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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr0b1

Z-value: 0.25

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Transcription factors associated with Nr0b1

Gene Symbol Gene ID Gene Info
Nr0b1
ENSRNOG00000003765 nuclear receptor subfamily 0, group B, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr0b1rn6_v1_chrX_+_54734385_547343850.172.7e-03Click!

Activity profile of Nr0b1 motif

Sorted Z-values of Nr0b1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_83471342 10.34 ENSRNOT00000019384
Neto1
neuropilin and tolloid like 1
chr12_+_31530699 8.58 ENSRNOT00000033379
ENSRNOT00000067867
Rimbp2
RIMS binding protein 2
chr3_-_39596718 4.98 ENSRNOT00000006784
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_186245342 4.07 ENSRNOT00000057062
ENSRNOT00000022292
Dclk2
doublecortin-like kinase 2
chr7_+_80351774 3.78 ENSRNOT00000081948
Oxr1
oxidation resistance 1
chr6_+_108167716 3.52 ENSRNOT00000064426
Lin52
lin-52 DREAM MuvB core complex component
chr2_-_84531192 3.15 ENSRNOT00000065312
ENSRNOT00000090540
Ropn1l
rhophilin associated tail protein 1-like
chr5_+_135074297 3.14 ENSRNOT00000000157
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr3_+_97721668 2.67 ENSRNOT00000065168
Mpped2
metallophosphoesterase domain containing 2
chr8_-_50277797 2.46 ENSRNOT00000082508
Pafah1b2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
chr8_+_49441106 2.19 ENSRNOT00000030152
Scn4b
sodium voltage-gated channel beta subunit 4
chr9_+_95221474 1.97 ENSRNOT00000066839
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chrX_-_134866210 1.92 ENSRNOT00000005331
Apln
apelin
chr2_+_113066885 1.68 ENSRNOT00000034960
Ghsr
growth hormone secretagogue receptor
chr9_+_66568074 1.41 ENSRNOT00000035238
Bmpr2
bone morphogenetic protein receptor type 2
chr19_-_26194198 1.31 ENSRNOT00000005917
Wdr83
WD repeat domain 83
chr3_+_153398130 0.57 ENSRNOT00000068135
Rpn2
ribophorin II
chr10_-_6870011 0.45 ENSRNOT00000003439
RGD1309748
similar to CG4768-PA
chr4_-_156427755 0.13 ENSRNOT00000085675
ENSRNOT00000014030
LOC103690024
peroxisomal targeting signal 1 receptor-like
chr4_-_157008947 0.09 ENSRNOT00000073341
Pex5
peroxisomal biogenesis factor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.6 1.7 GO:0043133 hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.5 1.9 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.5 1.4 GO:0003249 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) regulation of lung blood pressure(GO:0014916) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.4 3.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 2.0 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.2 4.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 3.1 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 2.2 GO:0086027 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.1 3.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 8.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:1901091 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.0 2.5 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 5.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 10.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.5 3.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 3.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.2 GO:0031514 motile cilium(GO:0031514)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 4.1 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.6 1.7 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.5 3.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 2.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 1.4 GO:0098821 BMP receptor activity(GO:0098821)
0.2 10.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 2.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 1.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 2.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP