ISMARA results: Nr1i2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr1i2

Z-value: 1.54

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Transcription factors associated with Nr1i2

Gene Symbol	Gene ID	Gene Info
Nr1i2 NCBI RGD Ensembl	ENSRNOG00000002906	nuclear receptor subfamily 1, group I, member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1i2	rn6_v1_chr11_+_65022100_65022100	0.19	5.4e-04	Click!

Activity profile of Nr1i2 motif

Sorted Z-values of Nr1i2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_22744407 Show fit	61.64	ENSRNOT00000073710	Cmya5 NCBI RGD Ensembl Show fit	cardiomyopathy associated 5
chr15_+_33606124 Show fit	59.34	ENSRNOT00000065210	AC115371.1 NCBI RGD Ensembl Show fit
chr10_+_11240138 Show fit	41.88	ENSRNOT00000048687	Srl NCBI RGD Ensembl Show fit	sarcalumenin
chr8_+_26652121 Show fit	41.76	ENSRNOT00000009342	Eepd1 NCBI RGD Ensembl Show fit	endonuclease/exonuclease/phosphatase family domain containing 1
chr17_-_18590536 Show fit	41.18	ENSRNOT00000078992	Cap2 NCBI RGD Ensembl Show fit	CAP, adenylate cyclase-associated protein, 2 (yeast)
chr19_-_56677084 Show fit	40.49	ENSRNOT00000024084	Acta1 NCBI RGD Ensembl Show fit	actin, alpha 1, skeletal muscle
chr8_-_84506328 Show fit	39.95	ENSRNOT00000064754	Mlip NCBI RGD Ensembl Show fit	muscular LMNA-interacting protein
chr1_+_72882806 Show fit	39.78	ENSRNOT00000024640	Tnni3 NCBI RGD Ensembl Show fit	troponin I3, cardiac type
chr2_-_200003443 Show fit	39.43	ENSRNOT00000024900 ENSRNOT00000088041	Pde4dip NCBI RGD Ensembl Show fit	phosphodiesterase 4D interacting protein
chr14_+_26662965 Show fit	37.81	ENSRNOT00000002621	Tecrl NCBI RGD Ensembl Show fit	trans-2,3-enoyl-CoA reductase-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1i2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	114.6	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
10.3	61.6	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
17.8	53.5	GO:0070237	positive regulation of activation-induced cell death of T cells(GO:0070237) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
2.7	48.4	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
5.8	46.8	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
10.5	41.9	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
10.1	40.5	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
6.7	40.5	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
1.7	39.9	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.7	39.8	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)

Showing 1 to 10 of 250 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	109.5	GO:0005604	basement membrane(GO:0005604)
2.3	97.8	GO:0043034	costamere(GO:0043034)
0.5	80.4	GO:0030016	myofibril(GO:0030016)
1.1	75.7	GO:0030315	T-tubule(GO:0030315)
0.2	66.1	GO:0031966	mitochondrial membrane(GO:0031966)
11.8	59.1	GO:0005927	muscle tendon junction(GO:0005927)
0.5	51.7	GO:0072562	blood microparticle(GO:0072562)
0.7	42.4	GO:0070469	respiratory chain(GO:0070469)
0.7	42.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.8	41.7	GO:0016528	sarcoplasm(GO:0016528)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.6	72.8	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	68.0	GO:0004984	olfactory receptor activity(GO:0004984)
2.6	51.2	GO:0017166	vinculin binding(GO:0017166)
2.1	49.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.4	48.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	44.6	GO:0005549	odorant binding(GO:0005549)
2.2	41.2	GO:0008179	adenylate cyclase binding(GO:0008179)
6.7	40.5	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5	39.9	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
9.9	39.8	GO:0030172	troponin C binding(GO:0030172)

Showing 1 to 10 of 196 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	65.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.0	53.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.7	41.3	PID RHOA PATHWAY	RhoA signaling pathway
0.2	38.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	32.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.7	27.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.6	27.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.6	25.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
1.4	23.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
1.6	17.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	91.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.9	81.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.6	61.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	57.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
1.2	46.1	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.7	36.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
2.0	34.1	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.8	29.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
2.0	27.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.1	25.4	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination

Showing 1 to 10 of 72 entries

Results for Nr1i2

Z-value: 1.54

Motif logo

Transcription factors associated with Nr1i2

Activity-expression correlation:

Activity profile of Nr1i2 motif

Sorted Z-values of Nr1i2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1i2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: