic process(GO:0046127)
0.7 2.8 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.7 4.8 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.7 2.6 GO:0009597 detection of virus(GO:0009597)
0.7 2.0 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.6 3.9 GO:0046836 glycolipid transport(GO:0046836)
0.6 4.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.6 3.8 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.6 20.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 4.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.5 5.8 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.5 16.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 3.2 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.4 2.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 2.1 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.4 4.6 GO:0006013 mannose metabolic process(GO:0006013)
0.4 6.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.4 9.3 GO:0006298 mismatch repair(GO:0006298)
0.4 43.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.4 4.6 GO:0097068 response to thyroxine(GO:0097068)
0.4 3.4 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.4 3.6 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.3 9.8 GO:0071361 cellular response to ethanol(GO:0071361)
0.3 3.0 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 5.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.3 3.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.3 5.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 3.7 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 1.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.2 1.7 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 4.1 GO:0071447 cellular response to hydroperoxide(GO:0071447) regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 1.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.2 0.8 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 2.9 GO:0031167 rRNA methylation(GO:0031167)
0.2 1.0 GO:0052055 modulation by symbiont of host molecular function(GO:0052055)
0.2 4.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.2 1.4 GO:0008228 opsonization(GO:0008228)
0.2 2.3 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.2 10.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.2 2.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 5.1 GO:0048266 behavioral response to pain(GO:0048266)
0.2 9.6 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.1 3.7 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 0.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 13.0 GO:0050715 positive regulation of cytokine secretion(GO:0050715)
0.1 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 19.9 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 4.8 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.6 GO:0000185 activation of MAPKKK activity(GO:0000185) positive regulation of protein sumoylation(GO:0033235)
0.1 0.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.4 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.1 2.1 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 2.6 GO:0019835 cytolysis(GO:0019835)
0.1 0.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 3.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 3.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 2.8 GO:0035902 response to immobilization stress(GO:0035902)
0.1 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.7 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.1 2.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 2.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 4.1 GO:0008344 adult locomotory behavior(GO:0008344)
0.0 3.9 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.0 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 6.3 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.6 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 2.1 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.5 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 1.4 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 1.3 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 1.7 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 4.7 GO:0006897 endocytosis(GO:0006897)
0.0 1.4 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 1.1 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.4 GO:0005713 chiasma(GO:0005712) recombination nodule(GO:0005713)
2.9 11.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
2.8 52.7 GO:0042589 zymogen granule membrane(GO:0042589)
1.6 4.9 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
1.5 7.3 GO:0072558 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
1.3 3.9 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.9 8.4 GO:1990075 periciliary membrane compartment(GO:1990075)
0.7 11.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.7 18.9 GO:0001891 phagocytic cup(GO:0001891)
0.6 2.4 GO:0005588 collagen type V trimer(GO:0005588)
0.5 4.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.5 13.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 7.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 1.0 GO:0032301 MutSalpha complex(GO:0032301)
0.5 18.8 GO:0001772 immunological synapse(GO:0001772)
0.5 2.8 GO:0000322 storage vacuole(GO:0000322)
0.5 3.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.4 13.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.4 6.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 9.1 GO:0031091 platelet alpha granule(GO:0031091)
0.4 5.6 GO:0044754 autolysosome(GO:0044754)
0.4 10.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 2.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 22.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 88.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 9.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 15.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 6.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 15.4 GO:0005902 microvillus(GO:0005902)
0.2 1.1 GO:0005608 laminin-3 complex(GO:0005608)
0.2 0.5 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.2 6.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.8 GO:0043196 varicosity(GO:0043196)
0.1 2.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 8.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 10.3 GO:0005884 actin filament(GO:0005884)
0.1 4.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.6 GO:0033290 eukaryotic 48S preinitiation complex(GO:0033290)
0.1 4.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.4 GO:0019013 viral nucleocapsid(GO:0019013)
0.1 3.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.4 GO:0005771 multivesicular body(GO:0005771)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 12.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0070469 respiratory chain(GO:0070469)
0.0 4.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 8.6 GO:0045177 apical part of cell(GO:0045177)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 52.7 GO:0035375 zymogen binding(GO:0035375)
3.6 10.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
3.0 21.3 GO:0004064 arylesterase activity(GO:0004064)
3.0 11.9 GO:0004743 pyruvate kinase activity(GO:0004743)
2.7 21.8 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
2.3 11.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.2 20.0 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.1 10.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
2.0 5.9 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
1.5 4.6 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
1.5 4.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
1.4 5.7 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
1.3 13.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.3 10.0 GO:0004630 phospholipase D activity(GO:0004630)
1.2 3.6 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
1.0 10.3 GO:0019957 C-C chemokine binding(GO:0019957)
1.0 5.8 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.9 2.8 GO:0032427 GBD domain binding(GO:0032427)
0.9 5.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.8 16.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.8 3.8 GO:0005534 galactose binding(GO:0005534)
0.7 2.9 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.7 2.2 GO:0017113 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.7 2.8 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.6 7.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.6 3.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.5 3.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.5 13.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.5 5.1 GO:0015925 galactosidase activity(GO:0015925)
0.5 4.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 20.8 GO:0070888 E-box binding(GO:0070888)
0.4 20.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 2.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 1.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 2.2 GO:0019767 IgE receptor activity(GO:0019767)
0.4 4.6 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 2.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.3 1.7 GO:0005148 prolactin receptor binding(GO:0005148)
0.3 0.8 GO:0008396 oxysterol 7-alpha-hydroxylase activity(GO:0008396)
0.3 3.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.3 5.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 18.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 75.6 GO:0030246 carbohydrate binding(GO:0030246)
0.2 6.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.4 GO:0001671 ATPase activator activity(GO:0001671)
0.2 11.7 GO:0003684 damaged DNA binding(GO:0003684)
0.2 11.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.5 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 4.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.9 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 9.1 GO:0005507 copper ion binding(GO:0005507)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 4.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 24.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 0.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 15.1 GO:0035326 enhancer binding(GO:0035326)
0.1 1.7 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 4.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 9.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.7 GO:0003840 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1 1.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 46.0 GO:0003779 actin binding(GO:0003779)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.5 GO:0034235 GPI-anchor transamidase activity(GO:0003923) GPI anchor binding(GO:0034235)
0.1 2.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 7.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 6.2 GO:0002020 protease binding(GO:0002020)
0.1 2.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 3.4 GO:0019843 rRNA binding(GO:0019843)
0.1 3.5 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.1 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 9.1 GO:0042393 histone binding(GO:0042393)
0.0 1.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 17.0 GO:0005525 GTP binding(GO:0005525)
0.0 4.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0031770 growth hormone-releasing hormone receptor binding(GO:0031770)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 11.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 5.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.8 GO:0044212 transcription regulatory region DNA binding(GO:0044212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 45.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.9 50.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.7 13.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.3 11.7 PID ALK1 PATHWAY ALK1 signaling events
0.3 15.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 18.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 13.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.3 5.3 ST G ALPHA I PATHWAY G alpha i Pathway
0.3 2.5 ST GAQ PATHWAY G alpha q Pathway
0.3 7.0 PID AURORA A PATHWAY Aurora A signaling
0.2 11.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 40.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 25.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 9.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 4.1 PID IFNG PATHWAY IFN-gamma pathway
0.1 3.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 7.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 7.4 PID NOTCH PATHWAY Notch signaling pathway
0.1 5.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.8 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 20.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.1 13.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.1 11.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.9 18.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.9 13.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.8 9.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.8 24.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.7 11.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.6 21.8 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.6 9.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.5 13.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.5 5.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 11.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.5 4.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.5 3.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.4 5.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.3 4.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 6.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 2.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 7.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 4.0 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.2 4.6 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 5.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 7.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 16.1 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.2 3.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 3.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 2.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.8 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 2.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 10.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 4.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 10.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.8 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 2.5 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 1.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 3.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex