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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax4

Z-value: 0.54

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Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
Pax4
ENSRNOG00000008020 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4rn6_v1_chr4_-_55740627_55740627-0.211.4e-04Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrM_+_3904 22.25 ENSRNOT00000040993
Mt-nd2
mitochondrially encoded NADH dehydrogenase 2
chr11_-_81639872 18.97 ENSRNOT00000047595
ENSRNOT00000090031
ENSRNOT00000081864
Hrg
histidine-rich glycoprotein
chrM_+_9870 16.83 ENSRNOT00000044582
Mt-nd4l
mitochondrially encoded NADH 4L dehydrogenase
chrM_+_10160 15.70 ENSRNOT00000042928
Mt-nd4
mitochondrially encoded NADH dehydrogenase 4
chr19_+_37476095 14.08 ENSRNOT00000092794
ENSRNOT00000023130
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr3_-_51297852 13.28 ENSRNOT00000001607
Cobll1
cordon-bleu WH2 repeat protein-like 1
chr1_-_248376750 12.71 ENSRNOT00000089073
Gldc
glycine decarboxylase
chr5_+_6373583 12.18 ENSRNOT00000084749
AABR07046778.1

chrM_+_11736 10.05 ENSRNOT00000048767
Mt-nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_+_105285419 8.60 ENSRNOT00000089693
Slc6a5
solute carrier family 6 member 5
chr4_-_176720012 8.57 ENSRNOT00000017965
Ldhb
lactate dehydrogenase B
chr2_+_252452269 8.02 ENSRNOT00000021970
Uox
urate oxidase
chr3_-_170955399 7.73 ENSRNOT00000084990
Bmp7
bone morphogenetic protein 7
chr15_+_43298794 7.47 ENSRNOT00000012736
Adra1a
adrenoceptor alpha 1A
chr8_+_87630916 6.58 ENSRNOT00000016428
Myo6
myosin VI
chr4_-_158704170 6.55 ENSRNOT00000082009
Ntf3
neurotrophin 3
chr14_-_103321270 6.48 ENSRNOT00000006157
Meis1
Meis homeobox 1
chr3_+_114176309 6.44 ENSRNOT00000023350
Sord
sorbitol dehydrogenase
chr7_-_119689938 6.36 ENSRNOT00000000200
Tmprss6
transmembrane protease, serine 6
chr14_+_99919485 6.24 ENSRNOT00000006087
Egfr
epidermal growth factor receptor
chr1_-_188407132 5.90 ENSRNOT00000073233
Gde1
glycerophosphodiester phosphodiesterase 1
chr6_-_103313074 5.55 ENSRNOT00000083677
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr13_-_80775230 5.41 ENSRNOT00000091389
ENSRNOT00000004762
Fmo2
flavin containing monooxygenase 2
chr12_-_44999074 5.25 ENSRNOT00000079177
ENSRNOT00000038293
Vsig10
V-set and immunoglobulin domain containing 10
chr8_-_54990604 5.20 ENSRNOT00000059192
Tex12
testis expressed 12
chr7_-_101140308 5.19 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr1_-_164308317 5.09 ENSRNOT00000022983
Serpinh1
serpin family H member 1
chr10_-_56558487 4.97 ENSRNOT00000023256
Slc2a4
solute carrier family 2 member 4
chr7_+_97559841 4.43 ENSRNOT00000007326
Zhx2
zinc fingers and homeoboxes 2
chrX_+_15035569 4.26 ENSRNOT00000006491
ENSRNOT00000078392
Porcn
porcupine homolog (Drosophila)
chr18_-_71829881 4.11 ENSRNOT00000088662
Ctif
cap binding complex dependent translation initiation factor
chr18_-_57245666 4.04 ENSRNOT00000080365
Ablim3
actin binding LIM protein family, member 3
chr16_-_62373253 3.98 ENSRNOT00000034325
Tex15
testis expressed 15, meiosis and synapsis associated
chr20_+_5049496 3.82 ENSRNOT00000088251
ENSRNOT00000001118
Ddah2
dimethylarginine dimethylaminohydrolase 2
chr7_+_37018459 3.65 ENSRNOT00000087297
Eea1
early endosome antigen 1
chr8_-_53901358 3.40 ENSRNOT00000047666
ENSRNOT00000042281
Ncam1
neural cell adhesion molecule 1
chrX_+_105537602 3.31 ENSRNOT00000029833
Armcx1
armadillo repeat containing, X-linked 1
chr5_-_172307431 3.26 ENSRNOT00000018453
Fam213b
family with sequence similarity 213, member B
chr3_-_113438801 3.18 ENSRNOT00000091665
Mfap1a
microfibrillar-associated protein 1A
chrX_-_102510007 3.17 ENSRNOT00000082854
AABR07040494.1

chr20_-_3818045 2.75 ENSRNOT00000091622
Hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
chr11_-_57993548 2.66 ENSRNOT00000002957
Nectin3
nectin cell adhesion molecule 3
chr3_-_162579201 2.64 ENSRNOT00000068328
Zmynd8
zinc finger, MYND-type containing 8
chrX_+_16337102 2.55 ENSRNOT00000003954
Ccnb3
cyclin B3
chr10_-_25845634 2.49 ENSRNOT00000004269
Mat2b
methionine adenosyltransferase 2B
chr1_+_80092403 2.30 ENSRNOT00000078336
Eml2
echinoderm microtubule associated protein like 2
chr12_-_37411525 2.26 ENSRNOT00000087698
Tctn2
tectonic family member 2
chr1_+_252894663 2.16 ENSRNOT00000054757
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
chr4_-_99810270 2.06 ENSRNOT00000078123
Ptcd3
Pentatricopeptide repeat domain 3
chr14_-_43143973 2.00 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr17_+_45801528 1.76 ENSRNOT00000089221
Olr1664
olfactory receptor 1664
chr17_-_27969433 1.76 ENSRNOT00000073967
Nrn1
neuritin 1
chrX_-_29825439 1.73 ENSRNOT00000048155
Gemin8
gem (nuclear organelle) associated protein 8
chr8_+_12823155 1.67 ENSRNOT00000011008
Sesn3
sestrin 3
chr15_+_27346731 1.66 ENSRNOT00000046317
Olr1619
olfactory receptor 1619
chr8_-_67040005 1.62 ENSRNOT00000038641
Glce
glucuronic acid epimerase
chr15_-_6587367 1.55 ENSRNOT00000038449
Zfp385d
zinc finger protein 385D
chr7_+_122203532 1.38 ENSRNOT00000025382
Sgsm3
small G protein signaling modulator 3
chr7_-_114573900 1.35 ENSRNOT00000011219
Ptk2
protein tyrosine kinase 2
chr18_+_30527705 1.33 ENSRNOT00000027168
Pcdhb14
protocadherin beta 14
chr9_+_20765296 1.29 ENSRNOT00000016291
Cd2ap
CD2-associated protein
chr3_+_160047296 1.28 ENSRNOT00000051590
Pkig
cAMP-dependent protein kinase inhibitor gamma
chr9_-_10047507 1.25 ENSRNOT00000072118
Alkbh7
alkB homolog 7
chr1_-_221370322 1.21 ENSRNOT00000028431
Capn1
calpain 1
chrX_+_128416722 1.18 ENSRNOT00000009336
ENSRNOT00000085110
Xiap
X-linked inhibitor of apoptosis
chr20_-_4401610 1.13 ENSRNOT00000091468
Ppt2
palmitoyl-protein thioesterase 2
chr9_-_10471176 1.10 ENSRNOT00000089164
Safb
scaffold attachment factor B
chr2_+_188561429 1.07 ENSRNOT00000076458
ENSRNOT00000027867
Krtcap2
keratinocyte associated protein 2
chr3_-_103043741 1.06 ENSRNOT00000052294
Olr775
olfactory receptor 775
chr4_-_99746560 1.04 ENSRNOT00000012021
Mrpl35
mitochondrial ribosomal protein L35
chr7_+_9279620 0.99 ENSRNOT00000011225
Olr1064
olfactory receptor 1064
chr6_-_114488880 0.99 ENSRNOT00000087560
AC118957.1

chr3_-_77800137 0.95 ENSRNOT00000071319
AABR07052831.1

chr4_+_87353254 0.89 ENSRNOT00000073670
Vom1r67
vomeronasal 1 receptor 67
chr8_+_19972793 0.86 ENSRNOT00000068066
Olr1159
olfactory receptor 1159
chr8_-_18062971 0.81 ENSRNOT00000045739
Olr1139
olfactory receptor 1139
chr3_-_148932878 0.81 ENSRNOT00000013881
Nol4l
nucleolar protein 4-like
chr18_+_25613831 0.81 ENSRNOT00000091040
Tslp
thymic stromal lymphopoietin
chr10_-_43912900 0.79 ENSRNOT00000029524
Olr1414
olfactory receptor 1414
chrX_-_70428364 0.76 ENSRNOT00000045907
P2ry4
pyrimidinergic receptor P2Y4
chr7_-_6754349 0.72 ENSRNOT00000085061
Olr956
olfactory receptor 956
chr7_+_117605050 0.71 ENSRNOT00000047380
Slc52a2
solute carrier family 52 member 2
chr8_-_70436028 0.70 ENSRNOT00000077152
Slc24a1
solute carrier family 24 member 1
chr13_-_53108713 0.63 ENSRNOT00000035404
RGD1311892
similar to hypothetical protein FLJ10901
chr4_+_71795768 0.57 ENSRNOT00000031921
Tas2r135
taste receptor, type 2, member 135
chr20_-_1878126 0.50 ENSRNOT00000000995
Ubd
ubiquitin D
chr6_+_28235695 0.33 ENSRNOT00000047210
Dnmt3a
DNA methyltransferase 3 alpha
chr10_-_87351030 0.32 ENSRNOT00000034889
ENSRNOT00000091152
Krt20
keratin 20
chr2_-_250862419 0.27 ENSRNOT00000017943
Clca4
chloride channel accessory 4
chr1_+_273854248 0.26 ENSRNOT00000044827
ENSRNOT00000017600
ENSRNOT00000086496
Add3
adducin 3
chr8_-_17524839 0.14 ENSRNOT00000081679
Naalad2
N-acetylated alpha-linked acidic dipeptidase 2
chr1_-_169845487 0.11 ENSRNOT00000039989
Olr179
olfactory receptor 179
chr7_-_138512952 0.08 ENSRNOT00000009187
Slc38a4
solute carrier family 38, member 4
chr3_+_102859815 0.06 ENSRNOT00000037906
Olr771
olfactory receptor 771
chrX_-_123486814 0.01 ENSRNOT00000016993
RGD1564541
similar to hypothetical protein FLJ22965

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:0097037 heme export(GO:0097037)
3.2 12.7 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
2.6 7.7 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)
2.5 7.5 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
2.1 6.4 GO:0006059 hexitol metabolic process(GO:0006059)
1.7 8.6 GO:0036233 glycine import(GO:0036233)
1.6 37.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
1.6 6.6 GO:0007403 glial cell fate determination(GO:0007403)
1.4 5.6 GO:0003343 proepicardium development(GO:0003342) septum transversum development(GO:0003343) mesendoderm development(GO:0048382) regulation of intracellular mRNA localization(GO:1904580)
1.4 5.4 GO:0072592 oxygen metabolic process(GO:0072592)
1.1 3.4 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.9 6.2 GO:1900019 astrocyte activation(GO:0048143) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.9 13.3 GO:0051639 actin filament network formation(GO:0051639)
0.9 14.1 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.8 8.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.7 5.2 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.7 7.6 GO:0097264 self proteolysis(GO:0097264)
0.7 2.0 GO:0007412 axon target recognition(GO:0007412)
0.7 2.6 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.6 5.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.6 26.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.5 2.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.4 1.3 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.4 1.6 GO:0030210 heparin biosynthetic process(GO:0030210)
0.4 2.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.4 8.6 GO:0006089 lactate metabolic process(GO:0006089)
0.3 9.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 1.3 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.3 2.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 6.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.3 2.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.3 3.8 GO:0006527 arginine catabolic process(GO:0006527)
0.3 1.7 GO:0038203 TORC2 signaling(GO:0038203)
0.3 1.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.2 0.7 GO:0032218 riboflavin transport(GO:0032218)
0.2 5.0 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.2 1.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 1.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483) plasma membrane to endosome transport(GO:0048227)
0.2 3.2 GO:0006020 inositol metabolic process(GO:0006020)
0.2 4.0 GO:0030539 male genitalia development(GO:0030539)
0.2 2.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 1.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 3.6 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 3.3 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 4.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.8 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 4.4 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.5 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.1 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 4.3 GO:0006497 protein lipidation(GO:0006497)
0.0 2.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 2.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0042135 neurotransmitter catabolic process(GO:0042135)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 19.0 GO:0061474 phagolysosome membrane(GO:0061474)
4.2 12.7 GO:0005960 glycine cleavage complex(GO:0005960)
1.6 6.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.3 64.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.8 2.5 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.6 3.6 GO:0044308 axonal spine(GO:0044308)
0.4 8.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 5.2 GO:0000801 central element(GO:0000801)
0.4 5.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 3.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 6.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.7 GO:0061700 GATOR2 complex(GO:0061700)
0.2 2.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 4.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.7 GO:0032797 SMN complex(GO:0032797)
0.1 7.5 GO:0030315 T-tubule(GO:0030315)
0.1 17.2 GO:0043209 myelin sheath(GO:0043209)
0.1 5.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 4.0 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.4 GO:0005921 gap junction(GO:0005921)
0.0 1.3 GO:0031941 filamentous actin(GO:0031941)
0.0 6.4 GO:0031514 motile cilium(GO:0031514)
0.0 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.5 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 4.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 21.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.4 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
2.9 8.6 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
2.5 7.5 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
2.4 64.8 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.1 8.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.6 6.2 GO:0048408 epidermal growth factor-activated receptor activity(GO:0005006) epidermal growth factor binding(GO:0048408)
1.3 3.8 GO:0016403 dimethylargininase activity(GO:0016403)
1.1 8.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.1 3.2 GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827)
1.0 5.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.9 2.7 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.8 6.6 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.8 18.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 7.7 GO:0070700 BMP receptor binding(GO:0070700)
0.6 12.7 GO:0016594 glycine binding(GO:0016594)
0.6 5.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 2.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.5 5.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 13.3 GO:0003785 actin monomer binding(GO:0003785)
0.4 5.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 0.8 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.2 0.7 GO:0032217 riboflavin transporter activity(GO:0032217)
0.2 3.4 GO:0030275 LRR domain binding(GO:0030275)
0.2 1.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 2.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 4.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 3.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 2.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 6.4 GO:0051287 NAD binding(GO:0051287)
0.1 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 5.1 GO:0005518 collagen binding(GO:0005518)
0.1 6.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 1.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 3.3 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 6.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.7 PID ALK2 PATHWAY ALK2 signaling events
0.3 6.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 6.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 5.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 6.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 16.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 1.3 PID IGF1 PATHWAY IGF1 pathway
0.1 1.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 4.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.4 8.6 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.4 8.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 6.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.3 5.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 5.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2 5.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 7.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 19.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 5.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 9.2 REACTOME MEIOSIS Genes involved in Meiosis
0.1 5.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades