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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx6-2

Z-value: 0.60

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Transcription factors associated with Nkx6-2

Gene Symbol Gene ID Gene Info
Nkx6-2
ENSRNOG00000017748 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx6-2rn6_v1_chr1_-_211923929_2119239290.115.1e-02Click!

Activity profile of Nkx6-2 motif

Sorted Z-values of Nkx6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_115387377 17.01 ENSRNOT00000036030
ENSRNOT00000077492
RGD1560146
similar to hypothetical protein MGC34837
chr1_+_83933942 11.53 ENSRNOT00000068690
Cyp2f4
cytochrome P450, family 2, subfamily f, polypeptide 4
chr20_+_20577561 11.14 ENSRNOT00000081113
Cdk1
cyclin-dependent kinase 1
chr10_+_45289741 10.56 ENSRNOT00000066190
Hist3h2ba
histone cluster 3, H2ba
chr10_-_86930947 10.32 ENSRNOT00000081440
Top2a
topoisomerase (DNA) II alpha
chr2_+_206064394 10.22 ENSRNOT00000077739
Syt6
synaptotagmin 6
chr17_+_43616247 8.62 ENSRNOT00000072019
Hist1h3a
histone cluster 1, H3a
chr2_+_92559929 8.29 ENSRNOT00000033404
tGap1
GTPase activating protein testicular GAP1
chr2_-_173800761 8.21 ENSRNOT00000039524
Wdr49
WD repeat domain 49
chr2_+_206064179 8.20 ENSRNOT00000025953
Syt6
synaptotagmin 6
chr8_+_23398030 7.08 ENSRNOT00000031893
RGD1561444
similar to RIKEN cDNA 9530077C05
chr19_+_25391700 6.79 ENSRNOT00000011163
LOC100359539
ribonucleotide reductase M2 polypeptide
chr15_+_87722221 6.60 ENSRNOT00000082688
Scel
sciellin
chr1_-_4550768 6.50 ENSRNOT00000061954
Adgb
androglobin
chr20_+_32450733 6.22 ENSRNOT00000036449
Rsph4a
radial spoke head 4 homolog A
chr14_-_43143973 5.93 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr3_-_60611924 5.73 ENSRNOT00000068745
Chn1
chimerin 1
chr2_-_96509424 5.61 ENSRNOT00000090866
Zc2hc1a
zinc finger, C2HC-type containing 1A
chr18_-_26211445 5.49 ENSRNOT00000027739
Nrep
neuronal regeneration related protein
chr18_-_58423196 5.49 ENSRNOT00000025556
Piezo2
piezo-type mechanosensitive ion channel component 2
chr7_-_120839577 5.44 ENSRNOT00000018526
Dmc1
DNA meiotic recombinase 1
chr2_-_124047044 5.27 ENSRNOT00000065384
Cetn4
centrin 4
chr5_+_119097715 5.25 ENSRNOT00000045987
Ror1
receptor tyrosine kinase-like orphan receptor 1
chr5_+_133819726 5.21 ENSRNOT00000081075
Stil
Scl/Tal1 interrupting locus
chr7_+_34402738 5.21 ENSRNOT00000030985
Ccdc38
coiled-coil domain containing 38
chr9_+_73378057 5.14 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
Map2
microtubule-associated protein 2
chr3_+_70327193 4.67 ENSRNOT00000089165
Fsip2
fibrous sheath-interacting protein 2
chr6_-_76552559 4.45 ENSRNOT00000065230
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chr3_+_113918629 4.25 ENSRNOT00000078978
ENSRNOT00000037168
Ctdspl2
CTD small phosphatase like 2
chr14_-_21299068 4.05 ENSRNOT00000065778
Amtn
amelotin
chr16_+_3817402 3.88 ENSRNOT00000015011
Tmem254
transmembrane protein 254
chr14_-_72025137 3.74 ENSRNOT00000080604
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr7_-_122644054 3.67 ENSRNOT00000025941
Dnajb7
DnaJ heat shock protein family (Hsp40) member B7
chr4_-_8502280 3.65 ENSRNOT00000036164
AABR07059201.1

chr3_-_121835360 3.61 ENSRNOT00000006126
ENSRNOT00000080818
Il1a
interleukin 1 alpha
chr6_-_95934296 3.55 ENSRNOT00000034338
Six1
SIX homeobox 1
chr3_-_56030744 3.55 ENSRNOT00000089637
Ccdc173
coiled-coil domain containing 173
chr3_+_94549180 3.49 ENSRNOT00000016318
Cstf3
cleavage stimulation factor subunit 3
chr8_+_85259982 3.35 ENSRNOT00000010409
Elovl5
ELOVL fatty acid elongase 5
chrX_+_6273733 3.31 ENSRNOT00000074275
Ndp
NDP, norrin cystine knot growth factor
chr3_-_37803112 3.20 ENSRNOT00000059461
Neb
nebulin
chr9_-_81879211 3.09 ENSRNOT00000085140
Rnf25
ring finger protein 25
chr14_-_72122158 2.94 ENSRNOT00000064495
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr20_+_42966140 2.93 ENSRNOT00000000707
Marcks
myristoylated alanine rich protein kinase C substrate
chr1_-_67284864 2.93 ENSRNOT00000082908
LOC691661
similar to zinc finger and SCAN domain containing 4
chr2_+_210880777 2.88 ENSRNOT00000026237
Gnat2
G protein subunit alpha transducin 2
chr16_+_46731403 2.88 ENSRNOT00000017624
Tenm3
teneurin transmembrane protein 3
chr2_-_198706428 2.82 ENSRNOT00000085006
Polr3gl
RNA polymerase III subunit G like
chr18_+_30904498 2.76 ENSRNOT00000026969
Pcdhga11
protocadherin gamma subfamily A, 11
chr4_-_727691 2.73 ENSRNOT00000008497
Shh
sonic hedgehog
chr12_+_39423596 2.67 ENSRNOT00000066952
Ift81
intraflagellar transport 81
chr5_+_173447784 2.63 ENSRNOT00000027251
Tnfrsf4
TNF receptor superfamily member 4
chr4_-_66955732 2.61 ENSRNOT00000084282
Kdm7a
lysine (K)-specific demethylase 7A
chr1_+_193424812 2.56 ENSRNOT00000019939
Aqp8
aquaporin 8
chr8_+_79638696 2.54 ENSRNOT00000085959
Dyx1c1
dyslexia susceptibility 1 candidate 1
chrX_+_31984612 2.53 ENSRNOT00000005181
Bmx
BMX non-receptor tyrosine kinase
chr14_+_88549947 2.52 ENSRNOT00000086177
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr1_+_99616447 2.45 ENSRNOT00000029197
Klk14
kallikrein related-peptidase 14
chr10_-_85717511 2.44 ENSRNOT00000005445
LOC691189
hypothetical protein LOC691189
chr9_-_78693028 2.41 ENSRNOT00000036359
Abca12
ATP binding cassette subfamily A member 12
chr2_+_243577082 2.38 ENSRNOT00000016556
Adh6a
alcohol dehydrogenase 6A (class V)
chr4_-_135069970 2.30 ENSRNOT00000008221
Cntn3
contactin 3
chr20_+_27173213 2.25 ENSRNOT00000073617
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
chr7_+_64769089 2.24 ENSRNOT00000088861
Grip1
glutamate receptor interacting protein 1
chr4_+_162281574 2.18 ENSRNOT00000087850
Clec2d
C-type lectin domain family 2, member D
chr3_+_8430829 2.16 ENSRNOT00000090440
ENSRNOT00000060969
Cercam
cerebral endothelial cell adhesion molecule
chr4_-_163762434 2.14 ENSRNOT00000081854
Ly49si1
immunoreceptor Ly49si1
chr1_-_14117021 2.12 ENSRNOT00000004344
RGD1560303
similar to hypothetical protein 4933423E17
chr8_+_115546893 2.10 ENSRNOT00000018932
Dcaf1
DDB1 and CUL4 associated factor 1
chrX_-_153457040 2.10 ENSRNOT00000084905
LOC689600
hypothetical protein LOC689600
chrX_+_131381134 2.07 ENSRNOT00000007474
AABR07041481.1

chr3_+_153491151 2.04 ENSRNOT00000047047
Manbal
mannosidase beta like
chrX_+_110016995 2.02 ENSRNOT00000093542
Nrk
Nik related kinase
chr4_-_51931112 2.02 ENSRNOT00000080575
Pot1
protection of telomeres 1
chr10_-_43599232 1.94 ENSRNOT00000044299
Gemin5
gem (nuclear organelle) associated protein 5
chr2_-_138833933 1.94 ENSRNOT00000013343
Pcdh18
protocadherin 18
chr13_-_104284068 1.86 ENSRNOT00000005407
LOC100912365
uncharacterized LOC100912365
chr2_-_128675408 1.75 ENSRNOT00000019256
Sclt1
sodium channel and clathrin linker 1
chr17_+_9596957 1.73 ENSRNOT00000017349
Fam193b
family with sequence similarity 193, member B
chr15_+_56666012 1.73 ENSRNOT00000013408
Htr2a
5-hydroxytryptamine receptor 2A
chrX_-_138112408 1.70 ENSRNOT00000077028
Frmd7
FERM domain containing 7
chr20_+_27212724 1.66 ENSRNOT00000032600
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
chr15_-_38096875 1.65 ENSRNOT00000032723
Ska3
spindle and kinetochore associated complex subunit 3
chr18_+_30496318 1.60 ENSRNOT00000027179
Pcdhb11
protocadherin beta 11
chr4_-_150522351 1.60 ENSRNOT00000079053
Zfp9
zinc finger protein 9
chr2_+_127459012 1.59 ENSRNOT00000093685
ENSRNOT00000072675
Intu
inturned planar cell polarity protein
chr6_+_100337226 1.52 ENSRNOT00000011220
Fut8
fucosyltransferase 8
chr10_+_65552897 1.46 ENSRNOT00000056217
Spag5
sperm associated antigen 5
chr7_-_144837583 1.41 ENSRNOT00000055289
Cbx5
chromobox 5
chr7_-_11223649 1.39 ENSRNOT00000061191
Mfsd12
major facilitator superfamily domain containing 12
chr9_+_20951260 1.36 ENSRNOT00000016906
Adgrf4
adhesion G protein-coupled receptor F4
chr4_+_168775111 1.36 ENSRNOT00000011096
Ddx47
DEAD-box helicase 47
chr16_+_90325304 1.35 ENSRNOT00000057310
Slc10a2
solute carrier family 10 member 2
chr13_+_104284660 1.30 ENSRNOT00000005400
Dusp10
dual specificity phosphatase 10
chr12_-_51877624 1.29 ENSRNOT00000056800
Chek2
checkpoint kinase 2
chr18_-_77535564 1.26 ENSRNOT00000041380
ENSRNOT00000090265
Atp9b
ATPase phospholipid transporting 9B (putative)
chr5_-_128730446 1.22 ENSRNOT00000089441
Osbpl9
oxysterol binding protein-like 9
chr17_-_53915076 1.21 ENSRNOT00000010836
Arid4b
AT-rich interaction domain 4B
chr1_+_99706780 1.15 ENSRNOT00000024758
Klk12
kallikrein related-peptidase 12
chr13_-_47916185 1.11 ENSRNOT00000087793
Dyrk3
dual specificity tyrosine phosphorylation regulated kinase 3
chr17_+_34704616 1.10 ENSRNOT00000090706
ENSRNOT00000083674
ENSRNOT00000077110
Exoc2
exocyst complex component 2
chr4_+_10748745 1.07 ENSRNOT00000046142
Rsbn1l
round spermatid basic protein 1-like
chr6_+_129621070 1.07 ENSRNOT00000091338
Papola
poly (A) polymerase alpha
chrX_-_123731294 0.99 ENSRNOT00000092574
ENSRNOT00000032618
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr7_+_23854846 0.95 ENSRNOT00000037290
Bpifc
BPI fold containing family C
chr15_-_82581916 0.91 ENSRNOT00000057891
RGD1560069
similar to ribosomal protein L27
chr4_+_162292305 0.90 ENSRNOT00000010098
Clec2d
C-type lectin domain family 2, member D
chr2_-_137153551 0.89 ENSRNOT00000083443
AABR07010476.1

chr15_+_30525754 0.88 ENSRNOT00000086842
AABR07017745.2

chr3_+_55461420 0.86 ENSRNOT00000073549
G6pc2
glucose-6-phosphatase catalytic subunit 2
chr10_-_104482838 0.86 ENSRNOT00000007246
Recql5
RecQ like helicase 5
chr17_+_35435079 0.83 ENSRNOT00000074800
Exoc2
exocyst complex component 2
chr3_+_152402520 0.81 ENSRNOT00000027086
Cnbd2
cyclic nucleotide binding domain containing 2
chr4_-_160662974 0.80 ENSRNOT00000089199
Tspan9
tetraspanin 9
chr9_+_73334618 0.75 ENSRNOT00000092717
Map2
microtubule-associated protein 2
chr9_+_1313209 0.72 ENSRNOT00000083387
Tbc1d5
TBC1 domain family, member 5
chrX_+_124631881 0.71 ENSRNOT00000009329
Atp1b4
ATPase Na+/K+ transporting family member beta 4
chr19_+_27603307 0.68 ENSRNOT00000074702
AABR07043347.1

chr13_-_52413681 0.66 ENSRNOT00000037100
ENSRNOT00000011801
Nav1
neuron navigator 1
chr13_+_88644520 0.64 ENSRNOT00000003979
Spata46
spermatogenesis associated 46
chr19_-_43192208 0.64 ENSRNOT00000025179
Exosc6
exosome component 6
chr10_+_38661901 0.64 ENSRNOT00000009098
Zcchc10
zinc finger CCHC-type containing 10
chr9_-_10369937 0.60 ENSRNOT00000071228
ENSRNOT00000072911
ENSRNOT00000072009
Ranbp3
RAN binding protein 3
chr1_-_229601032 0.59 ENSRNOT00000016690
Cntf
ciliary neurotrophic factor
chr15_-_88036354 0.58 ENSRNOT00000014747
Ednrb
endothelin receptor type B
chr1_-_150101177 0.53 ENSRNOT00000042931
Olr24
olfactory receptor 24
chr9_+_20251521 0.52 ENSRNOT00000005535
LOC100911625
gamma-enolase-like
chr15_-_19575914 0.52 ENSRNOT00000043897
AABR07017253.1

chr19_-_21970103 0.51 ENSRNOT00000074210
AABR07043115.1

chr15_-_32925673 0.49 ENSRNOT00000081045
Olr1646
olfactory receptor 1646
chrX_+_22342308 0.48 ENSRNOT00000079909
ENSRNOT00000087945
ENSRNOT00000077528
Kdm5c
lysine demethylase 5C
chr10_+_104483042 0.46 ENSRNOT00000007362
Sap30bp
SAP30 binding protein
chr3_-_104018861 0.45 ENSRNOT00000008387
Chrm5
cholinergic receptor, muscarinic 5
chr17_+_25082056 0.45 ENSRNOT00000037041
AABR07027339.1

chr4_-_157294047 0.43 ENSRNOT00000005601
Eno2
enolase 2
chr19_-_11669578 0.42 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr14_+_108007724 0.38 ENSRNOT00000014062
Xpo1
exportin 1
chr11_+_82415995 0.38 ENSRNOT00000051772
AABR07034641.1

chr9_+_53546018 0.36 ENSRNOT00000016842
Inpp1
inositol polyphosphate-1-phosphatase
chr8_-_76239995 0.36 ENSRNOT00000071321
LOC100912027
60S ribosomal protein L27-like
chr10_+_29033989 0.36 ENSRNOT00000088322
Slu7
SLU7 homolog, splicing factor
chr12_+_51878153 0.36 ENSRNOT00000056798
Hscb
HscB mitochondrial iron-sulfur cluster co-chaperone
chr5_-_102743417 0.31 ENSRNOT00000067389
Bnc2
basonuclin 2
chr1_-_150173316 0.31 ENSRNOT00000044676
Olr27
olfactory receptor 27
chr13_+_67545430 0.30 ENSRNOT00000003405
Pdc
phosducin
chr20_+_41266566 0.22 ENSRNOT00000000653
Frk
fyn-related Src family tyrosine kinase
chrX_-_138237157 0.07 ENSRNOT00000003414
Rap2c
RAP2C, member of RAS oncogene family
chr7_-_40315377 0.06 ENSRNOT00000091319
ENSRNOT00000036141
RGD1307947
similar to RIKEN cDNA C430008C19
chr16_-_930527 0.06 ENSRNOT00000014787
Spin1
spindlin 1
chr2_-_225025972 0.03 ENSRNOT00000091767
AABR07013154.2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0042196 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
3.7 18.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
2.1 6.3 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
1.7 10.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
1.6 11.1 GO:0090166 Golgi disassembly(GO:0090166)
1.3 4.0 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
1.2 3.6 GO:1904444 regulation of establishment of Sertoli cell barrier(GO:1904444)
0.8 5.4 GO:0042148 strand invasion(GO:0042148)
0.7 2.0 GO:0060383 positive regulation of DNA strand elongation(GO:0060383)
0.7 3.4 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.7 5.9 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.6 5.2 GO:0033504 floor plate development(GO:0033504)
0.6 1.7 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.6 3.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 2.1 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.5 2.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.5 2.4 GO:0035627 ceramide transport(GO:0035627)
0.4 6.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 2.5 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.4 2.9 GO:0031584 activation of phospholipase D activity(GO:0031584) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.4 2.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.4 1.5 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.4 2.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.3 2.0 GO:0060723 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.3 1.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 1.3 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.3 2.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 2.9 GO:0097264 self proteolysis(GO:0097264)
0.2 1.9 GO:0001927 exocyst assembly(GO:0001927) entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.2 2.9 GO:0046549 retinal cone cell development(GO:0046549)
0.2 2.5 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.1 GO:0035617 stress granule disassembly(GO:0035617)
0.2 0.9 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.2 5.8 GO:0014002 astrocyte development(GO:0014002)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 0.6 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.2 1.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 0.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 4.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.2 18.5 GO:0006334 nucleosome assembly(GO:0006334)
0.2 2.5 GO:0007320 insemination(GO:0007320)
0.1 5.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 2.1 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.1 1.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 11.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 0.6 GO:0071051 U4 snRNA 3'-end processing(GO:0034475) DNA deamination(GO:0045006) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.9 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.4 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 5.5 GO:0031103 axon regeneration(GO:0031103)
0.1 1.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.3 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.1 6.6 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 2.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.7 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 0.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 1.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 5.5 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 3.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.3 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.5 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 1.1 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 1.0 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 3.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 8.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 2.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 6.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.3 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.6 10.3 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.9 18.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.9 2.6 GO:0046691 intracellular canaliculus(GO:0046691)
0.8 2.5 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.7 2.9 GO:0042585 germinal vesicle(GO:0042585) dendritic branch(GO:0044307)
0.6 5.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 2.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 2.0 GO:0070187 telosome(GO:0070187)
0.2 0.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 19.2 GO:0000786 nucleosome(GO:0000786)
0.2 3.9 GO:0019013 viral nucleocapsid(GO:0019013)
0.2 1.8 GO:0071439 clathrin complex(GO:0071439)
0.2 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.9 GO:0032797 SMN complex(GO:0032797)
0.1 1.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 4.0 GO:0005605 basal lamina(GO:0005605)
0.1 2.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.7 GO:0070852 cell body fiber(GO:0070852)
0.1 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.7 GO:0097225 sperm midpiece(GO:0097225)
0.1 6.7 GO:0005581 collagen trimer(GO:0005581)
0.1 3.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.1 1.4 GO:0010369 chromocenter(GO:0010369)
0.1 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 2.1 GO:0008180 COP9 signalosome(GO:0008180)
0.1 5.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 6.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 5.2 GO:0005814 centriole(GO:0005814)
0.0 4.8 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.0 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.2 GO:0030018 Z disc(GO:0030018)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.3 GO:0000502 proteasome complex(GO:0000502)
0.0 2.3 GO:0055037 recycling endosome(GO:0055037)
0.0 8.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.3 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.9 5.7 GO:0001565 phorbol ester receptor activity(GO:0001565)
1.5 5.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.1 6.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 5.4 GO:0000150 recombinase activity(GO:0000150)
0.7 2.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.6 1.7 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
0.6 11.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.5 2.0 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.5 1.9 GO:0030622 U4atac snRNA binding(GO:0030622)
0.4 11.5 GO:0019825 oxygen binding(GO:0019825)
0.4 2.4 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.4 21.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 2.7 GO:0043237 laminin-1 binding(GO:0043237)
0.3 3.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 2.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 6.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 5.9 GO:0002162 dystroglycan binding(GO:0002162)
0.3 2.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.2 1.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 3.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 2.6 GO:0015250 water channel activity(GO:0015250)
0.2 5.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 0.9 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.1 GO:0035174 AMP-activated protein kinase activity(GO:0004679) histone serine kinase activity(GO:0035174)
0.1 1.5 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 3.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 3.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 1.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.6 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 3.3 GO:0005109 frizzled binding(GO:0005109)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 3.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.7 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 9.0 GO:0042393 histone binding(GO:0042393)
0.0 2.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.0 GO:0051087 chaperone binding(GO:0051087)
0.0 11.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 1.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.4 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.6 GO:0004532 exoribonuclease activity(GO:0004532)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 11.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 7.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 13.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.9 PID CONE PATHWAY Visual signal transduction: Cones
0.1 5.9 PID LKB1 PATHWAY LKB1 signaling events
0.1 4.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 4.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 1.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 2.0 PID TNF PATHWAY TNF receptor signaling pathway
0.0 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 3.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 8.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 2.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 2.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 4.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 2.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 5.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 2.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 3.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 2.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 4.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis