ISMARA results: Nr1h2

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Nr1h2

Z-value: 0.89

Motif logo

Transcription factors associated with Nr1h2

Gene Symbol	Gene ID	Gene Info
Nr1h2 NCBI RGD Ensembl	ENSRNOG00000019812	nuclear receptor subfamily 1, group H, member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1h2	rn6_v1_chr1_-_100559942_100559942	-0.12	3.3e-02	Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_7058314 Show fit	39.14	ENSRNOT00000045996	Haao NCBI RGD Ensembl Show fit	3-hydroxyanthranilate 3,4-dioxygenase
chr15_+_33632416 Show fit	35.30	ENSRNOT00000068212	AC130940.1 NCBI RGD Ensembl Show fit
chr9_+_27402381 Show fit	31.59	ENSRNOT00000077372	Gsta3 NCBI RGD Ensembl Show fit	glutathione S-transferase alpha 3
chr10_-_62273119 Show fit	31.05	ENSRNOT00000004322	Serpinf2 NCBI RGD Ensembl Show fit	serpin family F member 2
chr2_+_60337667 Show fit	28.06	ENSRNOT00000024035	Agxt2 NCBI RGD Ensembl Show fit	alanine-glyoxylate aminotransferase 2
chr13_-_82758004 Show fit	26.68	ENSRNOT00000003932	Atp1b1 NCBI RGD Ensembl Show fit	ATPase Na+/K+ transporting subunit beta 1
chr1_+_224824799 Show fit	26.39	ENSRNOT00000024757	Slc22a6 NCBI RGD Ensembl Show fit	solute carrier family 22 member 6
chr16_-_81797815 Show fit	24.86	ENSRNOT00000026666	Proz NCBI RGD Ensembl Show fit	protein Z, vitamin K-dependent plasma glycoprotein
chr4_+_122365093 Show fit	24.81	ENSRNOT00000024011	Klf15 NCBI RGD Ensembl Show fit	Kruppel-like factor 15
chr12_+_9446940 Show fit	22.32	ENSRNOT00000074791	Urad NCBI RGD Ensembl Show fit	ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

Showing 1 to 10 of 175 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
9.8	39.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	33.0	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
10.5	31.6	GO:0046223	toxin catabolic process(GO:0009407) mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) secondary metabolite catabolic process(GO:0090487) organic heteropentacyclic compound catabolic process(GO:1901377)
6.2	31.1	GO:0002034	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
1.1	28.5	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
9.4	28.1	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate(GO:0019265)
0.7	26.8	GO:0001702	gastrulation with mouth forming second(GO:0001702)
8.9	26.7	GO:1903281	positive regulation of calcium:sodium antiporter activity(GO:1903281)
4.4	26.4	GO:0031427	response to methotrexate(GO:0031427)
0.5	24.9	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)

Showing 1 to 10 of 74 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	62.8	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	49.7	GO:0031966	mitochondrial membrane(GO:0031966)
3.9	31.1	GO:0005577	fibrinogen complex(GO:0005577)
2.2	26.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3	26.6	GO:0005776	autophagosome(GO:0005776)
0.2	26.4	GO:0005901	caveola(GO:0005901)
0.5	17.5	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.6	17.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
1.2	15.5	GO:0042627	chylomicron(GO:0042627)
1.4	13.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	44.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.4	39.1	GO:0019825	oxygen binding(GO:0019825)
2.0	38.5	GO:0030955	potassium ion binding(GO:0030955)
0.8	31.6	GO:0004364	glutathione transferase activity(GO:0004364)
0.3	31.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
5.6	28.1	GO:0008453	alanine-glyoxylate transaminase activity(GO:0008453)
3.3	26.4	GO:0031404	chloride ion binding(GO:0031404)
0.3	24.8	GO:0051213	dioxygenase activity(GO:0051213)
0.5	22.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.2	18.5	GO:0043130	ubiquitin binding(GO:0043130)

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	32.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	9.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	9.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.4	8.7	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	7.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	5.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.1	2.8	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.3	39.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
1.1	31.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	31.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
2.2	28.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.9	26.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
2.4	26.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
2.5	24.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.6	16.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	13.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	12.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 29 entries

Results for Nr1h2

Z-value: 0.89

Motif logo

Transcription factors associated with Nr1h2

Activity-expression correlation:

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: