ISMARA results: Nrf1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nrf1

Z-value: 2.78

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Transcription factors associated with Nrf1

Gene Symbol	Gene ID	Gene Info
Nrf1 NCBI RGD Ensembl	ENSRNOG00000008752	nuclear respiratory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nrf1	rn6_v1_chr4_+_57378069_57378166	0.16	3.9e-03	Click!

Activity profile of Nrf1 motif

Sorted Z-values of Nrf1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_148193710 Show fit	38.24	ENSRNOT00000088568	Adgrb2 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor B2
chr20_+_3364814 Show fit	37.33	ENSRNOT00000001077	RGD1302996 NCBI RGD Ensembl Show fit	hypothetical protein MGC:15854
chr16_-_20939545 Show fit	36.83	ENSRNOT00000027457	Sugp2 NCBI RGD Ensembl Show fit	SURP and G patch domain containing 2
chr1_+_81372650 Show fit	36.27	ENSRNOT00000088829	Zfp428 NCBI RGD Ensembl Show fit	zinc finger protein 428
chr8_+_22648323 Show fit	33.03	ENSRNOT00000013165	Smarca4 NCBI RGD Ensembl Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr10_+_89069256 Show fit	32.70	ENSRNOT00000008576	Tubg2 NCBI RGD Ensembl Show fit	tubulin, gamma 2
chr16_-_62373253 Show fit	29.86	ENSRNOT00000034325	Tex15 NCBI RGD Ensembl Show fit	testis expressed 15, meiosis and synapsis associated
chr8_+_64440214 Show fit	27.97	ENSRNOT00000058339	Parp6 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 6
chr14_+_33108024 Show fit	27.10	ENSRNOT00000090350 ENSRNOT00000067650 ENSRNOT00000077242	Noa1 NCBI RGD Ensembl Show fit	nitric oxide associated 1
chr14_-_3846891 Show fit	26.48	ENSRNOT00000068520	Cdc7 NCBI RGD Ensembl Show fit	cell division cycle 7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nrf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	111.5	GO:0007129	synapsis(GO:0007129)
0.5	89.7	GO:0007059	chromosome segregation(GO:0007059)
2.4	62.8	GO:0007020	microtubule nucleation(GO:0007020)
0.3	61.2	GO:0000398	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
2.8	45.2	GO:0034587	piRNA metabolic process(GO:0034587)
3.1	43.6	GO:0019985	translesion synthesis(GO:0019985)
1.4	40.1	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
1.2	39.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
9.2	37.0	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)
0.6	36.5	GO:0016525	negative regulation of angiogenesis(GO:0016525)

Showing 1 to 10 of 510 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	82.0	GO:0005758	mitochondrial intermembrane space(GO:0005758)
1.5	74.4	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.7	62.8	GO:0044815	DNA packaging complex(GO:0044815)
6.9	61.7	GO:0071546	pi-body(GO:0071546)
0.7	61.2	GO:0005814	centriole(GO:0005814)
1.9	57.6	GO:0034451	centriolar satellite(GO:0034451)
5.9	47.3	GO:0000796	condensin complex(GO:0000796)
5.8	46.3	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2	42.6	GO:0000151	ubiquitin ligase complex(GO:0000151)
2.3	40.7	GO:0000930	gamma-tubulin complex(GO:0000930)

Showing 1 to 10 of 259 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	70.9	GO:0003924	GTPase activity(GO:0003924)
0.0	65.7	GO:0003676	nucleic acid binding(GO:0003676)
0.9	57.3	GO:0003743	translation initiation factor activity(GO:0003743)
0.5	57.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.8	48.6	GO:0035064	methylated histone binding(GO:0035064)
1.7	48.5	GO:0005540	hyaluronic acid binding(GO:0005540)
0.6	47.3	GO:0003697	single-stranded DNA binding(GO:0003697)
1.0	43.9	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.6	43.4	GO:0043130	ubiquitin binding(GO:0043130)
1.4	37.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Showing 1 to 10 of 351 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	73.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.1	63.0	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
1.3	61.7	PID AURORA B PATHWAY	Aurora B signaling
2.5	42.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.9	31.9	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.5	22.7	PID PLK1 PATHWAY	PLK1 signaling events
1.3	21.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	19.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.0	19.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
1.5	19.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Showing 1 to 10 of 57 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	83.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.0	75.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
5.7	68.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
1.9	67.4	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
1.0	64.6	REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	Genes involved in Recruitment of mitotic centrosome proteins and complexes
1.5	62.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.6	58.5	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.6	35.8	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
2.4	35.5	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
2.3	35.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis

Showing 1 to 10 of 114 entries

Results for Nrf1

Z-value: 2.78

Motif logo

Transcription factors associated with Nrf1

Activity-expression correlation:

Activity profile of Nrf1 motif

Sorted Z-values of Nrf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nrf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: