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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Otx1

Z-value: 0.74

Motif logo

Transcription factors associated with Otx1

Gene Symbol Gene ID Gene Info
ENSRNOG00000059469 orthodenticle homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Otx1rn6_v1_chr14_-_106864892_1068648920.356.7e-11Click!

Activity profile of Otx1 motif

Sorted Z-values of Otx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_106753592 38.92 ENSRNOT00000006930
potassium voltage-gated channel subfamily Q member 3
chr11_+_57505005 22.30 ENSRNOT00000002942
transgelin-3
chr2_-_265300868 21.95 ENSRNOT00000066024
ENSRNOT00000016073
ENSRNOT00000033502
leucine rich repeat containing 7
chr1_+_27476375 18.42 ENSRNOT00000047224
ENSRNOT00000075427
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like
chr11_+_60072727 17.64 ENSRNOT00000090230
transgelin 3
chr3_+_56862691 17.46 ENSRNOT00000087712
glutamate decarboxylase 1
chrX_-_157286936 16.52 ENSRNOT00000078100
ATPase plasma membrane Ca2+ transporting 3
chr9_+_12114977 16.38 ENSRNOT00000073673

chr6_-_2311781 14.44 ENSRNOT00000084171
cytochrome P450, family 1, subfamily b, polypeptide 1
chr11_-_4397361 14.22 ENSRNOT00000046370
cell adhesion molecule 2
chr2_+_66940057 13.78 ENSRNOT00000043050
cadherin 9
chrX_-_56765893 13.28 ENSRNOT00000076283
interleukin 1 receptor accessory protein-like 1
chr13_-_39643361 12.49 ENSRNOT00000003527
dipeptidylpeptidase 10
chr15_+_19547871 12.22 ENSRNOT00000036235
G protein-coupled receptor 137C
chr6_-_127319362 11.06 ENSRNOT00000012256
DEAD-box helicase 24
chr2_+_102685513 10.51 ENSRNOT00000033940
basic helix-loop-helix family, member e22
chr2_+_198797159 10.45 ENSRNOT00000056225
ankyrin repeat domain 35
chr12_-_10391270 9.85 ENSRNOT00000092340
WAS protein family, member 3
chr9_+_116652530 9.29 ENSRNOT00000029210
l(3)mbt-like 4 (Drosophila)
chr9_-_114327767 9.28 ENSRNOT00000085481

chr11_+_57207656 8.62 ENSRNOT00000038207
ENSRNOT00000085754
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr18_-_67224566 8.62 ENSRNOT00000064947
DCC netrin 1 receptor
chr10_-_66848388 8.44 ENSRNOT00000018891
oligodendrocyte-myelin glycoprotein
chr16_-_39476384 8.43 ENSRNOT00000092968
glycoprotein m6a
chr1_+_40529045 8.39 ENSRNOT00000026564
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr18_+_30496318 8.05 ENSRNOT00000027179
protocadherin beta 11
chr3_-_162059524 7.70 ENSRNOT00000033873
zinc finger protein 334
chr9_+_62291809 7.63 ENSRNOT00000090621
phospholipase C-like 1
chr1_-_214414763 7.52 ENSRNOT00000025240
ENSRNOT00000077776
mitochondrial glutamate carrier 1-like
chr19_+_14835822 7.32 ENSRNOT00000072804
RIKEN cDNA 1700007B14 gene
chr1_+_65522118 7.29 ENSRNOT00000058563
myeloid zinc finger 1
chr18_+_27047382 7.17 ENSRNOT00000027691
ENSRNOT00000090264
APC, WNT signaling pathway regulator
chr4_+_9981958 7.03 ENSRNOT00000015322
N-acyl phosphatidylethanolamine phospholipase D
chr1_-_755645 6.76 ENSRNOT00000073546
vomeronasal 2 receptor, 6
chr14_-_46153212 6.56 ENSRNOT00000079269
NACHT and WD repeat domain containing 2
chr8_+_64481172 6.40 ENSRNOT00000015332
pyruvate kinase, muscle
chr12_-_8418966 6.35 ENSRNOT00000085869
microtubule associated tumor suppressor candidate 2
chr6_-_104409005 6.34 ENSRNOT00000040965
coiled-coil domain containing 177
chr10_+_45258887 6.28 ENSRNOT00000048642
butyrophilin like 10
chr2_-_156807305 6.26 ENSRNOT00000080578
uncharacterized protein LOC302022
chr9_+_49837868 5.61 ENSRNOT00000021999
G protein-coupled receptor 45
chr8_+_129205931 5.61 ENSRNOT00000082377
ectonucleoside triphosphate diphosphohydrolase 3
chr14_+_3882398 5.53 ENSRNOT00000033794
HFM1, ATP-dependent DNA helicase homolog
chr6_-_114476723 5.37 ENSRNOT00000005162
deiodinase, iodothyronine, type II
chr6_-_67085390 5.31 ENSRNOT00000083277
NOVA alternative splicing regulator 1
chrX_-_17252877 5.12 ENSRNOT00000060213
retinitis pigmentosa 1-like 1 protein-like
chr11_+_45339366 4.91 ENSRNOT00000002241
transmembrane protein 30C
chr8_+_82038967 4.64 ENSRNOT00000079535
myosin VA
chr6_+_92864123 4.48 ENSRNOT00000087540
thioredoxin-related transmembrane protein 1
chr4_+_70776046 4.38 ENSRNOT00000040403
protease, serine 1
chr4_+_87026530 4.35 ENSRNOT00000018425
AVL9 cell migration associated
chr12_-_54885 4.18 ENSRNOT00000090447

chr10_+_56381813 4.14 ENSRNOT00000019687
zinc finger and BTB domain containing 4
chrX_+_984798 4.11 ENSRNOT00000073016
zinc finger protein 182
chr8_+_126975833 4.09 ENSRNOT00000088348

chr7_+_12006710 3.87 ENSRNOT00000045421
Kruppel-like factor 16
chr16_+_39144972 3.83 ENSRNOT00000086728
ADAM metallopeptidase domain 21
chr16_+_39353283 3.78 ENSRNOT00000080125
disintegrin and metalloproteinase domain-containing protein 21-like
chr4_+_117962319 3.78 ENSRNOT00000057441
transforming growth factor alpha
chr5_+_139385429 3.63 ENSRNOT00000078622
sex comb on midleg homolog 1 (Drosophila)
chr8_+_58347736 3.55 ENSRNOT00000080227
ENSRNOT00000066222
solute carrier family 35, member F2
chr1_-_217620420 3.49 ENSRNOT00000092783
cortactin
chr4_+_88119838 3.42 ENSRNOT00000073173
vomeronasal 1 receptor 82
chr18_-_55771730 3.33 ENSRNOT00000026426
small integral membrane protein 3
chr8_-_116855062 3.26 ENSRNOT00000050344
ring finger protein 123
chr5_+_156396695 3.25 ENSRNOT00000067631
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_93693690 3.24 ENSRNOT00000086745
N-acetyltransferase 10
chr9_-_65442257 3.24 ENSRNOT00000037660
family with sequence similarity 126, member B
chr16_+_39145230 3.20 ENSRNOT00000092942
ADAM metallopeptidase domain 21
chr5_+_70528688 3.19 ENSRNOT00000036799
fukutin
chr3_+_17009089 3.11 ENSRNOT00000048829
rCG64257-like
chr12_+_31536951 3.09 ENSRNOT00000086078
RIMS binding protein 2
chrM_-_14061 3.09 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr1_-_72464492 3.08 ENSRNOT00000068550
N-acetyltransferase 14
chr19_+_359271 3.03 ENSRNOT00000086313

chr2_+_260444227 3.01 ENSRNOT00000064249
solute carrier family 44, member 5
chr6_+_100337226 3.00 ENSRNOT00000011220
fucosyltransferase 8
chr20_-_14573519 2.90 ENSRNOT00000001772
RAB36, member RAS oncogene family
chr11_-_43099412 2.80 ENSRNOT00000002281
gamma-aminobutyric acid type A receptor rho3 subunit
chrM_+_14136 2.77 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr19_-_9931930 2.77 ENSRNOT00000085144
coiled-coil domain containing 113
chr8_-_104995725 2.75 ENSRNOT00000037120
solute carrier family 25 member 36
chr4_+_88207124 2.72 ENSRNOT00000082459
vomeronasal 1 receptor 84
chr20_+_37587687 2.69 ENSRNOT00000001050
male-specific lethal 3-like 2 (Drosophila)
chr1_-_70485888 2.49 ENSRNOT00000020514
olfactory receptor 7
chr3_-_21684132 2.47 ENSRNOT00000012364
zinc finger and BTB domain containing 6
chr14_+_36071376 2.46 ENSRNOT00000082183
ligand of numb-protein X 1
chr2_+_93520734 2.41 ENSRNOT00000083909
sorting nexin 16
chr19_+_26066127 2.38 ENSRNOT00000064289
retbindin
chr7_-_62162453 2.38 ENSRNOT00000010720
cullin-associated and neddylation-dissociated 1
chrM_+_10160 2.33 ENSRNOT00000042928
mitochondrially encoded NADH dehydrogenase 4
chr10_+_57218087 2.29 ENSRNOT00000089853
misshapen-like kinase 1
chr11_+_43329700 2.21 ENSRNOT00000060892
olfactory receptor 1540
chr1_+_224998172 2.17 ENSRNOT00000026321
zinc finger and BTB domain containing 3
chrM_+_11736 2.12 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr12_-_12945192 2.11 ENSRNOT00000082529
cytohesin 3
chr3_-_76696107 2.04 ENSRNOT00000044692
olfactory receptor 629
chr8_-_117820413 1.97 ENSRNOT00000075819
translation machinery associated 7 homolog
chr1_-_102699442 1.93 ENSRNOT00000056109
tryptophan hydroxylase 1
chr14_-_71973419 1.89 ENSRNOT00000079895
coiled-coil and C2 domain containing 2A
chr4_+_144985880 1.84 ENSRNOT00000009464
THUMP domain containing 3
chr3_+_9822580 1.82 ENSRNOT00000010786
ENSRNOT00000093718
ubiquitin specific peptidase 20
chr17_-_14373983 1.82 ENSRNOT00000071112

chr8_-_57830504 1.74 ENSRNOT00000017683
DEAD-box helicase 10
chr7_-_29171783 1.71 ENSRNOT00000079235
myosin binding protein C, slow type
chr10_-_48038647 1.64 ENSRNOT00000078448
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr3_+_73115052 1.62 ENSRNOT00000090772
olfactory receptor 454
chr4_+_2711385 1.61 ENSRNOT00000035996
DnaJ heat shock protein family (Hsp40) member B6
chr3_+_130008885 1.60 ENSRNOT00000070972
SLX4 interacting protein
chr3_+_111826297 1.60 ENSRNOT00000081897
phospholipase A2 group IVB
chr1_-_201942344 1.57 ENSRNOT00000027956
similar to RIKEN cDNA 2310057M21
chr6_-_143537030 1.56 ENSRNOT00000071876
rCG64220-like
chr4_-_117589464 1.50 ENSRNOT00000021167
N-acetyltransferase 8 (GCN5-related) family member 1
chr20_-_1099336 1.47 ENSRNOT00000071766
olfactory receptor-like protein-like
chr1_+_69853553 1.45 ENSRNOT00000042086
zinc finger protein 954
chr1_-_90035522 1.43 ENSRNOT00000028672
ubiquitin-like modifier activating enzyme 2
chr3_+_121596791 1.39 ENSRNOT00000024694
tubulin tyrosine ligase
chr1_+_230450529 1.39 ENSRNOT00000045383
olfactory receptor 371
chr7_+_123963381 1.39 ENSRNOT00000036586
serine hydrolase-like 2
chr13_+_94888078 1.36 ENSRNOT00000077995
ENSRNOT00000005647
ENSRNOT00000077345
serologically defined colon cancer antigen 8
chr2_+_112914375 1.33 ENSRNOT00000092737
neutral cholesterol ester hydrolase 1
chr4_-_121822781 1.24 ENSRNOT00000072082
vomeronasal 1 receptor 95
chr17_+_43900450 1.23 ENSRNOT00000023622
butyrophilin, subfamily 1, member A1
chr8_-_18762922 1.23 ENSRNOT00000008423
olfactory receptor 1122
chrX_+_152196129 1.19 ENSRNOT00000087679
melanoma antigen, family A, 4
chrX_+_123751089 1.18 ENSRNOT00000092384
NFKB activating protein
chr4_+_38240728 1.16 ENSRNOT00000047029
PHD finger protein 14
chr13_+_67545430 1.16 ENSRNOT00000003405
phosducin
chr5_+_6373583 1.16 ENSRNOT00000084749

chr5_+_159612762 1.16 ENSRNOT00000012147
spermatogenesis associated 21
chr7_-_17520780 1.15 ENSRNOT00000029672
similar to NACHT, leucine rich repeat and PYD containing 4A
chr13_+_51218468 1.14 ENSRNOT00000033636
similar to UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylgluco
chr7_-_70467915 1.14 ENSRNOT00000088995
solute carrier family 26, member 10
chr7_-_129919946 1.12 ENSRNOT00000079976

chr1_-_228263198 1.09 ENSRNOT00000028572
olfactory receptor 1874
chr7_-_12519154 1.09 ENSRNOT00000093376
ENSRNOT00000077681
glutathione peroxidase 4
chr1_-_149683357 1.08 ENSRNOT00000077975
olfactory receptor 17
chrM_+_9870 1.01 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr4_+_87312766 0.99 ENSRNOT00000052126
vomeronasal 1 receptor 71
chr4_-_38240848 0.98 ENSRNOT00000007567
NADH:ubiquinone oxidoreductase subunit A4
chr14_+_45033309 0.98 ENSRNOT00000002933
toll-like receptor 6
chr7_+_97760134 0.96 ENSRNOT00000086792
TBC1 domain family, member 31
chr1_+_80954858 0.93 ENSRNOT00000030440
zinc finger protein 112
chr1_+_229416489 0.90 ENSRNOT00000028617
olfactory receptor 336
chr1_-_155955173 0.87 ENSRNOT00000079345

chr3_+_11587941 0.87 ENSRNOT00000071505
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chr1_-_149633029 0.85 ENSRNOT00000048861
olfactory receptor 14A2-like
chr18_-_45380730 0.84 ENSRNOT00000037904
pseudouridine 5'-phosphatase
chr1_-_63457134 0.82 ENSRNOT00000083436

chr5_-_160619650 0.81 ENSRNOT00000089981
transmembrane protein 51
chr3_+_143151739 0.79 ENSRNOT00000006850
cystatin 13
chr8_+_40285637 0.75 ENSRNOT00000015369
olfactory receptor 1199
chr4_+_1640318 0.75 ENSRNOT00000083649
olfactory receptor 1249
chr9_-_15306465 0.75 ENSRNOT00000019404
fibroblast growth factor receptor substrate 3
chr1_+_67742949 0.73 ENSRNOT00000049350
vomeronasal 1 receptor 41
chr1_+_72580424 0.68 ENSRNOT00000022977
ubiquitin-conjugating enzyme E2S
chr1_-_72129269 0.68 ENSRNOT00000049179
vomeronasal 1 receptor 35
chr18_+_30909490 0.68 ENSRNOT00000026967
protocadherin gamma subfamily B, 8
chr17_+_39544281 0.67 ENSRNOT00000022871
Prolactin family 2, subfamily b, member 1
chr3_+_67870111 0.61 ENSRNOT00000012628
nucleoporin 35
chr1_-_229927937 0.61 ENSRNOT00000080145
olfactory receptor 349
chr11_-_14160697 0.60 ENSRNOT00000081096
heat shock protein 70 family, member 13
chr3_+_23301455 0.60 ENSRNOT00000019405
actin related protein 2/3 complex, subunit 5-like
chr3_+_16610086 0.59 ENSRNOT00000046231
rCG64257-like
chr17_-_63879166 0.59 ENSRNOT00000049391
ENSRNOT00000045183
zinc finger, MYND-type containing 11
chr12_-_24724997 0.59 ENSRNOT00000025560
abhydrolase domain containing 11
chr10_-_76039964 0.58 ENSRNOT00000003164
musashi RNA-binding protein 2
chr17_-_54808483 0.56 ENSRNOT00000075683

chr16_+_8823872 0.56 ENSRNOT00000027186
dorsal root ganglia homeobox
chr1_-_167606343 0.54 ENSRNOT00000025003
olfactory receptor 40
chr3_-_151724654 0.52 ENSRNOT00000026964
RNA binding motif protein 39
chr3_-_152259156 0.51 ENSRNOT00000065729
RNA-binding protein 39-like
chr12_-_41497610 0.50 ENSRNOT00000001860
IQ motif containing D
chr4_-_164900857 0.49 ENSRNOT00000078690
Ly49 inhibitory receptor 2
chr8_+_116336441 0.48 ENSRNOT00000090123
ENSRNOT00000021590
N-acetyltransferase 6
hyaluronoglucosaminidase 3
chr3_+_102859815 0.46 ENSRNOT00000037906
olfactory receptor 771
chr8_-_1450138 0.45 ENSRNOT00000008062
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr4_+_106323089 0.43 ENSRNOT00000091402

chr3_+_16571602 0.42 ENSRNOT00000048351
rCG64259-like
chr11_+_28945575 0.41 ENSRNOT00000061600
ENSRNOT00000090364

chr1_+_75298364 0.41 ENSRNOT00000018981
vomeronasal 1 receptor 61
chr3_-_76926151 0.39 ENSRNOT00000049517
olfactory receptor 641
chr7_-_116955148 0.38 ENSRNOT00000087328
pyrroline-5-carboxylate reductase-like
chr3_+_138174054 0.37 ENSRNOT00000007946
barrier to autointegration factor 2
chr4_+_87827582 0.36 ENSRNOT00000077211
putative vomeronasal receptor-like protein 4
chrX_-_123731294 0.36 ENSRNOT00000092574
ENSRNOT00000032618
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr3_+_75834770 0.34 ENSRNOT00000043371
olfactory receptor 582
chr3_-_75879716 0.32 ENSRNOT00000007553
olfactory receptor 584
chr3_+_125320680 0.28 ENSRNOT00000028891
hypothetical protein LOC681292
chr20_-_28783589 0.27 ENSRNOT00000071663
septin 10
chr3_-_16441030 0.27 ENSRNOT00000047784

chrX_+_134389417 0.26 ENSRNOT00000075721
high mobility group protein B4-like
chr9_-_71798265 0.24 ENSRNOT00000043766
crystallin, gamma B
chrX_+_43745604 0.23 ENSRNOT00000040825
rCG36365-like
chr7_-_18793289 0.23 ENSRNOT00000036375

chr8_-_43249887 0.22 ENSRNOT00000060094
olfactory receptor 1305
chr8_+_43628182 0.21 ENSRNOT00000090359
olfactory receptor 1320
chr1_-_169892850 0.20 ENSRNOT00000037868
olfactory receptor 183
chr2_+_196594303 0.20 ENSRNOT00000064442
ENSRNOT00000044738
aryl hydrocarbon receptor nuclear translocator
chrX_+_13992064 0.20 ENSRNOT00000036543
rCG42854-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Otx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.4 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
3.5 17.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.8 8.4 GO:0015942 formate metabolic process(GO:0015942)
2.2 8.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
2.1 16.5 GO:1990034 calcium ion export from cell(GO:1990034)
1.9 38.9 GO:0061548 ganglion development(GO:0061548)
1.8 7.2 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
1.8 7.0 GO:1903999 negative regulation of eating behavior(GO:1903999)
1.5 10.5 GO:0021960 anterior commissure morphogenesis(GO:0021960)
1.2 4.6 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.9 9.5 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.8 3.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.8 2.4 GO:0010265 SCF complex assembly(GO:0010265)
0.7 3.0 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.6 3.2 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.6 6.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.6 5.4 GO:0042447 phenol-containing compound catabolic process(GO:0019336) hormone catabolic process(GO:0042447)
0.6 7.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.6 5.6 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.5 9.8 GO:0031643 positive regulation of myelination(GO:0031643)
0.5 7.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.5 2.8 GO:0033590 response to cobalamin(GO:0033590)
0.4 3.5 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.4 18.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 1.2 GO:2000790 regulation of mesenchymal cell proliferation involved in lung development(GO:2000790) negative regulation of mesenchymal cell proliferation involved in lung development(GO:2000791)
0.3 8.4 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.3 1.0 GO:0042496 detection of diacyl bacterial lipopeptide(GO:0042496) detection of bacterial lipopeptide(GO:0070340)
0.3 1.9 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.3 4.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 1.9 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 14.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 3.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.2 2.8 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531) nucleotide transmembrane transport(GO:1901679)
0.2 8.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 4.4 GO:0030574 collagen catabolic process(GO:0030574)
0.2 1.6 GO:0060710 chorio-allantoic fusion(GO:0060710) chorion development(GO:0060717)
0.2 7.2 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 1.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.7 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) protein K29-linked ubiquitination(GO:0035519)
0.2 18.4 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 2.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 2.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 2.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 15.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0006553 lysine metabolic process(GO:0006553)
0.1 1.6 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 0.6 GO:0021559 trigeminal nerve development(GO:0021559)
0.1 1.2 GO:0019236 response to pheromone(GO:0019236)
0.1 1.1 GO:0019532 oxalate transport(GO:0019532)
0.1 4.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 2.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 19.7 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.1 1.4 GO:0061387 regulation of extent of cell growth(GO:0061387)
0.0 3.1 GO:0042220 response to cocaine(GO:0042220)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 1.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 1.5 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.0 5.3 GO:0021510 spinal cord development(GO:0021510)
0.0 1.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.6 GO:0006999 nuclear pore organization(GO:0006999)
0.0 2.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 1.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 3.6 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.4 GO:0031023 microtubule organizing center organization(GO:0031023)
0.0 0.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
2.3 60.9 GO:0043194 axon initial segment(GO:0043194)
1.5 4.6 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.1 8.6 GO:0032584 growth cone membrane(GO:0032584)
1.0 3.1 GO:0070469 respiratory chain(GO:0070469)
0.8 2.4 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.6 3.5 GO:0099571 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.5 1.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.4 17.5 GO:0060077 inhibitory synapse(GO:0060077)
0.3 14.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.6 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 1.0 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.3 0.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3 2.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 2.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 8.4 GO:0044295 axonal growth cone(GO:0044295)
0.2 3.6 GO:0010369 chromocenter(GO:0010369)
0.1 1.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 12.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 4.1 GO:0034451 centriolar satellite(GO:0034451)
0.1 6.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.9 GO:0036038 MKS complex(GO:0036038)
0.1 2.7 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 3.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 2.8 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 18.8 GO:0043209 myelin sheath(GO:0043209)
0.1 3.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 22.6 GO:0030424 axon(GO:0030424)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.4 GO:0055037 recycling endosome(GO:0055037)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 5.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 1.6 GO:0030018 Z disc(GO:0030018)
0.0 2.4 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 0.6 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 17.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.7 8.6 GO:0005042 netrin receptor activity(GO:0005042)
1.7 8.4 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.6 6.4 GO:0004743 pyruvate kinase activity(GO:0004743)
1.5 7.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.2 12.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
1.2 7.0 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
1.1 13.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.8 16.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 7.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.5 7.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.4 14.4 GO:0070330 aromatase activity(GO:0070330)
0.4 5.6 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.3 38.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 1.0 GO:0042498 Toll-like receptor 2 binding(GO:0035663) diacyl lipopeptide binding(GO:0042498)
0.3 8.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 0.9 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.3 1.9 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3 18.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 4.6 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.2 3.0 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 1.4 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.2 3.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 4.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 1.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 4.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 1.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 3.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 30.5 GO:0051015 actin filament binding(GO:0051015)
0.2 0.5 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.2 1.1 GO:0008430 selenium binding(GO:0008430)
0.1 1.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 2.8 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 1.3 GO:0042301 phosphate ion binding(GO:0042301)
0.1 2.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.2 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 8.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 21.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 1.6 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 8.3 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 6.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 3.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 6.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.3 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 3.8 GO:0001948 glycoprotein binding(GO:0001948)
0.0 5.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 6.4 GO:0008017 microtubule binding(GO:0008017)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 1.8 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 3.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 3.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 8.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 7.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 38.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.0 28.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.8 14.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.8 16.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.7 17.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.7 8.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 7.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.5 7.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 4.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 4.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 8.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 0.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 4.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm