ISMARA results: Onecut1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Onecut1_Cux2

Z-value: 1.61

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Transcription factors associated with Onecut1_Cux2

Gene Symbol	Gene ID	Gene Info
Onecut1 NCBI RGD Ensembl	ENSRNOG00000008095	one cut homeobox 1
Cux2 NCBI RGD Ensembl	ENSRNOG00000001259	cut-like homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Onecut1	rn6_v1_chr8_+_81766041_81766041	0.83	7.3e-81	Click!
Cux2	rn6_v1_chr12_+_40018937_40018937	0.19	4.9e-04	Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_81639872 Show fit	227.57	ENSRNOT00000047595 ENSRNOT00000090031 ENSRNOT00000081864	Hrg NCBI RGD Ensembl Show fit	histidine-rich glycoprotein
chr5_-_78985990 Show fit	210.53	ENSRNOT00000009248	Ambp NCBI RGD Ensembl Show fit	alpha-1-microglobulin/bikunin precursor
chr5_-_124403195 Show fit	205.42	ENSRNOT00000067850	C8a NCBI RGD Ensembl Show fit	complement C8 alpha chain
chr13_+_91080341 Show fit	187.01	ENSRNOT00000000058	Crp NCBI RGD Ensembl Show fit	C-reactive protein
chr2_+_114413410 Show fit	178.87	ENSRNOT00000015866	Slc2a2 NCBI RGD Ensembl Show fit	solute carrier family 2 member 2
chr17_+_9736577 Show fit	105.82	ENSRNOT00000066586	F12 NCBI RGD Ensembl Show fit	coagulation factor XII
chr17_+_9736786 Show fit	99.84	ENSRNOT00000081920	F12 NCBI RGD Ensembl Show fit	coagulation factor XII
chr10_+_65767053 Show fit	85.92	ENSRNOT00000078897	Vtn NCBI RGD Ensembl Show fit	vitronectin
chr7_-_119689938 Show fit	84.81	ENSRNOT00000000200	Tmprss6 NCBI RGD Ensembl Show fit	transmembrane protease, serine 6
chr9_+_95501778 Show fit	78.22	ENSRNOT00000086805	Spp2 NCBI RGD Ensembl Show fit	secreted phosphoprotein 2

Showing 1 to 10 of 92 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
75.9	227.6	GO:0097037	heme export(GO:0097037)
21.1	210.5	GO:0018298	protein-chromophore linkage(GO:0018298)
68.6	205.7	GO:0002254	kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541)
5.9	194.5	GO:0019835	cytolysis(GO:0019835)
31.2	187.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
35.8	178.9	GO:0009758	carbohydrate utilization(GO:0009758) fructose transport(GO:0015755)
11.9	118.5	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
7.8	85.9	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
7.7	84.8	GO:0097264	self proteolysis(GO:0097264)
0.7	78.2	GO:0046849	bone remodeling(GO:0046849)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	339.5	GO:0005615	extracellular space(GO:0005615)
2.2	269.4	GO:0072562	blood microparticle(GO:0072562)
56.9	227.6	GO:0061474	phagolysosome membrane(GO:0061474)
29.3	205.4	GO:0005579	membrane attack complex(GO:0005579)
1.9	178.9	GO:0031526	brush border membrane(GO:0031526)
1.5	170.2	GO:0030175	filopodium(GO:0030175)
0.9	118.5	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
14.3	85.9	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
2.9	66.7	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
4.8	61.8	GO:0042627	chylomicron(GO:0042627)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	290.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
20.2	242.4	GO:0001848	complement binding(GO:0001848)
10.3	227.6	GO:0019865	immunoglobulin binding(GO:0019865)
42.1	210.5	GO:0019862	IgA binding(GO:0019862)
26.7	187.0	GO:0001849	complement component C1q binding(GO:0001849)
19.9	178.9	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
23.7	118.5	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
3.7	85.9	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
2.6	73.1	GO:0008395	steroid hydroxylase activity(GO:0008395)
2.0	68.4	GO:0004407	histone deacetylase activity(GO:0004407)

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	680.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
6.2	338.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
3.1	187.0	PID IL6 7 PATHWAY	IL6-mediated signaling events
4.1	85.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.8	31.8	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
1.3	25.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	16.0	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.2	11.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	3.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	2.9	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	253.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
11.6	242.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
8.6	205.4	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
17.0	187.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
10.5	178.9	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
2.9	118.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
1.1	85.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	46.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.8	41.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.2	28.5	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters

Showing 1 to 10 of 20 entries

Results for Onecut1_Cux2

Z-value: 1.61

Motif logo

Transcription factors associated with Onecut1_Cux2

Activity-expression correlation:

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: