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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax6

Z-value: 0.72

Motif logo

Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
ENSRNOG00000004410 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6rn6_v1_chr3_+_95711555_957115550.062.8e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_197821936 24.68 ENSRNOT00000055027
CD19 molecule
chr4_+_98457810 24.41 ENSRNOT00000074175

chr3_+_16413080 21.59 ENSRNOT00000040386
Ig kappa chain V19-17-like
chr8_-_49280901 17.78 ENSRNOT00000021390
CD3g molecule
chr17_-_44840131 17.67 ENSRNOT00000083417
histone cluster 1, H3b
chr6_-_143195445 15.59 ENSRNOT00000078672

chr4_-_102124609 14.90 ENSRNOT00000048263

chr2_+_189997129 14.75 ENSRNOT00000015958
S100 calcium-binding protein A4
chr15_+_62406873 14.33 ENSRNOT00000047572
olfactomedin 4
chr6_-_140216072 14.31 ENSRNOT00000072365

chr3_-_52849907 13.17 ENSRNOT00000041096
sodium voltage-gated channel alpha subunit 7
chr3_+_16846412 13.12 ENSRNOT00000074266

chr6_-_143195143 12.83 ENSRNOT00000081337

chr9_-_103207190 12.51 ENSRNOT00000026010
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr1_-_280015358 12.11 ENSRNOT00000024548
heat shock protein family A (Hsp70) member 12A
chr15_+_32614002 11.99 ENSRNOT00000072962

chr1_-_141470380 11.80 ENSRNOT00000065759
perilipin 1
chr15_-_28081465 11.77 ENSRNOT00000033739
ribonuclease, RNase A family, 6
chr3_+_45538797 11.70 ENSRNOT00000007632
death associated protein-like 1
chr6_-_140215907 10.61 ENSRNOT00000086370

chr11_-_84931160 10.61 ENSRNOT00000071848
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr18_+_55666027 10.51 ENSRNOT00000045950
similar to CDNA sequence BC023105
chrX_-_77295426 10.34 ENSRNOT00000090833
TATA-box binding protein associated factor 9b
chr18_+_55463308 10.14 ENSRNOT00000073388
interferon-inducible GTPase 1-like
chr14_+_71542057 10.06 ENSRNOT00000082592
ENSRNOT00000083701
ENSRNOT00000084322
prominin 1
chr2_-_88553086 9.38 ENSRNOT00000042494
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chrX_+_159158194 9.01 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr7_+_42304534 8.77 ENSRNOT00000085097
KIT ligand
chr17_+_44738643 8.76 ENSRNOT00000087643
histone H2A type 1-like
chr6_-_102196138 8.75 ENSRNOT00000014132
transmembrane protein 229B
chr1_+_86938138 8.69 ENSRNOT00000075601
coiled-coil glutamate-rich protein 2
chr13_+_92264231 8.56 ENSRNOT00000066509
ENSRNOT00000004716
spectrin, alpha, erythrocytic 1
chr1_-_23556241 8.29 ENSRNOT00000072943
syntaxin-7-like
chr1_-_225952516 8.22 ENSRNOT00000043387
inner centromere protein
chr10_+_59652549 7.98 ENSRNOT00000073209
integrin subunit alpha E
chr4_+_102068556 7.91 ENSRNOT00000077412

chr4_-_179307095 7.79 ENSRNOT00000021193
branched chain amino acid transaminase 1
chr2_+_187322416 7.52 ENSRNOT00000025183
cellular retinoic acid binding protein 2
chr5_+_134691881 7.44 ENSRNOT00000091543
ENSRNOT00000067655
MAP kinase-interacting serine/threonine kinase 1
chr19_+_10563423 7.37 ENSRNOT00000021037
docking protein 4
chr20_-_45259928 7.16 ENSRNOT00000087226
solute carrier family 16 member 10
chrX_+_120859968 7.06 ENSRNOT00000085185
WD repeat domain 44
chr8_-_130429132 6.93 ENSRNOT00000026261
hedgehog acyltransferase-like
chr7_-_70476340 6.89 ENSRNOT00000006800
Rho guanine nucleotide exchange factor 25
chr1_-_80271001 6.65 ENSRNOT00000034266
CD3e molecule associated protein
chr18_+_402295 6.65 ENSRNOT00000033618
FUN14 domain containing 2
chr6_-_55647665 6.63 ENSRNOT00000007414
basic leucine zipper and W2 domains 2
chr18_+_30869628 6.36 ENSRNOT00000060470
protocadherin gamma subfamily B, 4
chr10_+_11046024 6.29 ENSRNOT00000084850
NmrA like redox sensor 1
chr3_+_17009089 6.26 ENSRNOT00000048829
rCG64257-like
chr12_-_2661565 6.24 ENSRNOT00000064859
CD209f antigen
chr12_+_37709860 6.20 ENSRNOT00000086244
M-phase phosphoprotein 9
chrX_+_120860178 6.13 ENSRNOT00000088661
WD repeat domain 44
chr2_-_41785792 6.13 ENSRNOT00000015871
RAB3C, member RAS oncogene family
chr5_+_141491223 6.02 ENSRNOT00000034839
rhomboid like 2
chr12_-_22472044 5.89 ENSRNOT00000073356
UFM1-specific peptidase 1
chr9_-_11108741 5.85 ENSRNOT00000072357
coiled-coil domain containing 94
chr4_+_101949285 5.82 ENSRNOT00000058446

chr11_+_43329700 5.66 ENSRNOT00000060892
olfactory receptor 1540
chr20_-_30327361 5.65 ENSRNOT00000000689
solute carrier family 29 member 3
chr6_-_26546545 5.61 ENSRNOT00000091264
sorting nexin 17
chr1_-_166943592 5.60 ENSRNOT00000026962
folate receptor 1
chr12_-_13157570 5.57 ENSRNOT00000001437
ENSRNOT00000067332
ENSRNOT00000092238
diacylglycerol lipase, beta
chr3_-_12944494 5.54 ENSRNOT00000023172
multivesicular body subunit 12B
chr13_-_113872097 5.51 ENSRNOT00000010799
ENSRNOT00000084320
complement C3b/C4b receptor 1 like
chr18_+_30880020 5.49 ENSRNOT00000060468
protocadherin gamma subfamily B, 5
chr5_-_148392689 5.46 ENSRNOT00000018464
ENSRNOT00000080166
tubulointerstitial nephritis antigen-like 1
chr2_+_116032455 5.40 ENSRNOT00000066495
polyhomeotic homolog 3
chr14_-_33164141 5.38 ENSRNOT00000002844
RE1-silencing transcription factor
chr10_-_25890639 5.36 ENSRNOT00000085499
hyaluronan-mediated motility receptor
chr12_-_36555694 5.33 ENSRNOT00000001292
acetoacetyl-CoA synthetase
chr2_-_205212681 5.28 ENSRNOT00000022575
thyroid stimulating hormone, beta
chr16_+_26906716 5.27 ENSRNOT00000064297
carboxypeptidase E
chr20_-_7142213 5.23 ENSRNOT00000078918
RGD1564450
chr20_-_45260119 5.17 ENSRNOT00000000718
solute carrier family 16 member 10
chr20_+_4369178 5.16 ENSRNOT00000088079
1-acylglycerol-3-phosphate O-acyltransferase 1
chr15_-_27815261 5.09 ENSRNOT00000032992
kelch-like family member 33
chr10_+_109073678 4.97 ENSRNOT00000005379
charged multivesicular body protein 6
chr10_+_58995556 4.81 ENSRNOT00000045100
gamma-glutamyl transferase 6
chr2_+_87418517 4.77 ENSRNOT00000048046
tyrosine-protein phosphatase non-receptor type substrate 1-like
chr18_+_30808404 4.67 ENSRNOT00000060475
protocadherin gamma subfamily A, 1
chr1_-_31528083 4.66 ENSRNOT00000061041
ribosomal protein L26, pseudogene 2
chr4_+_14212925 4.62 ENSRNOT00000076946
platelet glycoprotein 4-like
chr5_+_64892802 4.61 ENSRNOT00000059869
ring finger protein 20
chr12_+_2948570 4.58 ENSRNOT00000071450
hypothetical LOC100363914
chr1_+_114453275 4.53 ENSRNOT00000019245
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr5_+_153260930 4.49 ENSRNOT00000023289
ENSRNOT00000082184
arginine and serine rich protein 1
chr1_+_207654487 4.47 ENSRNOT00000025569
forkhead box I2
chr10_-_65424802 4.46 ENSRNOT00000018468
Tnf receptor associated factor 4
chr3_+_117422704 4.33 ENSRNOT00000085647
solute carrier family 12 member 1
chr18_+_63023930 4.19 ENSRNOT00000085655
inositol monophosphatase 2
chr10_+_53713938 4.16 ENSRNOT00000004236
ENSRNOT00000086599
ENSRNOT00000085582
myosin heavy chain 2
chr2_+_188139730 4.06 ENSRNOT00000056789
ENSRNOT00000077698
gon-4 like
chr7_+_13318533 3.83 ENSRNOT00000034545
similar to zinc finger protein 84 (HPF2)
chr3_+_159995064 3.83 ENSRNOT00000012606
alpha tocopherol transfer protein like
chr20_+_1322453 3.82 ENSRNOT00000075472
olfactory receptor 1868
chr1_-_166911694 3.78 ENSRNOT00000066915
inositol polyphosphate phosphatase-like 1
chr10_-_58771908 3.74 ENSRNOT00000018808
similar to 4933427D14Rik protein
chr5_-_141430659 3.62 ENSRNOT00000034944
akirin 1
chr10_+_46940965 3.51 ENSRNOT00000005366
LLGL1, scribble cell polarity complex component
chr14_+_86029335 3.35 ENSRNOT00000017375
drebrin-like
chr11_-_77703255 3.27 ENSRNOT00000083319
claudin 16
chr20_+_3230052 3.16 ENSRNOT00000078454
RT1 class I, locus T24, gene 3
chr8_-_49502647 3.14 ENSRNOT00000040313
transmembrane protease, serine 4
chr15_+_32386816 3.14 ENSRNOT00000060322

chrX_-_15707436 3.07 ENSRNOT00000085907
synaptophysin
chr3_+_128828331 2.96 ENSRNOT00000045393
phospholipase C, beta 4
chr1_+_254697247 2.96 ENSRNOT00000025412
ribonuclease P/MRP subunit p30
chr1_-_87777668 2.95 ENSRNOT00000037288

chr17_-_2705123 2.85 ENSRNOT00000024940
olfactory receptor 1652
chr3_-_96065711 2.77 ENSRNOT00000006431
DnaJ heat shock protein family (Hsp40) member C24
chr14_-_21878989 2.70 ENSRNOT00000072327
DAZ interacting protein 1, pseudogene 1
chr10_-_25847994 2.67 ENSRNOT00000082076
methionine adenosyltransferase 2B
chr2_+_166140112 2.60 ENSRNOT00000074564
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr20_+_4369394 2.55 ENSRNOT00000088734
ENSRNOT00000091491
1-acylglycerol-3-phosphate O-acyltransferase 1
chr13_+_48679774 2.53 ENSRNOT00000075674
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_+_214215992 2.48 ENSRNOT00000051755
ENSRNOT00000023376
PHD and ring finger domains 1
chr1_+_61268248 2.40 ENSRNOT00000082730
zinc finger protein 420-like
chr1_-_87777359 2.30 ENSRNOT00000074090

chr4_-_119399130 2.28 ENSRNOT00000042796
vomeronasal 1 receptor 101
chr1_-_4653210 2.25 ENSRNOT00000019121
RAB32, member RAS oncogene family
chr9_+_52687868 2.23 ENSRNOT00000083864
WD repeat domain 75
chr1_-_154170409 2.16 ENSRNOT00000089014
Hikeshi, heat shock protein nuclear import factor
chr12_+_38465130 2.15 ENSRNOT00000080785
VPS33A CORVET/HOPS core subunit
chr5_+_151573092 2.13 ENSRNOT00000011049
solute carrier family 9 member A1
chr6_-_8344897 2.12 ENSRNOT00000082353
prolyl endopeptidase-like
chr15_+_18941431 2.11 ENSRNOT00000092092

chr16_-_19583386 1.92 ENSRNOT00000090131
zinc finger protein 617
chrX_+_23146085 1.88 ENSRNOT00000068703
apurinic/apyrimidinic endodeoxyribonuclease 2
chr1_+_168575090 1.83 ENSRNOT00000048299
olfactory receptor 103
chrX_-_63291107 1.74 ENSRNOT00000092019
eukaryotic translation initiation factor 2 subunit gamma
chr3_+_121632043 1.73 ENSRNOT00000024882
RNA polymerase I subunit B
chr2_+_78245459 1.71 ENSRNOT00000089551
protein FAM134B
chr11_+_87549059 1.70 ENSRNOT00000002567
coiled-coil domain containing 74A
chr11_+_76147205 1.68 ENSRNOT00000071586
fibroblast growth factor 12
chr3_-_12467662 1.58 ENSRNOT00000051893
zinc finger and BTB domain containing 34
chr1_+_1771710 1.54 ENSRNOT00000080138
ENSRNOT00000073528
nucleoporin 43
chr3_+_102619672 1.54 ENSRNOT00000040285
olfactory receptor 756
chr1_+_72580424 1.46 ENSRNOT00000022977
ubiquitin-conjugating enzyme E2S
chr9_+_20004280 1.42 ENSRNOT00000075670
ankyrin repeat domain 66
chrX_+_136476823 1.36 ENSRNOT00000093183
Rho GTPase activating protein 36
chr15_+_30841153 1.31 ENSRNOT00000088305
uncharacterized LOC100911282
chr16_+_20704807 1.28 ENSRNOT00000027241
kelch-like family member 26
chr20_-_29558321 1.25 ENSRNOT00000000702
anaphase promoting complex subunit 16
chr1_-_79690434 1.22 ENSRNOT00000057986
ENSRNOT00000057988
carcinoembryonic antigen-related cell adhesion molecule 3-like
chr11_+_43161181 1.22 ENSRNOT00000071470
olfactory receptor 1530
chr15_+_93612971 1.17 ENSRNOT00000013182
aconitate decarboxylase 1
chr5_+_134679713 1.16 ENSRNOT00000067566
MOB kinase activator 3C
chr10_-_54967585 1.16 ENSRNOT00000005255
netrin 1
chr5_-_2982603 1.09 ENSRNOT00000045460
potassium voltage-gated channel subfamily B member 2
chr9_-_92963697 1.06 ENSRNOT00000023546
G protein-coupled receptor 55
chr10_-_39054142 0.97 ENSRNOT00000063772
RAD50 double strand break repair protein
chr4_-_33761163 0.97 ENSRNOT00000010079
asparagine synthetase (glutamine-hydrolyzing)
chr2_-_198834038 0.94 ENSRNOT00000031484
nudix hydrolase 17
chr2_+_205525204 0.94 ENSRNOT00000091210
cold shock domain containing E1
chr7_-_115963046 0.92 ENSRNOT00000007923
secreted Ly6/Plaur domain containing 1
chr5_+_103479767 0.86 ENSRNOT00000008999
SH3 domain-containing GRB2-like 2
chr3_-_66279155 0.76 ENSRNOT00000079887
ceramide kinase-like
chr9_-_24451435 0.74 ENSRNOT00000060805
defensin beta 49
chr4_-_66955732 0.64 ENSRNOT00000084282
lysine (K)-specific demethylase 7A
chr5_-_59208058 0.64 ENSRNOT00000020943
olfactory receptor 834
chr1_-_84812486 0.58 ENSRNOT00000078369

chr4_-_64981384 0.55 ENSRNOT00000017338
cAMP responsive element binding protein 3-like 2
chr19_+_11450760 0.55 ENSRNOT00000026297
nudix hydrolase 21
chr6_+_97110158 0.51 ENSRNOT00000088430
synaptotagmin 16
chr8_-_50126413 0.45 ENSRNOT00000072712
ENSRNOT00000022583
centrosomal protein 164
chr3_+_102553317 0.37 ENSRNOT00000043765
olfactory receptor 753
chr8_-_117237229 0.36 ENSRNOT00000071381
kelch domain containing 8B
chr17_-_69862110 0.36 ENSRNOT00000058312
aldo-keto reductase family 1, member C-like
chr4_+_87608301 0.35 ENSRNOT00000058702
vomeronasal 1 receptor 71
chr1_+_149963547 0.35 ENSRNOT00000042245
olfactory receptor 20
chr1_-_230729954 0.34 ENSRNOT00000017631
olfactory receptor 382
chr16_-_10952549 0.28 ENSRNOT00000091315
opsin 4
chr14_-_85982794 0.25 ENSRNOT00000076874
upregulator of cell proliferation
chr12_+_7208850 0.23 ENSRNOT00000001219
katanin catalytic subunit A1 like 1
chr14_+_36071376 0.22 ENSRNOT00000082183
ligand of numb-protein X 1
chr1_-_62316450 0.17 ENSRNOT00000079171

chr11_-_84090259 0.16 ENSRNOT00000002321
eukaryotic translation initiation factor 2B subunit 5 epsilon
chr5_+_173152964 0.14 ENSRNOT00000024349
SSU72 homolog, RNA polymerase II CTD phosphatase
chr6_-_1466201 0.08 ENSRNOT00000089185
eukaryotic translation initiation factor 2-alpha kinase 2
chr12_+_4546287 0.06 ENSRNOT00000001416
HIG1 hypoxia inducible domain family, member 2A-like 1
chr7_+_80750725 0.03 ENSRNOT00000079962
oxidation resistance 1
chr3_-_73854363 0.01 ENSRNOT00000051169
olfactory receptor 496

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
2.5 10.1 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
2.5 12.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
2.5 12.3 GO:0015801 aromatic amino acid transport(GO:0015801)
1.9 5.6 GO:0060974 cell migration involved in heart formation(GO:0060974)
1.8 24.7 GO:0006968 cellular defense response(GO:0006968)
1.8 8.8 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.4 4.3 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
1.4 14.3 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
1.3 5.4 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
1.2 6.9 GO:1903059 regulation of protein lipidation(GO:1903059)
1.2 4.6 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
1.1 5.3 GO:2000173 insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
1.0 3.1 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.7 2.1 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.6 2.5 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.6 4.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.6 7.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.5 7.5 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.5 2.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.5 5.3 GO:0034201 response to oleic acid(GO:0034201)
0.5 4.2 GO:0006021 inositol biosynthetic process(GO:0006021)
0.4 4.5 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.4 5.6 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.4 1.2 GO:0019541 propionate metabolic process(GO:0019541) negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.4 1.5 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) protein K29-linked ubiquitination(GO:0035519)
0.4 5.0 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.3 4.2 GO:0001778 plasma membrane repair(GO:0001778)
0.3 3.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.7 GO:0061709 reticulophagy(GO:0061709)
0.3 1.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 5.6 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.3 1.0 GO:0031860 telomeric 3' overhang formation(GO:0031860) negative regulation of telomere capping(GO:1904354)
0.3 1.0 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 11.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 10.1 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 2.3 GO:1903232 melanosome assembly(GO:1903232)
0.3 3.5 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.3 8.6 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 13.2 GO:0055078 sodium ion homeostasis(GO:0055078)
0.3 10.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.3 3.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3 11.8 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.2 17.8 GO:0070228 regulation of lymphocyte apoptotic process(GO:0070228)
0.2 5.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.2 3.3 GO:0051014 actin filament severing(GO:0051014)
0.2 2.2 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 9.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 1.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.7 GO:0007000 nucleolus organization(GO:0007000)
0.2 1.1 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.2 2.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.2 0.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 2.3 GO:0019236 response to pheromone(GO:0019236)
0.1 5.6 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.1 0.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 3.2 GO:0007602 phototransduction(GO:0007602)
0.1 8.3 GO:0048278 vesicle docking(GO:0048278)
0.1 3.7 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 7.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 5.3 GO:0033189 response to vitamin A(GO:0033189)
0.1 0.9 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 14.7 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 8.8 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.2 GO:0009303 rRNA transcription(GO:0009303)
0.1 5.5 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 14.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 11.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 9.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 6.7 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 8.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 0.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.9 GO:0006284 base-excision repair(GO:0006284)
0.0 4.1 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.1 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 6.4 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 1.2 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 7.2 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 8.7 GO:0030334 regulation of cell migration(GO:0030334)
0.0 4.9 GO:0001701 in utero embryonic development(GO:0001701)
0.0 0.8 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 6.1 GO:0016567 protein ubiquitination(GO:0016567)
0.0 2.1 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.1 GO:0071914 prominosome(GO:0071914)
2.2 17.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.2 4.6 GO:0033503 HULC complex(GO:0033503)
0.9 2.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.9 8.6 GO:0008091 spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731)
0.8 14.3 GO:0042581 specific granule(GO:0042581)
0.8 10.3 GO:0000124 SAGA complex(GO:0000124)
0.7 8.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.7 13.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 8.2 GO:0000801 central element(GO:0000801)
0.6 5.0 GO:0000815 ESCRT III complex(GO:0000815)
0.6 5.5 GO:0000813 ESCRT I complex(GO:0000813)
0.5 3.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.5 3.0 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.5 4.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.4 2.3 GO:0031904 endosome lumen(GO:0031904)
0.4 5.4 GO:0035102 PRC1 complex(GO:0035102)
0.4 5.3 GO:0031045 dense core granule(GO:0031045)
0.3 5.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 26.4 GO:0000786 nucleosome(GO:0000786)
0.2 2.2 GO:0033263 CORVET complex(GO:0033263) clathrin complex(GO:0071439)
0.2 6.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 8.0 GO:0008305 integrin complex(GO:0008305)
0.2 1.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 3.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 8.3 GO:0031201 SNARE complex(GO:0031201)
0.1 11.2 GO:0005811 lipid particle(GO:0005811)
0.1 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.0 GO:0030870 Mre11 complex(GO:0030870)
0.1 2.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 3.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 12.6 GO:0030175 filopodium(GO:0030175)
0.1 30.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 5.6 GO:0031902 late endosome membrane(GO:0031902)
0.1 3.3 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 15.9 GO:0010008 endosome membrane(GO:0010008)
0.1 0.5 GO:0042382 paraspeckles(GO:0042382)
0.1 6.7 GO:0005814 centriole(GO:0005814)
0.1 5.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 34.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 12.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 6.9 GO:0030017 sarcomere(GO:0030017)
0.0 5.6 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 10.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 9.0 GO:0005794 Golgi apparatus(GO:0005794)
0.0 2.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.7 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0005769 early endosome(GO:0005769)
0.0 8.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
2.6 7.8 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
2.1 12.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
1.6 14.8 GO:0050786 RAGE receptor binding(GO:0050786)
1.4 4.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
1.4 5.6 GO:0051870 methotrexate binding(GO:0051870)
1.3 10.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.3 8.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
1.1 11.7 GO:0070513 death domain binding(GO:0070513)
0.8 4.8 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.7 2.0 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.6 7.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.6 1.9 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.6 7.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 4.2 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832)
0.6 5.3 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.6 7.5 GO:0019841 retinol binding(GO:0019841)
0.4 5.3 GO:0050897 cobalt ion binding(GO:0050897)
0.4 13.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.4 3.8 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.3 1.0 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.3 3.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 10.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.3 5.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 5.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 1.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 6.1 GO:0031489 myosin V binding(GO:0031489)
0.2 5.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 5.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 2.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 4.5 GO:0031996 thioesterase binding(GO:0031996)
0.2 4.5 GO:0032183 SUMO binding(GO:0032183)
0.2 8.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 5.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.2 7.4 GO:0005158 insulin receptor binding(GO:0005158)
0.2 10.1 GO:0042805 actinin binding(GO:0042805)
0.2 0.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 0.8 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 3.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 5.9 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 24.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 11.8 GO:0004540 ribonuclease activity(GO:0004540)
0.1 3.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 9.4 GO:0015297 antiporter activity(GO:0015297)
0.1 3.2 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 16.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.8 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 10.7 GO:0044325 ion channel binding(GO:0044325)
0.1 50.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 6.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 24.8 GO:0045296 cadherin binding(GO:0045296)
0.1 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.5 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 20.9 GO:0005525 GTP binding(GO:0005525)
0.1 5.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 5.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 4.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 5.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 10.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 4.0 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 24.7 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.5 17.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.3 3.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 8.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 3.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 7.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 6.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 7.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 8.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 7.7 PID AURORA B PATHWAY Aurora B signaling
0.2 5.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 5.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 5.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 4.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 7.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 10.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.8 11.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.7 17.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.7 7.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.7 8.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.6 24.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6 21.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 7.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 5.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 7.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 12.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 5.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 8.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 5.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 5.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 1.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 5.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 7.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 8.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 8.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 2.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.9 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 1.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 6.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels