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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Onecut2_Onecut3

Z-value: 0.82

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Transcription factors associated with Onecut2_Onecut3

Gene Symbol Gene ID Gene Info
Onecut2
ENSRNOG00000052665 one cut domain, family member 2
Onecut3
ENSRNOG00000059889 one cut domain, family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut2rn6_v1_chr18_+_59830363_598304220.449.8e-17Click!
Onecut3rn6_v1_chr7_-_12085226_120852260.091.2e-01Click!

Activity profile of Onecut2_Onecut3 motif

Sorted Z-values of Onecut2_Onecut3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_161850875 46.32 ENSRNOT00000009467
Pzp
pregnancy-zone protein
chr2_+_60180215 25.66 ENSRNOT00000084624
Prlr
prolactin receptor
chr1_-_258766881 25.60 ENSRNOT00000015801
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
chr10_+_65767053 23.95 ENSRNOT00000078897
Vtn
vitronectin
chr1_-_76614279 23.41 ENSRNOT00000041367
ENSRNOT00000089371
LOC100912485
alcohol sulfotransferase-like
chr1_-_76780230 21.64 ENSRNOT00000002046
LOC100912485
alcohol sulfotransferase-like
chr1_-_89560719 19.09 ENSRNOT00000028653
Scn1b
sodium voltage-gated channel beta subunit 1
chr6_-_127620296 18.79 ENSRNOT00000012577
Serpina1
serpin family A member 1
chr1_-_89560469 17.48 ENSRNOT00000079091
Scn1b
sodium voltage-gated channel beta subunit 1
chr13_+_91080341 17.24 ENSRNOT00000000058
Crp
C-reactive protein
chr11_-_81660395 17.06 ENSRNOT00000048739
Fetub
fetuin B
chr2_-_98610368 16.85 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr15_+_33478148 16.70 ENSRNOT00000089954
AC115371.2

chr4_-_48928372 14.69 ENSRNOT00000083938
Tspan12
tetraspanin 12
chrX_+_51286737 13.85 ENSRNOT00000035692
Dmd
dystrophin
chr2_+_93827504 13.18 ENSRNOT00000032059
Pmp2
peripheral myelin protein 2
chr5_-_127878792 12.91 ENSRNOT00000014436
Zyg11b
zyg-11 family member B, cell cycle regulator
chr17_+_72160735 12.83 ENSRNOT00000038817
Itih2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_76517134 11.96 ENSRNOT00000064593
ENSRNOT00000085775
LOC100912485
alcohol sulfotransferase-like
chr1_+_248428099 11.71 ENSRNOT00000050984
Mbl2
mannose binding lectin 2
chr7_+_3216497 11.38 ENSRNOT00000008909
Mmp19
matrix metallopeptidase 19
chr2_+_235596907 11.14 ENSRNOT00000071463
ENSRNOT00000075728
Col25a1
collagen type XXV alpha 1 chain
chr16_+_18736154 11.05 ENSRNOT00000015723
Mbl1
mannose-binding lectin (protein A) 1
chr9_-_4327679 10.50 ENSRNOT00000073468
LOC100910235
sulfotransferase 1C1-like
chr2_+_241909832 10.47 ENSRNOT00000047975
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
chr4_-_145948996 10.42 ENSRNOT00000043476
Atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr3_+_129753742 9.84 ENSRNOT00000007998
ENSRNOT00000080581
Snap25
synaptosomal-associated protein 25
chr9_-_85617954 9.76 ENSRNOT00000077331
Serpine2
serpin family E member 2
chr15_-_14737704 9.64 ENSRNOT00000011307
Synpr
synaptoporin
chr7_+_14441476 9.47 ENSRNOT00000093687
Cyp4f39
cytochrome P450, family 4, subfamily f, polypeptide 39
chr13_+_89586283 9.38 ENSRNOT00000079355
ENSRNOT00000049873
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr11_+_80358211 9.37 ENSRNOT00000002519
Sst
somatostatin
chr10_+_35343189 9.23 ENSRNOT00000083688
Mapk9
mitogen-activated protein kinase 9
chr7_+_70980422 9.14 ENSRNOT00000077912
Rdh16
retinol dehydrogenase 16 (all-trans)
chr16_-_74408030 8.94 ENSRNOT00000026418
Slc20a2
solute carrier family 20 member 2
chrX_-_13279082 8.73 ENSRNOT00000051898
ENSRNOT00000060857
Tspan7
tetraspanin 7
chr2_+_18392142 8.69 ENSRNOT00000043196
Hapln1
hyaluronan and proteoglycan link protein 1
chr1_+_282557426 8.69 ENSRNOT00000088966
AABR07007134.1

chr11_+_36588404 8.64 ENSRNOT00000083003
AC142178.3

chr20_-_28263037 8.41 ENSRNOT00000030348
Edar
ectodysplasin-A receptor
chr3_+_129599353 8.33 ENSRNOT00000008734
Snap25
synaptosomal-associated protein 25
chr14_-_33977277 8.09 ENSRNOT00000002890
LOC100910308
multifunctional protein ADE2-like
chr9_+_6970507 7.80 ENSRNOT00000079488
St6gal2
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
chr8_-_70270309 7.66 ENSRNOT00000088311
AC107597.1

chr3_+_5519990 7.63 ENSRNOT00000070873
ENSRNOT00000007640
Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr1_+_256955652 7.63 ENSRNOT00000020411
Lgi1
leucine-rich, glioma inactivated 1
chrX_+_120901495 7.60 ENSRNOT00000040742
Wdr44
WD repeat domain 44
chr3_+_142383278 7.57 ENSRNOT00000017742
Foxa2
forkhead box A2
chr2_-_231409496 7.44 ENSRNOT00000055615
ENSRNOT00000015386
ENSRNOT00000068415
Ank2
ankyrin 2
chr10_-_27179254 7.43 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr5_-_105579959 7.38 ENSRNOT00000010827
Slc24a2
solute carrier family 24 member 2
chrX_+_6273733 7.34 ENSRNOT00000074275
Ndp
NDP, norrin cystine knot growth factor
chr6_+_47940183 7.14 ENSRNOT00000011951
Adi1
acireductone dioxygenase 1
chr15_-_23969011 7.05 ENSRNOT00000014821
Gch1
GTP cyclohydrolase 1
chr17_-_4454701 7.04 ENSRNOT00000080750
ENSRNOT00000066950
Dapk1
death associated protein kinase 1
chr16_+_23317953 7.03 ENSRNOT00000075287
AABR07024972.1

chr1_-_175657485 6.91 ENSRNOT00000024561
rnf141
ring finger protein 141
chr10_+_53621375 6.89 ENSRNOT00000004147
Myh3
myosin heavy chain 3
chr3_+_11653529 6.85 ENSRNOT00000091048
Ak1
adenylate kinase 1
chr5_+_27312928 6.85 ENSRNOT00000078102
Runx1t1
RUNX1 translocation partner 1
chr1_+_219764001 6.65 ENSRNOT00000082388
Pc
pyruvate carboxylase
chr5_+_76092287 6.61 ENSRNOT00000020207
Zfp483
zinc finger protein 483
chr3_+_51687809 6.50 ENSRNOT00000087242
Scn2a
sodium voltage-gated channel alpha subunit 2
chr2_+_115074344 6.36 ENSRNOT00000073657
LOC100910500
olfactory receptor 144-like
chr1_+_264741911 6.26 ENSRNOT00000019956
Sema4g
semaphorin 4G
chr5_-_88612626 6.09 ENSRNOT00000089560
Tle1
transducin like enhancer of split 1
chr2_-_209993250 6.08 ENSRNOT00000024519
Prok1
prokineticin 1
chr2_-_258932200 6.00 ENSRNOT00000045905
Adgrl2
adhesion G protein-coupled receptor L2
chr8_-_22821397 5.99 ENSRNOT00000045488
Kank2
KN motif and ankyrin repeat domains 2
chr15_-_33752665 5.89 ENSRNOT00000034102
Zfhx2
zinc finger homeobox 2
chr5_-_7941822 5.80 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_137860946 5.68 ENSRNOT00000031334
Agbl1
ATP/GTP binding protein-like 1
chr8_-_87245951 5.61 ENSRNOT00000015299
Tmem30a
transmembrane protein 30A
chr6_-_95934296 5.53 ENSRNOT00000034338
Six1
SIX homeobox 1
chr5_+_49311030 5.32 ENSRNOT00000010850
Cnr1
cannabinoid receptor 1
chr1_-_143392532 5.28 ENSRNOT00000026089
Fsd2
fibronectin type III and SPRY domain containing 2
chr8_-_80631873 5.20 ENSRNOT00000091661
ENSRNOT00000080662
Unc13c
unc-13 homolog C
chr11_-_61470046 5.17 ENSRNOT00000073436
LOC102553099
N-alpha-acetyltransferase 50-like
chr15_-_28746042 5.11 ENSRNOT00000017730
Sall2
spalt-like transcription factor 2
chr19_+_14346197 5.11 ENSRNOT00000043480
Gm18025
predicted gene, 18025
chrX_-_64908682 5.04 ENSRNOT00000084107
Zc4h2
zinc finger C4H2-type containing
chr2_-_35550204 4.99 ENSRNOT00000084377
Olr1280
olfactory receptor 1280
chr15_+_12407524 4.73 ENSRNOT00000009249
Psmd6
proteasome 26S subunit, non-ATPase 6
chrM_+_2740 4.73 ENSRNOT00000047550
Mt-nd1
mitochondrially encoded NADH dehydrogenase 1
chrX_+_44907521 4.68 ENSRNOT00000004901
Tbl1x
transducin (beta)-like 1 X-linked
chr18_-_85980833 4.67 ENSRNOT00000058179
Socs6
suppressor of cytokine signaling 6
chr11_-_15858281 4.56 ENSRNOT00000090586
AABR07033287.1

chr1_-_63457134 4.51 ENSRNOT00000083436
AABR07071874.1

chr1_-_263885169 4.50 ENSRNOT00000030782
Chuk
conserved helix-loop-helix ubiquitous kinase
chr14_-_103321270 4.48 ENSRNOT00000006157
Meis1
Meis homeobox 1
chr1_+_193424812 4.46 ENSRNOT00000019939
Aqp8
aquaporin 8
chr3_-_8924032 4.45 ENSRNOT00000023527
ENSRNOT00000085042
Sh3glb2
SH3 domain-containing GRB2-like endophilin B2
chr11_-_76888178 4.45 ENSRNOT00000049841
Ostn
osteocrin
chr4_-_160334910 4.33 ENSRNOT00000086772
Prmt8
protein arginine methyltransferase 8
chr10_-_91986632 4.29 ENSRNOT00000087824
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr8_+_14811627 4.18 ENSRNOT00000043392
LOC689840
LRRGT00142
chr7_+_93376277 4.15 ENSRNOT00000017602
LOC100359763
ribosomal protein S25-like
chr16_+_74408183 4.12 ENSRNOT00000036506
Smim19
small integral membrane protein 19
chrX_-_100632562 4.10 ENSRNOT00000073416
LOC102555578
zinc finger protein 120-like
chr8_+_97535777 4.07 ENSRNOT00000068394
Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr11_+_86421106 3.99 ENSRNOT00000002599
LOC100362453
serine/threonine-protein phosphatase 2A catalytic subunit alpha-like
chr14_-_22009300 3.98 ENSRNOT00000088491
ENSRNOT00000087923
Csn1s1
casein alpha s1
chr8_+_100260049 3.95 ENSRNOT00000011090
AABR07071101.1

chr3_-_143655864 3.95 ENSRNOT00000088666
AABR07054167.1

chr11_+_75434197 3.88 ENSRNOT00000032569
Mb21d2
Mab-21 domain containing 2
chr10_+_80790168 3.87 ENSRNOT00000073315
ENSRNOT00000075163
Car10
carbonic anhydrase 10
chr17_-_43537293 3.76 ENSRNOT00000091749
Slc17a3
solute carrier family 17 member 3
chrX_-_82986051 3.68 ENSRNOT00000077587
Hdx
highly divergent homeobox
chr2_+_113007549 3.65 ENSRNOT00000017758
Tnfsf10
tumor necrosis factor superfamily member 10
chr3_-_83306781 3.63 ENSRNOT00000014088
Ttc17
tetratricopeptide repeat domain 17
chr7_-_106465830 3.60 ENSRNOT00000044610
AABR07058253.1

chr10_-_66848388 3.59 ENSRNOT00000018891
Omg
oligodendrocyte-myelin glycoprotein
chr7_-_117788550 3.58 ENSRNOT00000021775
MGC94207
similar to RIKEN cDNA C030006K11
chr10_-_15465404 3.50 ENSRNOT00000077826
ENSRNOT00000027593
Decr2
2,4-dienoyl-CoA reductase 2
chr6_+_27535020 3.45 ENSRNOT00000076512
Adgrf3
adhesion G protein-coupled receptor F3
chr15_-_27408258 3.43 ENSRNOT00000043588
RGD1562558
similar to Cytochrome c, somatic
chrX_+_74304292 3.42 ENSRNOT00000057623
LOC680227
LRRGT00193
chr9_+_66045962 3.28 ENSRNOT00000058491
RGD1562399
similar to 40S ribosomal protein S2
chr14_+_1937041 3.27 ENSRNOT00000000040
Tmed11
transmembrane emp24 protein transport domain containing 11
chr3_-_143778353 3.25 ENSRNOT00000050369
P22k15
cystatin related protein 2
chr8_-_43480777 3.23 ENSRNOT00000060074
LOC688473
similar to 40S ribosomal protein S2
chr19_+_14345993 3.22 ENSRNOT00000084913
Gm18025
predicted gene, 18025
chr20_+_6356423 3.22 ENSRNOT00000000628
Cdkn1a
cyclin-dependent kinase inhibitor 1A
chr17_-_1999596 3.14 ENSRNOT00000072220
1190003K10Rik
RIKEN cDNA 1190003K10 gene
chr20_-_3439983 3.10 ENSRNOT00000080822
ENSRNOT00000001099
Ier3
immediate early response 3
chr6_-_26138414 3.10 ENSRNOT00000034712
Mrpl33
mitochondrial ribosomal protein L33
chr1_+_172892134 3.08 ENSRNOT00000087918
Olr276
olfactory receptor 276
chr2_-_96032722 3.06 ENSRNOT00000015746
LOC100360846
proteasome subunit beta type 6-like
chr4_-_79052633 3.05 ENSRNOT00000012694
RGD1563352
similar to ribosomal protein S11
chr8_-_43534620 3.02 ENSRNOT00000035386
LOC688473
similar to 40S ribosomal protein S2
chr8_+_59900651 2.93 ENSRNOT00000020410
Tmem266
transmembrane protein 266
chr4_-_23119005 2.92 ENSRNOT00000048061
Steap4
STEAP4 metalloreductase
chr4_-_30380119 2.91 ENSRNOT00000036460
Pon2
paraoxonase 2
chr11_+_40509078 2.88 ENSRNOT00000023108
AABR07033851.1

chr10_+_59259955 2.80 ENSRNOT00000021816
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr7_+_8210182 2.79 ENSRNOT00000075032
Olr1049
olfactory receptor 1049
chr2_-_242828629 2.78 ENSRNOT00000043369
LOC499715
LRRGT00095
chr5_-_107039925 2.74 ENSRNOT00000049705
Ifna5
interferon, alpha 5
chrX_-_45284341 2.73 ENSRNOT00000045436
Obp1f
odorant binding protein I f
chr9_-_50762082 2.73 ENSRNOT00000015492
Mettl21c
methyltransferase like 21C
chr1_-_103811148 2.72 ENSRNOT00000030162
Mrgprx2l
MAS-related G protein-coupled receptor, member X2-like
chr3_-_77883067 2.71 ENSRNOT00000087979
Olr677
olfactory receptor 677
chrX_-_84821775 2.70 ENSRNOT00000000174
Chm
CHM, Rab escort protein 1
chr3_-_158328881 2.68 ENSRNOT00000044466
Ptprt
protein tyrosine phosphatase, receptor type, T
chr7_-_12326392 2.68 ENSRNOT00000039728
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chrX_-_81817101 2.67 ENSRNOT00000003730
AABR07039648.1

chr15_+_35571103 2.66 ENSRNOT00000085376
Olr1293
olfactory receptor 1293
chr2_-_111793326 2.65 ENSRNOT00000092660
Nlgn1
neuroligin 1
chrX_+_45213228 2.64 ENSRNOT00000088538
LOC103690319
odorant-binding protein
chrX_-_124576133 2.59 ENSRNOT00000041904
Rhox3
reproductive homeobox on X chromosome 3
chr5_+_187312 2.55 ENSRNOT00000030857
LOC102557117
zinc finger protein 120-like
chr9_-_17212628 2.54 ENSRNOT00000002656
ENSRNOT00000007876
RGD1562399
similar to 40S ribosomal protein S2
chr8_-_19333047 2.50 ENSRNOT00000048500
Olr1144
olfactory receptor 1144
chr18_-_52047816 2.44 ENSRNOT00000018368
ENSRNOT00000077491
LOC100174910
glutaredoxin-like protein
chr18_-_74059533 2.44 ENSRNOT00000038767
RGD1308601
similar to hypothetical protein
chr15_-_27798408 2.43 ENSRNOT00000088981
Tep1
telomerase associated protein 1
chrX_-_83864150 2.42 ENSRNOT00000073734
Obp1f
odorant binding protein I f
chr15_+_51303909 2.40 ENSRNOT00000085237
ENSRNOT00000058663
Loxl2
lysyl oxidase-like 2
chr8_+_76754492 2.35 ENSRNOT00000085727
Myo1e
myosin IE
chr3_-_73484676 2.35 ENSRNOT00000040041
Olr481
olfactory receptor 481
chrX_-_74968405 2.34 ENSRNOT00000035653
RGD1561931
similar to KIAA2022 protein
chr19_-_39670909 2.31 ENSRNOT00000078388
AABR07043776.1

chr12_-_38916237 2.30 ENSRNOT00000074517
Tmem120b
transmembrane protein 120B
chr17_+_53962444 2.26 ENSRNOT00000080101
Ggps1
geranylgeranyl diphosphate synthase 1
chr7_-_17859653 2.26 ENSRNOT00000030164
Zscan4f
zinc finger and SCAN domain containing 4F
chrX_-_31013030 2.25 ENSRNOT00000004451
AABR07037798.1

chr4_-_118342176 2.25 ENSRNOT00000032477
AC139642.2

chr4_+_78140483 2.22 ENSRNOT00000048576
Zfp862
zinc finger protein 862
chr9_+_40817654 2.22 ENSRNOT00000037392
AABR07067339.1

chr3_+_145882819 2.21 ENSRNOT00000042110
LOC102549291
zinc finger protein 120-like
chr2_-_149088787 2.20 ENSRNOT00000064833
Clrn1
clarin 1
chr13_+_82355886 2.19 ENSRNOT00000076757
Sele
selectin E
chr8_+_19810959 2.18 ENSRNOT00000049712
Olr1156
olfactory receptor 1156
chr1_+_264059374 2.14 ENSRNOT00000075397
Scd2
stearoyl-Coenzyme A desaturase 2
chr3_+_134440195 2.13 ENSRNOT00000072928
AABR07054000.1

chr3_-_52849907 2.12 ENSRNOT00000041096
Scn7a
sodium voltage-gated channel alpha subunit 7
chr10_-_62393673 2.11 ENSRNOT00000070956
LOC100909578
olfactory receptor 1496-like
chr1_+_91746486 2.10 ENSRNOT00000047772
AC136661.1

chr7_+_144565392 2.08 ENSRNOT00000021589
Hoxc11
homeobox C11
chr20_-_31402483 2.08 ENSRNOT00000033529
H2afy2
H2A histone family, member Y2
chr1_+_84584596 2.07 ENSRNOT00000032933
LOC100910046
zinc finger protein 60-like
chr16_-_16762240 2.06 ENSRNOT00000080746
AABR07024790.1

chr2_+_115125790 2.06 ENSRNOT00000074937
LOC100909862
olfactory receptor 144-like
chr15_+_35942770 2.05 ENSRNOT00000072814
Olr1278
olfactory receptor 1278
chr13_+_56096834 2.04 ENSRNOT00000035129
Dennd1b
DENN domain containing 1B
chr14_-_15709518 2.03 ENSRNOT00000051054
RGD1559999
similar to DNA segment, Chr 5, ERATO Doi 577, expressed
chr4_-_120414118 2.01 ENSRNOT00000072795
LOC100911337
40S ribosomal protein S25-like
chr3_+_159902441 2.00 ENSRNOT00000089893
ENSRNOT00000011978
Hnf4a
hepatocyte nuclear factor 4, alpha
chr1_-_150262213 2.00 ENSRNOT00000049595
Olr32
olfactory receptor 32
chr3_+_158851436 1.99 ENSRNOT00000075251
LOC100912432
olfactory receptor 8B8-like
chr5_-_107416695 1.99 ENSRNOT00000045433
Ifna2
interferon alpha 2
chr6_-_41870046 1.98 ENSRNOT00000005863
Lpin1
lipin 1
chr1_+_84685931 1.98 ENSRNOT00000063839
Zfp780b
zinc finger protein 780B
chr4_-_129515435 1.98 ENSRNOT00000039353
Eogt
EGF domain specific O-linked N-acetylglucosamine transferase
chr4_+_64088900 1.96 ENSRNOT00000075341
Chrm2
cholinergic receptor, muscarinic 2
chr4_+_1371401 1.95 ENSRNOT00000071676
LOC100910899
olfactory receptor 143-like
chr1_-_90208036 1.94 ENSRNOT00000076255
ENSRNOT00000076967
Lsm14a
LSM14A mRNA processing body assembly factor
chr4_+_121778227 1.92 ENSRNOT00000084689
Vom1r93
vomeronasal 1 receptor 93
chr5_-_33664435 1.91 ENSRNOT00000009047
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr7_-_11400805 1.90 ENSRNOT00000027634
Dapk3
death-associated protein kinase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 36.6 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
6.3 18.8 GO:0033986 response to methanol(GO:0033986)
6.1 18.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
4.6 13.8 GO:0016203 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
2.9 11.7 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
2.9 17.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
2.9 25.7 GO:0038161 prolactin signaling pathway(GO:0038161)
2.6 10.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
2.5 7.6 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
2.4 9.8 GO:0061107 seminal vesicle development(GO:0061107)
2.4 7.1 GO:0014916 regulation of lung blood pressure(GO:0014916)
2.3 6.8 GO:0046103 inosine biosynthetic process(GO:0046103)
2.2 24.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.0 6.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.9 7.4 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.8 5.5 GO:2000729 response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
1.8 5.3 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
1.7 6.7 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
1.5 4.5 GO:0010034 response to acetate(GO:0010034)
1.5 4.4 GO:1903860 negative regulation of dendrite extension(GO:1903860)
1.4 8.4 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
1.3 8.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
1.3 9.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.3 10.4 GO:0048840 otolith development(GO:0048840)
1.3 11.4 GO:0001554 luteolysis(GO:0001554)
1.2 7.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.1 9.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 4.3 GO:0035494 SNARE complex disassembly(GO:0035494)
1.0 11.1 GO:0060385 axonogenesis involved in innervation(GO:0060385)
1.0 27.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.0 10.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.9 5.7 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.9 6.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.9 11.1 GO:0051852 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.8 46.3 GO:0007566 embryo implantation(GO:0007566)
0.8 2.3 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.7 4.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.7 2.7 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.6 4.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.6 7.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.6 2.8 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.6 1.7 GO:0071338 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 2.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.5 7.4 GO:0071420 cellular response to histamine(GO:0071420)
0.5 2.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.5 2.0 GO:0010534 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.5 5.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.5 2.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.5 5.6 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.5 3.2 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.4 15.7 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.4 1.7 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.4 1.2 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.4 12.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.4 4.4 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.4 10.6 GO:0010842 retina layer formation(GO:0010842)
0.4 2.4 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.4 11.8 GO:0033194 response to hydroperoxide(GO:0033194)
0.4 2.0 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 1.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 2.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.4 1.4 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751) positive regulation of pancreatic juice secretion(GO:0090187)
0.4 7.8 GO:0097503 sialylation(GO:0097503)
0.4 1.8 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.3 3.8 GO:0015747 urate transport(GO:0015747)
0.3 6.1 GO:2000811 negative regulation of anoikis(GO:2000811)
0.3 9.4 GO:0010447 response to acidic pH(GO:0010447)
0.3 3.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.3 0.9 GO:0036451 cap mRNA methylation(GO:0036451)
0.3 2.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 1.2 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.3 1.2 GO:1903094 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.3 2.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.3 7.6 GO:0035864 response to potassium ion(GO:0035864)
0.3 1.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.3 3.1 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.2 12.9 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.2 2.2 GO:0050957 equilibrioception(GO:0050957)
0.2 1.6 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.2 1.1 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.2 4.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 2.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 4.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 2.4 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 2.4 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.2 1.8 GO:0019336 phenol-containing compound catabolic process(GO:0019336) hormone catabolic process(GO:0042447)
0.2 1.4 GO:0007000 nucleolus organization(GO:0007000)
0.2 1.9 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.2 1.2 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.2 7.4 GO:0060292 long term synaptic depression(GO:0060292)
0.2 1.0 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.2 5.2 GO:0048679 regulation of axon regeneration(GO:0048679)
0.2 2.0 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.2 6.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 0.8 GO:0031584 activation of phospholipase D activity(GO:0031584) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.2 6.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 1.9 GO:0006517 protein deglycosylation(GO:0006517)
0.1 1.2 GO:2000303 regulation of ceramide biosynthetic process(GO:2000303)
0.1 4.7 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.3 GO:2000424 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.1 2.7 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 3.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.6 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 0.5 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 2.4 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 1.8 GO:0019236 response to pheromone(GO:0019236)
0.1 1.9 GO:0031033 myosin filament organization(GO:0031033)
0.1 1.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.1 0.7 GO:0003360 brainstem development(GO:0003360)
0.1 1.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 2.2 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 1.0 GO:0006670 sphingosine metabolic process(GO:0006670)
0.1 0.3 GO:0052422 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 1.6 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 0.7 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 11.7 GO:0030534 adult behavior(GO:0030534)
0.1 1.3 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 88.1 GO:0007608 sensory perception of smell(GO:0007608)
0.1 1.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 1.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 3.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.1 GO:0055078 sodium ion homeostasis(GO:0055078)
0.1 0.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 1.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.7 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 7.6 GO:0007411 axon guidance(GO:0007411)
0.0 8.9 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.3 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 1.0 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 1.5 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 2.0 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.0 GO:0071174 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.0 0.5 GO:0042438 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0 0.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 1.8 GO:0033574 response to testosterone(GO:0033574)
0.0 4.5 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 1.0 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 1.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 3.5 GO:0030041 actin filament polymerization(GO:0030041)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 2.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.5 GO:0006182 cGMP biosynthetic process(GO:0006182)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 24.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
3.6 18.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.3 45.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.7 10.5 GO:0005955 calcineurin complex(GO:0005955)
1.5 4.5 GO:0046691 intracellular canaliculus(GO:0046691)
1.1 3.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.9 12.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.9 10.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.8 9.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 13.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.7 2.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.6 5.2 GO:0044305 calyx of Held(GO:0044305)
0.5 1.5 GO:0045203 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.5 2.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.5 6.9 GO:0032982 myosin filament(GO:0032982)
0.4 9.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 7.6 GO:0001520 outer dense fiber(GO:0001520)
0.4 4.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 2.4 GO:0032437 cuticular plate(GO:0032437)
0.3 2.0 GO:0032280 symmetric synapse(GO:0032280)
0.3 22.4 GO:0005581 collagen trimer(GO:0005581)
0.3 1.2 GO:0033503 HULC complex(GO:0033503)
0.3 1.1 GO:0035363 histone locus body(GO:0035363)
0.3 2.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.3 1.7 GO:0000322 storage vacuole(GO:0000322)
0.3 7.4 GO:0031430 M band(GO:0031430)
0.3 2.1 GO:0001740 Barr body(GO:0001740)
0.2 5.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 2.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 5.1 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 4.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.2 2.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 0.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 1.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 12.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 7.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.1 GO:0005839 proteasome core complex(GO:0005839)
0.1 4.7 GO:0001772 immunological synapse(GO:0001772)
0.1 2.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 164.6 GO:0005615 extracellular space(GO:0005615)
0.1 0.9 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 15.5 GO:0043209 myelin sheath(GO:0043209)
0.1 4.7 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 4.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 9.3 GO:0043204 perikaryon(GO:0043204)
0.1 5.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 6.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 3.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 2.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 2.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 32.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 15.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 7.6 GO:0005874 microtubule(GO:0005874)
0.0 0.7 GO:0031672 A band(GO:0031672)
0.0 12.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 6.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 13.8 GO:0009986 cell surface(GO:0009986)
0.0 5.6 GO:0043005 neuron projection(GO:0043005)
0.0 5.5 GO:0030054 cell junction(GO:0030054)
0.0 2.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 44.3 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 46.3 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
8.6 25.7 GO:0004925 prolactin receptor activity(GO:0004925)
7.3 36.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
2.6 10.5 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
2.6 10.4 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
2.5 17.2 GO:0001849 complement component C1q binding(GO:0001849)
2.3 11.7 GO:0005534 galactose binding(GO:0005534)
2.2 6.7 GO:0004736 pyruvate carboxylase activity(GO:0004736)
1.9 7.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.8 8.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.5 35.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.5 10.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
1.5 4.5 GO:0008384 IkappaB kinase activity(GO:0008384)
1.4 17.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.3 5.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
1.1 3.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.1 7.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
1.0 34.7 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 7.1 GO:0019238 cyclohydrolase activity(GO:0019238)
1.0 2.9 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.9 9.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.9 27.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.9 3.5 GO:0019166 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.9 4.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.9 14.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.9 9.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.7 13.8 GO:0017166 vinculin binding(GO:0017166)
0.7 2.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.6 6.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.6 1.8 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.6 8.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.6 1.7 GO:0032427 GBD domain binding(GO:0032427)
0.5 2.1 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.5 7.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.5 2.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.5 2.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.5 2.3 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.4 4.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.4 3.8 GO:0019534 toxin transporter activity(GO:0019534)
0.4 9.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.4 1.2 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.4 2.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 6.9 GO:0000146 microfilament motor activity(GO:0000146)
0.4 43.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 8.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 1.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.3 4.5 GO:0015250 water channel activity(GO:0015250)
0.3 2.4 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.3 0.9 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.3 11.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 6.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 1.2 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.3 7.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.3 5.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 1.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 1.6 GO:0035375 zymogen binding(GO:0035375)
0.2 1.6 GO:0039706 co-receptor binding(GO:0039706)
0.2 8.2 GO:0015485 cholesterol binding(GO:0015485)
0.2 6.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 5.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 2.7 GO:0045295 alpha-catenin binding(GO:0045294) gamma-catenin binding(GO:0045295) delta-catenin binding(GO:0070097)
0.2 5.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 2.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 7.3 GO:0005109 frizzled binding(GO:0005109)
0.2 7.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 2.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 6.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 2.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 7.4 GO:0030507 spectrin binding(GO:0030507)
0.2 1.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 2.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 60.4 GO:0005549 odorant binding(GO:0005549)
0.1 1.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.4 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 16.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 3.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 2.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.1 1.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 9.5 GO:0004497 monooxygenase activity(GO:0004497)
0.1 13.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 3.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.7 GO:0008494 translation activator activity(GO:0008494)
0.1 1.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 11.3 GO:0005179 hormone activity(GO:0005179)
0.1 4.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 7.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 5.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.7 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 5.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 30.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 1.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 7.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 9.2 GO:0045296 cadherin binding(GO:0045296)
0.0 3.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 12.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.3 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 24.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5 19.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.5 27.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.5 26.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.5 8.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.4 94.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 17.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 3.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 7.0 PID IFNG PATHWAY IFN-gamma pathway
0.2 10.8 NABA COLLAGENS Genes encoding collagen proteins
0.2 8.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 7.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 10.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 18.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.7 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 29.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.3 18.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.3 45.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.2 25.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.7 9.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.6 7.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.6 7.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.6 9.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.5 20.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.4 7.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 9.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 7.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.4 9.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 10.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 4.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 6.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 24.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 4.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 4.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 10.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 10.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 18.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 11.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.7 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 3.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 15.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 4.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 7.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 2.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.9 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation