Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Nr1h4

Z-value: 1.56

Motif logo

Transcription factors associated with Nr1h4

Gene Symbol Gene ID Gene Info
ENSRNOG00000007197 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h4rn6_v1_chr7_-_30105132_301051320.604.7e-33Click!

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_55587946 182.67 ENSRNOT00000075107
ATP binding cassette subfamily B member 11
chr16_-_7007287 146.79 ENSRNOT00000041216
inter-alpha trypsin inhibitor, heavy chain 3
chr16_-_7007051 143.69 ENSRNOT00000023984
inter-alpha trypsin inhibitor, heavy chain 3
chr9_+_74124016 142.46 ENSRNOT00000019023
carbamoyl-phosphate synthase 1
chr7_+_2689501 123.29 ENSRNOT00000041341
apolipoprotein F
chr1_-_170431073 117.67 ENSRNOT00000024710
hemopexin
chr13_+_89597138 91.99 ENSRNOT00000004662
apolipoprotein A2
chr7_-_123655896 91.06 ENSRNOT00000012413
cytochrome P450, family 2, subfamily d, polypeptide 2
chr2_+_248649441 63.57 ENSRNOT00000067165
kynurenine aminotransferase 3
chr9_-_4945352 62.39 ENSRNOT00000082530
sulfotransferase family 1C member 3
chr20_-_4542073 61.17 ENSRNOT00000000477
complement factor B
chr8_+_116857684 54.33 ENSRNOT00000026711
macrophage stimulating 1
chr2_+_20857202 54.31 ENSRNOT00000078919
acyl-CoA thioesterase 12
chr1_+_100470722 53.41 ENSRNOT00000086917
aspartate dehydrogenase domain containing
chr6_+_107550904 51.20 ENSRNOT00000013760
acyl-CoA thioesterase 5
chr1_-_80617057 50.78 ENSRNOT00000080453
apolipoprotein E
chr4_+_61850348 44.97 ENSRNOT00000013423
aldo-keto reductase family 1, member B7
chr4_+_175814118 42.58 ENSRNOT00000013409
ENSRNOT00000013514
solute carrier organic anion transporter family, member 1B2
chrX_+_6430594 40.08 ENSRNOT00000044009
monoamine oxidase B
chr10_-_104748003 40.05 ENSRNOT00000042372
ENSRNOT00000046754
acyl-CoA oxidase 1
chr17_-_42127678 38.81 ENSRNOT00000024196
glycosylphosphatidylinositol specific phospholipase D1
chr1_-_89488223 37.84 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr11_+_83868655 35.16 ENSRNOT00000072402
thrombopoietin
chr5_+_151776004 34.97 ENSRNOT00000009683
nuclear receptor subfamily 0, group B, member 2
chr7_-_102298522 34.20 ENSRNOT00000006273
alpha-1-B glycoprotein
chr3_-_121835360 34.13 ENSRNOT00000006126
ENSRNOT00000080818
interleukin 1 alpha
chr6_-_10899200 33.57 ENSRNOT00000089104
multiple coagulation factor deficiency 2
chr8_+_115151627 31.01 ENSRNOT00000064252
abhydrolase domain containing 14b
chr7_-_124999137 27.64 ENSRNOT00000039228
patatin-like phospholipase domain containing 5
chr4_+_100277391 23.94 ENSRNOT00000086820
ENSRNOT00000084281
ENSRNOT00000017927
gamma-glutamyl carboxylase
chr1_+_264741911 22.79 ENSRNOT00000019956
semaphorin 4G
chr1_-_98486976 21.82 ENSRNOT00000024083
electron transfer flavoprotein beta subunit
chr10_-_46582854 20.81 ENSRNOT00000004753
sterol regulatory element binding transcription factor 1
chr16_-_6404957 19.18 ENSRNOT00000048459
calcium voltage-gated channel subunit alpha1 D
chr1_+_219833299 18.35 ENSRNOT00000087432
pyruvate carboxylase
chrX_-_139464798 18.33 ENSRNOT00000003282
glypican 4
chr5_+_136683592 17.41 ENSRNOT00000085527
solute carrier family 6 member 9
chrX_+_21696772 17.26 ENSRNOT00000043559
hydroxysteroid (17-beta) dehydrogenase 10
chr9_+_99795678 15.93 ENSRNOT00000056601
olfactory receptor 1353
chr16_-_6404578 15.56 ENSRNOT00000051371
calcium voltage-gated channel subunit alpha1 D
chr3_-_39596718 14.73 ENSRNOT00000006784
reprimo, TP53 dependent G2 arrest mediator candidate
chr11_-_31772984 13.63 ENSRNOT00000002771
DnaJ heat shock protein family (Hsp40) member C28
chr7_-_12882753 13.14 ENSRNOT00000011275
ENSRNOT00000044275
basigin
chr9_+_61810859 12.97 ENSRNOT00000079058

chr12_+_9034308 11.63 ENSRNOT00000001248
FMS-related tyrosine kinase 1
chr18_+_16616937 11.63 ENSRNOT00000093641
molybdenum cofactor sulfurase
chr1_+_72420352 11.23 ENSRNOT00000066307
SH3 domain binding kinase family, member 3
chr7_-_118474609 11.12 ENSRNOT00000089076

chr8_+_117455262 10.96 ENSRNOT00000027520
solute carrier family 25 member 20
chr1_-_198794947 10.64 ENSRNOT00000024639
zinc finger protein 768
chr14_+_36216002 10.37 ENSRNOT00000038506
sec1 family domain containing 2
chr1_+_255479261 9.79 ENSRNOT00000079808
tankyrase 2
chr10_+_37582706 9.46 ENSRNOT00000007630
similar to growth and transformation-dependent protein
chr3_+_8958090 8.97 ENSRNOT00000086789
ENSRNOT00000064557
dolichyldiphosphatase 1
chr13_-_89619398 8.95 ENSRNOT00000058423
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr14_+_2325308 8.87 ENSRNOT00000000072
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr10_-_109333899 8.79 ENSRNOT00000006225
solute carrier family 38, member 10
chr3_-_77961992 8.72 ENSRNOT00000089105

chr3_+_77921705 8.70 ENSRNOT00000064006

chr14_-_33580566 8.39 ENSRNOT00000063942
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr3_+_77584990 8.26 ENSRNOT00000046926
olfactory receptor 664
chr18_+_57011575 8.08 ENSRNOT00000026679
interleukin 17B
chr3_-_77696294 8.01 ENSRNOT00000050849
olfactory receptor 670
chr1_-_219259448 7.67 ENSRNOT00000024517
NADH:ubiquinone oxidoreductase core subunit V1
chr8_-_128622314 7.29 ENSRNOT00000084950
ENSRNOT00000024408
golgi reassembly stacking protein 1
chr18_-_62965538 7.20 ENSRNOT00000025164
metallophosphoesterase 1
chr9_+_64095978 7.14 ENSRNOT00000021533
matrix AAA peptidase interacting protein 1
chr19_-_15733412 6.93 ENSRNOT00000014831
iroquois homeobox 6
chr6_+_107245820 6.62 ENSRNOT00000012757
papilin, proteoglycan-like sulfated glycoprotein
chr5_-_154319629 6.55 ENSRNOT00000014415
lysophospholipase II
chr1_-_22548675 6.39 ENSRNOT00000061209
trace amine-associated receptor 5
chr3_-_77883067 6.27 ENSRNOT00000087979
olfactory receptor 677
chr12_-_22726982 6.25 ENSRNOT00000001921
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr4_+_68656928 6.17 ENSRNOT00000016232
taste receptor, type 2, member 108
chr1_-_266934303 6.02 ENSRNOT00000036202
calcium homeostasis modulator 3
chr15_+_61662264 5.86 ENSRNOT00000072969
mitochondrial translation release factor 1
chr6_+_99625306 5.50 ENSRNOT00000008573
pleckstrin homology and RhoGEF domain containing G3
chr4_+_7314369 5.06 ENSRNOT00000029724
autophagy related 9B
chr10_+_56576428 5.03 ENSRNOT00000079237
ENSRNOT00000023291
claudin 7
chr3_-_77605962 4.92 ENSRNOT00000090062
olfactory receptor 665
chr8_+_23014956 4.90 ENSRNOT00000018009
protein kinase C substrate 80K-H
chr19_-_41567013 4.85 ENSRNOT00000022757
zinc finger protein 612
chr1_-_64099277 4.82 ENSRNOT00000084846
tRNA splicing endonuclease subunit 34
chr14_+_33580541 4.75 ENSRNOT00000002905
phosphoribosyl pyrophosphate amidotransferase
chr6_+_124123228 4.73 ENSRNOT00000005329
proteasome 26S subunit, ATPase 1
chr14_+_48764670 4.52 ENSRNOT00000090271
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_60864478 4.51 ENSRNOT00000088653

chr3_-_37947283 4.46 ENSRNOT00000009181
ADP-ribosylation factor like GTPase 5A
chr9_+_10004805 4.45 ENSRNOT00000074117
solute carrier family 25, member 41
chr10_-_109913879 4.32 ENSRNOT00000072947
similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27)
chr2_+_240668195 4.28 ENSRNOT00000087371
mannosidase beta
chr3_-_78066123 4.24 ENSRNOT00000073165
olfactory receptor 690
chr7_-_117326551 3.92 ENSRNOT00000086087

chr1_+_100447998 3.82 ENSRNOT00000026259
leucine rich repeat containing 4B
chr14_-_83776863 3.49 ENSRNOT00000026481
smoothelin
chrM_+_8599 3.22 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chr10_-_29196252 3.20 ENSRNOT00000083910
fatty acid binding protein 6
chr3_-_151371501 3.13 ENSRNOT00000073178
family with sequence similarity 83, member C
chr20_+_11114164 2.98 ENSRNOT00000001602
1-acylglycerol-3-phosphate O-acyltransferase 3
chr3_-_79165698 2.86 ENSRNOT00000032617
olfactory receptor 744
chr12_+_47024442 2.75 ENSRNOT00000001545
cytochrome c oxidase subunit 6A1
chr9_+_43830630 2.66 ENSRNOT00000084742
cyclic nucleotide gated channel alpha 3
chr18_-_63185510 2.56 ENSRNOT00000024632
AFG3 like matrix AAA peptidase subunit 2
chrX_+_44830849 2.34 ENSRNOT00000079680
transducin (beta)-like 1 X-linked
chr14_+_88549947 2.10 ENSRNOT00000086177
heterogeneous nuclear ribonucleoprotein C
chr7_+_54031316 2.02 ENSRNOT00000039096
Bardet-Biedl syndrome 10
chr7_+_130542202 1.85 ENSRNOT00000079501
ENSRNOT00000045647
acrosin
chr3_-_153468221 1.73 ENSRNOT00000010443
growth hormone releasing hormone
chr5_+_59228199 1.64 ENSRNOT00000060282
histidine rich carboxyl terminus 1
chr7_-_12609868 1.61 ENSRNOT00000016396
KISS1 receptor
chr1_-_227047290 1.48 ENSRNOT00000037226
membrane spanning 4-domains A15
chr9_+_82647071 1.41 ENSRNOT00000027135
acid sensing ion channel subunit family member 4
chr8_-_25829569 1.32 ENSRNOT00000071884
dpy-19 like 2
chr10_+_11240138 1.32 ENSRNOT00000048687
sarcalumenin
chr17_-_1093873 1.29 ENSRNOT00000086130
patched 1
chr18_-_36579403 1.08 ENSRNOT00000025284
leucyl-tRNA synthetase
chr15_-_25521393 1.08 ENSRNOT00000085910
orthodenticle homeobox 2
chr7_-_30344426 1.05 ENSRNOT00000002638
ENSRNOT00000082016
SCY1 like pseudokinase 2
chr5_+_36024649 1.03 ENSRNOT00000013384
coenzyme Q3 methyltransferase
chr3_-_77677349 0.99 ENSRNOT00000084989
olfactory receptor 669
chr10_+_61033113 0.93 ENSRNOT00000043016
olfactory receptor 1513
chr20_+_5441876 0.79 ENSRNOT00000092476
ribosomal protein S18
chr13_-_84793463 0.54 ENSRNOT00000076886
flavin containing monooxygenase 9
chr15_+_27207645 0.54 ENSRNOT00000011549
olfactory receptor 1614
chr12_+_22727335 0.47 ENSRNOT00000077293
zinc finger, HIT-type containing 1
chr5_-_5691794 0.46 ENSRNOT00000089152

chr7_-_12609694 0.46 ENSRNOT00000093287
ENSRNOT00000079485
KISS1 receptor
chr13_-_68858781 0.31 ENSRNOT00000065944
ENSRNOT00000092053
ring finger protein 2
chr5_-_164585634 0.28 ENSRNOT00000065985
mitofusin 2
chr1_-_170628915 0.26 ENSRNOT00000042865
dachsous cadherin-related 1
chr9_+_61655963 0.16 ENSRNOT00000040461
coenzyme Q10B
chr3_+_76468294 0.08 ENSRNOT00000037779
olfactory receptor 619
chr20_+_11436267 0.06 ENSRNOT00000001631
transient receptor potential cation channel, subfamily M, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.7 92.0 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)
29.4 117.7 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
28.5 142.5 GO:0071400 cellular response to oleic acid(GO:0071400)
26.1 182.7 GO:0015722 canalicular bile acid transport(GO:0015722)
19.4 38.8 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
17.8 53.4 GO:0006742 NADP catabolic process(GO:0006742)
17.1 51.2 GO:0032789 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
16.9 50.8 GO:1903000 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
13.3 40.0 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
12.7 63.6 GO:0097052 L-kynurenine metabolic process(GO:0097052)
12.6 37.8 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
11.7 35.2 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
11.4 34.1 GO:1904444 regulation of establishment of Sertoli cell barrier(GO:1904444)
8.8 290.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
6.0 54.3 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
6.0 23.9 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
5.6 61.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
5.0 40.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
4.6 18.3 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
3.9 42.6 GO:0006857 oligopeptide transport(GO:0006857)
3.9 34.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
2.9 11.6 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
2.7 11.0 GO:0015879 carnitine transport(GO:0015879)
2.7 124.6 GO:0033344 cholesterol efflux(GO:0033344)
2.6 20.8 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
2.4 7.1 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
2.2 13.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
2.1 6.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
2.0 21.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.6 6.5 GO:0002084 protein depalmitoylation(GO:0002084)
1.6 17.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
1.5 54.3 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
1.4 91.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
1.3 5.1 GO:1902534 single-organism membrane invagination(GO:1902534)
1.2 4.8 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
1.1 27.6 GO:0019433 triglyceride catabolic process(GO:0019433)
1.1 11.6 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.8 17.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.6 6.9 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.6 8.1 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.6 13.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.6 13.1 GO:0046689 response to mercury ion(GO:0046689)
0.5 1.1 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.0 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.5 4.4 GO:0015866 ADP transport(GO:0015866)
0.4 2.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.4 35.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.4 1.1 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.4 5.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 2.1 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.3 1.3 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.3 1.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.3 5.9 GO:0006415 translational termination(GO:0006415)
0.3 4.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.3 8.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 1.7 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.3 15.4 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.3 7.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.3 1.9 GO:0007341 penetration of zona pellucida(GO:0007341)
0.3 4.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.2 2.7 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2 6.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 7.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 48.8 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.2 11.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.3 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.1 0.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 8.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 2.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 3.2 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 0.3 GO:0072137 mitral valve formation(GO:0003192) condensed mesenchymal cell proliferation(GO:0072137)
0.1 1.2 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 3.8 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 10.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.1 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 5.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 27.5 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 11.3 GO:0043436 carboxylic acid metabolic process(GO:0019752) oxoacid metabolic process(GO:0043436)
0.0 29.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 92.0 GO:0042627 chylomicron(GO:0042627)
14.5 174.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
14.1 182.7 GO:0046581 intercellular canaliculus(GO:0046581)
3.1 159.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.9 34.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
2.3 38.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.7 213.0 GO:0072562 blood microparticle(GO:0072562)
1.0 13.6 GO:0017119 Golgi transport complex(GO:0017119)
1.0 4.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.9 2.6 GO:0005745 m-AAA complex(GO:0005745)
0.7 20.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.7 2.1 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.7 8.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.7 4.7 GO:0031595 nuclear proteasome complex(GO:0031595)
0.6 40.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.5 10.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.5 40.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.5 13.1 GO:0002080 acrosomal membrane(GO:0002080)
0.5 26.5 GO:0034707 chloride channel complex(GO:0034707)
0.5 1.9 GO:0043159 acrosomal matrix(GO:0043159)
0.4 27.6 GO:0005811 lipid particle(GO:0005811)
0.4 3.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 15.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 2.7 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 35.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 5.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 5.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 5.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 18.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 46.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 6.2 GO:0060170 ciliary membrane(GO:0060170)
0.2 110.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 42.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.3 GO:0044294 dendritic growth cone(GO:0044294)
0.1 6.6 GO:0005604 basement membrane(GO:0005604)
0.1 119.4 GO:0005739 mitochondrion(GO:0005739)
0.1 1.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 202.2 GO:0070062 extracellular exosome(GO:0070062)
0.1 4.9 GO:0044432 endoplasmic reticulum part(GO:0044432)
0.1 60.2 GO:0005615 extracellular space(GO:0005615)
0.1 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.1 2.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 1.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 10.4 GO:0098793 presynapse(GO:0098793)
0.0 7.3 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
30.7 92.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
16.9 50.8 GO:0046911 metal chelating activity(GO:0046911)
15.9 63.6 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
15.6 62.4 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
14.1 225.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
13.6 54.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
13.1 117.7 GO:0015232 heme transporter activity(GO:0015232)
11.9 142.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
8.0 40.0 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
6.9 20.8 GO:0032810 sterol response element binding(GO:0032810)
6.1 18.3 GO:0004736 pyruvate carboxylase activity(GO:0004736)
5.8 34.7 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
4.9 38.8 GO:0004630 phospholipase D activity(GO:0004630)
3.7 45.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
3.7 11.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
3.6 40.1 GO:0008131 primary amine oxidase activity(GO:0008131)
3.5 17.3 GO:0030283 testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
3.0 53.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.9 11.6 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
2.5 297.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.4 51.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
2.2 91.1 GO:0070330 aromatase activity(GO:0070330)
2.1 6.2 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
1.8 34.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.5 5.9 GO:0016149 translation release factor activity, codon specific(GO:0016149)
1.5 11.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
1.4 35.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
1.4 27.6 GO:0004806 triglyceride lipase activity(GO:0004806)
1.3 17.4 GO:0005283 sodium:amino acid symporter activity(GO:0005283) glycine transmembrane transporter activity(GO:0015187)
1.2 7.2 GO:0034235 GPI anchor binding(GO:0034235)
1.1 6.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.0 4.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
1.0 19.3 GO:0005537 mannose binding(GO:0005537)
0.8 18.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.8 37.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.8 4.7 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.7 32.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.7 54.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.6 15.8 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 1.7 GO:0031770 growth hormone-releasing hormone receptor binding(GO:0031770)
0.5 4.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.4 6.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 1.3 GO:0005119 smoothened binding(GO:0005119)
0.4 9.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 3.2 GO:0032052 bile acid binding(GO:0032052)
0.4 1.1 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.3 1.0 GO:0008169 C-methyltransferase activity(GO:0008169)
0.3 2.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 15.7 GO:0009055 electron carrier activity(GO:0009055)
0.2 52.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.7 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 37.7 GO:0005125 cytokine activity(GO:0005125)
0.2 3.0 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.1 7.1 GO:0043022 ribosome binding(GO:0043022)
0.1 8.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 8.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 4.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 2.1 GO:0042923 neuropeptide binding(GO:0042923)
0.1 5.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.5 GO:0005272 sodium channel activity(GO:0005272)
0.0 3.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.2 GO:0048039 ubiquinone binding(GO:0048039)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 29.7 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 61.2 ST G ALPHA S PATHWAY G alpha s Pathway
2.1 35.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
1.3 40.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
1.3 54.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
1.2 295.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1 38.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.1 11.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
1.0 158.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9 20.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.9 34.1 PID IL1 PATHWAY IL1-mediated signaling events
0.3 13.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.3 14.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.2 7.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.2 6.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.5 PID ARF6 PATHWAY Arf6 signaling events
0.1 8.9 PID P73PATHWAY p73 transcription factor network
0.1 2.7 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 185.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
8.4 142.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
4.4 61.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
4.0 40.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
2.7 23.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.1 13.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.0 18.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
1.0 11.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.0 17.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.8 33.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.8 40.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.8 23.2 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.8 141.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.8 17.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.7 34.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.6 13.1 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.6 40.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.6 11.0 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.6 9.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.6 8.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.5 18.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 4.9 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.2 11.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 6.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 5.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 6.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors