ISMARA results: Otx1

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Otx1

Z-value: 0.74

Motif logo

Transcription factors associated with Otx1

Gene Symbol	Gene ID	Gene Info
Otx1 NCBI RGD Ensembl	ENSRNOG00000059469	orthodenticle homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Otx1	rn6_v1_chr14_-_106864892_106864892	0.35	6.7e-11	Click!

Activity profile of Otx1 motif

Sorted Z-values of Otx1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_106753592 Show fit	38.92	ENSRNOT00000006930	Kcnq3 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily Q member 3
chr11_+_57505005 Show fit	22.30	ENSRNOT00000002942	LOC103693564 NCBI RGD Ensembl Show fit	transgelin-3
chr2_-_265300868 Show fit	21.95	ENSRNOT00000066024 ENSRNOT00000016073 ENSRNOT00000033502	Lrrc7 NCBI RGD Ensembl Show fit	leucine rich repeat containing 7
chr1_+_27476375 Show fit	18.42	ENSRNOT00000047224 ENSRNOT00000075427	LOC102551716 NCBI RGD Ensembl Show fit	sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like
chr11_+_60072727 Show fit	17.64	ENSRNOT00000090230	Tagln3 NCBI RGD Ensembl Show fit	transgelin 3
chr3_+_56862691 Show fit	17.46	ENSRNOT00000087712	Gad1 NCBI RGD Ensembl Show fit	glutamate decarboxylase 1
chrX_-_157286936 Show fit	16.52	ENSRNOT00000078100	Atp2b3 NCBI RGD Ensembl Show fit	ATPase plasma membrane Ca2+ transporting 3
chr9_+_12114977 Show fit	16.38	ENSRNOT00000073673	AABR07066648.1 NCBI RGD Ensembl Show fit
chr6_-_2311781 Show fit	14.44	ENSRNOT00000084171	Cyp1b1 NCBI RGD Ensembl Show fit	cytochrome P450, family 1, subfamily b, polypeptide 1
chr11_-_4397361 Show fit	14.22	ENSRNOT00000046370	Cadm2 NCBI RGD Ensembl Show fit	cell adhesion molecule 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Otx1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	38.9	GO:0061548	ganglion development(GO:0061548)
0.1	19.7	GO:0010976	positive regulation of neuron projection development(GO:0010976)
0.2	18.4	GO:0002028	regulation of sodium ion transport(GO:0002028)
0.4	18.3	GO:0010501	RNA secondary structure unwinding(GO:0010501)
3.5	17.5	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.1	16.5	GO:1990034	calcium ion export from cell(GO:1990034)
0.1	15.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.8	14.4	GO:0071387	cellular response to cortisol stimulus(GO:0071387)
0.3	14.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.5	10.5	GO:0021960	anterior commissure morphogenesis(GO:0021960)

Showing 1 to 10 of 74 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	60.9	GO:0043194	axon initial segment(GO:0043194)
0.0	22.6	GO:0030424	axon(GO:0030424)
0.1	18.8	GO:0043209	myelin sheath(GO:0043209)
0.4	17.5	GO:0060077	inhibitory synapse(GO:0060077)
0.3	14.2	GO:0032809	neuronal cell body membrane(GO:0032809)
0.1	12.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
1.1	8.6	GO:0032584	growth cone membrane(GO:0032584)
0.2	8.4	GO:0044295	axonal growth cone(GO:0044295)
2.4	7.2	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.1	6.5	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	38.9	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.2	30.5	GO:0051015	actin filament binding(GO:0051015)
0.1	21.9	GO:0008022	protein C-terminus binding(GO:0008022)
0.3	18.3	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
3.5	17.5	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.8	16.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.4	14.4	GO:0070330	aromatase activity(GO:0070330)
1.1	13.3	GO:0019966	interleukin-1 binding(GO:0019966)
1.2	12.5	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
1.7	8.6	GO:0005042	netrin receptor activity(GO:0005042)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.6	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.3	7.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	7.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	3.8	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	3.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	2.5	PID NOTCH PATHWAY	Notch signaling pathway
0.1	2.1	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	1.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	38.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.0	28.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.7	17.5	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.8	16.5	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.8	14.4	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.7	8.6	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	8.4	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.5	7.3	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.5	7.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.2	4.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

Showing 1 to 10 of 21 entries

Results for Otx1

Z-value: 0.74

Motif logo

Transcription factors associated with Otx1

Activity-expression correlation:

Activity profile of Otx1 motif

Sorted Z-values of Otx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Otx1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: