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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr5a2

Z-value: 1.47

Motif logo

Transcription factors associated with Nr5a2

Gene Symbol Gene ID Gene Info
ENSRNOG00000000653 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr5a2rn6_v1_chr13_-_53870428_53870428-0.541.7e-25Click!

Activity profile of Nr5a2 motif

Sorted Z-values of Nr5a2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_33656089 67.79 ENSRNOT00000024186
myosin heavy chain 7
chr8_-_130429132 66.37 ENSRNOT00000026261
hedgehog acyltransferase-like
chr9_+_82741920 46.61 ENSRNOT00000027337
solute carrier family 4 member 3
chr13_+_52625441 43.58 ENSRNOT00000012095
troponin I1, slow skeletal type
chr8_-_84632817 41.95 ENSRNOT00000076942
muscular LMNA-interacting protein
chr11_-_71419223 41.90 ENSRNOT00000002407
transferrin receptor
chr5_+_173640780 40.46 ENSRNOT00000027476
PPARGC1 and ESRR induced regulator, muscle 1
chr4_-_176720012 40.00 ENSRNOT00000017965
lactate dehydrogenase B
chr12_-_30566032 36.09 ENSRNOT00000093378
glioblastoma amplified sequence
chr1_+_72882806 36.07 ENSRNOT00000024640
troponin I3, cardiac type
chr16_-_10941414 34.89 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
LIM domain binding 3
chr12_-_24365324 31.97 ENSRNOT00000032250
tripartite motif-containing 50
chr17_+_44758460 31.16 ENSRNOT00000089436
histone cluster 1, H2an
chrX_-_40086870 31.06 ENSRNOT00000010027
small muscle protein, X-linked
chr13_+_52667969 27.92 ENSRNOT00000084986
ENSRNOT00000050284
troponin T2, cardiac type
chr8_-_128266639 25.63 ENSRNOT00000064555
ENSRNOT00000066932
sodium voltage-gated channel alpha subunit 5
chr9_+_99998275 25.60 ENSRNOT00000074395
glypican 1
chr15_+_41069507 25.33 ENSRNOT00000018533
C1q and tumor necrosis factor related protein 9
chr20_+_34633157 24.88 ENSRNOT00000000469
phospholamban
chr8_+_59164572 24.59 ENSRNOT00000015102
isocitrate dehydrogenase 3 (NAD+) alpha
chr7_+_35125424 24.34 ENSRNOT00000085978
ENSRNOT00000010117
NADH:ubiquinone oxidoreductase subunit A12
chr10_+_27973681 24.21 ENSRNOT00000004970
gamma-aminobutyric acid type A receptor beta 2 subunit
chr4_+_51614676 21.38 ENSRNOT00000060494
ankyrin repeat and SOCS box containing 15
chr7_+_123102493 21.09 ENSRNOT00000038612
aconitase 2
chr18_+_402295 20.92 ENSRNOT00000033618
FUN14 domain containing 2
chr4_-_16130848 20.82 ENSRNOT00000042914
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr3_-_60813869 20.75 ENSRNOT00000058234
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr10_+_45289741 20.61 ENSRNOT00000066190
histone cluster 3, H2ba
chr4_-_16130563 20.16 ENSRNOT00000090240
ENSRNOT00000034969
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr9_+_43259709 19.70 ENSRNOT00000022487
cytochrome c oxidase subunit 5B
chr18_+_83777665 19.68 ENSRNOT00000018682
cerebellin 2 precursor
chr10_-_62698541 19.33 ENSRNOT00000019759
coronin 6
chr17_-_44748188 18.40 ENSRNOT00000081970
histone H2A type 1-E
chr5_+_118743632 18.39 ENSRNOT00000013785
phosphoglucomutase 1
chr3_+_132052612 17.80 ENSRNOT00000030148

chr2_-_119140110 17.71 ENSRNOT00000058810

chr2_+_119139717 17.39 ENSRNOT00000016051
NADH:ubiquinone oxidoreductase subunit B5
chr17_-_44758170 17.20 ENSRNOT00000091176
histone cluster 1 H2B family member o
chr7_+_12229379 17.05 ENSRNOT00000060811
ADAMTS-like 5
chr4_-_157679962 16.83 ENSRNOT00000050443
glyceraldehyde-3-phosphate dehydrogenase
chr8_+_116094851 16.56 ENSRNOT00000084120
similar to RIKEN cDNA 6430571L13 gene; similar to g20 protein
chr11_+_70687500 16.33 ENSRNOT00000037432

chr17_-_84247038 16.11 ENSRNOT00000068553
nebulette
chr4_-_80333326 15.88 ENSRNOT00000014058
cytochrome c, somatic-like
chr17_-_44834305 15.45 ENSRNOT00000084303
histone cluster 1, H2bd
chr7_+_117409576 15.33 ENSRNOT00000017067
cytochrome c-1
chr13_-_103080920 15.31 ENSRNOT00000034990

chr13_-_47831110 15.08 ENSRNOT00000061070
mitogen-activated protein kinase-activated protein kinase 2
chr3_-_79728879 14.63 ENSRNOT00000012425
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr18_-_63825408 14.55 ENSRNOT00000043709
similar to glyceraldehyde-3-phosphate dehydrogenase
chr16_+_16949232 14.26 ENSRNOT00000047499

chr17_+_44520537 14.13 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr19_-_57699113 14.06 ENSRNOT00000026767
egl-9 family hypoxia-inducible factor 1
chr10_+_110139783 14.05 ENSRNOT00000054939
solute carrier family 16 member 3
chr10_-_10881844 14.03 ENSRNOT00000087118
ENSRNOT00000004416
mahogunin ring finger 1
chr3_-_3476215 14.01 ENSRNOT00000024352
UBA domain containing 1
chr17_+_44748482 13.96 ENSRNOT00000083765
histone cluster 1 H2B family member l
chr7_-_11330278 13.95 ENSRNOT00000027730
megakaryocyte-associated tyrosine kinase
chr1_+_193537137 13.88 ENSRNOT00000029967

chr11_-_72109964 13.86 ENSRNOT00000058917

chr8_-_53901358 13.57 ENSRNOT00000047666
ENSRNOT00000042281
neural cell adhesion molecule 1
chr11_-_32088002 13.24 ENSRNOT00000002732
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr5_+_140923914 13.13 ENSRNOT00000020929
hes-related family bHLH transcription factor with YRPW motif-like
chr7_-_74735650 13.04 ENSRNOT00000014407
cytochrome c oxidase subunit 6C
chr10_-_109729019 12.81 ENSRNOT00000054959
protein phosphatase 1, regulatory subunit 27
chrX_+_156340925 12.75 ENSRNOT00000091810
ubiquitin-like 4A
chr16_-_7681576 12.69 ENSRNOT00000026550
collagen like tail subunit of asymmetric acetylcholinesterase
chr3_+_11607225 12.59 ENSRNOT00000072685
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr6_-_136145837 12.34 ENSRNOT00000015122
creatine kinase B
chr19_+_26084903 12.21 ENSRNOT00000004799
peroxiredoxin 2
chr8_+_49418965 12.14 ENSRNOT00000021819
sodium voltage-gated channel beta subunit 2
chr13_-_51076852 12.04 ENSRNOT00000078993
adenosine A1 receptor
chr19_+_54245950 12.01 ENSRNOT00000024033
cytochrome c oxidase subunit 4i1
chr17_+_43627930 11.93 ENSRNOT00000081719
histone H2B type 1-N-like
chr8_+_45797315 11.86 ENSRNOT00000059997

chr13_-_85622314 11.73 ENSRNOT00000005719
microsomal glutathione S-transferase 3
chr14_-_84937725 11.60 ENSRNOT00000083839
ubiquinol-cytochrome c reductase, complex III subunit X
chr20_+_21316826 11.56 ENSRNOT00000000785
similar to RIKEN cDNA 1700040L02
chr3_+_151126591 11.52 ENSRNOT00000025859
myosin heavy chain 7B
chr19_-_11326139 11.49 ENSRNOT00000025669
metallothionein 3
chr8_-_119157071 11.44 ENSRNOT00000028963
transmembrane inner ear
chr17_-_44520240 11.14 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr1_-_219144610 10.95 ENSRNOT00000023526
NADH:ubiquinone oxidoreductase core subunit S8
chr10_-_89958805 10.94 ENSRNOT00000084266
membrane palmitoylated protein 3
chr1_-_165606375 10.93 ENSRNOT00000024290
mitochondrial ribosomal protein L48
chrX_+_105575759 10.76 ENSRNOT00000088760
armadillo repeat containing, X-linked 3
chr3_+_113257688 10.56 ENSRNOT00000019320
microtubule-associated protein 1A
chr15_+_3936786 10.40 ENSRNOT00000066163
calcium/calmodulin-dependent protein kinase II gamma
chr19_-_10596851 10.17 ENSRNOT00000021716
coenzyme Q9
chr19_-_37427989 10.09 ENSRNOT00000022863
tubulin polymerization-promoting protein family member 3
chrX_+_15273933 9.97 ENSRNOT00000075082
erythroid transcription factor
chr13_-_51183269 9.91 ENSRNOT00000039540
PTPRF interacting protein alpha 4
chr3_+_57770948 9.82 ENSRNOT00000038429

chr5_-_160158386 9.69 ENSRNOT00000089345
filamin binding LIM protein 1
chrM_+_8599 9.61 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chr14_+_73674753 9.36 ENSRNOT00000040676
similar to High mobility group protein 2 (HMG-2)
chr4_+_115046693 9.35 ENSRNOT00000031583
bolA family member 3
chrX_+_71155894 9.31 ENSRNOT00000076479
forkhead box O4
chr14_-_83741969 9.06 ENSRNOT00000026293
inositol polyphosphate-5-phosphatase J
chr12_+_47254484 8.98 ENSRNOT00000001556
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr1_-_170404056 8.91 ENSRNOT00000024402
amyloid beta precursor protein binding family B member 1
chr6_-_135412312 8.91 ENSRNOT00000010610
ankyrin repeat domain 9
chr14_+_58877806 8.89 ENSRNOT00000051559
similar to 60S ribosomal protein L23a
chr8_-_55037604 8.70 ENSRNOT00000059169
succinate dehydrogenase complex subunit D
chr18_-_63185510 8.69 ENSRNOT00000024632
AFG3 like matrix AAA peptidase subunit 2
chr6_+_1516158 8.58 ENSRNOT00000062031
uncharacterized LOC103692531
chr15_-_52134140 8.51 ENSRNOT00000013390
RNA polymerase III subunit D
chr4_+_7260575 8.46 ENSRNOT00000064893
Fas-activated serine/threonine kinase
chr5_+_159484370 8.43 ENSRNOT00000010593
succinate dehydrogenase complex iron sulfur subunit B
chrX_-_15707436 8.42 ENSRNOT00000085907
synaptophysin
chr8_+_119524039 8.24 ENSRNOT00000056050
EPM2A interacting protein 1
chr8_+_55037750 8.23 ENSRNOT00000013188
translocase of inner mitochondrial membrane 8 homolog B
chr1_+_226435979 8.17 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
synaptotagmin 7
chr10_-_15235740 8.07 ENSRNOT00000027170
MAPK regulated co-repressor interacting protein 2
chr6_-_50618694 7.88 ENSRNOT00000008980
dihydrolipoamide dehydrogenase
chr10_-_107281235 7.87 ENSRNOT00000004196
cytohesin 1
chr10_-_89959176 7.84 ENSRNOT00000028264
membrane palmitoylated protein 3
chr13_+_56262190 7.83 ENSRNOT00000032908

chr10_+_109658032 7.68 ENSRNOT00000054965
mitochondrial ribosomal protein L12
chr4_+_66405166 7.62 ENSRNOT00000077486
ENSRNOT00000067097
C-type lectin domain family 2, member L
chr20_-_48294948 7.62 ENSRNOT00000072716
similar to Protein C6orf203
chr4_-_99746560 7.58 ENSRNOT00000012021
mitochondrial ribosomal protein L35
chr3_+_133232432 7.49 ENSRNOT00000006412
NADH:ubiquinone oxidoreductase complex assembly factor 5
chr3_-_7141522 7.30 ENSRNOT00000014572
carboxyl ester lipase
chr1_-_282251257 7.28 ENSRNOT00000015186
peroxiredoxin 3
chr3_+_4083864 7.13 ENSRNOT00000006186
family with sequence similarity 69, member B
chr4_+_67378188 7.04 ENSRNOT00000030892
NADH:ubiquinone oxidoreductase subunit B2
chr13_-_52413681 7.03 ENSRNOT00000037100
ENSRNOT00000011801
neuron navigator 1
chr16_+_21050243 6.88 ENSRNOT00000064308
neurocan
chr2_-_187742747 6.77 ENSRNOT00000026530
bone gamma-carboxyglutamate protein
chr1_-_143535583 6.73 ENSRNOT00000087785
homer scaffolding protein 2
chr10_+_67862054 6.71 ENSRNOT00000031746
cyclin-dependent kinase 5 regulatory subunit 1
chr16_+_1979191 6.67 ENSRNOT00000014382
peptidylprolyl isomerase F
chr3_+_79860179 6.60 ENSRNOT00000081160
ENSRNOT00000068444
receptor-associated protein of the synapse
chr14_-_18720357 6.60 ENSRNOT00000047708
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr3_+_177226417 6.53 ENSRNOT00000031328
opioid related nociceptin receptor 1
chr1_-_78968329 6.47 ENSRNOT00000023078
protein phosphatase 5, catalytic subunit
chr3_-_8981362 6.35 ENSRNOT00000086717
carnitine O-acetyltransferase
chr1_+_31545631 6.33 ENSRNOT00000018336
succinate dehydrogenase complex flavoprotein subunit A
chr8_-_130491998 6.31 ENSRNOT00000064114
HIG1 hypoxia inducible domain family, member 1A
chr7_+_121311024 6.23 ENSRNOT00000092260
ENSRNOT00000023066
ENSRNOT00000081377
synaptogyrin 1
chr1_+_222250995 6.15 ENSRNOT00000031458
tRNA phosphotransferase 1
chr1_-_175586802 6.09 ENSRNOT00000071333

chr15_-_93307420 6.08 ENSRNOT00000012195
SLIT and NTRK-like family, member 1
chr7_-_117259141 6.02 ENSRNOT00000040762
plectin
chr17_-_43627629 5.90 ENSRNOT00000022965
histone cluster 1, H2af
chr2_-_140464607 5.89 ENSRNOT00000058190
NADH:ubiquinone oxidoreductase subunit C1
chr4_-_123118186 5.63 ENSRNOT00000038096
coiled-coil-helix-coiled-coil-helix domain containing 4
chr2_-_183031214 5.61 ENSRNOT00000013260
similar to RIKEN cDNA D930015E06
chr13_+_52413241 5.57 ENSRNOT00000035157

chr7_+_2504695 5.56 ENSRNOT00000003965
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr19_+_22569999 5.46 ENSRNOT00000022573
DnaJ heat shock protein family (Hsp40) member A2
chr3_-_7796385 5.44 ENSRNOT00000082489
netrin G2
chr7_-_127058056 5.33 ENSRNOT00000022882
ceramide kinase
chr7_-_119768082 5.25 ENSRNOT00000009612
somatostatin receptor 3
chr7_+_144577465 5.20 ENSRNOT00000021647
homeo box C10
chr10_+_84986328 5.16 ENSRNOT00000085830
ENSRNOT00000067665
oxysterol binding protein-like 7
chr14_-_19159923 5.02 ENSRNOT00000003879
alpha-fetoprotein
chr6_+_128750795 4.91 ENSRNOT00000005781
glutaredoxin 5
chr1_+_221773254 4.80 ENSRNOT00000028646
RAS guanyl releasing protein 2
chr1_+_72956026 4.77 ENSRNOT00000031462
retinol dehydrogenase 13
chr2_+_206064179 4.72 ENSRNOT00000025953
synaptotagmin 6
chr7_+_110031696 4.58 ENSRNOT00000012753
KH RNA binding domain containing, signal transduction associated 3
chr11_+_24266345 4.55 ENSRNOT00000046973
junctional adhesion molecule 2
chr4_+_165732643 4.50 ENSRNOT00000034403
hypothetical protein LOC690326
chr5_-_155772040 4.45 ENSRNOT00000036788
chymotrypsin-like elastase family, member 3B
chr19_-_52750307 4.38 ENSRNOT00000023405
zinc finger, DHHC-type containing 7
chr5_-_157573183 4.38 ENSRNOT00000064418
mitochondrial inner membrane organizing system 1
chr8_+_1502877 4.36 ENSRNOT00000034482
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr5_+_156850206 4.26 ENSRNOT00000021833
mitochondrial E3 ubiquitin protein ligase 1
chr10_+_78168715 4.07 ENSRNOT00000072294
COX11 cytochrome c oxidase copper chaperone
chr2_-_210873024 3.96 ENSRNOT00000026051
adenosine monophosphate deaminase 2
chr3_+_58164931 3.92 ENSRNOT00000002078
distal-less homeobox 1
chr7_-_11777503 3.83 ENSRNOT00000026220
anti-Mullerian hormone
chr20_-_5618254 3.82 ENSRNOT00000092326
ENSRNOT00000000576
BCL2-antagonist/killer 1
chr4_-_82209933 3.76 ENSRNOT00000091106
homeobox protein Hox-A10-like
chr18_+_74299931 3.72 ENSRNOT00000078403
ectopic P-granules autophagy protein 5 homolog
chrX_-_116792707 3.67 ENSRNOT00000049482
angiomotin
chr7_-_12424367 3.64 ENSRNOT00000060698
midnolin
chr10_-_67478848 3.55 ENSRNOT00000005325
transcription elongation factor, mitochondrial
chr3_-_123702732 3.52 ENSRNOT00000028859
similar to RIKEN cDNA 1700037H04
chr7_-_121029754 3.50 ENSRNOT00000004703
neuronal pentraxin receptor
chr4_-_82295470 3.36 ENSRNOT00000091073
homeobox A10
chr9_-_71830730 3.33 ENSRNOT00000019963
crystallin, gamma A
chr19_-_37907714 3.30 ENSRNOT00000026361
chymotrypsin-like
chr5_+_169244778 3.26 ENSRNOT00000064841
pleckstrin homology and RhoGEF domain containing G5
chr4_+_145238947 3.23 ENSRNOT00000067396
ENSRNOT00000091934
copine family member 9
chr17_-_10952441 3.21 ENSRNOT00000024580
histamine receptor H 2
chr5_+_150001281 3.20 ENSRNOT00000034057
mitochondrial trans-2-enoyl-CoA reductase
chr6_+_55085313 3.16 ENSRNOT00000005458

chr3_+_93909156 3.13 ENSRNOT00000090365
LIM domain only 2
chr5_-_159962218 3.09 ENSRNOT00000050729
chloride voltage-gated channel Kb
chr1_-_72674271 3.07 ENSRNOT00000023744
lysine methyltransferase 5C
chr17_+_42133076 3.05 ENSRNOT00000031384
aldehyde dehydrogenase 5 family, member A1
chr1_+_142136452 2.96 ENSRNOT00000016445
HD domain containing 3
chrX_+_106253355 2.87 ENSRNOT00000004252
armadillo repeat-containing X-linked protein 5-like
chr1_+_197813963 2.81 ENSRNOT00000045531
ribosomal protein L36-like
chrX_-_116792864 2.69 ENSRNOT00000090918
angiomotin
chr12_-_13462038 2.67 ENSRNOT00000043110
ribosomal protein L36-like
chr1_+_224882439 2.65 ENSRNOT00000024785
cholinergic receptor, muscarinic 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr5a2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
22.6 67.8 GO:1905243 slow-twitch skeletal muscle fiber contraction(GO:0031444) response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243)
12.1 48.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
11.1 66.6 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
11.1 66.4 GO:1903059 regulation of protein lipidation(GO:1903059)
9.3 27.9 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
8.5 25.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
7.6 45.7 GO:0006102 isocitrate metabolic process(GO:0006102)
5.6 16.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
5.4 16.1 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
5.0 15.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
4.8 67.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
4.7 14.1 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
4.7 41.9 GO:0033572 transferrin transport(GO:0033572)
4.5 13.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
4.4 43.6 GO:0014883 transition between fast and slow fiber(GO:0014883)
4.2 12.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
4.0 12.0 GO:0042323 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
3.8 11.5 GO:2000295 cadmium ion homeostasis(GO:0055073) regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214) regulation of hydrogen peroxide catabolic process(GO:2000295)
3.0 9.0 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
2.8 8.4 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
2.7 8.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
2.6 7.9 GO:0009106 lipoate metabolic process(GO:0009106)
2.5 12.7 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
2.5 10.0 GO:0030221 basophil differentiation(GO:0030221)
2.5 19.7 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.3 18.4 GO:0019388 galactose catabolic process(GO:0019388)
2.2 6.6 GO:0000105 histidine biosynthetic process(GO:0000105)
2.1 4.3 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
2.1 6.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
2.0 12.2 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
2.0 27.4 GO:0071420 cellular response to histamine(GO:0071420)
1.9 15.1 GO:0044351 macropinocytosis(GO:0044351)
1.9 5.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
1.8 5.5 GO:0042197 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.8 14.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
1.7 8.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
1.7 6.7 GO:0021586 pons maturation(GO:0021586)
1.6 13.1 GO:0072014 proximal tubule development(GO:0072014)
1.6 4.9 GO:0009249 protein lipoylation(GO:0009249)
1.6 4.8 GO:0009644 response to high light intensity(GO:0009644)
1.6 6.3 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
1.5 7.7 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
1.5 37.9 GO:0006089 lactate metabolic process(GO:0006089)
1.5 40.5 GO:0014850 response to muscle activity(GO:0014850)
1.5 40.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.5 7.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
1.4 5.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
1.4 12.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
1.3 3.9 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
1.3 3.8 GO:0001546 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
1.2 12.1 GO:0046684 response to pyrethroid(GO:0046684) regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
1.2 9.3 GO:1990785 response to water-immersion restraint stress(GO:1990785)
1.0 8.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.0 3.0 GO:0006083 acetate metabolic process(GO:0006083)
1.0 18.4 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.9 4.7 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.9 5.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.9 8.7 GO:0036444 mitochondrial protein processing(GO:0034982) calcium ion transmembrane import into mitochondrion(GO:0036444)
0.9 20.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.9 11.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.8 6.8 GO:0032571 response to vitamin K(GO:0032571)
0.8 2.5 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.8 34.9 GO:0045214 sarcomere organization(GO:0045214)
0.8 5.6 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.8 65.4 GO:0006342 chromatin silencing(GO:0006342)
0.7 9.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.7 6.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.7 76.3 GO:0006334 nucleosome assembly(GO:0006334)
0.7 23.7 GO:0015701 bicarbonate transport(GO:0015701)
0.7 31.4 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.7 4.0 GO:0032264 IMP salvage(GO:0032264)
0.6 2.6 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.6 9.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.6 8.4 GO:0006105 succinate metabolic process(GO:0006105)
0.6 12.6 GO:0097503 sialylation(GO:0097503)
0.6 6.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.5 4.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.5 1.6 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.5 2.6 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.5 3.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.5 6.6 GO:1901626 regulation of postsynaptic membrane organization(GO:1901626)
0.5 6.9 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.5 2.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 5.0 GO:0042448 progesterone metabolic process(GO:0042448)
0.4 7.3 GO:0046514 ceramide catabolic process(GO:0046514)
0.4 6.7 GO:0035584 calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.3 6.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 6.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 24.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 6.3 GO:0090201 negative regulation of release of cytochrome c from mitochondria(GO:0090201)
0.3 14.6 GO:0021762 substantia nigra development(GO:0021762)
0.3 8.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 3.1 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.2 2.5 GO:0035524 proline transmembrane transport(GO:0035524)
0.2 0.7 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.2 7.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 18.2 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 1.3 GO:0015074 DNA integration(GO:0015074)
0.2 8.9 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.2 13.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 31.1 GO:0006941 striated muscle contraction(GO:0006941)
0.2 10.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.2 1.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 3.1 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 0.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 10.1 GO:0046785 microtubule polymerization(GO:0046785)
0.2 13.0 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.2 1.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 3.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 4.6 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.1 3.3 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.1 0.7 GO:0015851 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851)
0.1 11.4 GO:0042472 inner ear morphogenesis(GO:0042472)
0.1 3.7 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.9 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 3.4 GO:0060065 uterus development(GO:0060065)
0.1 1.4 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 5.3 GO:0006672 ceramide metabolic process(GO:0006672)
0.1 4.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.3 GO:0030222 eosinophil differentiation(GO:0030222)
0.1 1.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.4 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 1.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 3.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 7.0 GO:0001764 neuron migration(GO:0001764)
0.0 1.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0060178 regulation of exocyst localization(GO:0060178)
0.0 1.9 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 0.5 GO:0050798 activated T cell proliferation(GO:0050798)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
16.0 64.0 GO:1990584 cardiac Troponin complex(GO:1990584)
8.3 24.9 GO:0090534 calcium ion-transporting ATPase complex(GO:0090534)
8.2 24.6 GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
7.8 23.5 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
7.0 41.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
6.2 31.1 GO:0005927 muscle tendon junction(GO:0005927)
5.6 67.8 GO:0005859 muscle myosin complex(GO:0005859)
5.4 43.6 GO:0005861 troponin complex(GO:0005861)
3.4 41.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
3.2 12.7 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
2.9 8.7 GO:0005745 m-AAA complex(GO:0005745)
2.6 34.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
2.3 11.5 GO:0097512 cardiac myofibril(GO:0097512)
2.2 6.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.2 8.9 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.1 16.8 GO:0097452 GAIT complex(GO:0097452)
1.9 37.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.8 29.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.6 80.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.6 154.5 GO:0000786 nucleosome(GO:0000786)
1.6 7.9 GO:0043159 acrosomal matrix(GO:0043159)
1.6 17.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
1.4 37.5 GO:0070469 respiratory chain(GO:0070469)
1.4 11.5 GO:0097450 astrocyte end-foot(GO:0097450)
1.4 39.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.1 24.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.9 7.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.9 6.5 GO:1990635 proximal dendrite(GO:1990635)
0.8 12.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.7 32.0 GO:0016235 aggresome(GO:0016235)
0.6 5.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.6 8.9 GO:0032279 asymmetric synapse(GO:0032279)
0.5 9.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 8.2 GO:0031045 dense core granule(GO:0031045)
0.5 6.6 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.5 38.0 GO:0005581 collagen trimer(GO:0005581)
0.5 69.4 GO:0030018 Z disc(GO:0030018)
0.5 6.7 GO:0032426 stereocilium tip(GO:0032426)
0.5 10.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 26.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 7.0 GO:0043194 axon initial segment(GO:0043194)
0.4 7.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 1.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 9.7 GO:0045120 pronucleus(GO:0045120)
0.4 35.7 GO:0016605 PML body(GO:0016605)
0.3 4.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 6.0 GO:0030056 hemidesmosome(GO:0030056)
0.3 7.3 GO:0042588 zymogen granule(GO:0042588)
0.2 22.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 9.9 GO:0048786 presynaptic active zone(GO:0048786)
0.2 6.4 GO:0008180 COP9 signalosome(GO:0008180)
0.2 23.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 8.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 5.2 GO:0060170 ciliary membrane(GO:0060170)
0.2 11.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 3.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 1.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 6.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 7.2 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 3.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 17.9 GO:0043209 myelin sheath(GO:0043209)
0.1 6.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 17.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 37.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 6.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 7.1 GO:0005769 early endosome(GO:0005769)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)
0.0 6.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.9 GO:0043679 axon terminus(GO:0043679)
0.0 1.6 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.0 64.0 GO:0030172 troponin C binding(GO:0030172)
13.7 41.0 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
10.0 40.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
9.8 29.5 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
7.5 15.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
6.1 24.6 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
5.1 25.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
5.1 25.6 GO:0070052 collagen V binding(GO:0070052)
4.9 19.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
4.8 67.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
4.7 41.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
4.4 13.1 GO:0035939 microsatellite binding(GO:0035939)
4.2 16.8 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
4.0 12.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
3.7 18.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
3.6 24.9 GO:0042030 ATPase inhibitor activity(GO:0042030)
3.0 9.1 GO:0052743 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) inositol tetrakisphosphate phosphatase activity(GO:0052743)
3.0 11.9 GO:0043532 angiostatin binding(GO:0043532)
2.4 7.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
2.4 12.0 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
2.2 34.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.9 34.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.8 49.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.8 14.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.7 24.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.7 8.4 GO:0004985 opioid receptor activity(GO:0004985)
1.6 6.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
1.4 25.8 GO:0031005 filamin binding(GO:0031005)
1.3 15.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.2 3.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
1.2 3.5 GO:0001847 opsonin receptor activity(GO:0001847)
1.1 30.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
1.1 5.3 GO:0001729 ceramide kinase activity(GO:0001729)
1.1 65.7 GO:0009055 electron carrier activity(GO:0009055)
1.0 11.5 GO:0046870 cadmium ion binding(GO:0046870)
1.0 3.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
1.0 4.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.0 7.9 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
1.0 6.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.9 5.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.8 6.6 GO:0043495 protein anchor(GO:0043495)
0.8 3.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.8 6.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.6 3.2 GO:0004969 histamine receptor activity(GO:0004969)
0.6 9.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.6 1.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.6 8.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.6 13.6 GO:0030275 LRR domain binding(GO:0030275)
0.5 12.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.5 2.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 11.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.5 7.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.4 10.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 43.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.4 7.0 GO:0048156 tau protein binding(GO:0048156)
0.3 9.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 6.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 5.5 GO:0001671 ATPase activator activity(GO:0001671)
0.2 2.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 6.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 3.8 GO:0051400 BH domain binding(GO:0051400)
0.2 7.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 13.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 4.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 6.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 89.9 GO:0003779 actin binding(GO:0003779)
0.2 136.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 29.1 GO:0008201 heparin binding(GO:0008201)
0.2 2.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 6.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 10.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 3.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 5.3 GO:0051087 chaperone binding(GO:0051087)
0.1 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 12.8 GO:0019902 phosphatase binding(GO:0019902)
0.1 8.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 6.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 1.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 5.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 9.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 8.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 7.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 4.6 GO:0016874 ligase activity(GO:0016874)
0.0 1.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.6 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 74.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.7 24.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.7 25.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.6 15.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 10.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 12.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 32.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 6.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 18.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.3 20.3 PID FGF PATHWAY FGF signaling pathway
0.3 3.8 PID ALK2 PATHWAY ALK2 signaling events
0.3 3.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 12.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 6.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 7.9 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.2 4.3 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 4.8 PID RAS PATHWAY Regulation of Ras family activation
0.2 4.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 3.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 22.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 7.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 10.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 11.0 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 77.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
2.8 107.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
2.6 54.0 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
2.1 125.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
2.0 52.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
1.4 41.9 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.4 24.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.2 18.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.2 25.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
1.1 37.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.9 14.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.9 18.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.8 12.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.7 12.0 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.7 14.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.6 9.0 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 9.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 6.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.4 16.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 11.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 13.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.4 6.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 4.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 6.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 6.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.3 9.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.3 6.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 9.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 13.9 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.2 22.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 9.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 2.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 5.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 5.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 3.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 15.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 11.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 7.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling