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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nr1i3
Z-value: 1.58
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Transcription factors associated with Nr1i3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1i3 | rn6_v1_chr13_+_89586283_89586336 | 0.30 | 7.2e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_78985990 Show fit | 97.32 |
ENSRNOT00000009248
|
alpha-1-microglobulin/bikunin precursor |
|
| chr8_+_116857684 Show fit | 74.29 |
ENSRNOT00000026711
|
macrophage stimulating 1 |
|
| chr19_+_52077109 Show fit | 73.64 |
ENSRNOT00000020225
|
oxidative stress induced growth inhibitor 1 |
|
| chr12_-_11733099 Show fit | 64.78 |
ENSRNOT00000051244
ENSRNOT00000087257 |
cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 |
|
| chr2_-_182038178 Show fit | 63.71 |
ENSRNOT00000040708
|
fibrinogen beta chain |
|
| chr8_+_50525091 Show fit | 62.54 |
ENSRNOT00000074357
|
apolipoprotein A1 |
|
| chr12_-_22194287 Show fit | 62.44 |
ENSRNOT00000082895
ENSRNOT00000001905 |
transferrin receptor 2 |
|
| chr17_+_22620721 Show fit | 58.62 |
ENSRNOT00000019478
|
androgen-dependent TFPI-regulating protein |
|
| chr20_-_12820466 Show fit | 58.58 |
ENSRNOT00000001699
|
formimidoyltransferase cyclodeaminase |
|
| chr14_+_22724399 Show fit | 57.85 |
ENSRNOT00000002724
|
UDP glucuronosyltransferase 2 family, polypeptide B10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1i3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 239.6 | GO:0055114 | oxidation-reduction process(GO:0055114) |
| 5.8 | 186.2 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 160.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 50.1 | 150.2 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 10.2 | 132.1 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 27.1 | 108.6 | GO:0048252 | lauric acid metabolic process(GO:0048252) |
| 7.6 | 106.4 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 10.2 | 102.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 32.1 | 96.2 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) |
| 10.3 | 93.1 | GO:0046618 | drug export(GO:0046618) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 840.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 4.4 | 506.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 23.6 | 306.2 | GO:0042627 | chylomicron(GO:0042627) |
| 1.7 | 262.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.7 | 236.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.9 | 233.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 197.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 15.1 | 121.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 15.3 | 107.4 | GO:0005579 | membrane attack complex(GO:0005579) |
| 4.5 | 85.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 372.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.0 | 342.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 11.4 | 319.1 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 6.3 | 194.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 4.3 | 168.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 50.1 | 150.2 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 7.2 | 136.1 | GO:0001848 | complement binding(GO:0001848) |
| 6.3 | 125.5 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 1.0 | 102.0 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.6 | 98.7 | GO:0008083 | growth factor activity(GO:0008083) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 593.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 4.4 | 137.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.3 | 122.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.3 | 48.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.9 | 39.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 20.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 1.8 | 20.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.6 | 20.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.5 | 16.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.4 | 16.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 367.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 17.5 | 296.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 12.5 | 200.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 8.1 | 169.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 8.2 | 156.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 8.5 | 127.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 4.4 | 127.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 8.5 | 110.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 3.7 | 98.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.7 | 83.3 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |