ISMARA results: Onecut2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Onecut2_Onecut3

Z-value: 0.82

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Transcription factors associated with Onecut2_Onecut3

Gene Symbol	Gene ID	Gene Info
Onecut2 NCBI RGD Ensembl	ENSRNOG00000052665	one cut domain, family member 2
Onecut3 NCBI RGD Ensembl	ENSRNOG00000059889	one cut domain, family member 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Onecut2	rn6_v1_chr18_+_59830363_59830422	0.44	9.8e-17	Click!
Onecut3	rn6_v1_chr7_-_12085226_12085226	0.09	1.2e-01	Click!

Activity profile of Onecut2_Onecut3 motif

Sorted Z-values of Onecut2_Onecut3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_161850875 Show fit	46.32	ENSRNOT00000009467	Pzp NCBI RGD Ensembl Show fit	pregnancy-zone protein
chr2_+_60180215 Show fit	25.66	ENSRNOT00000084624	Prlr NCBI RGD Ensembl Show fit	prolactin receptor
chr1_-_258766881 Show fit	25.60	ENSRNOT00000015801	Cyp2c12 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily c, polypeptide 12
chr10_+_65767053 Show fit	23.95	ENSRNOT00000078897	Vtn NCBI RGD Ensembl Show fit	vitronectin
chr1_-_76614279 Show fit	23.41	ENSRNOT00000041367 ENSRNOT00000089371	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr1_-_76780230 Show fit	21.64	ENSRNOT00000002046	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr1_-_89560719 Show fit	19.09	ENSRNOT00000028653	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr6_-_127620296 Show fit	18.79	ENSRNOT00000012577	Serpina1 NCBI RGD Ensembl Show fit	serpin family A member 1
chr1_-_89560469 Show fit	17.48	ENSRNOT00000079091	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr13_+_91080341 Show fit	17.24	ENSRNOT00000000058	Crp NCBI RGD Ensembl Show fit	C-reactive protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut2_Onecut3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	88.1	GO:0007608	sensory perception of smell(GO:0007608)
0.8	46.3	GO:0007566	embryo implantation(GO:0007566)
7.3	36.6	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.0	27.1	GO:0019373	epoxygenase P450 pathway(GO:0019373)
2.9	25.7	GO:0038161	prolactin signaling pathway(GO:0038161)
2.2	24.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
6.3	18.8	GO:0033986	response to methanol(GO:0033986)
6.1	18.2	GO:1990926	short-term synaptic potentiation(GO:1990926)
2.9	17.2	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.4	15.7	GO:0007339	binding of sperm to zona pellucida(GO:0007339)

Showing 1 to 10 of 147 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	164.6	GO:0005615	extracellular space(GO:0005615)
2.3	45.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	44.3	GO:0005886	plasma membrane(GO:0005886)
0.0	32.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
4.0	24.0	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.3	22.4	GO:0005581	collagen trimer(GO:0005581)
3.6	18.2	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	15.5	GO:0043209	myelin sheath(GO:0043209)
0.0	15.2	GO:0005667	transcription factor complex(GO:0005667)
0.7	13.8	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	60.4	GO:0005549	odorant binding(GO:0005549)
9.3	46.3	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.4	43.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
7.3	36.6	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.5	35.0	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.0	34.7	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	30.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.9	27.1	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
8.6	25.7	GO:0004925	prolactin receptor activity(GO:0004925)
2.5	17.2	GO:0001849	complement component C1q binding(GO:0001849)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	94.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	27.6	PID ERBB4 PATHWAY	ErbB4 signaling events
0.5	26.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.1	24.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5	19.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	18.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	17.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	10.8	NABA COLLAGENS	Genes encoding collagen proteins
0.1	10.8	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.2	8.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	45.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.6	29.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.2	25.7	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.3	24.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.5	20.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.3	18.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	18.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	15.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	11.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	10.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation

Showing 1 to 10 of 44 entries

Results for Onecut2_Onecut3

Z-value: 0.82

Motif logo

Transcription factors associated with Onecut2_Onecut3

Activity-expression correlation:

Activity profile of Onecut2_Onecut3 motif

Sorted Z-values of Onecut2_Onecut3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut2_Onecut3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: