ISMARA results: Nr2e3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr2e3

Z-value: 1.05

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Transcription factors associated with Nr2e3

Gene Symbol	Gene ID	Gene Info
Nr2e3 NCBI RGD Ensembl	ENSRNOG00000050690	nuclear receptor subfamily 2, group E, member 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr2e3	rn6_v1_chr8_-_64800467_64800467	0.15	8.6e-03	Click!

Activity profile of Nr2e3 motif

Sorted Z-values of Nr2e3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_118108864 Show fit	51.99	ENSRNOT00000006184	Mb NCBI RGD Ensembl Show fit	myoglobin
chr18_-_28017925 Show fit	51.89	ENSRNOT00000075420	Lrrtm2 NCBI RGD Ensembl Show fit	leucine rich repeat transmembrane neuronal 2
chrX_-_142164220 Show fit	44.64	ENSRNOT00000064780	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr15_-_14737704 Show fit	44.56	ENSRNOT00000011307	Synpr NCBI RGD Ensembl Show fit	synaptoporin
chr4_+_175729726 Show fit	41.73	ENSRNOT00000013230	Slco1c1 NCBI RGD Ensembl Show fit	solute carrier organic anion transporter family, member 1c1
chr8_-_80631873 Show fit	40.80	ENSRNOT00000091661 ENSRNOT00000080662	Unc13c NCBI RGD Ensembl Show fit	unc-13 homolog C
chr4_-_727691 Show fit	31.24	ENSRNOT00000008497	Shh NCBI RGD Ensembl Show fit	sonic hedgehog
chr17_-_61332391 Show fit	31.09	ENSRNOT00000034599	LOC100362965 NCBI RGD Ensembl Show fit	SNRPN upstream reading frame protein-like
chr9_-_85243001 Show fit	30.61	ENSRNOT00000020219	Scg2 NCBI RGD Ensembl Show fit	secretogranin II
chr10_-_27366665 Show fit	29.27	ENSRNOT00000004725	Gabra1 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha1 subunit

Showing 1 to 10 of 100 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.3	52.0	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
6.5	51.9	GO:0002091	negative regulation of receptor internalization(GO:0002091)
6.4	44.6	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
3.8	41.7	GO:0070327	thyroid hormone transport(GO:0070327)
3.7	40.8	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
10.4	31.2	GO:0060769	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1	31.1	GO:0007519	skeletal muscle tissue development(GO:0007519)
2.2	30.6	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.1	30.4	GO:0001558	regulation of cell growth(GO:0001558)
2.1	29.3	GO:0071420	cellular response to histamine(GO:0071420)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	64.2	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	63.7	GO:0097458	neuron part(GO:0097458)
0.2	60.0	GO:0030133	transport vesicle(GO:0030133)
1.9	44.6	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6	44.6	GO:0016328	lateral plasma membrane(GO:0016328)
5.1	40.8	GO:0044305	calyx of Held(GO:0044305)
0.5	34.7	GO:0031594	neuromuscular junction(GO:0031594)
2.2	30.6	GO:0031045	dense core granule(GO:0031045)
1.4	29.3	GO:1902711	GABA-A receptor complex(GO:1902711)
0.2	28.2	GO:0005923	bicellular tight junction(GO:0005923)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	51.9	GO:0042043	neurexin family protein binding(GO:0042043)
3.3	50.0	GO:0005344	oxygen transporter activity(GO:0005344)
1.1	48.0	GO:0048487	beta-tubulin binding(GO:0048487)
5.2	41.7	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
5.2	41.4	GO:0043237	laminin-1 binding(GO:0043237)
0.0	41.0	GO:0005215	transporter activity(GO:0005215)
4.5	40.8	GO:0019992	diacylglycerol binding(GO:0019992)
1.1	30.6	GO:0042056	chemoattractant activity(GO:0042056)
5.9	29.3	GO:1904315	benzodiazepine receptor activity(GO:0008503) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1	28.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	31.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.5	26.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
1.1	24.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	21.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	15.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	10.4	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	10.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	9.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.3	9.0	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.2	8.8	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	55.0	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
4.2	41.7	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.3	31.2	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
1.7	29.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.3	19.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	12.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.7	11.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.6	11.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	10.2	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.9	10.1	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport

Showing 1 to 10 of 18 entries

Results for Nr2e3

Z-value: 1.05

Motif logo

Transcription factors associated with Nr2e3

Activity-expression correlation:

Activity profile of Nr2e3 motif

Sorted Z-values of Nr2e3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: