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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Obox1
Z-value: 0.99
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Transcription factors associated with Obox1
| Gene Symbol | Gene ID | Gene Info |
|---|
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_85645718 Show fit | 40.30 |
ENSRNOT00000032185
|
glutathione S-transferase alpha 2 |
|
| chr1_-_189199376 Show fit | 39.70 |
ENSRNOT00000021027
|
uromodulin |
|
| chr2_+_54466280 Show fit | 34.13 |
ENSRNOT00000033112
|
complement C6 |
|
| chr2_+_199796881 Show fit | 32.17 |
ENSRNOT00000024423
|
flavin containing monooxygenase 5 |
|
| chr3_+_159936856 Show fit | 29.57 |
ENSRNOT00000078703
|
hepatocyte nuclear factor 4, alpha |
|
| chr10_-_62273119 Show fit | 27.30 |
ENSRNOT00000004322
|
serpin family F member 2 |
|
| chr14_+_22375955 Show fit | 27.28 |
ENSRNOT00000063915
ENSRNOT00000034784 |
UDP-glucuronosyltransferase 2 family, member 37 |
|
| chr4_-_30276372 Show fit | 24.35 |
ENSRNOT00000011823
|
paraoxonase 1 |
|
| chr11_+_82945104 Show fit | 24.01 |
ENSRNOT00000002410
|
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
|
| chr7_+_141370491 Show fit | 23.60 |
ENSRNOT00000087662
|
glycerol-3-phosphate dehydrogenase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Obox1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 135.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 48.6 | GO:0055114 | oxidation-reduction process(GO:0055114) |
| 1.3 | 40.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 3.1 | 40.3 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 9.9 | 39.7 | GO:0072021 | ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218) |
| 11.4 | 34.1 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) |
| 4.2 | 33.2 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 1.7 | 32.4 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 31.1 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 7.4 | 29.6 | GO:0010534 | regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 87.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 81.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 58.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.1 | 55.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 7.2 | 50.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 49.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 1.7 | 45.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 43.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.7 | 39.3 | GO:0060170 | ciliary membrane(GO:0060170) |
| 6.3 | 31.6 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 69.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 65.3 | GO:0005549 | odorant binding(GO:0005549) |
| 1.9 | 51.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.3 | 41.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 3.4 | 40.8 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 2.2 | 40.3 | GO:0043295 | glutathione binding(GO:0043295) |
| 3.3 | 39.8 | GO:0019864 | IgG binding(GO:0019864) |
| 7.9 | 31.6 | GO:0004368 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) |
| 2.5 | 29.6 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 29.2 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 50.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 34.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 29.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 19.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 1.0 | 15.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 2.1 | 14.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.3 | 12.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 11.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 9.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 8.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 66.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.6 | 57.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 45.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.3 | 40.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.6 | 31.3 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 1.0 | 30.9 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 1.2 | 29.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.6 | 19.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 1.1 | 19.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.5 | 15.8 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |