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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nr3c2
Z-value: 0.75
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Transcription factors associated with Nr3c2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr3c2 | rn6_v1_chr19_-_34752695_34752695 | 0.39 | 6.9e-13 | Click! |
Top targets:  
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_147303346 Show fit | 35.06 |
ENSRNOT00000009153
|
hippocalcin |
|
| chr2_-_198016898 Show fit | 29.53 |
ENSRNOT00000025523
|
carbonic anhydrase 14 |
|
| chr1_+_27476375 Show fit | 29.43 |
ENSRNOT00000047224
ENSRNOT00000075427 |
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like |
|
| chr9_+_73319710 Show fit | 24.60 |
ENSRNOT00000092485
|
microtubule-associated protein 2 |
|
| chr7_-_138483612 Show fit | 23.62 |
ENSRNOT00000085620
|
solute carrier family 38, member 4 |
|
| chr20_-_53777159 Show fit | 23.14 |
ENSRNOT00000073994
|
|
|
| chr6_-_26624092 Show fit | 23.12 |
ENSRNOT00000008113
|
tripartite motif-containing 54 |
|
| chr14_-_43143973 Show fit | 19.31 |
ENSRNOT00000003248
|
ubiquitin C-terminal hydrolase L1 |
|
| chr8_-_55144087 Show fit | 18.76 |
ENSRNOT00000039045
|
DIX domain containing 1 |
|
| chr1_+_191344979 Show fit | 17.39 |
ENSRNOT00000023773
|
heparan sulfate-glucosamine 3-sulfotransferase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr3c2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 47.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 11.7 | 35.1 | GO:0030824 | negative regulation of cGMP metabolic process(GO:0030824) |
| 0.2 | 27.4 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.3 | 23.6 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 2.1 | 19.3 | GO:0019896 | axonal transport of mitochondrion(GO:0019896) |
| 2.7 | 18.8 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 2.3 | 13.6 | GO:0021759 | globus pallidus development(GO:0021759) |
| 2.2 | 13.4 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.0 | 10.5 | GO:0017157 | regulation of exocytosis(GO:0017157) |
| 1.0 | 8.9 | GO:1902414 | protein localization to cell junction(GO:1902414) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 35.1 | GO:0044327 | dendritic spine head(GO:0044327) |
| 2.7 | 24.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 23.1 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.4 | 19.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 17.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 16.6 | GO:0043679 | axon terminus(GO:0043679) |
| 3.8 | 11.4 | GO:0046691 | intracellular canaliculus(GO:0046691) |
| 0.1 | 10.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 8.9 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.1 | 6.2 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0003779 | actin binding(GO:0003779) |
| 2.3 | 29.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 1.1 | 24.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 23.6 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 23.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 4.8 | 19.3 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.6 | 18.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 2.9 | 17.4 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 1.0 | 13.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 3.3 | 13.4 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 19.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 18.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 10.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 4.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 29.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.6 | 17.4 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 13.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 4.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.2 | 3.4 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |