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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Pax2

Z-value: 0.36

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Transcription factors associated with Pax2

Gene Symbol Gene ID Gene Info
Pax2
ENSRNOG00000014253 paired box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax2rn6_v1_chr1_+_264504591_2645045910.254.9e-06Click!

Activity profile of Pax2 motif

Sorted Z-values of Pax2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_161298962 9.45 ENSRNOT00000066028
Ctsa
cathepsin A
chr4_+_33638709 7.72 ENSRNOT00000009888
ENSRNOT00000034719
ENSRNOT00000052333
Tac1
tachykinin, precursor 1
chrX_-_54303729 6.82 ENSRNOT00000087919
ENSRNOT00000064340
ENSRNOT00000051249
ENSRNOT00000087547
Gk
glycerol kinase
chr7_+_142912316 6.57 ENSRNOT00000010171
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr10_+_55940533 5.69 ENSRNOT00000012061
RGD1563441
similar to RIKEN cDNA A030009H04
chr19_+_24329023 5.56 ENSRNOT00000065558
Tbc1d9
TBC1 domain family member 9
chr1_+_263367266 5.39 ENSRNOT00000054714
Nkx2-3
NK2 homeobox 3
chr7_-_12741296 4.92 ENSRNOT00000060648
Arhgap45
Rho GTPase activating protein 45
chr5_-_164844586 4.61 ENSRNOT00000011287
Clcn6
chloride voltage-gated channel 6
chr7_+_53878610 4.18 ENSRNOT00000091910
Osbpl8
oxysterol binding protein-like 8
chr10_-_66602987 4.00 ENSRNOT00000017949
Wsb1
WD repeat and SOCS box-containing 1
chr11_+_60613882 3.85 ENSRNOT00000002853
Slc35a5
solute carrier family 35, member A5
chr18_+_27657628 3.84 ENSRNOT00000026303
Egr1
early growth response 1
chr6_-_108976489 3.73 ENSRNOT00000007350
Rps6kl1
ribosomal protein S6 kinase-like 1
chr20_+_6288267 3.47 ENSRNOT00000000627
Srsf3
serine and arginine rich splicing factor 3
chr10_-_56276764 3.35 ENSRNOT00000049048
Eif4a1
eukaryotic translation initiation factor 4A1
chr1_+_154377247 3.27 ENSRNOT00000092945
Picalm
phosphatidylinositol binding clathrin assembly protein
chr3_-_161322289 3.07 ENSRNOT00000022594
Pltp
phospholipid transfer protein
chr13_-_42263024 3.01 ENSRNOT00000004741
Lypd1
Ly6/Plaur domain containing 1
chr10_-_104637823 3.01 ENSRNOT00000010826
Wbp2
WW domain binding protein 2
chr2_+_188516582 2.98 ENSRNOT00000074727
Gba
glucosylceramidase beta
chr19_-_37525762 2.94 ENSRNOT00000023606
Atp6v0d1
ATPase H+ transporting V0 subunit D1
chr15_-_27855999 2.91 ENSRNOT00000013225
Tmem55b
transmembrane protein 55B
chr5_+_147375350 2.48 ENSRNOT00000010674
Yars
tyrosyl-tRNA synthetase
chr5_-_147375009 2.38 ENSRNOT00000009436
S100pbp
S100P binding protein
chr5_+_78222504 2.30 ENSRNOT00000019544
Slc31a1
solute carrier family 31 member 1
chr1_+_154377447 2.23 ENSRNOT00000084268
ENSRNOT00000092086
ENSRNOT00000091470
ENSRNOT00000025415
Picalm
phosphatidylinositol binding clathrin assembly protein
chr7_-_70498992 2.13 ENSRNOT00000067774
ENSRNOT00000079327
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr10_+_10725819 2.11 ENSRNOT00000004159
Glyr1
glyoxylate reductase 1 homolog
chr11_-_60613718 2.01 ENSRNOT00000002906
Atg3
autophagy related 3
chr3_+_163570532 1.94 ENSRNOT00000010054
Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr10_-_74070266 1.65 ENSRNOT00000005987
Cltc
clathrin heavy chain
chr3_-_164239250 1.58 ENSRNOT00000012604
Spata2
spermatogenesis associated 2
chr2_-_219693629 1.48 ENSRNOT00000020907
Mfsd14a
major facilitator superfamily domain containing 14A
chr9_+_16647598 1.33 ENSRNOT00000087413
Klc4
kinesin light chain 4
chr10_-_62287189 1.26 ENSRNOT00000004365
Wdr81
WD repeat domain 81
chr2_+_2456735 1.24 ENSRNOT00000032974
Ell2
elongation factor for RNA polymerase II 2
chr10_-_10725655 1.18 ENSRNOT00000061236
Ubn1
ubinuclein 1
chr1_-_102849430 1.13 ENSRNOT00000086856
Saa4
serum amyloid A4
chr8_-_103298927 1.09 ENSRNOT00000046873
ENSRNOT00000011609
U2surp
U2 snRNP-associated SURP domain containing
chr2_+_240396152 1.04 ENSRNOT00000034565
Cenpe
centromere protein E
chr15_-_20822740 0.99 ENSRNOT00000012957
Bmp4
bone morphogenetic protein 4
chr12_+_37593874 0.98 ENSRNOT00000057902
Sbno1
strawberry notch homolog 1
chr9_+_16647922 0.98 ENSRNOT00000031625
Klc4
kinesin light chain 4
chr7_-_92882068 0.97 ENSRNOT00000037809
Ext1
exostosin glycosyltransferase 1
chr3_-_161299024 0.91 ENSRNOT00000021216
Neurl2
neuralized E3 ubiquitin protein ligase 2
chr10_+_20591432 0.83 ENSRNOT00000059780
Pank3
pantothenate kinase 3
chr12_+_37594185 0.80 ENSRNOT00000088787
Sbno1
strawberry notch homolog 1
chr6_+_28663602 0.72 ENSRNOT00000005402
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chr6_+_108167716 0.72 ENSRNOT00000064426
Lin52
lin-52 DREAM MuvB core complex component
chr10_+_14492844 0.69 ENSRNOT00000023615
Clcn7
chloride voltage-gated channel 7
chr13_+_26172243 0.65 ENSRNOT00000003840
Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr12_+_19303387 0.63 ENSRNOT00000001820
Cops6
COP9 signalosome subunit 6
chr8_-_48674748 0.46 ENSRNOT00000014127
Hmbs
hydroxymethylbilane synthase
chr5_-_62001196 0.46 ENSRNOT00000012602
Trmo
tRNA methyltransferase O
chr1_-_274107138 0.39 ENSRNOT00000078670
Smndc1
survival motor neuron domain containing 1
chr11_-_38457373 0.34 ENSRNOT00000041177
Zfp295
zinc finger protein 295
chr1_+_103172987 0.34 ENSRNOT00000018688
Tmem86a
transmembrane protein 86A
chr2_+_207108552 0.30 ENSRNOT00000027234
Slc16a1
solute carrier family 16 member 1
chr6_-_109205004 0.19 ENSRNOT00000010512
Tmed10
transmembrane p24 trafficking protein 10
chr1_-_219450451 0.08 ENSRNOT00000025317
Rad9a
RAD9 checkpoint clamp component A
chr16_-_9658484 0.05 ENSRNOT00000065216
Mapk8
mitogen-activated protein kinase 8
chr10_-_56850085 0.01 ENSRNOT00000025767
Rnasek
ribonuclease K

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
1.8 5.5 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
1.6 9.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.5 7.7 GO:0046878 positive regulation of saliva secretion(GO:0046878) positive regulation of glucocorticoid secretion(GO:2000851)
1.3 3.8 GO:2000182 interleukin-1 biosynthetic process(GO:0042222) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
1.1 6.6 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.1 5.4 GO:0002317 plasma cell differentiation(GO:0002317)
1.0 4.2 GO:0090204 protein localization to nuclear pore(GO:0090204)
1.0 3.1 GO:0042360 vitamin E metabolic process(GO:0042360)
1.0 3.0 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.8 3.0 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.6 2.3 GO:1902861 copper ion import across plasma membrane(GO:0098705) copper ion import into cell(GO:1902861)
0.5 1.6 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.3 1.0 GO:1902462 intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.3 1.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 0.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 2.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 1.2 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2 2.0 GO:0044804 nucleophagy(GO:0044804)
0.1 3.0 GO:1904376 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1 5.3 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 2.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.1 2.9 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 5.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 0.5 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 3.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.6 GO:0000338 protein deneddylation(GO:0000338)
0.0 2.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 3.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 1.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.3 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 3.9 GO:0015992 proton transport(GO:0015992)
0.0 1.1 GO:0006953 acute-phase response(GO:0006953)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.4 4.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.3 1.9 GO:0032280 axonemal microtubule(GO:0005879) symmetric synapse(GO:0032280)
0.2 2.9 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.2 2.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 2.9 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.2 1.6 GO:0071439 clathrin complex(GO:0071439)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 1.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.9 GO:0031902 late endosome membrane(GO:0031902)
0.0 6.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.1 GO:0005776 autophagosome(GO:0005776)
0.0 5.3 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.3 GO:0005770 late endosome(GO:0005770)
0.0 2.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 5.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 8.2 GO:0030424 axon(GO:0030424)
0.0 1.6 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
2.3 6.8 GO:0004370 glycerol kinase activity(GO:0004370)
1.0 3.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.7 2.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.6 5.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.6 2.9 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.5 2.0 GO:0019776 Atg8 ligase activity(GO:0019776)
0.4 2.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.3 3.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 2.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 5.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 1.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 6.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 3.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 3.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 2.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 0.8 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 7.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 0.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 4.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.0 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.5 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.1 1.0 GO:0039706 co-receptor binding(GO:0039706)
0.1 3.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 3.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 5.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 3.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.7 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 9.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 7.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 1.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 3.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 6.8 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 2.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.3 REACTOME KINESINS Genes involved in Kinesins
0.1 0.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 3.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 7.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters