ISMARA results: Nkx6-1_Evx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx6-1_Evx1_Hesx1

Z-value: 1.04

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Transcription factors associated with Nkx6-1_Evx1_Hesx1

Gene Symbol	Gene ID	Gene Info
Nkx6-1 NCBI RGD Ensembl	ENSRNOG00000002149	NK6 homeobox 1
Hesx1 NCBI RGD Ensembl	ENSRNOG00000014133	HESX homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nkx6-1	rn6_v1_chr14_+_9555264_9555264	0.27	8.2e-07	Click!
Hesx1	rn6_v1_chr16_+_2634603_2634603	-0.09	1.0e-01	Click!

Activity profile of Nkx6-1_Evx1_Hesx1 motif

Sorted Z-values of Nkx6-1_Evx1_Hesx1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_84506328 Show fit	55.75	ENSRNOT00000064754	Mlip NCBI RGD Ensembl Show fit	muscular LMNA-interacting protein
chr9_-_30844199 Show fit	50.39	ENSRNOT00000017169	Col19a1 NCBI RGD Ensembl Show fit	collagen type XIX alpha 1 chain
chr16_+_29674793 Show fit	40.79	ENSRNOT00000059724	Anxa10 NCBI RGD Ensembl Show fit	annexin A10
chr1_+_198383201 Show fit	36.36	ENSRNOT00000037405	Sez6l2 NCBI RGD Ensembl Show fit	seizure related 6 homolog like 2
chr3_-_52447622 Show fit	34.74	ENSRNOT00000083552	Scn1a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 1
chr7_-_69982592 Show fit	34.29	ENSRNOT00000040010	RGD1564306 NCBI RGD Ensembl Show fit	similar to developmental pluripotency associated 5
chrX_+_118197217 Show fit	31.44	ENSRNOT00000090922	Htr2c NCBI RGD Ensembl Show fit	5-hydroxytryptamine receptor 2C
chr4_-_55011415 Show fit	28.68	ENSRNOT00000056996	Grm8 NCBI RGD Ensembl Show fit	glutamate metabotropic receptor 8
chr15_+_11298478 Show fit	28.45	ENSRNOT00000007672	Lrrc3b NCBI RGD Ensembl Show fit	leucine rich repeat containing 3B
chr8_+_33239139 Show fit	28.24	ENSRNOT00000011589	Arhgap32 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 32

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-1_Evx1_Hesx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	204.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.5	93.1	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
0.5	74.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.0	55.8	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
3.6	46.7	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
15.3	45.8	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
1.6	42.1	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
2.4	40.3	GO:0021860	pyramidal neuron development(GO:0021860)
1.9	36.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
9.0	35.9	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)

Showing 1 to 10 of 301 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	112.8	GO:0043025	neuronal cell body(GO:0043025)
1.9	95.3	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
3.9	77.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.1	63.6	GO:0005739	mitochondrion(GO:0005739)
7.0	62.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.5	55.8	GO:0016605	PML body(GO:0016605)
0.2	51.8	GO:0015629	actin cytoskeleton(GO:0015629)
0.1	41.2	GO:0016607	nuclear speck(GO:0016607)
2.6	39.4	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
1.2	36.9	GO:0031430	M band(GO:0031430)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	120.4	GO:0004984	olfactory receptor activity(GO:0004984)
3.6	97.7	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2	80.0	GO:0005549	odorant binding(GO:0005549)
2.8	75.2	GO:0031402	sodium ion binding(GO:0031402)
0.1	72.3	GO:0005509	calcium ion binding(GO:0005509)
1.3	49.4	GO:0015301	anion:anion antiporter activity(GO:0015301)
15.3	45.8	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
0.2	42.3	GO:0005096	GTPase activator activity(GO:0005096)
0.6	41.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.4	38.1	GO:0016503	pheromone receptor activity(GO:0016503)

Showing 1 to 10 of 236 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	48.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	37.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.7	33.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	27.2	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	27.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.0	25.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	21.0	PID LKB1 PATHWAY	LKB1 signaling events
0.3	16.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	14.4	PID FGF PATHWAY	FGF signaling pathway
0.3	14.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	45.8	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
1.3	34.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.5	33.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.1	33.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	27.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	27.0	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
2.6	23.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.4	23.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.8	22.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	20.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 78 entries

Results for Nkx6-1_Evx1_Hesx1

Z-value: 1.04

Motif logo

Transcription factors associated with Nkx6-1_Evx1_Hesx1

Activity-expression correlation:

Activity profile of Nkx6-1_Evx1_Hesx1 motif

Sorted Z-values of Nkx6-1_Evx1_Hesx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-1_Evx1_Hesx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: