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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr1i2

Z-value: 1.54

Motif logo

Transcription factors associated with Nr1i2

Gene Symbol Gene ID Gene Info
ENSRNOG00000002906 nuclear receptor subfamily 1, group I, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1i2rn6_v1_chr11_+_65022100_650221000.195.4e-04Click!

Activity profile of Nr1i2 motif

Sorted Z-values of Nr1i2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_22744407 61.64 ENSRNOT00000073710
cardiomyopathy associated 5
chr15_+_33606124 59.34 ENSRNOT00000065210

chr10_+_11240138 41.88 ENSRNOT00000048687
sarcalumenin
chr8_+_26652121 41.76 ENSRNOT00000009342
endonuclease/exonuclease/phosphatase family domain containing 1
chr17_-_18590536 41.18 ENSRNOT00000078992
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr19_-_56677084 40.49 ENSRNOT00000024084
actin, alpha 1, skeletal muscle
chr8_-_84506328 39.95 ENSRNOT00000064754
muscular LMNA-interacting protein
chr1_+_72882806 39.78 ENSRNOT00000024640
troponin I3, cardiac type
chr2_-_200003443 39.43 ENSRNOT00000024900
ENSRNOT00000088041
phosphodiesterase 4D interacting protein
chr14_+_26662965 37.81 ENSRNOT00000002621
trans-2,3-enoyl-CoA reductase-like
chrX_+_159158194 33.22 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr1_-_277181345 32.57 ENSRNOT00000038017
ENSRNOT00000038038
nebulin-related anchoring protein
chr19_+_37235001 31.83 ENSRNOT00000020908
nucleolar protein 3
chr5_-_78985990 31.63 ENSRNOT00000009248
alpha-1-microglobulin/bikunin precursor
chr4_+_51553454 28.97 ENSRNOT00000073466
leiomodin-2-like
chr4_+_99063181 28.84 ENSRNOT00000008840
fatty acid binding protein 1
chr5_+_173640780 28.52 ENSRNOT00000027476
PPARGC1 and ESRR induced regulator, muscle 1
chr7_+_38742051 27.73 ENSRNOT00000006070
decorin
chr13_-_105141030 27.58 ENSRNOT00000003313
transforming growth factor, beta 2
chr4_+_30313102 27.54 ENSRNOT00000012657
ankyrin repeat and SOCS box-containing 4
chr1_+_47605262 26.64 ENSRNOT00000089458
fibronectin type III domain containing 1
chr8_-_130429132 26.57 ENSRNOT00000026261
hedgehog acyltransferase-like
chrX_-_40086870 26.51 ENSRNOT00000010027
small muscle protein, X-linked
chr1_-_89488223 26.34 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr13_-_105140473 25.95 ENSRNOT00000087023
transforming growth factor, beta 2
chrX_-_23139694 25.46 ENSRNOT00000033656
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr3_+_80072489 25.43 ENSRNOT00000057176
protein kinase C and casein kinase substrate in neurons 3
chr12_+_45905371 24.64 ENSRNOT00000039275
heat shock protein family B (small) member 8
chr13_-_52136127 23.51 ENSRNOT00000009398
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr4_+_64088900 23.28 ENSRNOT00000075341
cholinergic receptor, muscarinic 2
chr1_+_18491384 23.24 ENSRNOT00000079138
ENSRNOT00000014917
laminin subunit alpha 2
chr12_+_42097626 22.50 ENSRNOT00000001893
T-box 5
chr8_-_78233430 22.43 ENSRNOT00000083220
cingulin-like 1
chr4_-_150829741 21.92 ENSRNOT00000051846
ENSRNOT00000052017
calcium voltage-gated channel subunit alpha1 C
chr1_+_47605415 21.74 ENSRNOT00000034842
fibronectin type III domain containing 1
chr14_-_16979760 21.46 ENSRNOT00000003020
starch binding domain 1
chr8_+_50525091 21.33 ENSRNOT00000074357
apolipoprotein A1
chr3_-_37803112 21.24 ENSRNOT00000059461
nebulin
chr16_-_8885797 21.03 ENSRNOT00000073370
similar to chromosome 10 open reading frame 71
chr5_+_74766636 20.28 ENSRNOT00000030913

chr2_+_27107318 20.14 ENSRNOT00000019553
Rho guanine nucleotide exchange factor 26
chr2_-_182038178 19.98 ENSRNOT00000040708
fibrinogen beta chain
chr12_+_19196611 19.77 ENSRNOT00000001801
alpha-2-glycoprotein 1, zinc-binding
chr2_-_257474733 19.74 ENSRNOT00000016967
ENSRNOT00000066780
nexilin (F actin binding protein)
chr3_+_58632476 19.73 ENSRNOT00000010630
Rap guanine nucleotide exchange factor 4
chr15_+_43298794 19.65 ENSRNOT00000012736
adrenoceptor alpha 1A
chr10_-_34439470 19.56 ENSRNOT00000072081
butyrophilin-like 9
chr6_-_109935533 19.29 ENSRNOT00000013516
transforming growth factor, beta 3
chr5_-_57372239 19.22 ENSRNOT00000012975
aquaporin 7
chr19_-_37440471 19.07 ENSRNOT00000066636
zinc finger, DHHC-type containing 1
chr2_+_61039053 19.05 ENSRNOT00000025693
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_+_87009730 18.82 ENSRNOT00000027537
enoyl-CoA hydratase 1
chr9_+_81968332 18.68 ENSRNOT00000023152
cytochrome P450, family 27, subfamily a, polypeptide 1
chr4_-_150829913 18.57 ENSRNOT00000041571
calcium voltage-gated channel subunit alpha1 C
chr1_-_222178725 18.40 ENSRNOT00000028697
estrogen related receptor, alpha
chr12_-_11733099 18.29 ENSRNOT00000051244
ENSRNOT00000087257
cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1
chr2_-_62634785 17.76 ENSRNOT00000017937
PDZ domain containing 2
chr13_+_52889737 17.58 ENSRNOT00000074366
calcium voltage-gated channel subunit alpha1 S
chr10_+_53778662 17.52 ENSRNOT00000045718
myosin heavy chain 2
chr3_-_120306551 17.39 ENSRNOT00000021082
mal, T-cell differentiation protein-like
chr7_+_35125424 16.79 ENSRNOT00000085978
ENSRNOT00000010117
NADH:ubiquinone oxidoreductase subunit A12
chr19_-_37427989 16.61 ENSRNOT00000022863
tubulin polymerization-promoting protein family member 3
chr18_+_70733872 16.51 ENSRNOT00000067018
acetyl-CoA acyltransferase 2
chr8_+_49441106 16.43 ENSRNOT00000030152
sodium voltage-gated channel beta subunit 4
chr4_-_82203154 16.41 ENSRNOT00000086210
homeobox protein Hox-A10-like
chr1_-_170397191 16.41 ENSRNOT00000090181
amyloid beta precursor protein binding family B member 1
chr1_+_7252349 16.36 ENSRNOT00000030329
PLAG1 like zinc finger 1
chr19_-_983556 16.33 ENSRNOT00000064781
brain expressed, associated with NEDD4, 1
chr5_-_17061837 16.29 ENSRNOT00000011892
proenkephalin
chr19_+_52077109 16.09 ENSRNOT00000020225
oxidative stress induced growth inhibitor 1
chr8_+_71168097 16.01 ENSRNOT00000081375
RNA binding protein with multiple splicing 2
chr8_-_85645718 15.70 ENSRNOT00000032185
glutathione S-transferase alpha 2
chr1_+_248723397 15.43 ENSRNOT00000072188
mannose-binding protein C-like
chr18_-_48384645 15.15 ENSRNOT00000023485
peptidylprolyl isomerase C
chr8_+_32018560 15.07 ENSRNOT00000007358
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr3_+_63379031 14.86 ENSRNOT00000068199
oxysterol binding protein-like 6
chr19_-_37448067 14.83 ENSRNOT00000092844
zinc finger, DHHC-type containing 1
chr5_+_119097715 14.79 ENSRNOT00000045987
receptor tyrosine kinase-like orphan receptor 1
chr4_-_123494742 14.66 ENSRNOT00000073268
solute carrier family 41, member 3
chr6_+_23337571 14.51 ENSRNOT00000011832
similar to hypothetical protein MGC38716
chr17_-_55300998 14.45 ENSRNOT00000064331
supervillin
chr13_-_56877611 14.23 ENSRNOT00000079040
ENSRNOT00000017195
complement factor H-related 1
chr19_+_52077501 14.01 ENSRNOT00000079240
oxidative stress induced growth inhibitor 1
chr13_-_56763981 13.99 ENSRNOT00000087916
complement factor H-related protein B
chr8_-_56393233 13.87 ENSRNOT00000016263
ferredoxin 1
chr3_-_48536235 13.73 ENSRNOT00000083536
fibroblast activation protein, alpha
chr1_-_81412251 13.73 ENSRNOT00000026946
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr9_+_97355924 13.70 ENSRNOT00000026558
atypical chemokine receptor 3
chr12_-_30566032 13.32 ENSRNOT00000093378
glioblastoma amplified sequence
chr1_-_90520012 13.27 ENSRNOT00000028698
potassium channel tetramerization domain containing 15
chr12_-_5822874 13.27 ENSRNOT00000075920
FRY microtubule binding protein
chr1_-_241155537 13.19 ENSRNOT00000034216
ENSRNOT00000073493
MAM domain containing 2
chr18_+_38292701 13.16 ENSRNOT00000037796
secretoglobin, family 3A, member 2
chr5_-_100647727 13.09 ENSRNOT00000067435
nuclear factor I/B
chr20_+_28989491 13.05 ENSRNOT00000074524
phospholipase A2, group XIIB
chr6_+_56846789 13.03 ENSRNOT00000032108
alkylglycerol monooxygenase
chr9_-_19613360 12.96 ENSRNOT00000029593
regulator of calcineurin 2
chr10_+_37582706 12.93 ENSRNOT00000007630
similar to growth and transformation-dependent protein
chr7_+_11490852 12.92 ENSRNOT00000044484
cAMP responsive element binding protein 3-like 3
chr17_+_12261102 12.81 ENSRNOT00000015525
nuclear factor, interleukin 3 regulated
chr7_-_29701586 12.74 ENSRNOT00000009084
ENSRNOT00000089269
anoctamin 4
chr8_+_71167305 12.62 ENSRNOT00000021337
RNA binding protein with multiple splicing 2
chr5_+_159484370 12.62 ENSRNOT00000010593
succinate dehydrogenase complex iron sulfur subunit B
chr9_+_17340341 12.45 ENSRNOT00000026637
ENSRNOT00000026559
ENSRNOT00000042790
ENSRNOT00000044163
ENSRNOT00000083811
vascular endothelial growth factor A
chr13_-_47377703 12.43 ENSRNOT00000005461
complement component 4 binding protein, alpha
chrX_+_120624518 12.41 ENSRNOT00000007967
solute carrier family 6 member 14
chr6_-_41870046 12.37 ENSRNOT00000005863
lipin 1
chr8_-_119889661 12.32 ENSRNOT00000011780
SH3 and cysteine rich domain
chr15_+_10120206 12.32 ENSRNOT00000033048
retinoic acid receptor, beta
chrX_-_142248369 12.28 ENSRNOT00000091330
fibroblast growth factor 13
chr5_-_100647298 12.26 ENSRNOT00000067538
ENSRNOT00000013092
nuclear factor I/B
chr1_-_127337882 12.24 ENSRNOT00000085158
aldehyde dehydrogenase 1 family, member A3
chr13_-_89518939 12.20 ENSRNOT00000004228
succinate dehydrogenase complex subunit C
chr20_-_4489281 12.19 ENSRNOT00000031548
cytochrome P450, family 21, subfamily a, polypeptide 1
chr2_-_231521052 12.11 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr2_-_196113149 12.04 ENSRNOT00000088465
selenium binding protein 1
chr7_+_144647587 11.97 ENSRNOT00000022398
homeo box C4
chr4_+_68653369 11.95 ENSRNOT00000046917
taste receptor, type 2, member 137
chr1_+_31264755 11.91 ENSRNOT00000028988
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr19_-_57699113 11.91 ENSRNOT00000026767
egl-9 family hypoxia-inducible factor 1
chr4_-_100783750 11.79 ENSRNOT00000078956
potassium channel modulatory factor 1
chr17_+_22620721 11.55 ENSRNOT00000019478
androgen-dependent TFPI-regulating protein
chr9_-_9702306 11.52 ENSRNOT00000082341
thyroid hormone receptor interactor 10
chr9_+_100511610 11.44 ENSRNOT00000033233
anoctamin 7
chr7_+_34533543 11.18 ENSRNOT00000007412
ENSRNOT00000084185
netrin 4
chr10_-_89187474 11.12 ENSRNOT00000064931
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr7_+_76059386 10.98 ENSRNOT00000009337
grainyhead-like transcription factor 2
chrX_-_72515320 10.98 ENSRNOT00000076725
phosphorylase kinase, alpha 1
chr3_+_151126591 10.97 ENSRNOT00000025859
myosin heavy chain 7B
chr3_+_79678201 10.89 ENSRNOT00000087604
ENSRNOT00000079709
mitochondrial carrier 2
chrX_+_139780386 10.82 ENSRNOT00000081147

chr19_-_22281778 10.74 ENSRNOT00000049624
phosphorylase kinase regulatory subunit beta
chr1_-_90520344 10.68 ENSRNOT00000078598
potassium channel tetramerization domain containing 15
chr13_+_48575091 10.65 ENSRNOT00000009838
peptidase M20 domain containing 1
chr16_+_16949232 10.56 ENSRNOT00000047499

chr2_-_243407608 10.52 ENSRNOT00000014631
microsomal triglyceride transfer protein
chr3_+_122544788 10.47 ENSRNOT00000063828
transglutaminase 3
chr3_+_54253949 10.39 ENSRNOT00000010018
Beta-1,3-galactosyltransferase 1
chr9_-_9985630 10.37 ENSRNOT00000071780
crumbs 3, cell polarity complex component
chr6_-_105097054 10.34 ENSRNOT00000048606
solute carrier family 8 member A3
chr2_-_14701903 10.32 ENSRNOT00000051895
cytochrome c oxidase subunit 7C
chr10_-_38782419 10.32 ENSRNOT00000073964
ubiquinol-cytochrome c reductase, complex III subunit VII
chr10_-_102289837 10.30 ENSRNOT00000044922

chr3_+_132052612 10.30 ENSRNOT00000030148

chrX_-_139464798 10.20 ENSRNOT00000003282
glypican 4
chr17_+_49417067 10.19 ENSRNOT00000090024
POU domain, class 6, transcription factor 2
chr7_+_74047814 10.17 ENSRNOT00000014879
odd-skipped related transciption factor 2
chr8_-_55087832 10.11 ENSRNOT00000032152
dihydrolipoamide S-acetyltransferase
chr8_-_94352246 10.09 ENSRNOT00000013244
malic enzyme 1
chr7_-_117576737 10.00 ENSRNOT00000039795
diacylglycerol O-acyltransferase 1
chr1_+_193537137 9.87 ENSRNOT00000029967

chr2_-_178389608 9.85 ENSRNOT00000013262
electron transfer flavoprotein dehydrogenase
chr1_-_167911961 9.82 ENSRNOT00000025097
olfactory receptor 59
chr1_+_197839430 9.80 ENSRNOT00000025043
rabaptin, RAB GTPase binding effector protein 2
chr19_-_25134055 9.79 ENSRNOT00000007519
MISP family member 3
chr7_-_74735650 9.77 ENSRNOT00000014407
cytochrome c oxidase subunit 6C
chr1_-_219144610 9.67 ENSRNOT00000023526
NADH:ubiquinone oxidoreductase core subunit S8
chr1_+_282557426 9.62 ENSRNOT00000088966

chr11_+_70687500 9.61 ENSRNOT00000037432

chr8_-_116993193 9.57 ENSRNOT00000026327
dystroglycan 1
chr8_-_49227273 9.54 ENSRNOT00000050878
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
chr11_+_61083757 9.52 ENSRNOT00000002790
BOC cell adhesion associated, oncogene regulated
chr1_+_72420352 9.43 ENSRNOT00000066307
SH3 domain binding kinase family, member 3
chr8_+_59507990 9.38 ENSRNOT00000018003
hydroxylysine kinase
chrX_-_72132886 9.24 ENSRNOT00000077678
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chrX_-_72132495 9.20 ENSRNOT00000076391
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr11_-_79703736 9.13 ENSRNOT00000044279
LIM domain containing preferred translocation partner in lipoma
chr13_+_56598957 9.09 ENSRNOT00000016944
ENSRNOT00000080335
ENSRNOT00000089913
coagulation factor XIII B chain
chr18_+_27956429 9.02 ENSRNOT00000080999
catenin alpha 1
chr8_+_117679278 9.01 ENSRNOT00000042114
ubiquinol-cytochrome c reductase core protein I
chr4_+_61771970 8.95 ENSRNOT00000078996
ENSRNOT00000013073
aldo-keto reductase family 1 member B10
chr4_+_14039977 8.86 ENSRNOT00000091249
ENSRNOT00000075878
CD36 molecule
chr3_-_12007570 8.75 ENSRNOT00000060186
leucine rich repeat and sterile alpha motif containing 1
chr15_-_39886613 8.66 ENSRNOT00000089963
cytidine and dCMP deaminase domain containing 1
chr7_-_124041594 8.66 ENSRNOT00000064700
cytochrome b5 reductase 3
chr1_-_89017290 8.62 ENSRNOT00000028438
presenilin enhancer gamma secretase subunit
chr2_+_60337667 8.61 ENSRNOT00000024035
alanine-glyoxylate aminotransferase 2
chr5_+_134492756 8.59 ENSRNOT00000012888
ENSRNOT00000057095
ENSRNOT00000051385
cytochrome P450, family 4, subfamily a, polypeptide 1
chr15_+_19603288 8.57 ENSRNOT00000035491
REST corepressor 2-like
chr6_+_73358112 8.49 ENSRNOT00000041373
Rho GTPase activating protein 5
chr3_+_12262822 8.48 ENSRNOT00000022585
angiopoietin-like 2
chr13_-_103080920 8.46 ENSRNOT00000034990

chr5_-_101138427 8.46 ENSRNOT00000058615
Fras1 related extracellular matrix 1
chr2_+_158097843 8.43 ENSRNOT00000016541
pentraxin 3
chr10_-_36419926 8.39 ENSRNOT00000004902
zinc finger protein 354B
chr9_-_55256340 8.32 ENSRNOT00000028907
serum deprivation response
chr4_+_102426224 8.25 ENSRNOT00000073768
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 pseudogene
chr18_+_61261418 8.18 ENSRNOT00000064250
zinc finger protein 532
chr11_+_57430166 8.17 ENSRNOT00000093201
pleckstrin homology-like domain, family B, member 2
chr4_+_122244711 8.13 ENSRNOT00000038251
urocanate hydratase 1
chr6_-_7961207 8.04 ENSRNOT00000007174
ATP binding cassette subfamily G member 5
chr11_-_62451149 8.02 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr17_-_42127678 7.98 ENSRNOT00000024196
glycosylphosphatidylinositol specific phospholipase D1
chr18_+_64114933 7.96 ENSRNOT00000022364
melanocortin 5 receptor
chr8_-_47339343 7.91 ENSRNOT00000081007
Rho guanine nucleotide exchange factor 12
chr8_-_22542997 7.87 ENSRNOT00000061009
transmembrane p24 trafficking protein 1
chr5_+_124476168 7.82 ENSRNOT00000077754
similar to novel protein
chr1_+_282715344 7.79 ENSRNOT00000074399
liver carboxylesterase-like
chr10_+_56662561 7.78 ENSRNOT00000025254
asialoglycoprotein receptor 1
chr2_-_119140110 7.76 ENSRNOT00000058810

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1i2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.8 53.5 GO:0070237 positive regulation of activation-induced cell death of T cells(GO:0070237) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
10.6 31.8 GO:0014736 negative regulation of muscle atrophy(GO:0014736)
10.5 41.9 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
10.3 61.6 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
10.1 40.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
9.6 28.8 GO:0051977 lysophospholipid transport(GO:0051977)
7.1 21.3 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
6.7 40.5 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
6.6 19.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
6.5 19.6 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
6.4 19.3 GO:1905073 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
6.3 25.4 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
6.2 18.7 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
5.8 46.8 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
5.4 16.3 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
5.3 26.6 GO:1903059 regulation of protein lipidation(GO:1903059)
5.3 26.3 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
4.8 24.2 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
4.7 23.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
4.6 18.4 GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
4.6 23.0 GO:0002074 extraocular skeletal muscle development(GO:0002074)
4.6 13.7 GO:0097325 melanocyte proliferation(GO:0097325)
4.5 22.5 GO:0051891 positive regulation of cardioblast differentiation(GO:0051891)
4.5 13.5 GO:0036023 embryonic skeletal limb joint morphogenesis(GO:0036023)
4.5 9.0 GO:0016487 sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488)
4.1 12.4 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) cardiac vascular smooth muscle cell development(GO:0060948) positive regulation of lymphangiogenesis(GO:1901492)
4.1 12.4 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
4.1 16.5 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
4.1 12.2 GO:0060166 olfactory pit development(GO:0060166)
4.0 20.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
4.0 12.0 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
4.0 8.0 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
3.8 19.2 GO:0015793 glycerol transport(GO:0015793)
3.6 29.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
3.6 10.7 GO:0043605 cellular amide catabolic process(GO:0043605)
3.4 10.3 GO:0021539 subthalamus development(GO:0021539)
3.3 10.0 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
3.3 13.3 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
3.3 9.8 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
3.2 25.5 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
3.0 12.1 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.0 9.0 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
3.0 29.9 GO:0018298 protein-chromophore linkage(GO:0018298)
3.0 11.9 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
2.9 14.4 GO:0006548 histidine catabolic process(GO:0006548)
2.9 8.6 GO:0019265 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265)
2.7 11.0 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
2.7 48.4 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
2.7 39.8 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
2.6 5.2 GO:0072143 mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
2.4 19.4 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
2.4 4.8 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
2.3 16.4 GO:0086027 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
2.3 6.8 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
2.3 6.8 GO:0043132 phospholipid transfer to membrane(GO:0006649) NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170)
2.2 28.6 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
2.2 6.6 GO:2001205 negative regulation of osteoclast development(GO:2001205)
2.2 19.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
2.2 8.8 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
2.1 27.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
2.1 8.4 GO:1903015 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
2.1 6.3 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
2.1 12.4 GO:0006642 triglyceride mobilization(GO:0006642)
2.0 15.8 GO:1990034 calcium ion export from cell(GO:1990034)
1.9 17.4 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.9 7.7 GO:0021564 vagus nerve development(GO:0021564)
1.9 7.5 GO:0009441 glycolate metabolic process(GO:0009441)
1.9 11.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.8 20.1 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
1.8 14.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
1.8 23.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.8 16.0 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.8 12.3 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
1.7 17.5 GO:0070995 NADPH oxidation(GO:0070995)
1.7 6.8 GO:1990375 baculum development(GO:1990375)
1.7 11.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.7 3.4 GO:0061354 cardiac right atrium morphogenesis(GO:0003213) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963)
1.7 39.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.6 6.6 GO:0042376 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
1.6 27.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.6 8.0 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
1.6 27.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
1.6 10.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
1.5 12.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
1.5 6.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.5 23.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
1.5 17.5 GO:0001778 plasma membrane repair(GO:0001778)
1.4 4.3 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
1.4 10.1 GO:0006108 malate metabolic process(GO:0006108)
1.4 7.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.4 4.3 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
1.4 5.7 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.4 18.3 GO:0070989 oxidative demethylation(GO:0070989)
1.4 4.2 GO:1901295 regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
1.3 5.3 GO:0071492 cellular response to UV-A(GO:0071492)
1.3 3.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.3 5.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.3 5.0 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
1.2 3.7 GO:0042335 cuticle development(GO:0042335)
1.2 15.7 GO:0042178 xenobiotic catabolic process(GO:0042178)
1.2 10.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
1.2 4.6 GO:0048252 lauric acid metabolic process(GO:0048252)
1.1 28.5 GO:0014850 response to muscle activity(GO:0014850)
1.1 34.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
1.1 15.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.1 6.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.1 13.0 GO:0046485 ether lipid metabolic process(GO:0046485)
1.1 12.9 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
1.1 10.6 GO:0006657 CDP-choline pathway(GO:0006657)
1.0 29.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.0 10.3 GO:0007220 Notch receptor processing(GO:0007220)
1.0 4.0 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.0 6.0 GO:0061525 hindgut development(GO:0061525)
1.0 13.0 GO:0007614 short-term memory(GO:0007614)
1.0 21.5 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
1.0 5.8 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
1.0 5.8 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
1.0 7.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.9 12.2 GO:0042448 progesterone metabolic process(GO:0042448)
0.9 13.8 GO:1901201 regulation of extracellular matrix assembly(GO:1901201)
0.9 29.8 GO:0018345 protein palmitoylation(GO:0018345)
0.9 9.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.9 1.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.9 2.6 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.8 5.9 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.8 9.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.8 4.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.8 34.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.7 10.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.7 2.2 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.7 2.9 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.7 3.5 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.7 6.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 18.4 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.6 3.0 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.6 11.5 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.6 6.2 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.6 5.0 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.6 6.1 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.5 15.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 14.8 GO:0014002 astrocyte development(GO:0014002)
0.5 12.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.5 6.9 GO:1903830 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.5 10.5 GO:0031424 keratinization(GO:0031424)
0.5 4.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.5 9.7 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 5.0 GO:0002024 diet induced thermogenesis(GO:0002024)
0.5 3.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.5 2.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.5 1.5 GO:0019086 late viral transcription(GO:0019086)
0.5 1.4 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.5 1.8 GO:0001555 oocyte growth(GO:0001555)
0.4 6.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.4 13.7 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.4 13.1 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.4 23.1 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.4 4.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 4.7 GO:0090201 negative regulation of release of cytochrome c from mitochondria(GO:0090201)
0.4 6.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.4 9.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.4 1.1 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.4 2.2 GO:0009820 alkaloid metabolic process(GO:0009820) quinolinate metabolic process(GO:0046874)
0.4 0.7 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.4 18.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 2.8 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.3 2.8 GO:0051255 spindle midzone assembly(GO:0051255)
0.3 10.5 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 1.2 GO:1902861 copper ion import across plasma membrane(GO:0098705) copper ion import into cell(GO:1902861)
0.3 8.5 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.3 1.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 2.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 0.6 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.3 15.0 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.3 0.5 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.3 1.9 GO:0042447 hormone catabolic process(GO:0042447)
0.3 8.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 16.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 12.9 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.2 8.1 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.2 8.0 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.2 2.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 3.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 1.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.2 2.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 0.2 GO:0032423 regulation of mismatch repair(GO:0032423)
0.2 1.0 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 3.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 1.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 4.0 GO:0003416 endochondral bone growth(GO:0003416) bone growth(GO:0098868)
0.2 7.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 6.3 GO:0042572 retinol metabolic process(GO:0042572)
0.2 3.6 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.2 19.3 GO:0006941 striated muscle contraction(GO:0006941)
0.2 4.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 0.5 GO:0042412 taurine biosynthetic process(GO:0042412)
0.2 1.4 GO:0009133 nucleoside diphosphate biosynthetic process(GO:0009133)
0.2 3.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 2.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.2 GO:0006729 L-phenylalanine catabolic process(GO:0006559) tetrahydrobiopterin biosynthetic process(GO:0006729) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.2 3.5 GO:0060632 regulation of microtubule-based movement(GO:0060632)
0.1 12.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 3.7 GO:0019835 cytolysis(GO:0019835)
0.1 3.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 3.9 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.1 6.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 4.8 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 3.8 GO:0042446 hormone biosynthetic process(GO:0042446)
0.1 0.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 4.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 4.4 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.4 GO:0072003 kidney rudiment formation(GO:0072003) metanephric tubule formation(GO:0072174)
0.1 1.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.9 GO:0002176 male germ cell proliferation(GO:0002176)
0.1 4.0 GO:0032543 mitochondrial translation(GO:0032543)
0.1 1.0 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 114.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 3.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.2 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.1 2.6 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 1.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.0 GO:0098880 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.1 3.4 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 1.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 5.0 GO:0032092 positive regulation of protein binding(GO:0032092)
0.1 3.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 1.7 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 2.4 GO:0007422 peripheral nervous system development(GO:0007422)
0.1 0.7 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.1 2.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 4.5 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 13.2 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 0.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 0.3 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 0.2 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 1.0 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 2.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 18.0 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 0.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 5.1 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 1.3 GO:0007566 embryo implantation(GO:0007566)
0.0 0.2 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 5.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 3.1 GO:0006520 cellular amino acid metabolic process(GO:0006520)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.4 GO:0000460 maturation of 5.8S rRNA(GO:0000460)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 59.1 GO:0005927 muscle tendon junction(GO:0005927)
9.9 39.8 GO:1990584 cardiac Troponin complex(GO:1990584)
6.2 24.8 GO:0045281 respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281)
5.8 34.9 GO:0032280 symmetric synapse(GO:0032280)
4.7 23.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
4.1 16.4 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
3.9 19.7 GO:0044316 cone cell pedicle(GO:0044316)
3.4 27.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
3.4 34.4 GO:0045179 apical cortex(GO:0045179)
3.4 40.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
2.7 21.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
2.7 8.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
2.5 25.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.5 20.0 GO:0005577 fibrinogen complex(GO:0005577)
2.5 12.4 GO:0043159 acrosomal matrix(GO:0043159)
2.3 23.5 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
2.3 97.8 GO:0043034 costamere(GO:0043034)
1.9 17.5 GO:0005826 actomyosin contractile ring(GO:0005826)
1.9 40.8 GO:0005865 striated muscle thin filament(GO:0005865)
1.8 11.0 GO:0097512 cardiac myofibril(GO:0097512)
1.8 19.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
1.7 5.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
1.5 9.3 GO:0030478 actin cap(GO:0030478)
1.5 16.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.5 19.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.4 8.6 GO:0070765 gamma-secretase complex(GO:0070765)
1.3 27.7 GO:0098644 complex of collagen trimers(GO:0098644)
1.3 6.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.2 15.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.1 6.8 GO:0032059 bleb(GO:0032059)
1.1 10.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
1.1 109.5 GO:0005604 basement membrane(GO:0005604)
1.1 75.7 GO:0030315 T-tubule(GO:0030315)
1.0 20.9 GO:0005614 interstitial matrix(GO:0005614)
1.0 6.2 GO:0089701 U2AF(GO:0089701)
1.0 3.9 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.9 9.0 GO:0005915 zonula adherens(GO:0005915)
0.9 3.4 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.8 17.4 GO:0070069 cytochrome complex(GO:0070069)
0.8 13.9 GO:0030061 mitochondrial crista(GO:0030061)
0.8 41.7 GO:0016528 sarcoplasm(GO:0016528)
0.7 42.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.7 4.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.7 42.4 GO:0070469 respiratory chain(GO:0070469)
0.6 22.4 GO:0016459 myosin complex(GO:0016459)
0.6 2.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.6 3.5 GO:0071438 invadopodium membrane(GO:0071438)
0.6 2.9 GO:1990716 axonemal central apparatus(GO:1990716)
0.6 15.9 GO:0014704 intercalated disc(GO:0014704)
0.6 5.6 GO:0031527 filopodium membrane(GO:0031527)
0.6 10.5 GO:0031528 microvillus membrane(GO:0031528)
0.5 3.3 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.5 4.3 GO:0000815 ESCRT III complex(GO:0000815)
0.5 80.4 GO:0030016 myofibril(GO:0030016)
0.5 8.2 GO:0045180 basal cortex(GO:0045180)
0.5 2.5 GO:0016939 kinesin II complex(GO:0016939)
0.5 51.7 GO:0072562 blood microparticle(GO:0072562)
0.5 34.2 GO:0042383 sarcolemma(GO:0042383)
0.5 2.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.5 8.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 9.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 19.7 GO:0045171 intercellular bridge(GO:0045171)
0.4 9.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.4 27.5 GO:0031526 brush border membrane(GO:0031526)
0.4 16.7 GO:0005581 collagen trimer(GO:0005581)
0.3 2.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.3 12.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.3 6.8 GO:0005839 proteasome core complex(GO:0005839)
0.3 3.0 GO:0042788 polysomal ribosome(GO:0042788)
0.3 2.8 GO:0070652 HAUS complex(GO:0070652)
0.3 4.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 2.7 GO:0060091 kinocilium(GO:0060091)
0.2 9.5 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 37.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 11.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 66.1 GO:0031966 mitochondrial membrane(GO:0031966)
0.2 1.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 2.6 GO:0043194 axon initial segment(GO:0043194)
0.2 22.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 3.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)
0.1 11.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 7.3 GO:0005811 lipid particle(GO:0005811)
0.1 40.7 GO:0005635 nuclear envelope(GO:0005635)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 3.1 GO:0005903 brush border(GO:0005903)
0.1 19.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 23.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.9 GO:0031902 late endosome membrane(GO:0031902)
0.1 1.9 GO:0001533 cornified envelope(GO:0001533)
0.1 2.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 4.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.8 GO:0005770 late endosome(GO:0005770)
0.1 3.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 32.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 6.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.8 GO:0043196 varicosity(GO:0043196)
0.0 7.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 4.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 17.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 2.9 GO:0005769 early endosome(GO:0005769)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0000502 proteasome complex(GO:0000502)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 72.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
9.9 39.8 GO:0030172 troponin C binding(GO:0030172)
8.0 31.8 GO:0035877 death effector domain binding(GO:0035877)
7.8 23.3 GO:1990763 arrestin family protein binding(GO:1990763)
7.2 21.5 GO:2001070 starch binding(GO:2001070)
7.1 21.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
6.7 40.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
6.5 19.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
6.4 19.2 GO:0015254 glycerol channel activity(GO:0015254)
6.3 31.6 GO:0019862 IgA binding(GO:0019862)
6.2 24.8 GO:0000104 succinate dehydrogenase activity(GO:0000104)
5.3 31.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
5.1 5.1 GO:0001846 opsonin binding(GO:0001846)
3.6 25.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
3.4 10.1 GO:0008948 oxaloacetate decarboxylase activity(GO:0008948)
3.2 13.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
3.0 6.1 GO:0031013 troponin I binding(GO:0031013)
3.0 9.0 GO:0045550 geranylgeranyl reductase activity(GO:0045550)
2.7 16.3 GO:0001515 opioid peptide activity(GO:0001515)
2.7 21.7 GO:0004689 phosphorylase kinase activity(GO:0004689)
2.6 23.5 GO:0015450 protein channel activity(GO:0015266) P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
2.6 13.0 GO:0004977 melanocortin receptor activity(GO:0004977)
2.6 51.2 GO:0017166 vinculin binding(GO:0017166)
2.5 10.0 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
2.5 22.5 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
2.5 24.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
2.5 9.9 GO:0048039 ubiquinone binding(GO:0048039)
2.4 16.5 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
2.2 41.2 GO:0008179 adenylate cyclase binding(GO:0008179)
2.1 49.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
2.1 10.4 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
2.1 16.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
2.0 12.2 GO:0001758 retinal dehydrogenase activity(GO:0001758)
2.0 16.1 GO:0008430 selenium binding(GO:0008430)
1.9 5.8 GO:0097677 STAT family protein binding(GO:0097677)
1.9 29.0 GO:0005523 tropomyosin binding(GO:0005523)
1.9 7.5 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973)
1.9 13.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
1.8 18.4 GO:0050693 LBD domain binding(GO:0050693)
1.8 5.5 GO:0047708 biotinidase activity(GO:0047708)
1.8 8.9 GO:0070538 oleic acid binding(GO:0070538) lipoteichoic acid receptor activity(GO:0070892)
1.7 8.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
1.7 5.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
1.6 6.6 GO:0055100 adiponectin binding(GO:0055100)
1.6 6.6 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
1.5 11.9 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.5 10.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.4 17.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.4 8.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
1.4 27.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
1.4 12.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
1.4 6.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
1.3 10.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.3 24.5 GO:0001848 complement binding(GO:0001848)
1.3 9.0 GO:0043237 laminin-1 binding(GO:0043237)
1.3 6.4 GO:0050816 phosphothreonine binding(GO:0050816)
1.3 7.6 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
1.3 10.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
1.3 6.3 GO:0016841 ammonia-lyase activity(GO:0016841)
1.2 8.4 GO:0016018 cyclosporin A binding(GO:0016018)
1.2 17.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.2 3.5 GO:0004925 prolactin receptor activity(GO:0004925)
1.1 5.7 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
1.1 12.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.1 6.7 GO:0008420 CTD phosphatase activity(GO:0008420)
1.1 8.8 GO:0004630 phospholipase D activity(GO:0004630)
1.0 10.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
1.0 11.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.0 3.0 GO:0050682 AF-2 domain binding(GO:0050682)
1.0 26.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.0 3.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.9 3.8 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.9 7.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.9 29.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.9 33.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.9 15.7 GO:0043295 glutathione binding(GO:0043295)
0.9 12.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.9 3.4 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.8 6.7 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.8 15.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.8 6.8 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.7 25.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.7 2.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.7 2.2 GO:0046911 metal chelating activity(GO:0046911)
0.7 4.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.7 1.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.7 8.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.7 5.4 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.7 11.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.7 3.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 3.2 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.6 5.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.6 5.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.6 6.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.6 6.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 32.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.6 14.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.6 4.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.6 10.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.6 1.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.6 1.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.6 4.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.6 6.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.6 16.4 GO:0070064 proline-rich region binding(GO:0070064)
0.5 6.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.5 20.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 39.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5 10.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 6.3 GO:0035497 cAMP response element binding(GO:0035497)
0.5 2.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.5 19.7 GO:0030552 cAMP binding(GO:0030552)
0.5 27.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.5 2.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.5 3.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 1.8 GO:0008940 nitrate reductase activity(GO:0008940)
0.4 3.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 1.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 11.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.4 1.2 GO:0070404 NADH binding(GO:0070404)
0.4 30.1 GO:0005518 collagen binding(GO:0005518)
0.4 2.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.4 48.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 3.9 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 7.7 GO:0071837 HMG box domain binding(GO:0071837)
0.3 5.9 GO:0001594 trace-amine receptor activity(GO:0001594)
0.3 9.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 4.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 1.8 GO:0048019 receptor antagonist activity(GO:0048019)
0.3 2.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.3 0.6 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.3 3.6 GO:0003796 lysozyme activity(GO:0003796)
0.3 4.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.3 6.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 20.0 GO:0051087 chaperone binding(GO:0051087)
0.2 8.2 GO:0042805 actinin binding(GO:0042805)
0.2 13.7 GO:0038024 cargo receptor activity(GO:0038024)
0.2 1.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 10.3 GO:0030507 spectrin binding(GO:0030507)
0.2 2.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 4.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.8 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 3.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 4.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 2.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 8.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 8.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 5.0 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.2 13.7 GO:0005178 integrin binding(GO:0005178)
0.2 1.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.8 GO:0042301 phosphate ion binding(GO:0042301)
0.1 6.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.0 GO:0019808 polyamine binding(GO:0019808)
0.1 3.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 3.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 17.5 GO:0003774 motor activity(GO:0003774)
0.1 12.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 13.3 GO:0044325 ion channel binding(GO:0044325)
0.1 7.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.4 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 44.6 GO:0005549 odorant binding(GO:0005549)
0.1 0.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.7 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.1 2.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 2.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.1 68.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.0 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 1.0 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.1 4.2 GO:0017022 myosin binding(GO:0017022)
0.1 0.2 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.1 2.8 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0004697 protein kinase C activity(GO:0004697)
0.1 2.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 12.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 7.4 GO:0016853 isomerase activity(GO:0016853)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.0 GO:0051018 protein kinase A binding(GO:0051018)
0.0 3.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 3.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 7.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 2.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 4.9 GO:0016491 oxidoreductase activity(GO:0016491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 53.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.1 6.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
1.6 17.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
1.4 23.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
1.4 9.6 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.7 27.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7 41.3 PID RHOA PATHWAY RhoA signaling pathway
0.6 27.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.6 32.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.6 11.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.6 13.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.6 25.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.6 17.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.6 11.4 PID AP1 PATHWAY AP-1 transcription factor network
0.5 9.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.5 9.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.4 11.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.4 6.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 12.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.4 3.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.4 6.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.4 4.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 8.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 10.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 15.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 11.6 PID LKB1 PATHWAY LKB1 signaling events
0.3 65.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 8.8 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.3 9.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 8.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 12.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 38.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 8.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 6.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 8.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 3.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 6.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 1.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.8 PID AURORA B PATHWAY Aurora B signaling
0.1 1.3 PID CD40 PATHWAY CD40/CD40L signaling
0.1 1.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 6.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 34.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.0 27.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.8 29.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.6 19.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.6 61.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.6 18.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.5 17.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.4 5.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.4 91.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.2 19.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.2 46.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
1.1 25.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.1 21.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
1.0 6.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.0 12.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.9 81.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.9 12.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.9 13.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.9 8.6 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.8 23.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.7 36.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.7 10.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.7 10.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.7 8.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 6.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 9.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.6 11.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.6 20.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 23.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.5 4.3 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.5 11.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 57.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.5 17.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.4 8.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 10.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 5.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.4 12.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 5.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 11.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 7.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 16.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 17.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 6.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 2.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 14.7 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.2 3.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 3.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 2.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 2.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 4.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 19.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 22.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 2.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 10.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 1.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.5 REACTOME KINESINS Genes involved in Kinesins
0.1 3.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.3 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.2 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors