ISMARA results: Nr1h4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr1h4

Z-value: 1.56

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Transcription factors associated with Nr1h4

Gene Symbol	Gene ID	Gene Info
Nr1h4 NCBI RGD Ensembl	ENSRNOG00000007197	nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1h4	rn6_v1_chr7_-_30105132_30105132	0.60	4.7e-33	Click!

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_55587946 Show fit	182.67	ENSRNOT00000075107	Abcb11 NCBI RGD Ensembl Show fit	ATP binding cassette subfamily B member 11
chr16_-_7007287 Show fit	146.79	ENSRNOT00000041216	Itih3 NCBI RGD Ensembl Show fit	inter-alpha trypsin inhibitor, heavy chain 3
chr16_-_7007051 Show fit	143.69	ENSRNOT00000023984	Itih3 NCBI RGD Ensembl Show fit	inter-alpha trypsin inhibitor, heavy chain 3
chr9_+_74124016 Show fit	142.46	ENSRNOT00000019023	Cps1 NCBI RGD Ensembl Show fit	carbamoyl-phosphate synthase 1
chr7_+_2689501 Show fit	123.29	ENSRNOT00000041341	Apof NCBI RGD Ensembl Show fit	apolipoprotein F
chr1_-_170431073 Show fit	117.67	ENSRNOT00000024710	Hpx NCBI RGD Ensembl Show fit	hemopexin
chr13_+_89597138 Show fit	91.99	ENSRNOT00000004662	Apoa2 NCBI RGD Ensembl Show fit	apolipoprotein A2
chr7_-_123655896 Show fit	91.06	ENSRNOT00000012413	Cyp2d2 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily d, polypeptide 2
chr2_+_248649441 Show fit	63.57	ENSRNOT00000067165	Kyat3 NCBI RGD Ensembl Show fit	kynurenine aminotransferase 3
chr9_-_4945352 Show fit	62.39	ENSRNOT00000082530	Sult1c3 NCBI RGD Ensembl Show fit	sulfotransferase family 1C member 3

Showing 1 to 10 of 133 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.8	290.5	GO:0030212	hyaluronan metabolic process(GO:0030212)
26.1	182.7	GO:0015722	canalicular bile acid transport(GO:0015722)
28.5	142.5	GO:0071400	cellular response to oleic acid(GO:0071400)
2.7	124.6	GO:0033344	cholesterol efflux(GO:0033344)
29.4	117.7	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
30.7	92.0	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)
1.4	91.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
12.7	63.6	GO:0097052	L-kynurenine metabolic process(GO:0097052)
5.6	61.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
6.0	54.3	GO:0060763	mammary duct terminal end bud growth(GO:0060763)

Showing 1 to 10 of 80 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	213.0	GO:0072562	blood microparticle(GO:0072562)
0.1	202.2	GO:0070062	extracellular exosome(GO:0070062)
14.1	182.7	GO:0046581	intercellular canaliculus(GO:0046581)
14.5	174.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
3.1	159.7	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	119.4	GO:0005739	mitochondrion(GO:0005739)
0.2	110.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
15.3	92.0	GO:0042627	chylomicron(GO:0042627)
0.1	60.2	GO:0005615	extracellular space(GO:0005615)
0.2	46.3	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	297.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
14.1	225.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
11.9	142.5	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
13.1	117.7	GO:0015232	heme transporter activity(GO:0015232)
30.7	92.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
2.2	91.1	GO:0070330	aromatase activity(GO:0070330)
15.9	63.6	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
15.6	62.4	GO:0004027	alcohol sulfotransferase activity(GO:0004027)
13.6	54.3	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.7	54.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)

Showing 1 to 10 of 68 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	295.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.0	158.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.1	61.2	ST G ALPHA S PATHWAY	G alpha s Pathway
1.3	54.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
1.3	40.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
1.1	38.8	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
2.1	35.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.9	34.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.9	20.8	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	14.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.5	185.9	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
8.4	142.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.8	141.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
4.4	61.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.6	40.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.8	40.1	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
4.0	40.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.7	34.1	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.8	33.6	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
2.7	23.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 33 entries

Results for Nr1h4

Z-value: 1.56

Motif logo

Transcription factors associated with Nr1h4

Activity-expression correlation:

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: