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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nkx2-9
Z-value: 1.06
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Transcription factors associated with Nkx2-9
| Gene Symbol | Gene ID | Gene Info |
|---|
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-8 | rn6_v1_chr6_-_77508585_77508585 | 0.32 | 2.9e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_107952530 Show fit | 46.58 |
ENSRNOT00000052043
|
claudin 18 |
|
| chr6_-_138662365 Show fit | 40.53 |
ENSRNOT00000066209
ENSRNOT00000084892 |
immunoglobulin heavy constant mu |
|
| chr6_-_142903440 Show fit | 31.74 |
ENSRNOT00000075707
|
|
|
| chr10_-_31493419 Show fit | 28.27 |
ENSRNOT00000009211
|
IL2-inducible T-cell kinase |
|
| chr6_-_140880070 Show fit | 24.73 |
ENSRNOT00000073779
|
uncharacterized LOC691828 |
|
| chr6_-_140102325 Show fit | 24.25 |
ENSRNOT00000072238
|
|
|
| chr5_-_157199441 Show fit | 24.05 |
ENSRNOT00000022559
|
phospholipase A2, group IIF |
|
| chr14_+_48726045 Show fit | 21.41 |
ENSRNOT00000086646
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chrX_-_105390580 Show fit | 21.23 |
ENSRNOT00000077547
|
Bruton tyrosine kinase |
|
| chr7_+_28654733 Show fit | 21.02 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx2-9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.5 | 46.6 | GO:2001205 | negative regulation of osteoclast development(GO:2001205) |
| 2.6 | 28.3 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.7 | 24.1 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 5.3 | 21.2 | GO:0002343 | peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344) cellular response to molecule of fungal origin(GO:0071226) |
| 4.2 | 21.0 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 1.7 | 19.8 | GO:1900165 | negative regulation of interleukin-6 secretion(GO:1900165) |
| 5.4 | 16.1 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) |
| 5.3 | 16.0 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 3.1 | 15.3 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.1 | 14.4 | GO:0009791 | post-embryonic development(GO:0009791) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.2 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 1.3 | 36.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 24.0 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 21.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 19.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 15.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.8 | 13.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 12.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 11.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 11.4 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 53.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.8 | 42.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.5 | 28.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.7 | 24.1 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.5 | 21.0 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 16.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 16.0 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 5.1 | 15.3 | GO:0004918 | interleukin-8 receptor activity(GO:0004918) |
| 0.8 | 14.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 14.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 49.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.6 | 32.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 21.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.4 | 16.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.6 | 15.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 14.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 9.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 46.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 29.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.0 | 28.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 1.5 | 24.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.2 | 23.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 21.2 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.5 | 20.2 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.3 | 15.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.3 | 13.1 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.5 | 12.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |