ISMARA results: Pax5

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax5

Z-value: 1.36

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Transcription factors associated with Pax5

Gene Symbol	Gene ID	Gene Info
Pax5 NCBI RGD Ensembl	ENSRNOG00000024729	paired box 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pax5	rn6_v1_chr5_-_60191941_60191941	0.33	9.9e-10	Click!

Activity profile of Pax5 motif

Sorted Z-values of Pax5 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_119441487 Show fit	54.85	ENSRNOT00000067635	Pvalb NCBI RGD Ensembl Show fit	parvalbumin
chr10_-_56167426 Show fit	41.77	ENSRNOT00000013955	Efnb3 NCBI RGD Ensembl Show fit	ephrin B3
chr10_+_65586993 Show fit	32.73	ENSRNOT00000086036	Aldoc NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate C
chr10_-_15928169 Show fit	32.21	ENSRNOT00000028069	Nsg2 NCBI RGD Ensembl Show fit	neuron specific gene family member 2
chr13_-_90676629 Show fit	28.98	ENSRNOT00000058143	Atp1a2 NCBI RGD Ensembl Show fit	ATPase Na+/K+ transporting subunit alpha 2
chr1_-_93949187 Show fit	28.66	ENSRNOT00000018956	Zfp536 NCBI RGD Ensembl Show fit	zinc finger protein 536
chr3_-_72602548 Show fit	28.36	ENSRNOT00000031745	Lrrc55 NCBI RGD Ensembl Show fit	leucine rich repeat containing 55
chr5_+_147323240 Show fit	28.31	ENSRNOT00000047152	Fndc5 NCBI RGD Ensembl Show fit	fibronectin type III domain containing 5
chr20_-_4823475 Show fit	26.95	ENSRNOT00000082536 ENSRNOT00000001114	Atp6v1g2 NCBI RGD Ensembl Show fit	ATPase H+ transporting V1 subunit G2
chr8_-_98738446 Show fit	26.25	ENSRNOT00000019860	Zic1 NCBI RGD Ensembl Show fit	Zic family member 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	52.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.7	51.5	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
14.0	41.9	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
4.2	41.8	GO:0016198	axon choice point recognition(GO:0016198)
1.4	39.7	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.3	39.5	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
7.2	29.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
3.2	28.7	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.1	28.3	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.6	26.3	GO:0007628	adult walking behavior(GO:0007628)

Showing 1 to 10 of 268 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	90.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.2	72.9	GO:0030424	axon(GO:0030424)
0.4	69.2	GO:0043204	perikaryon(GO:0043204)
0.5	46.2	GO:0043195	terminal bouton(GO:0043195)
1.9	44.5	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.5	37.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.5	34.5	GO:0031594	neuromuscular junction(GO:0031594)
0.1	30.4	GO:0043235	receptor complex(GO:0043235)
0.2	29.5	GO:0098793	presynapse(GO:0098793)
2.4	29.0	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)

Showing 1 to 10 of 123 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	106.5	GO:0005509	calcium ion binding(GO:0005509)
1.6	55.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.4	53.7	GO:0005179	hormone activity(GO:0005179)
7.4	51.5	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.8	43.6	GO:0015459	potassium channel regulator activity(GO:0015459)
3.4	34.1	GO:1990239	steroid hormone binding(GO:1990239)
6.1	30.3	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.8	30.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.3	28.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
3.0	27.0	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Showing 1 to 10 of 182 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	44.9	PID EPHB FWD PATHWAY	EPHB forward signaling
0.9	30.3	PID REELIN PATHWAY	Reelin signaling pathway
0.9	21.4	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.8	18.0	PID ARF 3PATHWAY	Arf1 pathway
0.5	16.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.4	13.9	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.4	13.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	13.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.3	13.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	12.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	51.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.7	33.0	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.3	31.4	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.7	29.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.6	24.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.1	20.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.9	20.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	20.0	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
1.1	19.9	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
1.0	18.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 65 entries

Results for Pax5

Z-value: 1.36

Motif logo

Transcription factors associated with Pax5

Activity-expression correlation:

Activity profile of Pax5 motif

Sorted Z-values of Pax5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: