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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pbx1_Pbx3

Z-value: 1.52

Motif logo

Transcription factors associated with Pbx1_Pbx3

Gene Symbol Gene ID Gene Info
ENSRNOG00000004693 PBX homeobox 1
ENSRNOG00000022162 PBX homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pbx1rn6_v1_chr13_-_86451002_864510020.351.5e-10Click!
Pbx3rn6_v1_chr3_-_13525983_13525983-0.045.2e-01Click!

Activity profile of Pbx1_Pbx3 motif

Sorted Z-values of Pbx1_Pbx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_55669626 121.20 ENSRNOT00000033352
cadherin 15
chrX_+_107496072 72.86 ENSRNOT00000003283
proteolipid protein 1
chr17_+_10384511 55.99 ENSRNOT00000024357
synuclein, beta
chrX_-_64726210 52.67 ENSRNOT00000076012
ENSRNOT00000086265
ankyrin repeat and SOCS box-containing 12
chr17_+_41798783 48.74 ENSRNOT00000023519
neurensin 1
chr6_+_58468155 42.37 ENSRNOT00000091263
ets variant 1
chr5_+_58393603 40.04 ENSRNOT00000080082
DnaJ heat shock protein family (Hsp40) member B5
chr5_+_43603043 39.58 ENSRNOT00000009899
Eph receptor A7
chrX_-_64715823 39.22 ENSRNOT00000076297
ankyrin repeat and SOCS box-containing 12
chr18_+_56193978 37.58 ENSRNOT00000041533
ENSRNOT00000080177
calcium/calmodulin-dependent protein kinase II alpha
chr14_-_86047162 37.30 ENSRNOT00000018227
phosphoglycerate mutase 2
chr5_-_59025631 35.97 ENSRNOT00000049000
ENSRNOT00000022801
tropomyosin 2, beta
chr5_+_58393233 35.70 ENSRNOT00000000142
DnaJ heat shock protein family (Hsp40) member B5
chrX_-_64702441 35.68 ENSRNOT00000051132
APC membrane recruitment protein 1
chr19_+_17290178 34.53 ENSRNOT00000060865
AKT interacting protein
chrX_+_106774980 34.06 ENSRNOT00000046091
transcription elongation factor A like 7
chr2_+_198655437 33.89 ENSRNOT00000028781
hemochromatosis type 2 (juvenile)
chr1_+_99762253 33.84 ENSRNOT00000065876
kallikrein related-peptidase 6
chr1_+_48077033 33.10 ENSRNOT00000020100
MAS1 proto-oncogene, G protein-coupled receptor
chr8_-_72842228 32.89 ENSRNOT00000090288
tropomyosin 1, alpha
chr6_+_132242328 32.57 ENSRNOT00000081088
cytochrome P450, family 46, subfamily a, polypeptide 1
chr18_-_6782996 32.00 ENSRNOT00000090320
aquaporin 4
chr18_-_6782757 31.73 ENSRNOT00000068150
aquaporin 4
chrX_-_105622156 31.42 ENSRNOT00000029511
armadillo repeat containing, X-linked 2
chr2_-_22744407 30.33 ENSRNOT00000073710
cardiomyopathy associated 5
chr3_-_172566010 29.08 ENSRNOT00000071913
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr16_+_20432899 28.35 ENSRNOT00000026271
MPV17 mitochondrial inner membrane protein like 2
chr5_-_136748980 28.32 ENSRNOT00000026844
importin 13
chr2_-_142885604 27.89 ENSRNOT00000031487
Fras1 related extracellular matrix protein 2
chr7_-_25743537 24.87 ENSRNOT00000083450
uncharacterized LOC100910996
chr15_-_28313841 23.70 ENSRNOT00000085897
NDRG family member 2
chr7_-_124982566 23.51 ENSRNOT00000075099
sulfotransferase family 4A, member 1
chr5_+_26493212 23.50 ENSRNOT00000061328
triple QxxK/R motif containing
chr2_+_174542667 22.78 ENSRNOT00000076793
follistatin-like 5
chr8_-_72841496 22.78 ENSRNOT00000057641
ENSRNOT00000040808
ENSRNOT00000085894
ENSRNOT00000024575
ENSRNOT00000048044
ENSRNOT00000024493
tropomyosin 1, alpha
chr4_+_110700403 22.55 ENSRNOT00000092379
leucine rich repeat transmembrane neuronal 4
chr3_+_113257688 22.31 ENSRNOT00000019320
microtubule-associated protein 1A
chr3_+_171832500 22.17 ENSRNOT00000007554
VAMP associated protein B and C
chr14_+_78640620 21.88 ENSRNOT00000034730
wolframin ER transmembrane glycoprotein
chr2_+_95320283 21.85 ENSRNOT00000015537
hes-related family bHLH transcription factor with YRPW motif 1
chr8_-_95387363 21.67 ENSRNOT00000014657
T-box18
chr3_-_105512939 21.65 ENSRNOT00000011773
actin, alpha, cardiac muscle 1
chr4_+_78168117 21.60 ENSRNOT00000010853
ATPase, H+ transporting V0 subunit e2
chr5_+_33580944 21.46 ENSRNOT00000092054
ENSRNOT00000036050
regulator of microtubule dynamics 1
chr5_+_76812931 21.46 ENSRNOT00000059458
hydroxysteroid dehydrogenase like 2
chr1_+_240908483 21.39 ENSRNOT00000019367
Kruppel-like factor 9
chr15_-_28314459 21.18 ENSRNOT00000042055
ENSRNOT00000040540
NDRG family member 2
chr10_-_77918191 20.57 ENSRNOT00000055664
HLF, PAR bZIP transcription factor
chr2_-_140618405 20.18 ENSRNOT00000017736
SET domain containing (lysine methyltransferase) 7
chr8_-_33017854 20.06 ENSRNOT00000011386
BARX homeobox 2
chr13_-_88061108 19.99 ENSRNOT00000003774
regulator of G-protein signaling 4
chr6_-_39363367 19.25 ENSRNOT00000088687
ENSRNOT00000065531
family with sequence similarity 84, member A
chr9_-_40008680 18.99 ENSRNOT00000016578
KH RNA binding domain containing, signal transduction associated 2
chr6_-_99783047 18.87 ENSRNOT00000009028
spectrin, beta, erythrocytic
chr10_-_47724499 18.69 ENSRNOT00000085011
ring finger protein 112
chr1_+_101427195 18.62 ENSRNOT00000028271
glycogen synthase 1
chr14_+_63095720 17.68 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr19_+_25095089 17.52 ENSRNOT00000041717
protein kinase cAMP-activated catalytic subunit alpha
chr6_-_124735741 17.46 ENSRNOT00000064716
ENSRNOT00000091693
ribosomal protein S6 kinase A5
chr2_+_98252925 17.04 ENSRNOT00000011579
peroxisomal biogenesis factor 2
chr2_-_220535751 16.96 ENSRNOT00000089082
palmdelphin
chr10_+_86303727 16.75 ENSRNOT00000037752
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr10_-_46720907 16.50 ENSRNOT00000083093
ENSRNOT00000067866
target of myb1 like 2 membrane trafficking protein
chr4_-_150520774 15.98 ENSRNOT00000009095
zinc finger protein 9
chr1_+_60717386 15.34 ENSRNOT00000015019
protein phosphatase 2 scaffold subunit A alpha
chr4_-_108008484 15.28 ENSRNOT00000007971
catenin alpha 2
chr3_+_11593655 15.18 ENSRNOT00000074122
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr9_+_118586179 15.16 ENSRNOT00000022351
DLG associated protein 1
chrX_+_9436707 15.16 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr20_+_4369178 15.00 ENSRNOT00000088079
1-acylglycerol-3-phosphate O-acyltransferase 1
chr10_+_63327555 14.44 ENSRNOT00000084535
carboxypeptidase D
chr10_-_71383602 14.38 ENSRNOT00000083300
dual specificity phosphatase 14
chr17_+_5281727 14.31 ENSRNOT00000024781
iron-sulfur cluster assembly 1
chr10_-_103816287 13.97 ENSRNOT00000004477
glutamate ionotropic receptor NMDA type subunit 2C
chr15_+_2526368 13.76 ENSRNOT00000048713
ENSRNOT00000074803
dual specificity phosphatase 13
dual specificity phosphatase 13
chr1_-_216971183 13.76 ENSRNOT00000077911
MAS related GPR family member E
chr4_+_9966891 13.67 ENSRNOT00000086609
N-acyl phosphatidylethanolamine phospholipase D
chr8_-_8524643 13.54 ENSRNOT00000009418
contactin 5
chr1_+_97632473 13.14 ENSRNOT00000023671
V-set and transmembrane domain containing 2B
chr15_+_2733114 13.13 ENSRNOT00000074545
dual specificity protein phosphatase 13
chr8_+_1502877 13.01 ENSRNOT00000034482
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr13_+_77602249 12.46 ENSRNOT00000003407
ENSRNOT00000076589
tenascin R
chr11_+_64790801 12.44 ENSRNOT00000004023
translocase of inner mitochondrial membrane domain containing 1
chr14_-_51462721 12.01 ENSRNOT00000015044
high mobility group box 3
chr8_-_94563760 11.83 ENSRNOT00000032792
synaptosomal-associated protein 91
chrX_+_110016995 11.78 ENSRNOT00000093542
Nik related kinase
chrX_+_105911925 11.74 ENSRNOT00000052422
armadillo repeat-containing X-linked protein 1
chr5_+_5866897 11.70 ENSRNOT00000011940
solute carrier organic anion transporter family, member 5A1
chr3_+_9822580 11.70 ENSRNOT00000010786
ENSRNOT00000093718
ubiquitin specific peptidase 20
chr2_+_198726118 11.62 ENSRNOT00000056237
limb and CNS expressed 1 like
chr4_+_61912210 11.60 ENSRNOT00000013569
bisphosphoglycerate mutase
chr8_+_22189600 11.58 ENSRNOT00000061100
phosphodiesterase 4A
chr9_+_73334618 11.43 ENSRNOT00000092717
microtubule-associated protein 2
chr18_-_69944632 11.39 ENSRNOT00000047271
mitogen-activated protein kinase 4
chr12_+_18516946 11.36 ENSRNOT00000029485
dehydrogenase/reductase X-linked
chr6_+_55812747 11.29 ENSRNOT00000008106
sclerostin domain containing 1
chr2_+_46980976 11.26 ENSRNOT00000083668
ENSRNOT00000082990
molybdenum cofactor synthesis 2
chr1_-_56683731 11.25 ENSRNOT00000014552
thrombospondin 2
chrX_+_82143789 10.90 ENSRNOT00000003724
POU class 3 homeobox 4
chr8_+_131845696 10.76 ENSRNOT00000005440
T cell activation inhibitor, mitochondrial
chr9_-_82699551 10.61 ENSRNOT00000020673
obscurin-like 1
chr10_+_91830654 10.61 ENSRNOT00000005176
wingless-type MMTV integration site family, member 3
chrX_-_106558366 10.35 ENSRNOT00000042126
brain expressed X-linked 2
chr8_+_117820538 10.33 ENSRNOT00000028075
coiled-coil domain containing 51
chr18_-_14016713 10.27 ENSRNOT00000041125
nucleolar protein 4
chr3_-_121488540 10.27 ENSRNOT00000023845
zinc finger CCCH type containing 8
chr20_+_4369394 9.98 ENSRNOT00000088734
ENSRNOT00000091491
1-acylglycerol-3-phosphate O-acyltransferase 1
chr1_+_101688297 9.97 ENSRNOT00000091606
D-box binding PAR bZIP transcription factor
chr2_+_188528979 9.96 ENSRNOT00000087934
thrombospondin 3
chr17_+_36690249 9.91 ENSRNOT00000089476
ENSRNOT00000082140
similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a)
chr1_+_101687855 9.63 ENSRNOT00000028546
ENSRNOT00000091597
D-box binding PAR bZIP transcription factor
chr12_+_52670898 9.56 ENSRNOT00000056632
putative GTP-binding protein 6-like
chr4_-_113954272 9.52 ENSRNOT00000039966
ENSRNOT00000082996
WW domain-binding protein 1
chr14_-_18704059 9.46 ENSRNOT00000081455
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr1_+_78933372 9.39 ENSRNOT00000029810
coiled-coil domain containing 8
chr5_+_74727494 9.12 ENSRNOT00000076683

chr8_-_94564525 9.08 ENSRNOT00000084437
synaptosomal-associated protein 91
chr4_-_114819848 9.02 ENSRNOT00000084381
WW domain binding protein 1
chr5_+_159484370 8.94 ENSRNOT00000010593
succinate dehydrogenase complex iron sulfur subunit B
chr8_+_59561721 8.86 ENSRNOT00000093107
ENSRNOT00000065771
ENSRNOT00000088304
cholinergic receptor nicotinic alpha 5 subunit
chr5_-_169017295 8.63 ENSRNOT00000067481
calmodulin binding transcription activator 1
chr5_-_168123395 8.54 ENSRNOT00000024932
period circadian clock 3
chr5_+_165724027 8.42 ENSRNOT00000018000
castor zinc finger 1
chr12_-_22680630 8.41 ENSRNOT00000041808
VGF nerve growth factor inducible
chr19_+_27404712 8.41 ENSRNOT00000023657
myosin light chain kinase 3
chr3_+_160207913 8.26 ENSRNOT00000014346
WNT1 inducible signaling pathway protein 2
chr3_-_120076788 7.98 ENSRNOT00000047158
potassium voltage-gated channel interacting protein 3
chr18_+_79326738 7.81 ENSRNOT00000089879
myelin basic protein
chr16_+_23447366 7.65 ENSRNOT00000068629
pleckstrin and Sec7 domain containing 3
chr2_+_196334626 7.59 ENSRNOT00000050914
ENSRNOT00000028645
ENSRNOT00000090729
semaphorin 6C
chr10_+_40812858 7.38 ENSRNOT00000018149
G3BP stress granule assembly factor 1
chr12_+_52637000 7.32 ENSRNOT00000063905
GTP binding protein 6 (putative)
chr7_+_80750725 7.29 ENSRNOT00000079962
oxidation resistance 1
chr1_-_53802658 7.23 ENSRNOT00000032667
afadin, adherens junction formation factor
chr3_+_148234193 7.16 ENSRNOT00000010418
cytochrome c oxidase subunit 4i2
chr7_+_123578878 7.09 ENSRNOT00000011316
single-pass membrane protein with aspartate-rich tail 1
chr3_+_155297566 6.92 ENSRNOT00000021435
ENSRNOT00000084866
DEAH-box helicase 35
chr4_+_168976859 6.91 ENSRNOT00000068663
family with sequence similarity 234, member B
chr3_-_60795951 6.89 ENSRNOT00000002174
activating transcription factor 2
chr10_-_109604899 6.66 ENSRNOT00000080188
NPL4 homolog, ubiquitin recognition factor
chr1_+_261229347 6.60 ENSRNOT00000018485
ubiquitin domain containing 1
chr5_+_137497363 6.58 ENSRNOT00000072522
olfactory receptor 2A5-like
chr9_+_65933018 6.33 ENSRNOT00000047929
similar to coiled-coil-helix-coiled-coil-helix domain containing 4
chr20_+_18493538 6.31 ENSRNOT00000000749
CDGSH iron sulfur domain 1
chr3_-_148407778 6.28 ENSRNOT00000011262
forkhead box S1
chr12_-_17522534 6.21 ENSRNOT00000047287
Sad1 and UNC84 domain containing 1
chr15_-_108898703 6.14 ENSRNOT00000067577
Zic family member 5
chr15_-_34400449 6.00 ENSRNOT00000048455
Rab geranylgeranyltransferase, alpha subunit
chr6_-_8956276 5.93 ENSRNOT00000079027
SIX homeobox 2
chr8_+_94686938 5.89 ENSRNOT00000013285
ripply transcriptional repressor 2
chr20_-_11626876 5.73 ENSRNOT00000001635
keratin associated protein 12-1-like
chr3_-_9822182 5.69 ENSRNOT00000076637
ENSRNOT00000010115
similar to Hypothetical protein MGC11690
chr4_+_57034675 5.69 ENSRNOT00000080223
smoothened, frizzled class receptor
chr2_-_19808937 5.55 ENSRNOT00000044237
ATPase H+ transporting accessory protein 1 like
chr20_-_29199224 5.34 ENSRNOT00000071477
mitochondrial calcium uniporter
chr2_+_203301838 5.31 ENSRNOT00000043146
tripartite motif-containing 45
chr10_-_20658100 5.18 ENSRNOT00000010252
arginyl-tRNA synthetase
chr3_-_1116677 5.16 ENSRNOT00000050371
TATA box binding protein-like 2
chr19_+_37229120 5.13 ENSRNOT00000076335
heat shock transcription factor 4
chr12_-_2603705 5.13 ENSRNOT00000001367
ecotropic viral integration site 5-like
chrX_+_156429585 5.09 ENSRNOT00000083203
ENSRNOT00000077322
deoxyribonuclease 1-like 1
chr4_-_114820127 5.09 ENSRNOT00000079376
WW domain binding protein 1
chr4_+_88694583 5.05 ENSRNOT00000009202
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr1_-_4011353 5.02 ENSRNOT00000049699
syntaxin binding protein 5
chr7_-_9630611 5.01 ENSRNOT00000011176
olfactory receptor 1072
chr19_-_43215077 4.99 ENSRNOT00000082151
alanyl-tRNA synthetase
chr8_-_117820413 4.88 ENSRNOT00000075819
translation machinery associated 7 homolog
chr1_+_215701544 4.83 ENSRNOT00000027585
mitochondrial ribosomal protein L23
chr2_+_78407414 4.73 ENSRNOT00000084541
ENSRNOT00000087109
zinc finger protein 622
chr7_+_11545024 4.71 ENSRNOT00000073221
solute carrier family 39 member 3
chrX_-_71127237 4.60 ENSRNOT00000076403
ENSRNOT00000076635
ENSRNOT00000068098
sorting nexin 12
chr2_+_187512164 4.58 ENSRNOT00000051394
myocyte enhancer factor 2D
chr3_-_113231790 4.57 ENSRNOT00000019025
tumor protein p53 binding protein 1
chr6_+_8219385 4.49 ENSRNOT00000040509
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr2_+_78262839 4.44 ENSRNOT00000066879
protein FAM134B
chr6_-_109103999 4.43 ENSRNOT00000009086
ENSRNOT00000080009
acylphosphatase 1
chr7_+_11737293 4.41 ENSRNOT00000046059
leucine rich repeat and Ig domain containing 3
chr3_+_38367556 4.34 ENSRNOT00000049144
similar to developmental pluripotency associated 5
chr10_-_104179523 4.28 ENSRNOT00000005292
solute carrier family 25 member 19
chr12_-_18487178 4.24 ENSRNOT00000030757
zinc finger protein 157
chr1_+_222844144 4.23 ENSRNOT00000032879
phospholipase A2, group XVI
chr1_+_248402980 4.12 ENSRNOT00000043517
coiled-coil-helix-coiled-coil-helix domain containing 4
chr5_+_81431600 4.05 ENSRNOT00000013675
tripartite motif-containing 32
chr1_-_4011511 4.04 ENSRNOT00000040559
syntaxin binding protein 5
chrX_-_139464798 4.02 ENSRNOT00000003282
glypican 4
chr15_+_34234193 4.02 ENSRNOT00000077584
DDB1 and CUL4 associated factor 11
chr10_-_104358253 4.01 ENSRNOT00000005942
cask-interacting protein 2
chr16_+_52024690 3.98 ENSRNOT00000048104

chr9_+_61720583 3.91 ENSRNOT00000020536
MOB family member 4, phocein
chr17_-_84830185 3.91 ENSRNOT00000040697
SKI/DACH domain containing 1
chr4_-_56453563 3.87 ENSRNOT00000060362
proline-rich transmembrane protein 4
chr19_+_14392423 3.82 ENSRNOT00000018880
target of myb1 membrane trafficking protein
chr10_+_88245532 3.76 ENSRNOT00000019863
gastrin
chr12_-_13251112 3.63 ENSRNOT00000044378
Grid2 interacting protein
chr19_-_43215281 3.63 ENSRNOT00000025052
alanyl-tRNA synthetase
chr9_+_72052966 3.58 ENSRNOT00000021099
parathyroid hormone 2 receptor
chr1_-_215373234 3.55 ENSRNOT00000034299

chr1_-_229804614 3.52 ENSRNOT00000049665
olfactory receptor 343
chr7_+_8210182 3.46 ENSRNOT00000075032
olfactory receptor 1049
chrX_+_106823491 3.37 ENSRNOT00000045997
brain expressed X-linked 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
18.6 55.7 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
15.9 63.7 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
11.2 44.9 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
7.5 37.6 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628)
7.3 21.9 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
7.3 21.8 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
7.2 21.7 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
7.1 21.4 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
7.0 48.9 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
6.6 39.6 GO:0051964 negative regulation of synapse assembly(GO:0051964)
5.9 17.7 GO:0080033 cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) response to resveratrol(GO:1904638) regulation of progesterone biosynthetic process(GO:2000182)
5.7 28.3 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
5.4 21.7 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
5.2 41.6 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
5.1 30.3 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
4.9 72.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
4.7 14.0 GO:0033058 directional locomotion(GO:0033058)
4.4 22.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725)
4.4 17.5 GO:0043988 histone H3-S10 phosphorylation(GO:0043987) histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
3.8 11.3 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
3.7 43.9 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.5 10.6 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696) Spemann organizer formation(GO:0060061)
3.4 13.7 GO:1903999 negative regulation of eating behavior(GO:1903999)
3.2 9.5 GO:0000105 histidine biosynthetic process(GO:0000105)
3.1 15.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
3.0 20.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
2.9 17.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
2.8 8.4 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.6 7.8 GO:1904685 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
2.5 22.5 GO:0097113 AMPA glutamate receptor clustering(GO:0097113)
2.4 16.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
2.4 33.1 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
2.3 32.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.3 6.9 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
2.2 8.6 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
2.1 33.9 GO:0016540 protein autoprocessing(GO:0016540)
2.1 8.4 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
2.1 12.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.0 14.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
2.0 20.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
2.0 11.8 GO:0060721 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
1.9 25.0 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
1.9 5.7 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.9 15.2 GO:0070842 aggresome assembly(GO:0070842)
1.8 14.4 GO:0071352 cellular response to interleukin-2(GO:0071352)
1.7 10.3 GO:2000399 negative regulation of T cell differentiation in thymus(GO:0033085) snRNA transcription from RNA polymerase III promoter(GO:0042796) positive regulation of thymocyte apoptotic process(GO:0070245) negative regulation of thymocyte aggregation(GO:2000399)
1.7 15.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.4 7.2 GO:0034334 adherens junction maintenance(GO:0034334)
1.4 4.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
1.4 4.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
1.3 5.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.3 11.3 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
1.2 12.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.2 28.3 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
1.2 33.8 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
1.2 10.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.2 15.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
1.2 4.6 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
1.1 8.9 GO:0035095 behavioral response to nicotine(GO:0035095)
1.1 27.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
1.0 54.0 GO:0042417 dopamine metabolic process(GO:0042417)
1.0 29.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.0 10.9 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
1.0 6.7 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.9 34.5 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.9 17.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.9 4.4 GO:0061709 reticulophagy(GO:0061709)
0.9 33.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.8 3.3 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.8 3.1 GO:1902534 single-organism membrane invagination(GO:1902534)
0.7 2.2 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.7 7.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.7 16.6 GO:0001502 cartilage condensation(GO:0001502)
0.7 2.0 GO:0035408 histone H3-T6 phosphorylation(GO:0035408) regulation of dense core granule biogenesis(GO:2000705)
0.7 4.0 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.7 6.0 GO:0018344 protein geranylgeranylation(GO:0018344)
0.7 7.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.6 57.8 GO:0006986 response to unfolded protein(GO:0006986)
0.6 2.4 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.6 91.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 10.0 GO:0043931 ossification involved in bone maturation(GO:0043931)
0.6 1.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.6 6.2 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.6 8.9 GO:0006105 succinate metabolic process(GO:0006105)
0.6 11.7 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.6 14.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.5 4.2 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.5 8.4 GO:0043084 penile erection(GO:0043084)
0.5 11.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.5 18.7 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.5 20.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.5 2.3 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.5 5.9 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.4 18.9 GO:0051693 actin filament capping(GO:0051693)
0.4 5.1 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.4 4.6 GO:0007512 adult heart development(GO:0007512)
0.4 27.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.4 18.6 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.4 6.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 4.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.3 20.6 GO:0043462 regulation of ATPase activity(GO:0043462)
0.3 1.3 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628) cellular response to magnetism(GO:0071259)
0.3 1.8 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.3 8.0 GO:0048266 behavioral response to pain(GO:0048266)
0.3 9.0 GO:0097352 autophagosome maturation(GO:0097352)
0.3 8.5 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.3 20.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.0 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.2 0.2 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 14.9 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 1.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.2 5.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 1.3 GO:0006983 ER overload response(GO:0006983)
0.2 1.7 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.2 2.5 GO:0035357 peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.2 1.4 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 4.2 GO:0010453 regulation of cell fate commitment(GO:0010453)
0.2 4.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.2 1.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 8.1 GO:0032392 DNA geometric change(GO:0032392)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.4 GO:0006567 threonine catabolic process(GO:0006567)
0.1 9.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.5 GO:1990564 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 7.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.9 GO:0016180 snRNA processing(GO:0016180)
0.1 2.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 10.1 GO:0050818 regulation of coagulation(GO:0050818)
0.1 4.1 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 2.5 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 8.4 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 4.8 GO:0032543 mitochondrial translation(GO:0032543)
0.1 3.6 GO:0060292 long term synaptic depression(GO:0060292)
0.1 7.4 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 66.2 GO:0016567 protein ubiquitination(GO:0016567)
0.1 3.8 GO:0032094 response to food(GO:0032094)
0.1 7.9 GO:0048839 inner ear development(GO:0048839)
0.1 2.6 GO:0006284 base-excision repair(GO:0006284)
0.1 3.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 1.7 GO:0097502 mannosylation(GO:0097502)
0.0 13.6 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.0 7.6 GO:0007411 axon guidance(GO:0007411)
0.0 4.1 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 3.7 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.0 2.2 GO:0001942 hair follicle development(GO:0001942) skin epidermis development(GO:0098773)
0.0 2.4 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.4 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 19.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.1 91.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
9.4 37.6 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
7.1 28.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
7.0 20.9 GO:0098833 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
6.9 34.5 GO:0070695 FHF complex(GO:0070695)
5.5 33.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
3.7 29.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
3.3 20.0 GO:1990393 3M complex(GO:1990393)
3.1 18.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
3.1 21.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
3.0 8.9 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
2.6 10.3 GO:0035363 histone locus body(GO:0035363)
2.5 12.5 GO:0072534 perineuronal net(GO:0072534)
2.4 17.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
2.1 12.4 GO:1990246 uniplex complex(GO:1990246)
2.0 176.1 GO:0031594 neuromuscular junction(GO:0031594)
1.8 63.7 GO:0046930 pore complex(GO:0046930)
1.7 21.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
1.5 6.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.3 7.8 GO:0033269 internode region of axon(GO:0033269)
1.3 11.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.2 15.2 GO:0005652 nuclear lamina(GO:0005652)
1.1 22.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.0 17.7 GO:0097440 apical dendrite(GO:0097440)
0.9 17.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.8 14.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.8 30.3 GO:0043034 costamere(GO:0043034)
0.7 6.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 22.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 155.3 GO:0030426 growth cone(GO:0030426)
0.7 2.0 GO:0036488 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.6 15.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 32.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.5 3.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.5 11.3 GO:0031091 platelet alpha granule(GO:0031091)
0.5 5.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 7.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 2.6 GO:0097512 cardiac myofibril(GO:0097512)
0.4 4.0 GO:0005859 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
0.3 71.8 GO:0043209 myelin sheath(GO:0043209)
0.3 24.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 2.2 GO:0044327 dendritic spine head(GO:0044327)
0.2 6.2 GO:0002080 acrosomal membrane(GO:0002080)
0.2 2.4 GO:0035102 PRC1 complex(GO:0035102)
0.2 19.6 GO:0000502 proteasome complex(GO:0000502)
0.2 21.7 GO:0005884 actin filament(GO:0005884)
0.2 11.6 GO:0005840 ribosome(GO:0005840)
0.2 23.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.2 6.9 GO:0035861 site of double-strand break(GO:0035861)
0.2 18.1 GO:0005604 basement membrane(GO:0005604)
0.2 17.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.9 GO:0032039 integrator complex(GO:0032039)
0.2 23.0 GO:0000922 spindle pole(GO:0000922)
0.2 24.5 GO:0043197 dendritic spine(GO:0043197)
0.2 4.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 4.3 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 2.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 22.7 GO:0014069 postsynaptic density(GO:0014069)
0.1 3.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 5.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 8.1 GO:0045095 keratin filament(GO:0045095)
0.1 4.6 GO:1990391 DNA repair complex(GO:1990391)
0.1 3.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 5.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 7.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 2.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0097361 MMXD complex(GO:0071817) CIA complex(GO:0097361)
0.0 8.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 4.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 13.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 42.4 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 48.9 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
7.3 21.8 GO:0035939 microsatellite binding(GO:0035939)
6.7 80.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
5.6 33.9 GO:0098821 BMP receptor activity(GO:0098821)
5.6 56.0 GO:1903136 cuprous ion binding(GO:1903136)
5.6 16.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
5.5 22.2 GO:0033149 FFAT motif binding(GO:0033149)
4.7 33.1 GO:0001595 angiotensin receptor activity(GO:0001595)
4.6 63.7 GO:0015250 water channel activity(GO:0015250)
4.4 17.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
4.0 39.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
3.3 39.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
3.0 8.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
2.7 18.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
2.4 9.5 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
2.3 20.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
2.3 13.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
2.2 102.2 GO:0008307 structural constituent of muscle(GO:0008307)
2.2 8.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
2.1 8.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.1 25.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
2.0 6.0 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
1.9 15.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.8 5.3 GO:0015292 uniporter activity(GO:0015292)
1.8 35.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.4 4.3 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
1.4 14.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.3 6.7 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
1.3 5.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618)
1.3 10.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.2 21.9 GO:0000400 four-way junction DNA binding(GO:0000400)
1.2 21.6 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.2 19.0 GO:0008143 poly(A) binding(GO:0008143)
1.2 15.2 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
1.1 26.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.1 10.9 GO:0003680 AT DNA binding(GO:0003680)
1.1 15.2 GO:0042043 neurexin family protein binding(GO:0042043)
1.0 11.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.9 5.7 GO:0005113 patched binding(GO:0005113)
0.9 7.2 GO:0030274 LIM domain binding(GO:0030274)
0.9 14.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.9 8.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.9 28.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.9 2.6 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.9 20.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.9 32.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.8 4.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.8 3.4 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.8 18.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.8 74.7 GO:0051082 unfolded protein binding(GO:0051082)
0.7 21.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.7 26.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 11.4 GO:0002162 dystroglycan binding(GO:0002162)
0.7 18.9 GO:0030506 ankyrin binding(GO:0030506)
0.6 11.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.6 7.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 1.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.6 14.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 8.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.5 35.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.5 20.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 15.8 GO:0050699 WW domain binding(GO:0050699)
0.4 1.7 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.4 31.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 11.4 GO:0004707 MAP kinase activity(GO:0004707)
0.4 28.1 GO:0017022 myosin binding(GO:0017022)
0.4 20.3 GO:0030276 clathrin binding(GO:0030276)
0.4 10.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 22.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 23.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.3 8.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 20.2 GO:0002039 p53 binding(GO:0002039)
0.3 22.3 GO:0005518 collagen binding(GO:0005518)
0.3 8.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 7.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 33.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 5.2 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.2 1.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 1.2 GO:0019808 polyamine binding(GO:0019808)
0.2 105.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 59.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 28.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.1 GO:0048018 receptor agonist activity(GO:0048018)
0.1 6.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 2.4 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.4 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.5 GO:0004966 galanin receptor activity(GO:0004966)
0.1 4.1 GO:0043022 ribosome binding(GO:0043022)
0.0 2.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.0 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 2.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 12.4 GO:0005549 odorant binding(GO:0005549)
0.0 3.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 17.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 42.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
1.4 37.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.4 25.8 PID LPA4 PATHWAY LPA4-mediated signaling events
1.1 31.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.9 3.8 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.9 18.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.8 15.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.8 45.2 PID BMP PATHWAY BMP receptor signaling
0.8 33.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.7 22.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.6 17.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 6.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 19.5 PID P53 REGULATION PATHWAY p53 pathway
0.3 20.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.3 12.5 PID LKB1 PATHWAY LKB1 signaling events
0.2 4.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 28.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 2.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 5.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 19.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 1.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 2.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 63.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
4.3 121.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
3.4 51.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
3.4 91.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
2.7 32.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.8 29.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.8 23.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.8 49.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.0 34.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.9 37.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.9 17.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.8 4.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.8 25.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.7 8.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.6 6.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.6 22.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 18.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 8.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 18.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.4 19.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4 97.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 4.6 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.4 20.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 4.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 13.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 12.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.2 7.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 4.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 2.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 4.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 11.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 1.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 15.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 1.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 2.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 4.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 5.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 4.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway