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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr4a2

Z-value: 0.67

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Transcription factors associated with Nr4a2

Gene Symbol Gene ID Gene Info
Nr4a2
ENSRNOG00000005600 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr4a2rn6_v1_chr3_-_43119159_431191590.282.9e-07Click!

Activity profile of Nr4a2 motif

Sorted Z-values of Nr4a2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_159775643 26.93 ENSRNOT00000010939
Jph2
junctophilin 2
chr9_+_2202511 25.53 ENSRNOT00000017556
Satb1
SATB homeobox 1
chr1_-_206282575 20.67 ENSRNOT00000024974
Adam12
ADAM metallopeptidase domain 12
chr16_+_49266903 19.51 ENSRNOT00000014704
Slc25a4
solute carrier family 25 member 4
chrX_+_53053609 18.78 ENSRNOT00000058357
Dmd
dystrophin
chr2_+_153830586 17.03 ENSRNOT00000042576
Mme
membrane metallo-endopeptidase
chr10_+_57278307 16.12 ENSRNOT00000005612
Eno3
enolase 3
chr9_+_64745051 15.32 ENSRNOT00000021527
Spats2l
spermatogenesis associated, serine-rich 2-like
chr16_-_22561496 14.56 ENSRNOT00000016543
Lpl
lipoprotein lipase
chr19_+_51317425 11.66 ENSRNOT00000019298
Cdh13
cadherin 13
chr2_-_203494391 10.69 ENSRNOT00000021162
Ptgfrn
prostaglandin F2 receptor inhibitor
chr15_+_11298478 10.25 ENSRNOT00000007672
Lrrc3b
leucine rich repeat containing 3B
chr12_-_5822874 10.08 ENSRNOT00000075920
Fry
FRY microtubule binding protein
chr3_+_62648447 9.88 ENSRNOT00000002111
Agps
alkylglycerone phosphate synthase
chr7_-_81592206 9.00 ENSRNOT00000007979
Angpt1
angiopoietin 1
chr7_+_74047814 8.98 ENSRNOT00000014879
Osr2
odd-skipped related transciption factor 2
chr2_-_196304169 8.48 ENSRNOT00000028639
Scnm1
sodium channel modifier 1
chr6_+_8669722 7.99 ENSRNOT00000048550
Camkmt
calmodulin-lysine N-methyltransferase
chr3_+_155297566 7.90 ENSRNOT00000021435
ENSRNOT00000084866
Dhx35
DEAH-box helicase 35
chr1_-_16203838 7.82 ENSRNOT00000018556
ENSRNOT00000078586
Pde7b
phosphodiesterase 7B
chr3_+_121596791 7.80 ENSRNOT00000024694
Ttl
tubulin tyrosine ligase
chr3_+_131351587 7.52 ENSRNOT00000010835
Btbd3
BTB domain containing 3
chr9_-_69953182 7.51 ENSRNOT00000015852
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr7_-_117288018 7.24 ENSRNOT00000091285
Plec
plectin
chr20_+_3827367 7.20 ENSRNOT00000079967
Rxrb
retinoid X receptor beta
chr1_+_219000844 7.16 ENSRNOT00000022486
Kmt5b
lysine methyltransferase 5B
chr18_+_79813759 7.13 ENSRNOT00000021768
Zfp516
zinc finger protein 516
chr20_+_3827086 6.62 ENSRNOT00000081588
Rxrb
retinoid X receptor beta
chr11_-_69201380 6.51 ENSRNOT00000085618
Mylk
myosin light chain kinase
chr2_-_250862419 6.43 ENSRNOT00000017943
Clca4
chloride channel accessory 4
chr7_+_53630621 6.33 ENSRNOT00000067011
ENSRNOT00000080598
Csrp2
cysteine and glycine-rich protein 2
chr17_-_80807181 6.19 ENSRNOT00000040052
ENSRNOT00000090064
Cubn
cubilin
chr9_+_88918433 5.90 ENSRNOT00000021730
Ccl20
C-C motif chemokine ligand 20
chr19_+_49637016 5.84 ENSRNOT00000016880
Bco1
beta-carotene oxygenase 1
chrX_-_68562301 5.55 ENSRNOT00000076720
Ophn1
oligophrenin 1
chr12_+_41486076 5.49 ENSRNOT00000057242
Rita1
RBPJ interacting and tubulin associated 1
chr1_-_71173216 5.43 ENSRNOT00000020523
Zfp28
zinc finger protein 28
chr5_-_101138427 4.88 ENSRNOT00000058615
Frem1
Fras1 related extracellular matrix 1
chr18_+_59096643 4.49 ENSRNOT00000025325
Wdr7
WD repeat domain 7
chr3_+_66673071 4.42 ENSRNOT00000034769
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr1_-_80864846 4.27 ENSRNOT00000074412
Igsf23
immunoglobulin superfamily, member 23
chr9_+_94702129 4.25 ENSRNOT00000080930
Neu2
neuraminidase 2
chr2_+_196304492 4.23 ENSRNOT00000028640
Lysmd1
LysM domain containing 1
chr14_+_83889089 4.06 ENSRNOT00000078980
Morc2
MORC family CW-type zinc finger 2
chr7_+_35070284 3.74 ENSRNOT00000009578
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr4_-_131694755 3.51 ENSRNOT00000013271
Foxp1
forkhead box P1
chrX_+_77263359 3.47 ENSRNOT00000077604
Pgk1
phosphoglycerate kinase 1
chr3_+_113257688 3.46 ENSRNOT00000019320
Map1a
microtubule-associated protein 1A
chr1_+_255185629 3.39 ENSRNOT00000083002
Hectd2
HECT domain E3 ubiquitin protein ligase 2
chrX_+_156863754 3.38 ENSRNOT00000083611
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chrX_-_15768522 3.28 ENSRNOT00000077391
Foxp3
forkhead box P3
chr18_+_61261418 3.09 ENSRNOT00000064250
Zfp532
zinc finger protein 532
chr3_-_72602548 2.84 ENSRNOT00000031745
Lrrc55
leucine rich repeat containing 55
chr2_-_184289126 2.74 ENSRNOT00000081678
Fbxw7
F-box and WD repeat domain containing 7
chr12_-_24537313 2.63 ENSRNOT00000001975
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr7_+_117001084 2.61 ENSRNOT00000066233
Zfp707l1
zinc finger protein 707-like 1
chr7_+_144080614 2.61 ENSRNOT00000077687
Pcbp2
poly(rC) binding protein 2
chr10_-_36372436 2.16 ENSRNOT00000039827
Znf454
zinc finger protein 454
chr3_-_72113680 2.08 ENSRNOT00000009708
Zdhhc5
zinc finger, DHHC-type containing 5
chr16_+_20110148 1.94 ENSRNOT00000080146
ENSRNOT00000025312
Jak3
Janus kinase 3
chr3_+_80676820 1.93 ENSRNOT00000084809
Ambra1
autophagy and beclin 1 regulator 1
chr11_-_61530830 1.93 ENSRNOT00000059666
ENSRNOT00000068345
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_-_168004724 1.92 ENSRNOT00000024711
Park7
Parkinsonism associated deglycase
chr4_-_157331905 1.74 ENSRNOT00000020647
Tpi1
triosephosphate isomerase 1
chr10_-_49009156 1.68 ENSRNOT00000072970
Mapk7
mitogen-activated protein kinase 7
chr8_+_114867062 1.58 ENSRNOT00000074771
Wdr82
WD repeat domain 82
chr2_+_51672722 1.56 ENSRNOT00000016485
Fgf10
fibroblast growth factor 10
chr3_-_2123820 1.47 ENSRNOT00000086843
Ehmt1
euchromatic histone lysine methyltransferase 1
chr9_+_20213776 1.36 ENSRNOT00000071439
LOC100911515
triosephosphate isomerase-like
chr10_+_34975708 1.04 ENSRNOT00000064984
Nhp2
NHP2 ribonucleoprotein
chr7_+_35069814 0.90 ENSRNOT00000089228
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr7_-_40316532 0.89 ENSRNOT00000083347
RGD1307947
similar to RIKEN cDNA C430008C19
chr15_-_14510828 0.88 ENSRNOT00000039347
Sntn
sentan, cilia apical structure protein
chr10_+_36590325 0.74 ENSRNOT00000085203
Zfp354a
zinc finger protein 354A
chr3_-_118635268 0.67 ENSRNOT00000086357
Atp8b4
ATPase phospholipid transporting 8B4 (putative)
chr10_+_37069344 0.60 ENSRNOT00000073317
ENSRNOT00000090404
LOC103690013
H/ACA ribonucleoprotein complex subunit 2
chr13_+_100817359 0.58 ENSRNOT00000004330
Tp53bp2
tumor protein p53 binding protein, 2
chr4_-_56438465 0.37 ENSRNOT00000064007
Rbm28
RNA binding motif protein 28
chr3_-_60813869 0.36 ENSRNOT00000058234
Atp5g3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr8_+_117455262 0.35 ENSRNOT00000027520
Slc25a20
solute carrier family 25 member 20
chr6_+_26537707 0.29 ENSRNOT00000050102
Zfp513
zinc finger protein 513
chrX_+_22302703 0.26 ENSRNOT00000078617
ENSRNOT00000086952
Kdm5c
lysine demethylase 5C
chr1_-_81144024 0.19 ENSRNOT00000088431
Zfp94
zinc finger protein 94
chr8_+_71591360 0.17 ENSRNOT00000090096
Csnk1g1
casein kinase 1, gamma 1
chr6_+_50725085 0.14 ENSRNOT00000009473
Slc26a3
solute carrier family 26 member 3
chr4_+_145653602 0.10 ENSRNOT00000038964
Tatdn2
TatD DNase domain containing 2
chrX_-_23144324 0.08 ENSRNOT00000000178
ENSRNOT00000081239
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr5_+_119097715 0.03 ENSRNOT00000045987
Ror1
receptor tyrosine kinase-like orphan receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.8 GO:0016203 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
5.4 21.4 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
4.3 17.0 GO:0071492 cellular response to UV-A(GO:0071492)
3.8 26.9 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
3.3 26.2 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
3.0 9.0 GO:0048014 Tie signaling pathway(GO:0048014)
3.0 9.0 GO:0036023 embryonic skeletal limb joint morphogenesis(GO:0036023)
2.5 10.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
2.0 5.9 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
1.8 25.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.6 6.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.4 9.9 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.2 6.2 GO:0015889 cobalamin transport(GO:0015889)
1.2 3.5 GO:0061470 T follicular helper cell differentiation(GO:0061470)
1.1 3.4 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
1.1 3.3 GO:0045077 peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) negative regulation of interferon-gamma biosynthetic process(GO:0045077)
1.1 4.3 GO:0051692 cellular oligosaccharide catabolic process(GO:0051692)
1.0 7.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.9 2.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.8 4.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.8 10.7 GO:0034389 lipid particle organization(GO:0034389)
0.6 1.9 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.5 1.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648) submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.4 13.8 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.4 7.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 2.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.4 16.1 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.3 1.7 GO:0019563 glycerol catabolic process(GO:0019563)
0.3 5.8 GO:0042574 retinal metabolic process(GO:0042574)
0.3 2.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.3 1.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.2 1.9 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 4.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 1.7 GO:0071499 cellular response to laminar fluid shear stress(GO:0071499)
0.2 5.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 7.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 4.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 7.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 7.8 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 5.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 3.5 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.6 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 1.9 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.4 GO:0015879 carnitine transport(GO:0015879)
0.1 3.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.1 8.0 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.1 1.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 2.1 GO:0018345 protein palmitoylation(GO:0018345)
0.1 7.5 GO:0030516 regulation of axon extension(GO:0030516)
0.1 6.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 7.5 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.6 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 5.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 8.5 GO:0008380 RNA splicing(GO:0008380)
0.0 1.4 GO:0045445 myoblast differentiation(GO:0045445)
0.0 7.9 GO:0006396 RNA processing(GO:0006396)
0.0 0.1 GO:0033133 NADH regeneration(GO:0006735) positive regulation of glucokinase activity(GO:0033133) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) positive regulation of hexokinase activity(GO:1903301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 26.9 GO:0030314 junctional membrane complex(GO:0030314)
2.7 16.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.1 14.6 GO:0042627 chylomicron(GO:0042627)
1.0 18.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.8 5.3 GO:0031415 NatA complex(GO:0031415)
0.5 2.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.4 6.2 GO:0043202 lysosomal lumen(GO:0043202)
0.4 25.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 7.2 GO:0030056 hemidesmosome(GO:0030056)
0.3 7.2 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.2 1.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 2.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 9.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.6 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.6 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 6.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 7.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 11.7 GO:0005901 caveola(GO:0005901)
0.1 17.2 GO:0005903 brush border(GO:0005903)
0.1 31.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 7.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 6.3 GO:0016605 PML body(GO:0016605)
0.0 10.0 GO:0030427 site of polarized growth(GO:0030427)
0.0 5.6 GO:0043195 terminal bouton(GO:0043195)
0.0 3.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 4.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 26.2 GO:0005730 nucleolus(GO:0005730)
0.0 1.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.5 GO:0005813 centrosome(GO:0005813)
0.0 3.8 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.7 GO:0055100 adiponectin binding(GO:0055100)
2.7 16.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.4 7.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
2.3 13.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
2.2 19.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
1.7 24.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
1.6 6.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.5 5.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.2 3.5 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
1.1 3.4 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
1.1 4.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.0 3.1 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
0.9 18.8 GO:0017166 vinculin binding(GO:0017166)
0.9 6.2 GO:0030492 hemoglobin binding(GO:0030492)
0.6 1.9 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.6 4.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.5 2.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.5 2.6 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.4 7.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 3.3 GO:0051525 NFAT protein binding(GO:0051525)
0.4 7.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 6.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 1.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.3 37.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 7.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 5.8 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 7.2 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 1.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 9.6 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 4.4 GO:0071949 FAD binding(GO:0071949)
0.1 30.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 9.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.4 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 3.5 GO:0050681 androgen receptor binding(GO:0050681)
0.1 2.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 7.9 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 5.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 2.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 3.5 GO:0005518 collagen binding(GO:0005518)
0.0 3.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 10.1 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 0.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 6.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 8.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 4.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 5.2 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 13.7 GO:0005102 receptor binding(GO:0005102)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 20.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 25.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.4 13.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 1.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 9.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 6.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.7 PID MYC PATHWAY C-MYC pathway
0.1 3.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 4.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 5.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 7.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 19.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.5 21.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 32.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.5 18.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.4 9.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 11.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.4 9.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 6.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 6.5 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 20.7 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.2 1.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 13.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 14.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 1.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 5.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.6 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 7.6 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 2.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 4.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 7.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases